JP2022548078A5 - - Google Patents

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Publication number
JP2022548078A5
JP2022548078A5 JP2022516301A JP2022516301A JP2022548078A5 JP 2022548078 A5 JP2022548078 A5 JP 2022548078A5 JP 2022516301 A JP2022516301 A JP 2022516301A JP 2022516301 A JP2022516301 A JP 2022516301A JP 2022548078 A5 JP2022548078 A5 JP 2022548078A5
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JP
Japan
Prior art keywords
cancer
binding molecule
sequence
molecule according
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2022516301A
Other languages
English (en)
Japanese (ja)
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JP2022548078A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/051589 external-priority patent/WO2021055816A1/en
Publication of JP2022548078A publication Critical patent/JP2022548078A/ja
Publication of JP2022548078A5 publication Critical patent/JP2022548078A5/ja
Ceased legal-status Critical Current

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JP2022516301A 2019-09-18 2020-09-18 志賀毒素aサブユニット足場を含むpd-l1結合分子 Ceased JP2022548078A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962902243P 2019-09-18 2019-09-18
US62/902,243 2019-09-18
US201962933197P 2019-11-08 2019-11-08
US62/933,197 2019-11-08
US202062970610P 2020-02-05 2020-02-05
US62/970,610 2020-02-05
US202063041288P 2020-06-19 2020-06-19
US63/041,288 2020-06-19
PCT/US2020/051589 WO2021055816A1 (en) 2019-09-18 2020-09-18 Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds

Publications (2)

Publication Number Publication Date
JP2022548078A JP2022548078A (ja) 2022-11-16
JP2022548078A5 true JP2022548078A5 (https=) 2023-09-12

Family

ID=74868414

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022516301A Ceased JP2022548078A (ja) 2019-09-18 2020-09-18 志賀毒素aサブユニット足場を含むpd-l1結合分子

Country Status (9)

Country Link
US (1) US11136395B2 (https=)
EP (1) EP4031576A1 (https=)
JP (1) JP2022548078A (https=)
KR (1) KR20220081977A (https=)
CN (1) CN114423793A (https=)
AU (1) AU2020348861B2 (https=)
CA (1) CA3149621A1 (https=)
IL (1) IL291402A (https=)
MX (1) MX2022003195A (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112851769A (zh) 2014-01-27 2021-05-28 分子模板公司 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
EP3303373B1 (en) 2015-05-30 2020-04-08 Molecular Templates, Inc. De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
WO2018106895A1 (en) 2016-12-07 2018-06-14 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
MX2019008840A (es) * 2017-01-25 2019-09-09 Molecular Templates Inc Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
EP4262858A1 (en) 2020-12-16 2023-10-25 Molecular Templates, Inc. Clinical methods for use of a pd-l1-binding molecule comprising a shiga toxin effector
WO2022197945A1 (en) * 2021-03-17 2022-09-22 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
CN115806630A (zh) * 2022-08-23 2023-03-17 上海交通大学 用于肿瘤免疫/靶向性治疗的pd-1蛋白-细胞毒素偶联物及其制备方法、应用
CN116240239B (zh) * 2023-04-18 2024-12-27 华东师范大学 程序可控的蛋白质快速分泌释放系统及其构建方法和应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
ATE183513T1 (de) 1993-06-03 1999-09-15 Therapeutic Antibodies Inc Herstellung von antikörperfragmenten
JP5004390B2 (ja) 1999-08-23 2012-08-22 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 新規b7−4分子およびその用途
DK1234031T3 (en) 1999-11-30 2017-07-03 Mayo Foundation B7-H1, AN UNKNOWN IMMUNE REGULATORY MOLECULE
US6979564B2 (en) 2000-10-20 2005-12-27 Millennium Pharmaceuticals, Inc. 80090, human fucosyltransferase nucleic acid molecules and uses thereof
ATE525398T1 (de) 2002-05-10 2011-10-15 Medimmune Inc Epha2 monoklonale antikörper und deren anwendungsverfahren
EP1727827B1 (en) 2004-03-26 2010-05-12 Molecular Templates, Inc. Library of toxin mutants, and methods of using same
DK1810026T3 (en) 2004-10-06 2018-07-16 Mayo Found Medical Education & Res B7-H1 AND PD-1 FOR TREATMENT OF RENAL CELL CARCINOM
PT1907424E (pt) 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
EP1945660B1 (en) 2005-09-26 2014-05-07 Molecular Templates, Inc. Library from toxin mutants, and methods of using same
KR20090114430A (ko) 2007-02-02 2009-11-03 베일러 리서치 인스티튜트 항원-제시 세포 상에서 발현된 dcir에 대한 항원 표적화에 기초한 백신
EP2130552B1 (en) 2007-02-27 2016-06-15 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising anti-grp78 antibody as active ingredient
US7887801B2 (en) 2007-07-13 2011-02-15 Topotarget Germany Ag Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins
US8552154B2 (en) 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
US9290577B2 (en) 2009-07-03 2016-03-22 Avipep Pty Limited Immuno-conjugates and methods for producing them
US9174169B2 (en) 2009-08-14 2015-11-03 Unifrax I Llc Mounting mat for exhaust gas treatment device
PL2504364T3 (pl) 2009-11-24 2017-12-29 Medimmune Limited Ukierunkowane środki wiążące przeciwko B7-H1
KR101764096B1 (ko) 2011-11-28 2017-08-02 메르크 파텐트 게엠베하 항-pd-l1 항체 및 그의 용도
EP3666795A1 (en) 2013-03-12 2020-06-17 Molecular Templates, Inc. Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
CN112851769A (zh) * 2014-01-27 2021-05-28 分子模板公司 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽
US20210138076A2 (en) * 2014-01-27 2021-05-13 Molecular Templates, Inc. Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes
US20160177284A1 (en) * 2014-01-27 2016-06-23 Molecular Templates, Inc. Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
ES2809729T3 (es) * 2014-03-11 2021-03-05 Molecular Templates Inc Proteínas que comprenden regiones efectoras de la subunidad A de la toxina Shiga próximas al extremo amino terminal y regiones de unión de tipo inmunoglobulina de reconocimiento celular capaces de unirse específicamente a HER2/neu/ErbB2
US11142584B2 (en) * 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
JP6935195B2 (ja) * 2014-03-11 2021-09-15 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 結合領域、志賀毒素aサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質
CN106604934A (zh) * 2014-06-11 2017-04-26 分子模板公司 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
US9535074B2 (en) 2014-09-08 2017-01-03 Merck Sharp & Dohme Corp. Immunoassay for soluble PD-L1
EP3253799B1 (en) 2015-02-05 2020-12-02 Molecular Templates, Inc. Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
EP3303373B1 (en) * 2015-05-30 2020-04-08 Molecular Templates, Inc. De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same
KR20180030085A (ko) 2015-07-26 2018-03-21 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 작동체 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
US10537633B2 (en) 2016-03-04 2020-01-21 Jn Biosciences Llc Antibodies to TIGIT
ES2883297T3 (es) * 2016-03-29 2021-12-07 Stcube Inc Anticuerpos de función doble específicos para PD-L1 glucosilado y métodos de uso de los mismos
WO2018080812A1 (en) 2016-10-30 2018-05-03 Henlix, Inc. Anti-pd-l1 antibodies and variants
WO2018106895A1 (en) 2016-12-07 2018-06-14 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
MX2019008840A (es) * 2017-01-25 2019-09-09 Molecular Templates Inc Moleculas con direccion hacia las celulas que comprenden efectores de la sub-unidad a de la toxina shiga desinmunizados y epitopos de las celulas t cd8+.
DK3592769T3 (da) 2017-03-09 2024-08-12 Genmab As Antistoffer mod pd-l1
EP3689893A4 (en) 2017-09-25 2021-12-15 JSR Corporation IMMUNOGLOBULIN-BINDING PROTEIN AND AFFINITY CARRIERS THEREFORE
CN108059678B (zh) * 2017-12-08 2020-05-22 浙江大学 全人源抗pdl-1单链抗体b30及其应用
AU2019239850A1 (en) * 2018-03-19 2020-10-29 Lanier Biotherapeutics, Inc. High affinity neutralizing monoclonal antibodies to programmed death ligand 1 (PD-L1) and uses thereof
WO2020081493A1 (en) * 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
WO2020154475A1 (en) * 2019-01-23 2020-07-30 Molecular Templates, Inc. Proteins comprising modified immunoglobulin variable light chains
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds

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