JP2021526377A5 - - Google Patents
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- JP2021526377A5 JP2021526377A5 JP2020567251A JP2020567251A JP2021526377A5 JP 2021526377 A5 JP2021526377 A5 JP 2021526377A5 JP 2020567251 A JP2020567251 A JP 2020567251A JP 2020567251 A JP2020567251 A JP 2020567251A JP 2021526377 A5 JP2021526377 A5 JP 2021526377A5
- Authority
- JP
- Japan
- Prior art keywords
- isvd
- specific
- dimer
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/090012 | 2018-06-05 | ||
| CN2018090012 | 2018-06-05 | ||
| CN2019086821 | 2019-05-14 | ||
| CNPCT/CN2019/086821 | 2019-05-14 | ||
| PCT/CN2019/089980 WO2019233413A1 (en) | 2018-06-05 | 2019-06-04 | Dimer and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021526377A JP2021526377A (ja) | 2021-10-07 |
| JP2021526377A5 true JP2021526377A5 (https=) | 2021-11-18 |
| JP7359785B2 JP7359785B2 (ja) | 2023-10-11 |
Family
ID=68769178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567251A Active JP7359785B2 (ja) | 2018-06-05 | 2019-06-04 | 二量体及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12281163B2 (https=) |
| EP (1) | EP3802613A4 (https=) |
| JP (1) | JP7359785B2 (https=) |
| CN (2) | CN112399973B (https=) |
| TW (1) | TWI831789B (https=) |
| WO (1) | WO2019233413A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11377497B2 (en) * | 2017-01-23 | 2022-07-05 | Suzhou Alphamab Co., Ltd. | PD-L1 binding polypeptide or composite |
| CN112399973B (zh) * | 2018-06-05 | 2022-12-16 | 江苏康宁杰瑞生物制药有限公司 | 二聚体及其用途 |
| US12565531B2 (en) | 2019-12-04 | 2026-03-03 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | Bispecific fusion protein for tumor treatment |
| WO2021110107A1 (en) * | 2019-12-04 | 2021-06-10 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | COMBINATION OF BISPECIFIC FUSION PROTEIN AND ANTI-Her2 ANTIBODY FOR TUMOR TREATMENT |
| JP2024510111A (ja) * | 2021-02-23 | 2024-03-06 | 江蘇康寧杰瑞生物制薬有限公司 | 腫瘍の予防、軽減、又は治療方法 |
| WO2023070160A1 (en) * | 2021-10-28 | 2023-05-04 | Monash University | Variant ctla4 proteins |
| WO2025085590A1 (en) * | 2023-10-20 | 2025-04-24 | Jecho Laboratories, Inc. | Multifunctional pd1 fusion proteins |
| EP4574165A1 (en) | 2023-12-21 | 2025-06-25 | Egle Therapeutics | Immunocytokine for cancer treatment |
| WO2025133175A1 (en) | 2023-12-21 | 2025-06-26 | Egle Therapeutics | Immunocytokine for cancer treatment |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2195342A1 (en) | 2007-09-07 | 2010-06-16 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
| JP6072771B2 (ja) | 2011-04-20 | 2017-02-01 | メディミューン，エルエルシー | Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子 |
| EP2931747B1 (en) | 2012-12-11 | 2020-06-10 | Vib Vzw | Anti-influenza antibody |
| US20160145355A1 (en) * | 2013-06-24 | 2016-05-26 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
| WO2015048312A1 (en) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
| CA2936244A1 (en) | 2014-01-21 | 2015-07-30 | Medimmune, Llc | Compositions and methods for modulating and redirecting immune responses |
| US20160177284A1 (en) | 2014-01-27 | 2016-06-23 | Molecular Templates, Inc. | Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions |
| CN105296433B (zh) * | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| PL3240801T3 (pl) | 2014-12-31 | 2021-06-14 | Checkmate Pharmaceuticals, Inc. | Skojarzona immunoterapia nowotworów |
| WO2016197367A1 (en) | 2015-06-11 | 2016-12-15 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| CN106397592A (zh) * | 2015-07-31 | 2017-02-15 | 苏州康宁杰瑞生物科技有限公司 | 针对程序性死亡配体(pd-l1)的单域抗体及其衍生蛋白 |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| US20180346571A1 (en) | 2015-11-17 | 2018-12-06 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
| ES2979210T3 (es) | 2015-12-15 | 2024-09-24 | Oncoc4 Inc | Anticuerpos monoclonales anti-CTLA4 humano quiméricos y humanizados y usos de los mismos |
| KR20180096789A (ko) * | 2016-01-11 | 2018-08-29 | 인히브릭스, 인크. | 다가 및 다중특이적 41bb-결합 융합 단백질 |
| CN105754990A (zh) * | 2016-01-29 | 2016-07-13 | 深圳精准医疗科技有限公司 | 一种pd-1/ctla-4双特异性抗体的制备方法及其应用 |
| CN116769054A (zh) | 2016-02-05 | 2023-09-19 | 奥里尼斯生物科学私人有限公司 | 双特异性信号传导剂及其用途 |
| AR108377A1 (es) | 2016-05-06 | 2018-08-15 | Medimmune Llc | Proteínas de unión biespecíficas y sus usos |
| CN107400166A (zh) | 2016-05-19 | 2017-11-28 | 苏州康宁杰瑞生物科技有限公司 | 针对ctla4的单域抗体及其衍生蛋白 |
| JP7010854B2 (ja) | 2016-06-14 | 2022-01-26 | ゼンコア インコーポレイテッド | 二重特異性チェックポイント阻害剤抗体 |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| NL2017270B1 (en) | 2016-08-02 | 2018-02-09 | Aduro Biotech Holdings Europe B V | New anti-hCTLA-4 antibodies |
| EP3494130A4 (en) | 2016-08-03 | 2020-01-08 | The Feinstein Institute for Medical Research | C1Q AND HMGB1 FUSION PROTEINS AND USES THEREOF |
| CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| CN111051350B (zh) | 2017-09-07 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | 包含信号调节蛋白α的免疫缀合物 |
| EP3710480A4 (en) | 2017-11-17 | 2021-12-15 | Nanjing Legend Biotech Co., Ltd. | SINGLE-DOMAIN ANTIBODIES AND VARIANTS OF THEM DIRECTED AGAINST PD-L1 |
| US11773171B2 (en) | 2017-12-19 | 2023-10-03 | Surrozen Operating, Inc. | WNT surrogate molecules and uses thereof |
| CN112399973B (zh) | 2018-06-05 | 2022-12-16 | 江苏康宁杰瑞生物制药有限公司 | 二聚体及其用途 |
| US12565531B2 (en) * | 2019-12-04 | 2026-03-03 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | Bispecific fusion protein for tumor treatment |
| WO2021110107A1 (en) * | 2019-12-04 | 2021-06-10 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | COMBINATION OF BISPECIFIC FUSION PROTEIN AND ANTI-Her2 ANTIBODY FOR TUMOR TREATMENT |
-
2019
- 2019-06-04 CN CN201980037301.2A patent/CN112399973B/zh active Active
- 2019-06-04 CN CN202211470101.6A patent/CN115991787A/zh active Pending
- 2019-06-04 TW TW108119327A patent/TWI831789B/zh active
- 2019-06-04 EP EP19816129.1A patent/EP3802613A4/en active Pending
- 2019-06-04 WO PCT/CN2019/089980 patent/WO2019233413A1/en not_active Ceased
- 2019-06-04 JP JP2020567251A patent/JP7359785B2/ja active Active
-
2020
- 2020-09-30 US US17/038,863 patent/US12281163B2/en active Active
-
2021
- 2021-04-13 US US17/229,392 patent/US11634492B2/en active Active
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