JP2022547716A5 - - Google Patents
Info
- Publication number
- JP2022547716A5 JP2022547716A5 JP2022516375A JP2022516375A JP2022547716A5 JP 2022547716 A5 JP2022547716 A5 JP 2022547716A5 JP 2022516375 A JP2022516375 A JP 2022516375A JP 2022516375 A JP2022516375 A JP 2022516375A JP 2022547716 A5 JP2022547716 A5 JP 2022547716A5
- Authority
- JP
- Japan
- Prior art keywords
- ligase
- targeted
- group
- bind
- binder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962901161P | 2019-09-16 | 2019-09-16 | |
| US62/901,161 | 2019-09-16 | ||
| US201962905849P | 2019-09-25 | 2019-09-25 | |
| US62/905,849 | 2019-09-25 | ||
| PCT/IB2020/058535 WO2021053495A1 (en) | 2019-09-16 | 2020-09-14 | Bifunctional degraders and their methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022547716A JP2022547716A (ja) | 2022-11-15 |
| JP2022547716A5 true JP2022547716A5 (https=) | 2023-09-22 |
| JP7785663B2 JP7785663B2 (ja) | 2025-12-15 |
Family
ID=72603497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022516375A Active JP7785663B2 (ja) | 2019-09-16 | 2020-09-14 | 二機能性分解誘導薬及びそれらの使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220387602A1 (https=) |
| EP (1) | EP4031247A1 (https=) |
| JP (1) | JP7785663B2 (https=) |
| CN (1) | CN114521196A (https=) |
| WO (1) | WO2021053495A1 (https=) |
Families Citing this family (28)
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|---|---|---|---|---|
| TW202146412A (zh) | 2020-03-05 | 2021-12-16 | 美商Ｃ４醫藥公司 | 用於標靶降解brd9之化合物 |
| CN116981675A (zh) * | 2020-12-31 | 2023-10-31 | 百济神州有限公司 | 通过布鲁顿氏酪氨酸激酶（btk）抑制剂与e3连接酶配体的缀合降解btk和使用方法 |
| US20240216513A1 (en) * | 2021-03-12 | 2024-07-04 | Novartis Ag | Fatty acid-bifunctional degrader conjugates and their methods of use |
| CN115232108B (zh) * | 2021-04-23 | 2025-04-18 | 领泰生物医药(绍兴)有限公司 | Sos1降解剂及其制备方法和应用 |
| AU2022270089A1 (en) * | 2021-05-03 | 2023-11-16 | Nurix Therapeutics, Inc. | Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use |
| TW202309039A (zh) * | 2021-05-05 | 2023-03-01 | 美商百健Ｍａ公司 | 用於靶向布魯頓氏酪胺酸激酶降解之化合物 |
| WO2022266248A1 (en) * | 2021-06-16 | 2022-12-22 | Biotheryx, Inc. | Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| WO2022272061A1 (en) * | 2021-06-25 | 2022-12-29 | Celgene Corporation | Cereblon binding compounds, compositions thereof, and methods of treatment therewith |
| CN117561249A (zh) * | 2021-06-25 | 2024-02-13 | 细胞基因公司 | Cereblon结合化合物、其组合物及其用于治疗的方法 |
| PE20240894A1 (es) * | 2021-08-10 | 2024-04-24 | Uppthera Inc | Compuesto inductor de la degradacion de plk1 novedoso |
| US20240382600A1 (en) | 2021-09-01 | 2024-11-21 | Novartis Ag | Bifunctional degraders comprising a tead binder |
| WO2023088406A1 (zh) * | 2021-11-18 | 2023-05-25 | 正大天晴药业集团股份有限公司 | 稠合酰亚胺类衍生物 |
| EP4452978A4 (en) * | 2021-12-22 | 2025-12-17 | Anaxis Pharma Pty Ltd | BIFUNCTIONAL ARYLSULFONAMIDE COMPOUNDS |
| MX2024007883A (es) * | 2021-12-22 | 2024-09-23 | Anaxis Pharma Pty Ltd | Compuestos de sulfonamida bifuncionales. |
| CN116354933B (zh) * | 2021-12-27 | 2025-06-20 | 青岛普泰科生物医药科技有限公司 | 作为雄激素受体调节剂的杂环化合物及其应用 |
| KR20240128831A (ko) | 2021-12-30 | 2024-08-27 | 베이진 스위찰랜드 게엠베하 | 브루톤 티로신 키나아제(btk) 억제제와 e3 리가아제 리간드의 접합에 의한 btk의 분해 및 사용 방법 |
| JP7805983B2 (ja) * | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| WO2024020221A1 (en) * | 2022-07-21 | 2024-01-25 | Arvinas Operations, Inc. | Modulators of tyk2 proteolysis and associated methods of use |
| JPWO2024043319A1 (https=) * | 2022-08-26 | 2024-02-29 | ||
| CN120530094A (zh) * | 2023-01-12 | 2025-08-22 | 田边三菱制药株式会社 | Cereblon E3连接酶结合化合物、包含其的药物组合物及其制造方法 |
| KR20260029501A (ko) | 2023-05-24 | 2026-03-04 | 베액티카 테라퓨틱스 아베 | Tead에 대한 결합제로서의 방향족 아미드 및 이의 접합체 |
| PE20260307A1 (es) | 2023-06-14 | 2026-02-11 | Astrazeneca Ab | Degradadores de smarca2 y usos de estos |
| PE20260301A1 (es) | 2023-06-14 | 2026-02-10 | Astrazeneca Ab | Derivados de 3-[3-amino-6-(2-hidroxifenil)piridazin-4-il]-3,8-diazabiciclo[3.2.1]octano como protacs degradantes de smarca2 para el tratamiento del cancer |
| CN117257796B (zh) * | 2023-11-08 | 2025-09-16 | 复旦大学 | 奥巴克拉甲磺酸盐在制备抗bkv药物中的应用 |
| CN120623148A (zh) * | 2024-03-11 | 2025-09-12 | 北京深势科技有限公司 | 一种c-Myc降解剂及其制备方法和用途 |
| WO2025232885A1 (en) * | 2024-05-10 | 2025-11-13 | Beigene (Suzhou) Co., Ltd. | Preparation method of a bruton's tyrosine kinase degrader thereof |
| CN121405700A (zh) * | 2024-07-26 | 2026-01-27 | 苏州亚盛药业有限公司 | Btk降解剂及其用途 |
| WO2026052637A1 (en) * | 2024-09-03 | 2026-03-12 | Monte Rosa Therapeutics Ag | Targeted protein degradation |
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| US5141943A (en) * | 1990-04-12 | 1992-08-25 | Brown University Research Foundation | 5-benzyl barbiturate derivatives |
| JP5167350B2 (ja) * | 2007-05-30 | 2013-03-21 | エフ．ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド系逆転写酵素阻害剤 |
| CN101918369B (zh) * | 2007-09-17 | 2016-02-24 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| PA8796201A1 (es) * | 2007-09-17 | 2009-04-23 | Abbott Lab | Agentes anti-infecciosos y su uso |
| EA021439B1 (ru) | 2009-11-03 | 2015-06-30 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Хиназолиновые соединения |
| WO2013157021A1 (en) * | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| WO2015197028A1 (en) * | 2014-06-28 | 2015-12-30 | Sunshine Lake Pharma Co., Ltd. | Compounds as hepatitis c virus (hcv) inhibitors and uses thereof in medicine |
| US10865205B2 (en) * | 2016-04-22 | 2020-12-15 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of CDK8 inhibitors with E3 ligase ligand and methods of use |
| EP3445765A4 (en) * | 2016-04-22 | 2019-09-18 | Dana Farber Cancer Institute, Inc. | DECREASE OF CYCLINE-DEPENDENT KINASE 4/6 (CDK4 / 6) BY CONJUGATION OF CDK4 / 6 INHIBITORS WITH E3-LIGASE LIGANDS AND METHODS OF USE |
| CA3018429A1 (en) * | 2016-04-22 | 2017-10-26 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use |
| WO2017223452A1 (en) * | 2016-06-23 | 2017-12-28 | Dana-Farber Cancer Institute, Inc. | Degradation of bromodomain-containing protein 9 (brd9) by conjugation of brd9 inhibitors with e3 ligase ligand and methods of use |
| CN110506039A (zh) * | 2016-10-11 | 2019-11-26 | 阿尔维纳斯股份有限公司 | 用于雄激素受体靶向降解的化合物和方法 |
| CA3042294A1 (en) * | 2016-11-22 | 2018-05-31 | Dana-Farber Cancer Institute, Inc. | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| ES2965049T3 (es) * | 2017-07-12 | 2024-04-10 | Dana Farber Cancer Inst Inc | Compuestos para la degradación de la proteína tau |
| CN109518406B (zh) | 2017-09-18 | 2021-11-16 | 青岛海尔洗涤电器有限公司 | 一种衣物洗干一体机及其控制方法 |
| WO2019140387A1 (en) * | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| CN111936498B (zh) * | 2018-03-26 | 2024-04-16 | 诺华股份有限公司 | N-(3-(7H-吡咯并[2,3-d]嘧啶-4-基)苯基)苯甲酰胺衍生物 |
| EP3774808A1 (en) * | 2018-03-26 | 2021-02-17 | Novartis AG | 3-hydroxy-n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)pyrrolidine-1-carboxamide derivatives |
| CN120698983A (zh) * | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| US20230065463A1 (en) * | 2019-01-29 | 2023-03-02 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| CN114174299B (zh) * | 2019-07-26 | 2024-10-25 | 百济神州有限公司 | 通过btk抑制剂与e3连接酶配体缀合对布鲁顿氏酪氨酸激酶(btk)的降解以及使用方法 |
| JP2022547952A (ja) * | 2019-09-16 | 2022-11-16 | ノバルティス アーゲー | Ｂｒｄ９二機能性分解誘導薬及びその使用方法 |
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2020
- 2020-09-14 CN CN202080064750.9A patent/CN114521196A/zh active Pending
- 2020-09-14 US US17/642,285 patent/US20220387602A1/en active Pending
- 2020-09-14 JP JP2022516375A patent/JP7785663B2/ja active Active
- 2020-09-14 EP EP20775721.2A patent/EP4031247A1/en active Pending
- 2020-09-14 WO PCT/IB2020/058535 patent/WO2021053495A1/en not_active Ceased