JP2022544412A - 免疫賦活特性が減少したｒｎａ組み合わせおよび組成物 - Google Patents

免疫賦活特性が減少したｒｎａ組み合わせおよび組成物 Download PDF

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JP2022544412A
JP2022544412A JP2022509092A JP2022509092A JP2022544412A JP 2022544412 A JP2022544412 A JP 2022544412A JP 2022509092 A JP2022509092 A JP 2022509092A JP 2022509092 A JP2022509092 A JP 2022509092A JP 2022544412 A JP2022544412 A JP 2022544412A
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rna
combination
component
nucleic acid
therapeutic
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JP2022544412A5 (https=
Inventor
テス，アンドレアス
シュヴシエ－テュネセン，フレデリック
ルッツ，ヨハンネス
シュラーケ，トーマス
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Curevac SE
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Curevac AG
Curevac SE
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    • A—HUMAN NECESSITIES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/50—Methods for regulating/modulating their activity
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2022509092A 2019-08-14 2020-08-11 免疫賦活特性が減少したｒｎａ組み合わせおよび組成物 Pending JP2022544412A (ja)

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JP2025061893A JP2025106391A (ja) 2019-08-14 2025-04-03 免疫賦活特性が減少したｒｎａ組み合わせおよび組成物

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EP2019071878 2019-08-14
EPPCT/EP2019/071878 2019-08-14
PCT/EP2020/072516 WO2021028439A1 (en) 2019-08-14 2020-08-11 Rna combinations and compositions with decreased immunostimulatory properties

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JP2022544412A5 JP2022544412A5 (https=) 2023-08-21

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JP2025061893A Pending JP2025106391A (ja) 2019-08-14 2025-04-03 免疫賦活特性が減少したｒｎａ組み合わせおよび組成物

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US (1) US20220296628A1 (https=)
EP (1) EP4013880A1 (https=)
JP (2) JP2022544412A (https=)
KR (1) KR20220047319A (https=)
CN (1) CN114502204A (https=)
AU (1) AU2020328855A1 (https=)
BR (1) BR112022001947A2 (https=)
CA (1) CA3144902A1 (https=)
IL (1) IL289958A (https=)
MX (1) MX2022001870A (https=)
WO (1) WO2021028439A1 (https=)

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HRP20240586T1 (hr) 2018-10-09 2024-07-19 The University Of British Columbia Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima
TW202039534A (zh) 2018-12-14 2020-11-01 美商美國禮來大藥廠 KRAS變體mRNA分子
SG11202106666UA (en) 2018-12-21 2021-07-29 Curevac Ag Methods for rna analysis
CN114901360A (zh) 2019-12-20 2022-08-12 库瑞瓦格股份公司 用于递送核酸的新型脂质纳米颗粒
US12194089B2 (en) 2020-02-04 2025-01-14 CureVac SE Coronavirus vaccine
US20240102065A1 (en) 2021-01-27 2024-03-28 CureVac SE Method of reducing the immunostimulatory properties of in vitro transcribed rna
US20240342206A1 (en) 2021-07-30 2024-10-17 CureVac SE mRNAS FOR TREATMENT OR PROPHYLAXIS OF LIVER DISEASES
US20240398940A1 (en) 2021-09-03 2024-12-05 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids
US20240398933A1 (en) 2021-09-03 2024-12-05 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine
WO2023144193A1 (en) 2022-01-25 2023-08-03 CureVac SE Mrnas for treatment of hereditary tyrosinemia type i
US20250099614A1 (en) 2022-01-28 2025-03-27 CureVac SE Nucleic acid encoded transcription factor inhibitors
CN115287060B (zh) * 2022-03-24 2023-05-26 辽宁科技大学 蓝光碳点、荧光粉和白光发光二极管及其制备方法
US20250345407A1 (en) 2022-05-25 2025-11-13 CureVac SE Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide
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WO2024260570A1 (en) 2023-06-23 2024-12-26 CureVac SE Nucleic acid encoded antibodies
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