JP2022543230A5 - - Google Patents
Info
- Publication number
- JP2022543230A5 JP2022543230A5 JP2022506568A JP2022506568A JP2022543230A5 JP 2022543230 A5 JP2022543230 A5 JP 2022543230A5 JP 2022506568 A JP2022506568 A JP 2022506568A JP 2022506568 A JP2022506568 A JP 2022506568A JP 2022543230 A5 JP2022543230 A5 JP 2022543230A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- ethyl
- hydroxy
- trifluoromethoxy
- pentanamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19189744.6 | 2019-08-02 | ||
| EP19189744 | 2019-08-02 | ||
| PCT/EP2020/071514 WO2021023616A1 (en) | 2019-08-02 | 2020-07-30 | Alcohol derivatives as kv7 potassium channel openers for use in epilepsy or seizures |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022543230A JP2022543230A (ja) | 2022-10-11 |
| JP2022543230A5 true JP2022543230A5 (https=) | 2023-08-04 |
| JP7591036B2 JP7591036B2 (ja) | 2024-11-27 |
Family
ID=67539335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506568A Active JP7591036B2 (ja) | 2019-08-02 | 2020-07-30 | てんかん又はてんかん発作において使用するためのＫｖ７カリウムチャネル開口薬としてのアルコール誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12508239B2 (https=) |
| EP (1) | EP4007571B1 (https=) |
| JP (1) | JP7591036B2 (https=) |
| CN (2) | CN114206328B (https=) |
| ES (1) | ES3034153T3 (https=) |
| WO (1) | WO2021023616A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| RS66130B1 (sr) * | 2019-08-02 | 2024-11-29 | H Lundbeck As | Derivati alkohola kao otvarači kv7 kalijumovih kanala |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9915414D0 (en) | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
| WO2001092526A1 (en) | 2000-05-26 | 2001-12-06 | Bristol-Myers Squibb Company | Human kcnq5 potassium channel, methods and compositions thereof |
| WO2001096540A2 (en) | 2000-06-11 | 2001-12-20 | Dupont Pharmaceuticals Company | Hepatitis c protease exosite for inhibitor design |
| US7091202B2 (en) | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
| KR20080043314A (ko) * | 2005-09-09 | 2008-05-16 | 하. 룬트벡 아크티에 셀스카브 | 피리미딘 유도체 및 ｋｃｎｑ 포타슘 채널 개방제로서의그의 용도 |
| WO2007057447A1 (en) | 2005-11-18 | 2007-05-24 | Neurosearch A/S | Novel quinazoline derivatives and their medical use |
| TWI453013B (zh) | 2006-02-07 | 2014-09-21 | Lundbeck & Co As H | N-(2,4-二甲基-6-嗎啉-4-基-吡啶-3-基〉3,3-二甲基-丁醯胺之用途以及包含該化合物之醫藥品 |
| WO2007104717A1 (en) | 2006-03-15 | 2007-09-20 | Neurosearch A/S | Quinazolinones and their use as potassium channels activators |
| AR070513A1 (es) | 2007-08-01 | 2010-04-14 | Lundbeck & Co As H | Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor |
| TW201024286A (en) | 2008-11-27 | 2010-07-01 | Neurosearch As | Novel compounds |
| TW201041857A (en) | 2009-05-11 | 2010-12-01 | Lundbeck & Co As H | Stable forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide |
| WO2014145852A2 (en) | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| SMT202300362T1 (it) | 2014-09-12 | 2023-11-13 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-il-ammidi come attivatori di canale kv7 |
| JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
| CN105663136A (zh) | 2016-01-15 | 2016-06-15 | 河北中医学院 | 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用 |
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| EP4241843B1 (en) * | 2018-02-20 | 2025-05-21 | H. Lundbeck A/S | Alcohol derivatives as kv7 potassium channel openers |
| AR119521A1 (es) | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
-
2020
- 2020-07-30 CN CN202080054003.7A patent/CN114206328B/zh active Active
- 2020-07-30 US US17/631,762 patent/US12508239B2/en active Active
- 2020-07-30 ES ES20749878T patent/ES3034153T3/es active Active
- 2020-07-30 WO PCT/EP2020/071514 patent/WO2021023616A1/en not_active Ceased
- 2020-07-30 EP EP20749878.3A patent/EP4007571B1/en active Active
- 2020-07-30 JP JP2022506568A patent/JP7591036B2/ja active Active
- 2020-07-30 CN CN202411458022.2A patent/CN119490430A/zh active Pending
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