JP2021524453A5 - - Google Patents

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Publication number
JP2021524453A5
JP2021524453A5 JP2020564577A JP2020564577A JP2021524453A5 JP 2021524453 A5 JP2021524453 A5 JP 2021524453A5 JP 2020564577 A JP2020564577 A JP 2020564577A JP 2020564577 A JP2020564577 A JP 2020564577A JP 2021524453 A5 JP2021524453 A5 JP 2021524453A5
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JP
Japan
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compound
general formula
alkyl
groups
group
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JP2020564577A
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English (en)
Japanese (ja)
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JPWO2019220147A5 (https=
JP2021524453A (ja
JP7333793B2 (ja
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Priority claimed from GBGB1808093.7A external-priority patent/GB201808093D0/en
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JP2020564577A 2018-05-18 2019-05-17 化合物 Active JP7333793B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1808093.7A GB201808093D0 (en) 2018-05-18 2018-05-18 Compounds
GB1808093.7 2018-05-18
PCT/GB2019/051383 WO2019220147A1 (en) 2018-05-18 2019-05-17 Compounds

Publications (4)

Publication Number Publication Date
JP2021524453A JP2021524453A (ja) 2021-09-13
JP2021524453A5 true JP2021524453A5 (https=) 2022-05-09
JPWO2019220147A5 JPWO2019220147A5 (https=) 2022-05-09
JP7333793B2 JP7333793B2 (ja) 2023-08-25

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JP2020564577A Active JP7333793B2 (ja) 2018-05-18 2019-05-17 化合物

Country Status (5)

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US (1) US12037336B2 (https=)
EP (1) EP3794002B1 (https=)
JP (1) JP7333793B2 (https=)
GB (1) GB201808093D0 (https=)
WO (1) WO2019220147A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201908453D0 (en) 2019-06-12 2019-07-24 Enterprise Therapeutics Ltd Compounds for treating respiratory disease
PH12021553110A1 (en) 2019-06-12 2022-08-01 Tmem16A Ltd Compounds for treating respiratory disease
EP4259607A1 (en) 2020-12-11 2023-10-18 Tmem16A Limited Benzimidazole derivatives for treating respiratory disease
US12414916B2 (en) 2021-06-10 2025-09-16 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US11932648B2 (en) 2021-06-28 2024-03-19 Blueprint Medicines Corporation CDK2 inhibitors
CN117946013B (zh) * 2024-01-25 2024-07-02 白银康寓信生物科技有限公司 一锅法合成5,6-二卤代-3-氨基吡嗪-2-甲酸甲酯的方法
US20260108686A1 (en) 2024-10-21 2026-04-23 Belhaven BioPharma Inc. Compositions, devices, and methods for intranasal delivery of dry powder epinephrine

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
ES2432529T3 (es) 2003-08-18 2013-12-04 Parion Sciences, Inc. Bloqueadores del canal de sodio de pirazinoilguanidina rematada
US7375107B2 (en) 2003-08-18 2008-05-20 Parion Sciences, Inc. Alaphatic pyrazinoylguanidine sodium channel blockers
JP2007502829A (ja) 2003-08-18 2007-02-15 パリオン・サイエンシィズ・インコーポレーテッド 環状ピラジノイルグアニジンナトリウムチャネルブロッカー
US20050090505A1 (en) 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US7399766B2 (en) 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7807834B2 (en) 2005-08-03 2010-10-05 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
US8288391B2 (en) 2007-04-03 2012-10-16 Parion Sciences, Inc. Pyrazinoylguanidine compounds for use as taste modulators
DE602008005140D1 (de) 2007-05-07 2011-04-07 Novartis Ag Organische verbindungen
WO2009019506A1 (en) 2007-08-03 2009-02-12 Astrazeneca Ab Heterocyclyc sulfonamides having edg-1 antagonistic activity
MX2010006421A (es) 2007-12-10 2010-06-25 Novartis Ag Compuestos organicos.
ES2485642T3 (es) 2008-02-26 2014-08-14 Parion Sciences, Inc. Bloqueantes poli-aromáticos de los canales de sodio
CA2723938A1 (en) 2008-05-13 2009-11-19 Novartis Ag 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases
JP2011522860A (ja) 2008-06-10 2011-08-04 ノバルティス アーゲー 上皮性ナトリウムチャネルブロッカーとしてのピラジン誘導体
WO2011028740A1 (en) 2009-09-03 2011-03-10 Glaxo Group Limited ENaC BLOCKERS
WO2011079087A1 (en) 2009-12-23 2011-06-30 Glaxo Group Limited Enac blockers
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
KR102006612B1 (ko) 2011-11-02 2019-08-02 베링거 인겔하임 인터내셔날 게엠베하 헤테로사이클릭 화합물, 상기 화합물을 포함하는 약제, 이의 용도, 및 이의 제조 방법
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
HUE039734T2 (hu) 2012-05-29 2019-01-28 Parion Sciences Inc Nátriumcsatorna-blokkoló aktivitású, dendrimerszerû amino-amid-származékok száraz szem és más nyálkahártya-megbetegedések kezelésére
US8841309B2 (en) 2012-09-24 2014-09-23 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
CN108658876A (zh) 2012-12-17 2018-10-16 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
CA2895512C (en) 2012-12-17 2021-10-19 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
EP2991981B1 (en) 2013-04-30 2017-03-01 Boehringer Ingelheim International GmbH Diaminopyrazine compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
AU2014284268A1 (en) 2013-07-02 2016-01-07 The California Institute For Biomedical Research Compounds for treatment of cystic fibrosis
EP3019492B1 (en) 2013-07-08 2017-09-06 Boehringer Ingelheim International GmbH Amiloride-type compounds as inhibitors in epithelial sodium channels for the treatment of diseases of the lungs and airways
EP3022197B1 (en) 2013-07-15 2017-09-06 Boehringer Ingelheim International GmbH Novel tetra- and pentasubstituted benzimidazolium compounds
WO2015007516A1 (en) 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Novel 5-substituted benzimidazolium compounds
JP6461134B2 (ja) 2013-07-15 2019-01-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ベンゾイミダゾリウム化合物
WO2015018754A1 (en) 2013-08-08 2015-02-12 Boehringer Ingelheim International Gmbh Novel pyrazine amide compounds
JP6847838B2 (ja) 2015-01-12 2021-03-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 上皮ナトリウムチャネル阻害剤としての2−(ピラジン−2−イルカルボニルアミノメチル)ベンズイミダゾリウム化合物
EP3245199B1 (en) 2015-01-12 2020-01-01 Boehringer Ingelheim International GmbH Substituted benzimidazolium compounds useful in the treatment of respiratory diseases
WO2016113169A1 (en) 2015-01-12 2016-07-21 Boehringer Ingelheim International Gmbh Tetra- and pentasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases
US9932324B2 (en) 2015-01-12 2018-04-03 Boehringer Ingelheim International Gmbh Substituted benzimidazolium compounds useful in the treatment of respiratory diseases
MX370598B (es) 2015-08-20 2019-12-18 Boehringer Ingelheim Int Fenoxiacetamidas apareadas novedosas.
EA201890532A1 (ru) 2015-08-20 2018-09-28 Бёрингер Ингельхайм Интернациональ Гмбх Новые аннелированные бензамиды
GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) * 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds

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