JP2021524453A5 - - Google Patents

Info

Publication number
JP2021524453A5
JP2021524453A5 JP2020564577A JP2020564577A JP2021524453A5 JP 2021524453 A5 JP2021524453 A5 JP 2021524453A5 JP 2020564577 A JP2020564577 A JP 2020564577A JP 2020564577 A JP2020564577 A JP 2020564577A JP 2021524453 A5 JP2021524453 A5 JP 2021524453A5
Authority
JP
Japan
Prior art keywords
compound
general formula
alkyl
groups
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020564577A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021524453A (ja
JP7333793B2 (ja
Filing date
Publication date
Priority claimed from GBGB1808093.7A external-priority patent/GB201808093D0/en
Application filed filed Critical
Publication of JP2021524453A publication Critical patent/JP2021524453A/ja
Publication of JP2021524453A5 publication Critical patent/JP2021524453A5/ja
Application granted granted Critical
Publication of JP7333793B2 publication Critical patent/JP7333793B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020564577A 2018-05-18 2019-05-17 化合物 Active JP7333793B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1808093.7A GB201808093D0 (en) 2018-05-18 2018-05-18 Compounds
GB1808093.7 2018-05-18
PCT/GB2019/051383 WO2019220147A1 (en) 2018-05-18 2019-05-17 Compounds

Publications (3)

Publication Number Publication Date
JP2021524453A JP2021524453A (ja) 2021-09-13
JP2021524453A5 true JP2021524453A5 (https=) 2022-05-09
JP7333793B2 JP7333793B2 (ja) 2023-08-25

Family

ID=62723333

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020564577A Active JP7333793B2 (ja) 2018-05-18 2019-05-17 化合物

Country Status (5)

Country Link
US (1) US12037336B2 (https=)
EP (1) EP3794002B1 (https=)
JP (1) JP7333793B2 (https=)
GB (1) GB201808093D0 (https=)
WO (1) WO2019220147A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201908453D0 (en) 2019-06-12 2019-07-24 Enterprise Therapeutics Ltd Compounds for treating respiratory disease
CR20220006A (es) 2019-06-12 2022-06-06 Tmem16A Ltd Compuestos para tratar enfermedad respiratoria
EP4259607A1 (en) 2020-12-11 2023-10-18 Tmem16A Limited Benzimidazole derivatives for treating respiratory disease
US12414916B2 (en) 2021-06-10 2025-09-16 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US11932648B2 (en) 2021-06-28 2024-03-19 Blueprint Medicines Corporation CDK2 inhibitors
CN117946013B (zh) * 2024-01-25 2024-07-02 白银康寓信生物科技有限公司 一锅法合成5,6-二卤代-3-氨基吡嗪-2-甲酸甲酯的方法
US20260108686A1 (en) 2024-10-21 2026-04-23 Belhaven BioPharma Inc. Compositions, devices, and methods for intranasal delivery of dry powder epinephrine

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7375107B2 (en) 2003-08-18 2008-05-20 Parion Sciences, Inc. Alaphatic pyrazinoylguanidine sodium channel blockers
JP2007502829A (ja) 2003-08-18 2007-02-15 パリオン・サイエンシィズ・インコーポレーテッド 環状ピラジノイルグアニジンナトリウムチャネルブロッカー
AU2004266704B2 (en) 2003-08-18 2012-02-23 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US7399766B2 (en) 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7807834B2 (en) 2005-08-03 2010-10-05 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
US8288391B2 (en) 2007-04-03 2012-10-16 Parion Sciences, Inc. Pyrazinoylguanidine compounds for use as taste modulators
CN101687851B (zh) 2007-05-07 2013-02-27 诺瓦提斯公司 有机化合物
WO2009019506A1 (en) 2007-08-03 2009-02-12 Astrazeneca Ab Heterocyclyc sulfonamides having edg-1 antagonistic activity
CL2008003651A1 (es) 2007-12-10 2009-06-19 Novartis Ag Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias.
WO2009139948A1 (en) 2008-02-26 2009-11-19 Johnson Michael R Poly aromatic sodium channel blockers
AU2009248179A1 (en) 2008-05-13 2009-11-19 Novartis Ag 3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of arway diseases
CA2727196A1 (en) 2008-06-10 2009-12-17 Novartis Ag Organic compounds
WO2011028740A1 (en) 2009-09-03 2011-03-10 Glaxo Group Limited ENaC BLOCKERS
WO2011079087A1 (en) 2009-12-23 2011-06-30 Glaxo Group Limited Enac blockers
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
WO2013064450A1 (en) 2011-11-02 2013-05-10 Boehringer Ingelheim International Gmbh Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
MX2014014648A (es) 2012-05-29 2015-09-04 Parion Sciences Inc Aminoamidas tipo dendrimero que poseen actividad bloqueadora del canal de sodio para el tratamiento de ojo reseco y otras enfermedades mucosas.
WO2014044849A1 (en) 2012-09-24 2014-03-27 Boehringer Ingelheim International Gmbh Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
RU2018138195A (ru) 2012-12-17 2018-12-18 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
SG10201708931XA (en) 2012-12-17 2017-12-28 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
WO2014177469A1 (en) 2013-04-30 2014-11-06 Boehringer Ingelheim International Gmbh,M Diaminopyrazine compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof
US9656972B2 (en) 2013-07-02 2017-05-23 The California Institute For Biomedical Research Compounds for treatment of cystic fibrosis
JP6449870B2 (ja) 2013-07-08 2019-01-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物
EP3022198B1 (en) 2013-07-15 2019-09-11 Boehringer Ingelheim International GmbH Novel 5-substituted benzimidazolium compounds
EP3022196B1 (en) 2013-07-15 2017-09-06 Boehringer Ingelheim International GmbH Novel benzimidazolium compounds
EP3022197B1 (en) 2013-07-15 2017-09-06 Boehringer Ingelheim International GmbH Novel tetra- and pentasubstituted benzimidazolium compounds
JP6449880B2 (ja) 2013-08-08 2019-01-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ピラジンアミド化合物
JP6667538B2 (ja) 2015-01-12 2020-03-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器系疾患の治療に有用な置換ベンズイミダゾリウム化合物
US9981954B2 (en) 2015-01-12 2018-05-29 Boehringer Ingelheim International Gmbh 2-(pyrazin-2-ylcarbonylaminomethyl) benzimidazolium compounds as epithelial sodium channel inhibitors
EP3245202B1 (en) 2015-01-12 2020-03-11 Boehringer Ingelheim International GmbH Tetrasubstituted benzimidazolium compounds useful in the treatment of respiratory diseases
JP6671378B2 (ja) 2015-01-12 2020-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器系疾患の治療に有用な置換ベンズイミダゾリウム化合物
BR112018002115A2 (pt) 2015-08-20 2018-09-18 Boehringer Ingelheim Int benzamidas aneladas
CA2996087A1 (en) 2015-08-20 2017-02-23 Boehringer Ingelheim International Gmbh Annelated phenoxyacetamides
GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds

Similar Documents

Publication Publication Date Title
JP2021524453A5 (https=)
JP2019535747A5 (https=)
ES2315425T3 (es) Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.
AU2013365742B2 (en) Autotaxin inhibitors
HRP20230294T1 (hr) Modulatori tmem16a
JP2013530179A5 (https=)
JP2009535340A5 (https=)
JP2021512143A5 (https=)
JP2013510883A5 (https=)
JP2011162556A5 (https=)
JP2007500187A5 (https=)
JP2018529657A5 (https=)
JP2020537658A5 (https=)
AU2018303782A1 (en) New crystalline forms of vilanterol trifenatate and processes for their preparation
JP2009040767A5 (https=)
JP2008508251A5 (https=)
US6946486B2 (en) Quaternary ammonium compounds
RU2007128080A (ru) Производные пирролидиния в качестве мускариновых рецепторов мз
JP2016506946A (ja) 吸入療法用の多成分結晶粒子
JP2006506402A (ja) 四級アンモニウム化合物およびその抗ムスカリン薬としての使用
RU2015115677A (ru) Производные 6-аминоиндола в качестве антагонистов канала с транзиторным рецепторным потенциалом (trp)
US6878730B2 (en) Quaternary ammonium compounds
NZ753048B2 (en) Benzodiazolium compounds as enac inhibitors
JP2006511494A (ja) 抗ムスカリン剤としてのキヌクリジニウム誘導体
NZ753048A (en) Benzodiazolium compounds as enac inhibitors