JP2022542389A5 - - Google Patents
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- Publication number
- JP2022542389A5 JP2022542389A5 JP2022506087A JP2022506087A JP2022542389A5 JP 2022542389 A5 JP2022542389 A5 JP 2022542389A5 JP 2022506087 A JP2022506087 A JP 2022506087A JP 2022506087 A JP2022506087 A JP 2022506087A JP 2022542389 A5 JP2022542389 A5 JP 2022542389A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- lipid
- nanoparticle composition
- lipid nanoparticle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962879731P | 2019-07-29 | 2019-07-29 | |
| US62/879,731 | 2019-07-29 | ||
| PCT/US2020/043512 WO2021021634A1 (en) | 2019-07-29 | 2020-07-24 | Nanomaterials containing constrained lipids and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022542389A JP2022542389A (ja) | 2022-10-03 |
| JP2022542389A5 true JP2022542389A5 (OSRAM) | 2023-07-21 |
| JP7600208B2 JP7600208B2 (ja) | 2024-12-16 |
Family
ID=74228270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506087A Active JP7600208B2 (ja) | 2019-07-29 | 2020-07-24 | 拘束された脂質を含むナノ材料およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12569438B2 (OSRAM) |
| EP (1) | EP4003967A4 (OSRAM) |
| JP (1) | JP7600208B2 (OSRAM) |
| KR (1) | KR20220040484A (OSRAM) |
| CN (1) | CN114502542A (OSRAM) |
| AU (1) | AU2020323897A1 (OSRAM) |
| CA (1) | CA3145913A1 (OSRAM) |
| WO (1) | WO2021021634A1 (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| IL239317B (en) | 2012-12-12 | 2022-07-01 | Broad Inst Inc | Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications |
| JP6665088B2 (ja) | 2013-06-17 | 2020-03-13 | ザ・ブロード・インスティテュート・インコーポレイテッド | 配列操作のための最適化されたＣＲＩＳＰＲ−Ｃａｓ二重ニッカーゼ系、方法および組成物 |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| RU2016128077A (ru) | 2013-12-12 | 2018-12-06 | Те Брод Инститьют Инк. | Доставка, применение и применения в терапии систем и композиций crispr-cas для лечения обусловленных hbv и вирусных заболеваний и нарушений |
| BR112016013213A2 (pt) * | 2013-12-12 | 2017-12-05 | Massachusetts Inst Technology | administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas |
| BR112016013547A2 (pt) | 2013-12-12 | 2017-10-03 | Broad Inst Inc | Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos |
| WO2015089473A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| EP3230451B1 (en) | 2014-12-12 | 2021-04-07 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| CA2970370A1 (en) | 2014-12-24 | 2016-06-30 | Massachusetts Institute Of Technology | Crispr having or associated with destabilization domains |
| IL293323B2 (en) | 2015-06-18 | 2024-01-01 | Massachusetts Inst Technology | Crispr enzyme mutations reducing off-target effects |
| WO2016205759A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation |
| CN113166783B (zh) | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| JP7600208B2 (ja) | 2019-07-29 | 2024-12-16 | ジョージア テック リサーチ コーポレイション | 拘束された脂質を含むナノ材料およびその使用 |
| AU2020396940A1 (en) * | 2019-12-06 | 2022-06-16 | Guide Therapeutics, Llc | Nanomaterials |
| WO2021141969A1 (en) | 2020-01-09 | 2021-07-15 | Guide Therapeutics, Inc. | Nanomaterials |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| US12059477B2 (en) | 2021-01-20 | 2024-08-13 | Beam Therapeutics Inc. | Nanomaterials |
| MX2023008328A (es) | 2021-01-20 | 2023-08-15 | Beam Therapeutics Inc | Nanomateriales que comprenden una caracteristica biodegradable. |
| MX2023012235A (es) * | 2021-04-17 | 2024-01-23 | Intellia Therapeutics Inc | Composiciones de nanopartículas lípidicas. |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| CN113637708B (zh) * | 2021-08-09 | 2023-07-25 | 中国科学院过程工程研究所 | 一种CRISPR-cas9基因编辑系统递送载体及其制备方法和应用 |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| EP4402121A1 (en) | 2021-09-14 | 2024-07-24 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
| WO2023122611A1 (en) * | 2021-12-23 | 2023-06-29 | Georgia Tech Research Corporation | Ionizable lipids with bioactive motifs |
| US20250387490A9 (en) * | 2022-01-04 | 2025-12-25 | Massachusetts Institute Of Technology | Ionizable lipids for multiple organ targeting |
| CN114436994B (zh) * | 2022-01-26 | 2024-02-27 | 中国药科大学 | 金刚烷尾链脂质及其在细胞转染中的应用 |
| WO2023230601A1 (en) | 2022-05-27 | 2023-11-30 | Beam Therapeutics Inc. | Identification of nanoparticles for preferential tissue or cell targeting |
| WO2024006960A1 (en) * | 2022-06-29 | 2024-01-04 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids |
| AU2023311822A1 (en) | 2022-07-20 | 2025-01-09 | Beam Therapeutics Inc. | Nanomaterials comprising triols |
| WO2024081639A1 (en) * | 2022-10-11 | 2024-04-18 | Seawolf Therapeutics, Inc. | Novel lipid nanoparticle compositions for the delivery of nucleic acids |
| WO2024102677A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Circular rna compositions |
| CN115925563B (zh) * | 2023-02-28 | 2023-05-16 | 清华大学 | 一种可用于靶向肺部递送核酸的脂质分子及其制备方法与应用 |
| CN116199646B (zh) * | 2023-03-07 | 2024-01-26 | 山东大学 | 一种基于Tris的可电离脂质及其制备方法与应用 |
| AU2024269222A1 (en) | 2023-05-05 | 2025-10-09 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2025007148A1 (en) | 2023-06-30 | 2025-01-02 | Orna Therapeutics, Inc. | Polymer lipid nanoparticle compositions for delivering circular polynucleotides |
| WO2025049690A1 (en) | 2023-08-29 | 2025-03-06 | Orna Therapeutics, Inc. | Circular polyethylene glycol lipids |
| KR20250036032A (ko) * | 2023-09-05 | 2025-03-13 | 한국생명공학연구원 | 지질 나노 입자를 이용한 핵산 전달 시스템 |
| WO2025101501A1 (en) | 2023-11-07 | 2025-05-15 | Orna Therapeutics, Inc. | Circular rna compositions |
| WO2025117969A1 (en) | 2023-12-01 | 2025-06-05 | Orna Therapeutics, Inc. | Process for manufacturing lipid nanoparticles |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025147545A1 (en) * | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025166238A1 (en) | 2024-01-31 | 2025-08-07 | Orna Therapeutics, Inc. | Fast-shedding polyethylene glycol lipids |
| WO2025250751A1 (en) | 2024-05-31 | 2025-12-04 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL257307A (OSRAM) | 1959-10-28 | |||
| US3686238A (en) | 1970-01-19 | 1972-08-22 | Syntex Corp | Glycerol esterified with 2-naphthyl-acetic acids and fatty acids |
| WO1999014346A2 (en) | 1997-09-19 | 1999-03-25 | Sequitur, Inc. | SENSE mRNA THERAPY |
| US6670499B1 (en) | 1999-11-08 | 2003-12-30 | Daicel Chemical Industries, Ltd. | Adamantane derivatives and processes for the preparation thereof |
| KR100872437B1 (ko) | 2000-12-01 | 2008-12-05 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자 |
| US20040077888A1 (en) | 2002-05-31 | 2004-04-22 | The Regents Of The University Of California | Polyamine-mediated transfection |
| JP2005181734A (ja) | 2003-12-19 | 2005-07-07 | Fuji Photo Film Co Ltd | 画像記録材料 |
| DE102007029471A1 (de) | 2007-06-20 | 2008-12-24 | Novosom Ag | Neue fakultativ kationische Sterole |
| NZ588583A (en) | 2008-04-15 | 2012-08-31 | Protiva Biotherapeutics Inc | Novel lipid formulations for nucleic acid delivery |
| CA2800401C (en) | 2010-06-03 | 2020-09-15 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| KR20150000461A (ko) | 2011-10-27 | 2015-01-02 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| ES3065854T3 (en) | 2011-12-07 | 2026-05-08 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| EP3608308B1 (en) | 2013-03-08 | 2021-07-21 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| PT3083556T (pt) * | 2013-12-19 | 2020-03-05 | Novartis Ag | Lípidos e composições lipídicas para a entrega de agentes ativos |
| WO2015095346A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| CN107072946B (zh) | 2014-09-05 | 2022-01-11 | 诺华股份有限公司 | 用于递送活性剂的脂质和脂质组合物 |
| WO2016187531A1 (en) | 2015-05-21 | 2016-11-24 | Ohio State Innovation Foundation | Benzene-1,3,5-tricarboxamide derivatives and uses thereof |
| RS63030B1 (sr) | 2015-09-17 | 2022-04-29 | Modernatx Inc | Jedinjenja i kompozicije za intracelularno isporučivanje terapeutskih sredstava |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| RS63986B1 (sr) | 2015-10-28 | 2023-03-31 | Acuitas Therapeutics Inc | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| SI3436077T1 (sl) * | 2016-03-30 | 2025-07-31 | Intellia Therapeutics, Inc. | Formulacije lipidnih nanodelcev za komponente crispr/cas |
| HUE064463T2 (hu) * | 2016-07-11 | 2024-03-28 | Opko Biologics Ltd | Hosszantartó hatású VII. koagulációs faktor és az elõállítására vonatkozó eljárások |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| KR20190132405A (ko) | 2017-03-15 | 2019-11-27 | 모더나티엑스, 인크. | 치료제의 세포내 전달을 위한 화합물 및 조성물 |
| WO2018220553A1 (en) | 2017-05-30 | 2018-12-06 | Glaxosmithkline Biologicals Sa | Methods for manufacturing a liposome encapsulated rna |
| EP3649142A4 (en) | 2017-07-04 | 2021-09-01 | Intocell, Inc. | JOINTS WITH SPLITABLE LINKER AND USES THEREOF |
| CA3081414A1 (en) | 2017-10-30 | 2019-05-09 | Georgia Tech Research Corporation | Multiplexed analysis of materials for tissue delivery |
| EP3709987B1 (en) | 2017-11-14 | 2026-04-29 | Ohio State Innovation Foundation | Benzene-1,3,5-tricarboxamide derived ester lipids and uses thereof |
| WO2019126378A1 (en) | 2017-12-19 | 2019-06-27 | Ariya Therapeutics, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| MX2020006843A (es) | 2017-12-27 | 2020-09-03 | Takeda Pharmaceuticals Co | Nanoparticula de lipido que contiene acido nucleico y uso de la misma. |
| WO2020028787A1 (en) | 2018-08-02 | 2020-02-06 | PureTech Health LLC | Lipid prodrugs of pregnane neurosteroids and uses thereof |
| EP3842538A4 (en) | 2018-08-10 | 2022-06-08 | Kyoto University | METHOD OF TRANSFECTION INTO CARDIOMYOCYTES USING CATIONIC LIPID |
| CN113039174B (zh) | 2018-10-02 | 2023-11-17 | 英特利亚治疗股份有限公司 | 可电离的胺脂质 |
| KR20210108969A (ko) | 2018-12-05 | 2021-09-03 | 인텔리아 테라퓨틱스, 인크. | 변형된 아민 지질 |
| CA3123886A1 (en) | 2019-01-17 | 2020-07-23 | James DAHLMAN | Drug delivery systems containing oxidized cholesterols |
| WO2020152037A1 (en) | 2019-01-24 | 2020-07-30 | Agfa Nv | Radiation curable inkjet inks for interior decoration |
| AU2020221366A1 (en) | 2019-02-13 | 2021-08-26 | Beam Therapeutics Inc. | Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence |
| WO2020176868A1 (en) | 2019-02-28 | 2020-09-03 | Puretech Lyt, Inc. | Lipid prodrugs of btk inhibitors and uses thereof |
| CA3130349A1 (en) | 2019-02-28 | 2020-09-03 | Puretech Lyt, Inc. | Lipid prodrugs of jak inhibitors and uses thereof |
| WO2020176856A1 (en) | 2019-02-28 | 2020-09-03 | Puretech Lyt, Inc. | Lipid prodrugs of glucocorticoids and uses thereof |
| BR112021021313A2 (pt) * | 2019-04-25 | 2022-01-18 | Intellia Therapeutics Inc | Lipídios de amina ionizáveis e nanopartículas de lipídio |
| US20220233459A1 (en) | 2019-06-05 | 2022-07-28 | Guide Therapeutics, Inc. | Analysis of materials for tissue delivery |
| WO2020246581A1 (ja) | 2019-06-07 | 2020-12-10 | 富士フイルム株式会社 | 脂質組成物 |
| EP4004207A4 (en) | 2019-07-29 | 2023-08-23 | Georgia Tech Research Corporation | OLIGONUCLEOTIDE ANTAGONISTS FOR RNA-GUIDED GENO EDITING |
| JP7600208B2 (ja) | 2019-07-29 | 2024-12-16 | ジョージア テック リサーチ コーポレイション | 拘束された脂質を含むナノ材料およびその使用 |
| IL292337A (en) | 2019-10-21 | 2022-06-01 | Flaskworks Llc | Systems and methods for cell culturing |
| AU2020396940A1 (en) | 2019-12-06 | 2022-06-16 | Guide Therapeutics, Llc | Nanomaterials |
| WO2021141969A1 (en) | 2020-01-09 | 2021-07-15 | Guide Therapeutics, Inc. | Nanomaterials |
| JP2024503976A (ja) | 2020-12-21 | 2024-01-30 | ビーム セラピューティクス インク． | アセタールを含むナノ材料 |
| IL303365A (en) | 2020-12-21 | 2023-08-01 | Beam Therapeutics Inc | Nanomaterials comprising ester-linked acetals |
| JP2024505327A (ja) | 2020-12-21 | 2024-02-06 | ビーム セラピューティクス インク． | 炭酸塩を含むナノ材料 |
| MX2023008328A (es) | 2021-01-20 | 2023-08-15 | Beam Therapeutics Inc | Nanomateriales que comprenden una caracteristica biodegradable. |
| CA3203784A1 (en) | 2021-01-20 | 2022-07-28 | Beam Therapeutics Inc. | Ionizable lipids for nanomaterials |
| US12059477B2 (en) | 2021-01-20 | 2024-08-13 | Beam Therapeutics Inc. | Nanomaterials |
| WO2022159475A1 (en) | 2021-01-20 | 2022-07-28 | Beam Therapeutics Inc. | Nanomaterials comprising an ionizable lipid |
| CA3220689A1 (en) | 2021-05-28 | 2022-12-01 | Ciaran LAWLOR | Lipid nanoparticles and methods of use thereof |
| AU2022358824A1 (en) | 2021-10-08 | 2024-04-11 | Suzhou Abogen Biosciences Co., Ltd. | Lipid compounds and lipid nanoparticle compositions |
| CA3241503A1 (en) | 2021-12-20 | 2023-06-29 | Beam Therapeutics Inc. | Nanomaterials comprising tetravalent lipid compounds |
| EP4452935A1 (en) | 2021-12-20 | 2024-10-30 | Beam Therapeutics Inc. | Ionizable amine lipids and lipid nanoparticles |
| AU2023311822A1 (en) | 2022-07-20 | 2025-01-09 | Beam Therapeutics Inc. | Nanomaterials comprising triols |
-
2020
- 2020-07-24 JP JP2022506087A patent/JP7600208B2/ja active Active
- 2020-07-24 AU AU2020323897A patent/AU2020323897A1/en active Pending
- 2020-07-24 EP EP20846355.4A patent/EP4003967A4/en active Pending
- 2020-07-24 CN CN202080068505.5A patent/CN114502542A/zh not_active Withdrawn
- 2020-07-24 CA CA3145913A patent/CA3145913A1/en active Pending
- 2020-07-24 US US17/630,861 patent/US12569438B2/en active Active
- 2020-07-24 WO PCT/US2020/043512 patent/WO2021021634A1/en not_active Ceased
- 2020-07-24 KR KR1020227006660A patent/KR20220040484A/ko not_active Ceased
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