JP2022530018A5 - - Google Patents

Info

Publication number
JP2022530018A5
JP2022530018A5 JP2021562869A JP2021562869A JP2022530018A5 JP 2022530018 A5 JP2022530018 A5 JP 2022530018A5 JP 2021562869 A JP2021562869 A JP 2021562869A JP 2021562869 A JP2021562869 A JP 2021562869A JP 2022530018 A5 JP2022530018 A5 JP 2022530018A5
Authority
JP
Japan
Prior art keywords
lipid
nanoparticle according
anchor portion
peg
lipid nanoparticle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2021562869A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022530018A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/029907 external-priority patent/WO2020219941A1/en
Publication of JP2022530018A publication Critical patent/JP2022530018A/ja
Publication of JP2022530018A5 publication Critical patent/JP2022530018A5/ja
Abandoned legal-status Critical Current

Links

JP2021562869A 2019-04-26 2020-04-24 脂質ナノ粒子 Abandoned JP2022530018A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962839452P 2019-04-26 2019-04-26
US62/839,452 2019-04-26
US201962867098P 2019-06-26 2019-06-26
US62/867,098 2019-06-26
PCT/US2020/029907 WO2020219941A1 (en) 2019-04-26 2020-04-24 Lipid nanoparticles

Publications (2)

Publication Number Publication Date
JP2022530018A JP2022530018A (ja) 2022-06-27
JP2022530018A5 true JP2022530018A5 (OSRAM) 2023-04-27

Family

ID=72941858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021562869A Abandoned JP2022530018A (ja) 2019-04-26 2020-04-24 脂質ナノ粒子

Country Status (8)

Country Link
US (1) US20220168222A1 (OSRAM)
EP (1) EP3959314A4 (OSRAM)
JP (1) JP2022530018A (OSRAM)
CN (1) CN114026233A (OSRAM)
AU (1) AU2020262437A1 (OSRAM)
CA (1) CA3137450A1 (OSRAM)
MA (1) MA55766A (OSRAM)
WO (1) WO2020219941A1 (OSRAM)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202191315A1 (ru) * 2018-11-09 2021-09-08 Арбутус Биофарма Корпорэйшн Катионные липиды, содержащие кремний
CN114901360A (zh) 2019-12-20 2022-08-12 库瑞瓦格股份公司 用于递送核酸的新型脂质纳米颗粒
US12023376B1 (en) 2020-04-17 2024-07-02 Triad National Security, Llc Conserved region T cell vaccines for coronavirus and methods of use
CN115768438A (zh) * 2020-07-10 2023-03-07 盖纳万科学有限公司 用于向肺递送治疗剂的脂质纳米颗粒
WO2022023284A1 (en) 2020-07-27 2022-02-03 Anjarium Biosciences Ag Compositions of dna molecules, methods of making therefor, and methods of use thereof
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
KR20230118715A (ko) 2020-10-14 2023-08-11 조지 메이슨 리서치 파운데이션 인코포레이티드 이온화 가능 지질 및 이의 제조 및 사용 방법
US11771652B2 (en) 2020-11-06 2023-10-03 Sanofi Lipid nanoparticles for delivering mRNA vaccines
CA3200234A1 (en) 2020-11-25 2022-06-02 Daryl C. Drummond Lipid nanoparticles for delivery of nucleic acids, and related methods of use
CN117479963A (zh) * 2020-12-18 2024-01-30 盖纳万科学有限公司 Peg脂质和脂质纳米粒子
WO2022198229A1 (en) * 2021-03-17 2022-09-22 Board Of Regents Of The University Of Nebraska Lipid nanoparticle formulations and methods of use thereof
WO2022221736A2 (en) 2021-04-16 2022-10-20 Genentech, Inc. Optimized tlr7 ligands and uses thereof
CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
CN117940158A (zh) 2021-09-03 2024-04-26 库瑞瓦格欧洲公司 用于核酸递送的包含磷脂酰丝氨酸的新型脂质纳米颗粒
EP4419677A4 (en) 2021-10-18 2025-09-24 Flagship Pioneering Innovations Vii Llc DNA COMPOSITIONS AND RELATED METHODS
KR20230061895A (ko) * 2021-10-29 2023-05-09 주식회사 아이큐어비앤피 지질 나노입자 및 세포 투과성을 갖는 신규 펩타이드의 복합체
CN117203186A (zh) * 2022-05-13 2023-12-08 南方科技大学 一种含有二硫键的脂质化合物及其组合物
WO2023218431A1 (en) 2022-05-13 2023-11-16 BioNTech SE Rna compositions targeting hiv
EP4529472A1 (en) 2022-05-23 2025-04-02 Logicbio Therapeutics, Inc. Gene therapy compositions and methods of use thereof
EP4531819A2 (en) 2022-05-25 2025-04-09 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof
WO2023230295A1 (en) 2022-05-25 2023-11-30 BioNTech SE Rna compositions for delivery of monkeypox antigens and related methods
CN119562807A (zh) 2022-05-30 2025-03-04 生物技术公司 用于递送核酸的复合物
TWI858802B (zh) * 2022-07-06 2024-10-11 南韓商綠十字股份有限公司 使用陽離子膽固醇用於核酸遞送的局部遞送的脂質納米顆粒
CA3263437A1 (en) 2022-07-29 2024-02-01 Fujifilm Corporation COMPOSITIONS AND METHODS FOR INHIBITING THE EXPRESSION OF THE SIGNAL REGULATOR ALPHA PROTEIN (SIRPα) GENE
WO2024037577A1 (en) * 2022-08-18 2024-02-22 Suzhou Abogen Biosciences Co., Ltd. Composition of lipid nanoparticles
WO2024057237A1 (en) 2022-09-16 2024-03-21 Pfizer Inc. Lipid nanoparticles
EP4342460A1 (en) 2022-09-21 2024-03-27 NovoArc GmbH Lipid nanoparticle with nucleic acid cargo
EP4637718A1 (en) * 2022-12-21 2025-10-29 Suzhou Abogen Biosciences Co., Ltd. Lipid nanoparticles comprising sterol-modified phospholipids
EP4642797A1 (en) 2022-12-28 2025-11-05 BioNTech SE Rna compositions targeting hiv
EP4410316A1 (en) * 2023-02-01 2024-08-07 4basebio UK Ltd Nanoparticles for delivery of nucleic acid cargos
AU2024217077A1 (en) * 2023-02-06 2025-09-18 University Of Tennessee Research Foundation Multi-functional lipid nanoparticles and uses thereof
WO2024205499A1 (en) * 2023-03-27 2024-10-03 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof
WO2024259158A2 (en) * 2023-06-13 2024-12-19 Cornell University Lipid nanoparticles for peptide delivery and methods of making and using the same
WO2025027579A2 (en) 2023-08-03 2025-02-06 BioNTech SE Rna compositions targeting hiv
CN121866336A (zh) 2023-08-03 2026-04-14 百欧恩泰欧洲股份公司 靶向hiv的rna组合物
CN121752256A (zh) 2023-09-01 2026-03-27 诺沃阿克有限责任公司 具有核酸负载物和可电离脂质的脂质纳米颗粒
WO2025124711A1 (en) 2023-12-13 2025-06-19 BioNTech SE Glycolipid compositions
WO2025219570A1 (en) 2024-04-17 2025-10-23 Johannes Kepler Universität Linz Composition for inhibiting protein translocation and methods using the same
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates
GB202408360D0 (en) 2024-06-11 2024-07-24 Cancer Research Tech Ltd Tumour sensitisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3007955A1 (en) * 2015-12-10 2017-06-15 Modernatx, Inc. Lipid nanoparticles for delivery of therapeutic agents
AU2017286980B2 (en) * 2016-06-30 2023-10-26 Arbutus Biopharma Corporation Compositions and methods for delivering messenger RNA

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