JP2022541545A5 - - Google Patents

Info

Publication number
JP2022541545A5
JP2022541545A5 JP2022503439A JP2022503439A JP2022541545A5 JP 2022541545 A5 JP2022541545 A5 JP 2022541545A5 JP 2022503439 A JP2022503439 A JP 2022503439A JP 2022503439 A JP2022503439 A JP 2022503439A JP 2022541545 A5 JP2022541545 A5 JP 2022541545A5
Authority
JP
Japan
Prior art keywords
compound according
nhc
following formula
polar
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022503439A
Other languages
English (en)
Japanese (ja)
Other versions
JP7695229B2 (ja
JP2022541545A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/042788 external-priority patent/WO2021016191A1/en
Publication of JP2022541545A publication Critical patent/JP2022541545A/ja
Publication of JP2022541545A5 publication Critical patent/JP2022541545A5/ja
Priority to JP2025094850A priority Critical patent/JP2025131767A/ja
Application granted granted Critical
Publication of JP7695229B2 publication Critical patent/JP7695229B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022503439A 2019-07-19 2020-07-20 C17極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法 Active JP7695229B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025094850A JP2025131767A (ja) 2019-07-19 2025-06-06 C17極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962876467P 2019-07-19 2019-07-19
US62/876,467 2019-07-19
US201962952048P 2019-12-20 2019-12-20
US62/952,048 2019-12-20
PCT/US2020/042788 WO2021016191A1 (en) 2019-07-19 2020-07-20 C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025094850A Division JP2025131767A (ja) 2019-07-19 2025-06-06 C17極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法

Publications (3)

Publication Number Publication Date
JP2022541545A JP2022541545A (ja) 2022-09-26
JP2022541545A5 true JP2022541545A5 (enExample) 2023-07-27
JP7695229B2 JP7695229B2 (ja) 2025-06-18

Family

ID=74192606

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022503439A Active JP7695229B2 (ja) 2019-07-19 2020-07-20 C17極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法
JP2025094850A Pending JP2025131767A (ja) 2019-07-19 2025-06-06 C17極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025094850A Pending JP2025131767A (ja) 2019-07-19 2025-06-06 C17極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法

Country Status (10)

Country Link
US (2) US12344631B2 (enExample)
EP (1) EP3999522B1 (enExample)
JP (2) JP7695229B2 (enExample)
KR (1) KR102891865B1 (enExample)
CN (2) CN120248001A (enExample)
AU (1) AU2020316351A1 (enExample)
CA (2) CA3144603C (enExample)
MX (2) MX2022000781A (enExample)
TW (1) TWI861163B (enExample)
WO (1) WO2021016191A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS58392B1 (sr) 2008-04-18 2019-04-30 Reata Pharmaceuticals Inc Antioksidantni modulatori inflamacije: derivati oleanoličke kiseline sa amino i drugim modifikacijama na c-17
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
US12060340B2 (en) 2018-06-20 2024-08-13 Reata Pharmaceuticals, Inc Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith
CN120248001A (zh) * 2019-07-19 2025-07-04 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法
CN120349366A (zh) * 2025-03-07 2025-07-22 国科大杭州高等研究院 五环三萜类衍生物、制备方法及其医药用途

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395423A (en) 1978-10-10 1983-07-26 Sterling Drug Inc. Polycyclic cyanoketones
US5064823A (en) 1988-08-24 1991-11-12 Research Triangle Institute Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers
DE19817262A1 (de) 1998-04-18 1999-10-21 Bayer Ag Neue 2-heterocyclisch substituierte Dihydropyrimidine
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
PT1178952E (pt) 1999-05-14 2007-12-04 Univ California Novos moduladores da interleucina-1 e do factor alfa de necrose tumoral, síntese dos referidos moduladores e métodos de utilização dos referidos moduladores
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
WO2002003996A1 (en) 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
US6689767B2 (en) 2000-09-29 2004-02-10 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US6951847B2 (en) 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
JP2004509972A (ja) 2000-09-29 2004-04-02 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 酵母に対する殺真菌活性を有するトリテルペン
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
WO2002047611A2 (en) 2000-11-28 2002-06-20 Board Of Regents, The University Of Texas System Cddo-compounds and combination therapies thereof
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
DE60325329D1 (de) 2002-01-18 2009-01-29 Univ Minnesota Quaternäre terpensalze als biologisch aktive tenside
EP1507541A4 (en) 2002-05-13 2009-06-03 Dartmouth College HEMMER AND APPLICATION METHOD THEREFOR
AU2005282437B2 (en) 2004-09-07 2013-01-10 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
US20050208151A1 (en) 2003-10-30 2005-09-22 Entelos, Inc. Treatment of rheumatoid arthritis with FLIP antagonists
WO2005046732A2 (en) 2003-11-04 2005-05-26 THE UNITED SATES OF AMERICA as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES, NIH Methods and compositions for the inhibition of hiv-1 replication
US20060258752A1 (en) 2004-02-12 2006-11-16 Vander Jagt David L Method and compounds for cancer treatment utilizing NFkB as a direct or ultimate target for small molecule inhibitors
AU2006265113A1 (en) 2005-07-01 2007-01-11 The Johns Hopkins University Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
US20070232577A1 (en) 2006-03-23 2007-10-04 Advanced Life Sciences, Inc. Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
WO2007127791A2 (en) 2006-04-25 2007-11-08 The Administrators Of The Tulane Educational Fund New pharmacological method for treatment of neuropathic pain
WO2008000070A1 (en) 2006-06-27 2008-01-03 Wellington Laboratories Inc. Glycyrrhetinic acid derivatives
WO2008016095A1 (en) 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. PREVENTIVE OR REMEDY FOR KERATOCONJUNCTIVAL DISORDERS CONTAINING Nrf2 ACTIVATOR AS THE ACTIVE INGREDIENT
EP2094651A1 (en) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
WO2012106190A1 (en) 2011-01-31 2012-08-09 Bristol-Myers Squibb Company C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
EP2653873B8 (en) 2007-02-08 2022-08-24 Biogen MA Inc. Compositions and uses for treating Multiple Sclerosis
JP2008247898A (ja) 2007-03-08 2008-10-16 Santen Pharmaceut Co Ltd トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
WO2008136838A1 (en) 2007-05-04 2008-11-13 Trustees Of Dartmouth College Novel amide derivatives of cddo and methods of use thereof
US8088824B2 (en) 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
US20090048205A1 (en) 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
US9012439B2 (en) 2007-10-29 2015-04-21 University Of Rochester Use of electrophilic compounds for inducing platelet production or maintaining platelet function
ME03529B (me) 2008-01-11 2020-04-20 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
HUE033288T2 (en) 2008-04-18 2017-11-28 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives
TW201006474A (en) 2008-04-18 2010-02-16 Reata Pharmaceuticals Inc Natural products including an anti-flammatory pharmacore and methods of use
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
EP2279197B1 (en) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
RS58392B1 (sr) 2008-04-18 2019-04-30 Reata Pharmaceuticals Inc Antioksidantni modulatori inflamacije: derivati oleanoličke kiseline sa amino i drugim modifikacijama na c-17
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
WO2010053817A1 (en) 2008-11-04 2010-05-14 Trustees Of Dartmouth College Betulinic acid derivatives and methods of use thereof
SG173601A1 (en) 2009-02-13 2011-09-29 Reata Pharmaceuticals Inc Delayed release, oral dosage compositions that contain amorphous cddo-me
AU2011240690C1 (en) 2010-04-12 2014-11-06 Reata Pharmaceuticals Holdings, LLC Method of treating obesity using antioxidant inflammation modulators
US8618125B2 (en) 2011-01-14 2013-12-31 Heptiva LLC Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance
EA026847B1 (ru) * 2011-03-11 2017-05-31 Рита Фармасьютикалз, Инк. C4-монометилтритерпеноидные производные и способы их применения
EP2841445B1 (en) 2012-04-27 2017-06-14 Reata Pharmaceuticals, Inc. 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
WO2013169740A2 (en) 2012-05-08 2013-11-14 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
CN103665087A (zh) 2012-09-03 2014-03-26 上海源力生物技术有限公司 一种萜类化合物及其在医药上的应用
MX2015003021A (es) 2012-09-10 2015-11-09 Abbvie Inc Derivados de acido glicirretinico y metodos de uso de los mismos.
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
TWI630212B (zh) 2012-09-10 2018-07-21 瑞塔醫藥有限責任公司 丁香油素(oleanolic acid)之c17-烷二基與烯二基衍生物及其使用方法
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
LT2892911T (lt) * 2012-09-10 2017-11-10 Reata Pharmaceuticals, Inc. Oleanolinės rūgšties c17 heteroarilo dariniai ir jų panaudojimo būdas
TWI649330B (zh) 2013-04-24 2019-02-01 艾伯維有限公司 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法
IL285832B2 (en) 2013-08-23 2024-01-01 Reata Pharmaceuticals Inc Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof
US9896475B2 (en) 2014-08-26 2018-02-20 Trustees Of Dartmouth College Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals, Inc. métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
CN120248001A (zh) 2019-07-19 2025-07-04 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法

Similar Documents

Publication Publication Date Title
JP2025524914A5 (enExample)
JP2023500611A5 (enExample)
JP2024119812A5 (enExample)
JP2022515197A5 (enExample)
JP2023531311A5 (enExample)
JP2023524598A5 (enExample)
JP2003515601A5 (enExample)
JP2002525329A5 (enExample)
JP6261011B2 (ja) 眼疾患処置薬
JP2019014758A5 (enExample)
JP2022522694A5 (enExample)
WO2009009501A4 (en) Non-basic melanin concentrating hormone receptor-1 antagonists and methods
RU97105381A (ru) Соединения и способы для лечения рака
JP2022553954A5 (enExample)
JP2022137237A5 (enExample)
JP2020122016A5 (enExample)
JP2024509981A5 (enExample)
CN110248662A (zh) 一种治疗前列腺癌的组合、药物组合物及治疗方法
JP2024510939A5 (enExample)
JP2021536510A5 (enExample)
JP2023544716A5 (enExample)
RU2002101622A (ru) Нафтохиноновые производные и их использование для лечения и борьбы с туберкулезом
JP2024504257A5 (enExample)
CA2491612A1 (en) 4-'7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents
JP2005538974A5 (enExample)