JP2022541453A - 生体イメージングのための蛍光系及びそれらの使用 - Google Patents

生体イメージングのための蛍光系及びそれらの使用 Download PDF

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JP2022541453A
JP2022541453A JP2022502406A JP2022502406A JP2022541453A JP 2022541453 A JP2022541453 A JP 2022541453A JP 2022502406 A JP2022502406 A JP 2022502406A JP 2022502406 A JP2022502406 A JP 2022502406A JP 2022541453 A JP2022541453 A JP 2022541453A
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compound
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compounds
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JPWO2021009506A5 (https=
JP2022541453A5 (https=
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ホワイティング アンドリュー
アンブラー キャリー
チザム デイヴィッド
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Lightox Ltd
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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JP2022502406A 2019-07-17 2020-07-14 生体イメージングのための蛍光系及びそれらの使用 Pending JP2022541453A (ja)

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GBGB1910239.1A GB201910239D0 (en) 2019-07-17 2019-07-17 Fluorescent systems for biological imaging and uses thereof
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PCT/GB2020/051694 WO2021009506A1 (en) 2019-07-17 2020-07-14 Fluorescent systems for biological imaging and uses thereof

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US (1) US20220347299A1 (https=)
EP (1) EP3921373A1 (https=)
JP (2) JP2022541453A (https=)
KR (1) KR20220036949A (https=)
CN (1) CN114127046A (https=)
AU (1) AU2020312791B2 (https=)
BR (1) BR112022000364A2 (https=)
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EP4281449A1 (en) * 2021-01-20 2023-11-29 Lightox Limited Protected hdac (histone deacetylase) inhibitors
CN115010678A (zh) * 2022-06-21 2022-09-06 南阳理工学院 不对称合成含有季碳手性中心烯丙基吖内酯衍生物的方法
CN116239584B (zh) * 2023-02-15 2024-06-11 东南大学 一种单体m1、二聚体d1及其制备方法和应用
GB202313555D0 (en) * 2023-09-05 2023-10-18 Lightox Ltd Compositions and methods for the treatment and prevention of bacterial infections casued by gram-positive bacteria

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