JP2022540913A5 - - Google Patents

Info

Publication number
JP2022540913A5
JP2022540913A5 JP2022502530A JP2022502530A JP2022540913A5 JP 2022540913 A5 JP2022540913 A5 JP 2022540913A5 JP 2022502530 A JP2022502530 A JP 2022502530A JP 2022502530 A JP2022502530 A JP 2022502530A JP 2022540913 A5 JP2022540913 A5 JP 2022540913A5
Authority
JP
Japan
Prior art keywords
nmdar
protein
construct
protein construct
ecd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022502530A
Other languages
English (en)
Japanese (ja)
Other versions
JP7659905B2 (ja
JP2022540913A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/068732 external-priority patent/WO2021008890A1/en
Publication of JP2022540913A publication Critical patent/JP2022540913A/ja
Publication of JP2022540913A5 publication Critical patent/JP2022540913A5/ja
Priority to JP2025049513A priority Critical patent/JP2025094198A/ja
Application granted granted Critical
Publication of JP7659905B2 publication Critical patent/JP7659905B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022502530A 2019-07-16 2020-07-02 Ｎｍｄａｒ自己抗体を検出及び単離するためのｎｍｄａ受容体コンストラクト Active JP7659905B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025049513A JP2025094198A (ja) 2019-07-16 2025-03-25 Ｎｍｄａｒ自己抗体を検出及び単離するためのｎｍｄａ受容体コンストラクト

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19186524.5 2019-07-16
EP19186524 2019-07-16
LU101308 2019-07-18
LULU101308 2019-07-18
PCT/EP2020/068732 WO2021008890A1 (en) 2019-07-16 2020-07-02 Nmda receptor constructs to detect and isolate nmdar autoantibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025049513A Division JP2025094198A (ja) 2019-07-16 2025-03-25 Ｎｍｄａｒ自己抗体を検出及び単離するためのｎｍｄａ受容体コンストラクト

Publications (3)

Publication Number Publication Date
JP2022540913A JP2022540913A (ja) 2022-09-20
JP2022540913A5 true JP2022540913A5 (enExample) 2023-06-27
JP7659905B2 JP7659905B2 (ja) 2025-04-10

Family

ID=71143759

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022502530A Active JP7659905B2 (ja) 2019-07-16 2020-07-02 Ｎｍｄａｒ自己抗体を検出及び単離するためのｎｍｄａ受容体コンストラクト
JP2025049513A Pending JP2025094198A (ja) 2019-07-16 2025-03-25 Ｎｍｄａｒ自己抗体を検出及び単離するためのｎｍｄａ受容体コンストラクト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025049513A Pending JP2025094198A (ja) 2019-07-16 2025-03-25 Ｎｍｄａｒ自己抗体を検出及び単離するためのｎｍｄａ受容体コンストラクト

Country Status (6)

Country Link
US (1) US20230280340A1 (enExample)
EP (1) EP3999850A1 (enExample)
JP (2) JP7659905B2 (enExample)
CN (1) CN114144427A (enExample)
CA (1) CA3144900A1 (enExample)
WO (1) WO2021008890A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3999850A1 (en) * 2019-07-16 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Nmda receptor constructs to detect and isolate nmdar autoantibodies
KR20230029671A (ko) 2020-05-27 2023-03-03 아리아리스 테라퓨틱스, 인크. 항-인간 nr1 항체 유도체
CN114957446B (zh) * 2022-05-31 2023-09-15 陕西脉元生物科技有限公司 与nmdar脑炎患者中的自身抗体结合的nmdar突变体及其构建方法
CN114891091B (zh) * 2022-06-13 2024-04-26 四川携光生物技术有限公司 一种抗nmdar脑炎重组抗原及应用
WO2024075803A1 (ja) * 2022-10-06 2024-04-11 国立大学法人 東京医科歯科大学 脳神経疾患の検査、治療もしくは予防のための方法
CN116253790A (zh) * 2022-12-13 2023-06-13 迪亚莱博（张家港）生物科技有限公司 一种用于抗nmdar抗体检测的nmdar重组蛋白及其制备方法及其应用
CN116440950B (zh) * 2023-02-24 2023-09-12 华东理工大学 一种催化剂及其制备方法和应用
WO2024206667A1 (en) * 2023-03-30 2024-10-03 Arialys Therapeutics, Inc. Detection of autoantibodies against nr1
IL326167A (en) * 2023-08-01 2026-03-01 Merida Biosciences Inc Molecules for controlling autoimmune response
CN118566499B (zh) * 2024-08-02 2024-10-08 成都海默云因医学检验实验室有限公司 一种GluN1和GluN2B亚基融合表达检测抗NMDAR抗体的CBA方法及检测试剂
CN119985969B (zh) * 2024-10-11 2025-11-18 杭州臻源生物医药科技有限公司 一种使用双色荧光检测试剂盒测定抗nmdar抗体的方法
CN120721960B (zh) * 2025-08-19 2025-11-21 上海金域医学检验所有限公司 一种自身免疫性脑炎抗体检测指示试剂、试剂盒与制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770460B1 (en) * 1998-01-29 2004-08-03 Wallac Oy Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
DE19818790A1 (de) 1998-04-27 1999-10-28 Affina Immuntechnik Gmbh Immunadsorptionsmatrix, Verfahren zu ihrer Herstellung und ihre Verwendung
AU2002220577A1 (en) 2000-09-28 2002-04-08 Affina Immuntechnik Gmbh Circulatory device for separating substances in bodily fluids, especially blood,and the use of said device
US6896872B2 (en) * 2001-06-27 2005-05-24 Svetlana A. Dambinova Rapid multiple panel of biomarkers in laboratory blood tests for TIA/stroke
ATE555383T1 (de) * 2006-06-22 2012-05-15 Novo Nordisk As Lösliche heterodimere rezeptoren und ihre verwendung
CA2697742C (en) * 2006-08-15 2017-10-03 The Trustees Of The University Of Pennsylvania Methods and compositions for treatment and diagnosis of autoimmune encephalitis or epilepsy
DE102010053432A1 (de) * 2010-12-06 2012-06-06 Euroimmun Medizinische Labordiagnostika Ag Verfahren zum Nachweis von anti-NMDA-Rezeptor Autoantikörpern zum Einsatz in Diagnoseverfahren
WO2013041029A1 (en) * 2011-09-23 2013-03-28 Igenimed Pharmaceuticals Inc. Novel soluble ctla4 variants
WO2015142880A1 (en) * 2014-03-18 2015-09-24 Sanford Health Reagents and methods for breast cancer detection
GB201409234D0 (en) * 2014-05-23 2014-07-09 Isis Innovation Method
EP3999850A1 (en) * 2019-07-16 2022-05-25 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Nmda receptor constructs to detect and isolate nmdar autoantibodies

Similar Documents

Publication Publication Date Title
Dambinova et al. Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke
US20230280340A1 (en) Nmda receptor constructs to detect and isolate nmdar autoantibodies
US10451620B2 (en) Treating conditions associated with metabolic syndrome
JP2021128177A (ja) 心臓血管疾患及び事象のための診断及び予後方法
JP2016105097A5 (enExample)
Gupta et al. An epitope‐imprinted piezoelectric diagnostic tool for Neisseria meningitidis detection
CA2527916A1 (en) Biological markers for diagnosing rheumatoid arthritis
Luker et al. Imaging CXCR4 signaling with firefly luciferase complementation
JP2006284567A (ja) ヘリコバクター・ピロリ感染の診断方法及び診断キット
WO2012039614A1 (en) Novel method for diagnosing lyme disease using a cellular immunological test
US20180275090A1 (en) SYSTEMS AND METHODS FOR THE DETECTION OF HbA1c
CN106257287B (zh) 生长分化因子15评估高血压患者首发脑卒中的新应用
KR20220034725A (ko) 브루가다 증후군과 관련된 바이오마커의 검출
Frank et al. Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28
WO2008017363A2 (en) Improved immunoassay involving mutant antigens to reduce unspecific binding
JP2010523963A (ja) 診断アッセイ
PT2274623E (pt) Método para o diagnóstico de hipertensão arterial pulmonar
CN107110848A (zh) 以脱氧羟腐胺缩赖氨酸合酶基因作为指标使用的动脉硬化及癌的检测方法
JP7006926B2 (ja) 高安動脈炎の診断方法、診断マーカー及び診断キット
JP7620324B2 (ja) 炎症性腸疾患の診断方法、診断プローブ及び診断キット
WO2012104624A2 (en) Biomarkers for osteoarthritis
JP7421183B2 (ja) 抗原固相化デバイス
JP2015515264A5 (enExample)
JP2009244225A (ja) 脳炎の診断方法及び脳炎の診断システム
CN110325862B (zh) 用于检测缺血性发生的慢性脑病理学的诊断试剂盒