JP2015515264A5 - - Google Patents
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- Publication number
- JP2015515264A5 JP2015515264A5 JP2014561534A JP2014561534A JP2015515264A5 JP 2015515264 A5 JP2015515264 A5 JP 2015515264A5 JP 2014561534 A JP2014561534 A JP 2014561534A JP 2014561534 A JP2014561534 A JP 2014561534A JP 2015515264 A5 JP2015515264 A5 JP 2015515264A5
- Authority
- JP
- Japan
- Prior art keywords
- pathogen
- protein
- derived
- recognition module
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000052769 pathogen Species 0.000 claims description 60
- 230000001717 pathogenic effect Effects 0.000 claims description 60
- 235000018102 proteins Nutrition 0.000 claims description 34
- 102000004169 proteins and genes Human genes 0.000 claims description 34
- 108090000623 proteins and genes Proteins 0.000 claims description 34
- 102000037865 fusion proteins Human genes 0.000 claims description 18
- 108020001507 fusion proteins Proteins 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 108010078070 scavenger receptors Proteins 0.000 claims description 18
- 102000014452 scavenger receptors Human genes 0.000 claims description 18
- 239000007790 solid phase Substances 0.000 claims description 14
- 238000012360 testing method Methods 0.000 claims description 10
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 8
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 8
- 239000012472 biological sample Substances 0.000 claims description 8
- 230000007923 virulence factor Effects 0.000 claims description 8
- 239000000304 virulence factor Substances 0.000 claims description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
- 235000001014 amino acid Nutrition 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 150000007523 nucleic acids Chemical group 0.000 claims description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 102000014944 Lysosome-Associated Membrane Glycoproteins Human genes 0.000 claims description 4
- 108010064171 Lysosome-Associated Membrane Glycoproteins Proteins 0.000 claims description 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 102000035013 scavenger receptor class A Human genes 0.000 claims description 4
- 108091005451 scavenger receptor class A Proteins 0.000 claims description 4
- 108050009406 C-type lectin-like Proteins 0.000 claims description 2
- 102000002086 C-type lectin-like Human genes 0.000 claims description 2
- 108050002150 EGF-like domains Proteins 0.000 claims description 2
- 102000012545 EGF-like domains Human genes 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 101710154606 Hemagglutinin Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- 102100035971 Molybdopterin molybdenumtransferase Human genes 0.000 claims description 2
- 101710119577 Molybdopterin molybdenumtransferase Proteins 0.000 claims description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 2
- 101710176177 Protein A56 Proteins 0.000 claims description 2
- 108050008568 SRCR domains Proteins 0.000 claims description 2
- 102000000185 SRCR domains Human genes 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000185 hemagglutinin Substances 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261609523P | 2012-03-12 | 2012-03-12 | |
| US61/609,523 | 2012-03-12 | ||
| PCT/IB2013/000845 WO2013136180A2 (en) | 2012-03-12 | 2013-03-12 | Chimeric proteins for treatment of diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015515264A JP2015515264A (ja) | 2015-05-28 |
| JP2015515264A5 true JP2015515264A5 (enExample) | 2016-04-28 |
Family
ID=48670612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561534A Pending JP2015515264A (ja) | 2012-03-12 | 2013-03-12 | 疾患の処置のためのキメラタンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150099297A1 (enExample) |
| EP (1) | EP2825554A2 (enExample) |
| JP (1) | JP2015515264A (enExample) |
| CN (1) | CN104321339A (enExample) |
| WO (1) | WO2013136180A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017075189A1 (en) * | 2015-10-27 | 2017-05-04 | University Of Massachusetts | Factor h-fc immunotherapy |
| AU2022426854A1 (en) * | 2021-12-31 | 2024-06-13 | The Trustees Of Columbia University In The City Of New York | Bispecific molecules to target the first cell |
| WO2023168292A2 (en) * | 2022-03-01 | 2023-09-07 | Hemogenyx Pharmaceuticals Llc | Chimeric bait receptors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916766A (en) * | 1996-05-23 | 1999-06-29 | Smithkline Beecham Corporation | Human marco scavenger receptor |
| WO1998047916A1 (en) * | 1997-04-18 | 1998-10-29 | President And Fellows Of Harvard College | Bifunctional polypeptides for cell-specific viral targeting |
| FR2816059B1 (fr) * | 2000-10-27 | 2003-04-11 | Pf Medicament | Procede d'identification de nouvelles molecules se liant aux recepteurs scavenger et signalees via un recepteur toll |
| US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
| JPWO2005033307A1 (ja) * | 2003-09-30 | 2006-12-14 | 技術研究組合 生物分子工学研究所 | 新規のリフォールディング方法およびその方法によって得られたタンパク質 |
| WO2007001332A2 (en) * | 2004-08-04 | 2007-01-04 | University Of Massachusetts | Anti-pathogen immunoadhesins |
-
2013
- 2013-03-12 US US14/385,013 patent/US20150099297A1/en not_active Abandoned
- 2013-03-12 EP EP13730634.6A patent/EP2825554A2/en not_active Withdrawn
- 2013-03-12 WO PCT/IB2013/000845 patent/WO2013136180A2/en not_active Ceased
- 2013-03-12 JP JP2014561534A patent/JP2015515264A/ja active Pending
- 2013-03-12 CN CN201380024894.1A patent/CN104321339A/zh active Pending
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