JP2007526919A5 - - Google Patents

Info

Publication number

JP2007526919A5

JP2007526919A5 JP2007501755A JP2007501755A JP2007526919A5 JP 2007526919 A5 JP2007526919 A5 JP 2007526919A5 JP 2007501755 A JP2007501755 A JP 2007501755A JP 2007501755 A JP2007501755 A JP 2007501755A JP 2007526919 A5 JP2007526919 A5 JP 2007526919A5

Authority

JP

Japan

Prior art keywords

peptide

heterologous

carrier

linker

seq

Prior art date

2004-03-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 165
• 150000001413 amino acids Chemical class 0.000 claims description 43
• 238000000034 method Methods 0.000 claims description 34
• 101000945318 Homo sapiens Calponin-1 Proteins 0.000 claims description 33
• 101000652736 Homo sapiens Transgelin Proteins 0.000 claims description 33
• 102100031013 Transgelin Human genes 0.000 claims description 33
• JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims description 33
• 235000001014 amino acid Nutrition 0.000 claims description 28
• 239000004005 microsphere Substances 0.000 claims description 22
• 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 18
• 238000001514 detection method Methods 0.000 claims description 13
• 235000018102 proteins Nutrition 0.000 claims description 11
• 102000004169 proteins and genes Human genes 0.000 claims description 11
• 108090000623 proteins and genes Proteins 0.000 claims description 11
• 238000000684 flow cytometry Methods 0.000 claims description 9
• 229920000642 polymer Polymers 0.000 claims description 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
• 125000000539 amino acid group Chemical group 0.000 claims description 3
• LQILVUYCDHSGEU-UHFFFAOYSA-N 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1CN1C(=O)C=CC1=O LQILVUYCDHSGEU-UHFFFAOYSA-N 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 30
• 108091003079 Bovine Serum Albumin Proteins 0.000 claims 19
• 125000003275 alpha amino acid group Chemical group 0.000 claims 18
• 229940098773 bovine serum albumin Drugs 0.000 claims 11
• 239000012472 biological sample Substances 0.000 claims 5
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
• 239000004816 latex Substances 0.000 claims 2
• 229920000126 latex Polymers 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 1
• 210000003097 mucus Anatomy 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 210000001625 seminal vesicle Anatomy 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 238000011895 specific detection Methods 0.000 claims 1
• 201000010653 vesiculitis Diseases 0.000 claims 1
• 238000002965 ELISA Methods 0.000 description 4
• 239000000427 antigen Substances 0.000 description 4
• 102000036639 antigens Human genes 0.000 description 4
• 108091007433 antigens Proteins 0.000 description 4
• 229910052799 carbon Inorganic materials 0.000 description 3
• 102000004196 processed proteins & peptides Human genes 0.000 description 3
• 230000001588 bifunctional effect Effects 0.000 description 2
• 229920001184 polypeptide Polymers 0.000 description 2
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• -1 polyethylene Polymers 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1