JP2022539579A5 - - Google Patents
Info
- Publication number
- JP2022539579A5 JP2022539579A5 JP2021578216A JP2021578216A JP2022539579A5 JP 2022539579 A5 JP2022539579 A5 JP 2022539579A5 JP 2021578216 A JP2021578216 A JP 2021578216A JP 2021578216 A JP2021578216 A JP 2021578216A JP 2022539579 A5 JP2022539579 A5 JP 2022539579A5
- Authority
- JP
- Japan
- Prior art keywords
- provides
- present
- following table
- synthesizing compounds
- synthesizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023177565A JP2023171659A (ja) | 2020-03-27 | 2023-10-13 | Ｐｌｋ１の選択的分解誘導化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200037875 | 2020-03-27 | ||
| KR10-2020-0037875 | 2020-03-27 | ||
| PCT/KR2021/003807 WO2021194318A1 (en) | 2020-03-27 | 2021-03-27 | Plk1 selective degradation inducing compound |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023177565A Division JP2023171659A (ja) | 2020-03-27 | 2023-10-13 | Ｐｌｋ１の選択的分解誘導化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022539579A JP2022539579A (ja) | 2022-09-12 |
| JP2022539579A5 true JP2022539579A5 (cg-RX-API-DMAC10.html) | 2023-03-29 |
| JP7440940B2 JP7440940B2 (ja) | 2024-02-29 |
Family
ID=77892014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021578216A Active JP7440940B2 (ja) | 2020-03-27 | 2021-03-27 | Ｐｌｋ１の選択的分解誘導化合物 |
| JP2023177565A Pending JP2023171659A (ja) | 2020-03-27 | 2023-10-13 | Ｐｌｋ１の選択的分解誘導化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023177565A Pending JP2023171659A (ja) | 2020-03-27 | 2023-10-13 | Ｐｌｋ１の選択的分解誘導化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20230158158A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3911654A4 (cg-RX-API-DMAC10.html) |
| JP (2) | JP7440940B2 (cg-RX-API-DMAC10.html) |
| KR (8) | KR102313753B1 (cg-RX-API-DMAC10.html) |
| CN (1) | CN113784969A (cg-RX-API-DMAC10.html) |
| WO (4) | WO2021194318A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020356484A1 (en) | 2019-09-27 | 2022-03-17 | Dana-Farber Cancer Institute, Inc. | ERK5 degraders as therapeutics in cancer and inflammatory diseases |
| US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
| TW202317546A (zh) | 2021-07-09 | 2023-05-01 | 美商普萊克斯姆公司 | 調節ikzf2之芳基化合物及醫藥組合物 |
| JP7555155B2 (ja) * | 2021-08-10 | 2024-09-24 | オップテラ インコーポレイテッド | 新規ｐｌｋ１分解誘導化合物 |
| WO2023016518A1 (zh) | 2021-08-11 | 2023-02-16 | 四川海思科制药有限公司 | 一种杂环衍生物及其组合物和药学上的应用 |
| CN114380682A (zh) * | 2021-10-27 | 2022-04-22 | 上海毕得医药科技股份有限公司 | 一种2,3-二氟-4-甲氧基苯乙酸合成方法 |
| WO2023104195A1 (zh) * | 2021-12-10 | 2023-06-15 | 正大天晴药业集团股份有限公司 | 一种异噻唑并[5,4-d]嘧啶类IRAK4抑制剂的制备方法 |
| JP2024546115A (ja) * | 2021-12-10 | 2024-12-17 | シャンドン ルイ ファーマシューティカル カンパニー リミテッド | プロテインキナーゼ阻害剤及びその製造方法と応用 |
| CN116924929A (zh) * | 2022-07-08 | 2023-10-24 | 重庆圣华曦药业股份有限公司 | 一种碘比醇异构体的合成方法 |
| CN115490675B (zh) * | 2022-09-19 | 2024-11-12 | 安阳师范学院 | 季酮酸衍生物及其制备方法与应用 |
| CN120603831A (zh) * | 2022-11-29 | 2025-09-05 | 厄普特拉株式会社 | 具有增加的刚性的plk1降解诱导化合物 |
| WO2024153110A1 (zh) * | 2023-01-17 | 2024-07-25 | 北京哲源科技有限责任公司 | 吡唑并喹唑啉类化合物的立体异构体和氘代衍生物及应用 |
| EP4658658A1 (en) * | 2023-02-02 | 2025-12-10 | Uppthera, Inc. | Novel plk1 degradation inducing compound |
| CN116554044A (zh) * | 2023-05-16 | 2023-08-08 | 上海师范大学 | 一种无氨基保护的2,6-二异丙基-4-羧基苯胺及其合成方法 |
| KR20250058831A (ko) | 2023-10-23 | 2025-05-02 | 주식회사 펩토이드 | Ｐｌｋ－１의 폴로박스 도메인에 결합하는 저분자 화합물을 함유하는 항암제 |
| WO2025239662A1 (ko) * | 2024-05-13 | 2025-11-20 | (주) 업테라 | 분해 약물-항체 접합체용 plk1 분해 유도 화합물 |
| CN119707950A (zh) * | 2024-12-24 | 2025-03-28 | 无锡市南京大学锡山应用生物技术研究所 | 一种用于免疫蛋白靶向降解的嵌合体及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008003173A (es) * | 2005-09-06 | 2008-03-18 | Smithkline Beecham Corp | Compuestos de bencimidazol-tiofeno como inhibidores de plk. |
| PL2125822T3 (pl) * | 2006-12-21 | 2015-04-30 | Nerviano Medical Sciences Srl | Podstawione pochodne pirazolochinazoliny, sposób ich wytwarzania oraz ich zastosowanie jako inhibitory kinaz |
| CN101636399B (zh) * | 2007-03-22 | 2012-04-18 | 武田药品工业株式会社 | 可用作plk1抑制剂的取代的嘧啶并二氮杂* |
| BRPI0817315A2 (pt) | 2007-09-25 | 2015-03-17 | Takeda Pharmaceutical | Inibidores de quinase do tipo polo |
| WO2009153197A1 (en) * | 2008-06-18 | 2009-12-23 | F. Hoffmann-La Roche Ag | Halo-substituted pyrimidodiazepines as plkl inhibitors |
| AR076784A1 (es) * | 2009-05-26 | 2011-07-06 | Nerviano Medical Sciences Srl | Combinacion terapeutica que comprende un inhibidor de plk1 y un agente antineoplasico |
| KR102438072B1 (ko) | 2012-01-12 | 2022-08-31 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| EP4649963A3 (en) | 2014-04-14 | 2026-05-13 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| AU2016232705C1 (en) | 2015-03-18 | 2021-06-17 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| BR112018008918A8 (pt) * | 2015-11-02 | 2019-02-26 | Univ Yale | compostos de quimera proteólise dirigida e métodos para preparação e uso dos mesmos |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| CN106543185B (zh) * | 2016-11-10 | 2017-12-15 | 吉林大学 | 一种靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| IL319363A (en) * | 2017-01-31 | 2025-05-01 | Arvinas Operations Inc | Cervalon ligands and bifunctional compounds containing them |
| CN106977584B (zh) * | 2017-04-19 | 2019-12-06 | 吉林大学 | 靶向泛素化降解plk1和brd4蛋白的化合物及其应用 |
| WO2019114770A1 (zh) | 2017-12-13 | 2019-06-20 | 上海科技大学 | Alk蛋白降解剂及其抗肿瘤应用 |
| KR102127289B1 (ko) * | 2018-09-18 | 2020-06-26 | 고려대학교 산학협력단 | 암 세포를 표적화하기 위한 plk 선택적 형광 프로브 화합물 및 이를 포함하는 plk 검출용 형광 센서 |
| CN111018857B (zh) * | 2018-10-09 | 2023-06-02 | 嘉兴优博生物技术有限公司 | 靶向蛋白酶降解平台(ted) |
| CN109879877B (zh) | 2019-03-04 | 2021-08-10 | 吉林大学 | 一种可降解plk1和brd4蛋白的化合物及其应用 |
| US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
| JP7555155B2 (ja) * | 2021-08-10 | 2024-09-24 | オップテラ インコーポレイテッド | 新規ｐｌｋ１分解誘導化合物 |
-
2021
- 2021-03-27 US US17/914,545 patent/US20230158158A1/en active Pending
- 2021-03-27 US US17/914,574 patent/US20230203006A1/en active Pending
- 2021-03-27 KR KR1020210040038A patent/KR102313753B1/ko active Active
- 2021-03-27 US US17/914,565 patent/US12403198B2/en active Active
- 2021-03-27 US US17/428,467 patent/US11833208B2/en active Active
- 2021-03-27 KR KR1020210040035A patent/KR102337029B1/ko active Active
- 2021-03-27 EP EP21749059.8A patent/EP3911654A4/en active Pending
- 2021-03-27 JP JP2021578216A patent/JP7440940B2/ja active Active
- 2021-03-27 KR KR1020210040037D patent/KR20210122164A/ko active Granted
- 2021-03-27 KR KR1020210040037A patent/KR102319264B1/ko active Active
- 2021-03-27 KR KR1020210040036D patent/KR20210122163A/ko active Granted
- 2021-03-27 KR KR1020210040036A patent/KR102313752B1/ko active Active
- 2021-03-27 WO PCT/KR2021/003807 patent/WO2021194318A1/en not_active Ceased
- 2021-03-27 WO PCT/KR2021/003810 patent/WO2021194321A1/en not_active Ceased
- 2021-03-27 CN CN202180002576.XA patent/CN113784969A/zh active Pending
- 2021-03-27 WO PCT/KR2021/003809 patent/WO2021194320A1/en not_active Ceased
- 2021-03-27 KR KR1020210040038D patent/KR20210122165A/ko active Granted
- 2021-03-27 WO PCT/KR2021/003808 patent/WO2021194319A1/en not_active Ceased
- 2021-12-02 KR KR1020210171223A patent/KR102529222B1/ko active Active
-
2023
- 2023-08-02 US US18/229,353 patent/US20230372498A1/en not_active Abandoned
- 2023-10-13 JP JP2023177565A patent/JP2023171659A/ja active Pending
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