JP2022536845A - Ｐｄ－ｌ１疾患の治療のための化合物 - Google Patents

Ｐｄ－ｌ１疾患の治療のための化合物 Download PDF

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JP2022536845A
JP2022536845A JP2021574927A JP2021574927A JP2022536845A JP 2022536845 A JP2022536845 A JP 2022536845A JP 2021574927 A JP2021574927 A JP 2021574927A JP 2021574927 A JP2021574927 A JP 2021574927A JP 2022536845 A JP2022536845 A JP 2022536845A
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cancer
agents
group
compound
pharmaceutically acceptable
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JPWO2020257549A5 (OSRAM
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マラソン ビエンカム
ファン ピンチェン
ランゲ クリストファー
レディ マリ ベンカット
ジェイ．マクマートリー ダレン
パナ スリーニバス
エス．ロス ハワード
シン ラジンダー
チュイ ヤン
ジャーン ペングリー
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ケモセントリックス，インコーポレイティド
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Priority to JP2025123800A priority Critical patent/JP2025170244A/ja
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    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
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