JP2022536692A - 調節不全の血漿カリクレインによって媒介される疾患の治療のための抗体のアデノ随伴ウイルスベクター送達 - Google Patents
調節不全の血漿カリクレインによって媒介される疾患の治療のための抗体のアデノ随伴ウイルスベクター送達 Download PDFInfo
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- plasma kallikrein
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Immunology (AREA)
- General Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962860101P | 2019-06-11 | 2019-06-11 | |
| US62/860,101 | 2019-06-11 | ||
| PCT/US2020/037189 WO2020252136A1 (en) | 2019-06-11 | 2020-06-11 | Adeno associated viral vector delivery of antibodies for the treatment of disease mediated dysregulated plasma kallikrein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022536692A true JP2022536692A (ja) | 2022-08-18 |
| JPWO2020252136A5 JPWO2020252136A5 (https=) | 2023-06-20 |
| JP2022536692A5 JP2022536692A5 (https=) | 2023-06-20 |
Family
ID=71995023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573442A Pending JP2022536692A (ja) | 2019-06-11 | 2020-06-11 | 調節不全の血漿カリクレインによって媒介される疾患の治療のための抗体のアデノ随伴ウイルスベクター送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230038502A1 (https=) |
| EP (1) | EP3983449A1 (https=) |
| JP (1) | JP2022536692A (https=) |
| CN (1) | CN114207135A (https=) |
| AR (1) | AR119271A1 (https=) |
| TW (1) | TW202115126A (https=) |
| WO (1) | WO2020252136A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024056707A (ja) * | 2019-12-20 | 2024-04-23 | ノバルティス アーゲー | 抗癌剤として有用なピラゾリル誘導体 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4213890A1 (en) * | 2020-09-15 | 2023-07-26 | RegenxBio Inc. | Vectorized lanadelumab and administration thereof |
| CA3094859A1 (en) * | 2020-10-01 | 2022-04-01 | Entos Pharmaceuticals Inc. | Proteolipid vesicles formulated with fusion associated small transmembrane proteins |
| CN114790245A (zh) * | 2021-01-25 | 2022-07-26 | 成都康弘生物科技有限公司 | 一种抗体及其用途 |
| KR20230137410A (ko) * | 2021-01-28 | 2023-10-04 | 아스트리아 테라퓨틱스, 인크. | 혈장 칼리크레인 항체 및 이의 용도 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014511180A (ja) * | 2011-02-22 | 2014-05-15 | カリフォルニア インスティチュート オブ テクノロジー | アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達 |
| JP2015530983A (ja) * | 2012-08-08 | 2015-10-29 | ロシュ グリクアート アーゲー | インターロイキン−10融合タンパク質及びその使用 |
| JP2018513678A (ja) * | 2015-03-17 | 2018-05-31 | フリーイェ・ユニヴェルシテイト・ブリュッセルVrije Universieit Brussel | Fviiiおよびfix用の最適化された肝臓特異的発現系 |
| WO2018217731A1 (en) * | 2017-05-22 | 2018-11-29 | Baxalta Incorporated | Viral vectors encoding recombinant fix with increased expression for gene therapy of hemophilia b |
| WO2019079496A2 (en) * | 2017-10-18 | 2019-04-25 | Regenxbio, Inc. | FULLY HUMAN ANTIBODY-BASED THERAPEUTIC AGENTS HAVING POST-TRANSLATION MODIFICATION |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6136597A (en) | 1997-09-18 | 2000-10-24 | The Salk Institute For Biological Studies | RNA export element |
| US7419829B2 (en) | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
| US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| EP1438075A4 (en) | 2001-10-02 | 2006-04-19 | Inst Clayton De La Rech | METHOD AND COMPOSITIONS ASSOCIATED WITH LENTIVIRAL VECTORS WITH LIMITED EXPRESSION AND ITS APPLICATIONS |
| US7816131B2 (en) | 2004-04-02 | 2010-10-19 | Board Of Regents, The University Of Texas System | Cancer specific promoters |
| US9725485B2 (en) * | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
| GB201206455D0 (en) | 2012-04-12 | 2012-05-30 | Royal Holloway & Bedford New College | Gene expression |
| JP2016517440A (ja) | 2013-03-15 | 2016-06-16 | ブイエルピー バイオテック,インコーポレイテッド | パリビズマブエピトープベースのウイルス様粒子 |
| WO2014152232A2 (en) | 2013-03-15 | 2014-09-25 | Dyax Corp. | Anti-plasma kallikrein antibodies |
| IL295414B2 (en) * | 2014-03-27 | 2026-02-01 | Takeda Pharmaceuticals Co | Compositions and methods for treating macular edema due to diabetes |
| US20160130324A1 (en) * | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| CN107249646B (zh) | 2014-12-16 | 2021-06-29 | 内布拉斯加大学董事会 | 用于青少年巴滕病的基因疗法 |
| CL2014003590A1 (es) | 2014-12-30 | 2015-07-10 | Univ Chile | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. |
| MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
| US10179918B2 (en) | 2015-05-07 | 2019-01-15 | Sangamo Therapeutics, Inc. | Methods and compositions for increasing transgene activity |
| GB2547179A (en) | 2015-10-26 | 2017-08-16 | Quethera Ltd | Genetic construct |
| CN108291238A (zh) | 2015-10-27 | 2018-07-17 | 赛尔希恩公司 | 嵌合转录后调控元件 |
| CN109415687A (zh) | 2016-04-07 | 2019-03-01 | 蓝鸟生物公司 | 嵌合抗原受体t细胞组合物 |
| JP7632835B2 (ja) | 2016-05-20 | 2025-02-19 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 加齢関連疾患及び症状の遺伝子治療法 |
| CN110662839A (zh) | 2017-02-17 | 2020-01-07 | 珀杜研究基金会 | 用于细胞疗法的基于靶向性配体-有效负载的药物递送 |
-
2020
- 2020-06-11 US US17/618,193 patent/US20230038502A1/en not_active Abandoned
- 2020-06-11 CN CN202080055596.9A patent/CN114207135A/zh active Pending
- 2020-06-11 AR ARP200101656A patent/AR119271A1/es unknown
- 2020-06-11 WO PCT/US2020/037189 patent/WO2020252136A1/en not_active Ceased
- 2020-06-11 JP JP2021573442A patent/JP2022536692A/ja active Pending
- 2020-06-11 TW TW109119759A patent/TW202115126A/zh unknown
- 2020-06-11 EP EP20753482.7A patent/EP3983449A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014511180A (ja) * | 2011-02-22 | 2014-05-15 | カリフォルニア インスティチュート オブ テクノロジー | アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達 |
| JP2015530983A (ja) * | 2012-08-08 | 2015-10-29 | ロシュ グリクアート アーゲー | インターロイキン−10融合タンパク質及びその使用 |
| JP2018513678A (ja) * | 2015-03-17 | 2018-05-31 | フリーイェ・ユニヴェルシテイト・ブリュッセルVrije Universieit Brussel | Fviiiおよびfix用の最適化された肝臓特異的発現系 |
| WO2018217731A1 (en) * | 2017-05-22 | 2018-11-29 | Baxalta Incorporated | Viral vectors encoding recombinant fix with increased expression for gene therapy of hemophilia b |
| WO2019079496A2 (en) * | 2017-10-18 | 2019-04-25 | Regenxbio, Inc. | FULLY HUMAN ANTIBODY-BASED THERAPEUTIC AGENTS HAVING POST-TRANSLATION MODIFICATION |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024056707A (ja) * | 2019-12-20 | 2024-04-23 | ノバルティス アーゲー | 抗癌剤として有用なピラゾリル誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3983449A1 (en) | 2022-04-20 |
| WO2020252136A1 (en) | 2020-12-17 |
| AR119271A1 (es) | 2021-12-09 |
| TW202115126A (zh) | 2021-04-16 |
| CN114207135A (zh) | 2022-03-18 |
| US20230038502A1 (en) | 2023-02-09 |
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