CL2014003590A1 - Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. - Google Patents
Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje.Info
- Publication number
- CL2014003590A1 CL2014003590A1 CL2014003590A CL2014003590A CL2014003590A1 CL 2014003590 A1 CL2014003590 A1 CL 2014003590A1 CL 2014003590 A CL2014003590 A CL 2014003590A CL 2014003590 A CL2014003590 A CL 2014003590A CL 2014003590 A1 CL2014003590 A1 CL 2014003590A1
- Authority
- CL
- Chile
- Prior art keywords
- xbp1s
- aav
- cognitive
- virus
- optimization
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2014003590A CL2014003590A1 (es) | 2014-12-30 | 2014-12-30 | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. |
PCT/CL2015/000069 WO2016106458A1 (es) | 2014-12-30 | 2015-12-24 | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimización y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje |
EP15874441.7A EP3254702B1 (en) | 2014-12-30 | 2015-12-24 | Aav/xbp1s-ha virus, gene therapy method and use thereof in the optimisation and improvement of learning, memory and cognitive capacities |
PL15874441.7T PL3254702T3 (pl) | 2014-12-30 | 2015-12-24 | Wirus aav/xbp1s-ha, sposób terapii genowej i jego stosowanie w optymalizacji i poprawie zdolności uczenia się, pamięci i zdolności poznawczych |
ES15874441T ES2949828T3 (es) | 2014-12-30 | 2015-12-24 | Virus AAV/XBP1S-HA, método de terapia génica y uso de este en la optimización y mejora de las capacidades de aprendizaje, memoria y cognitivas |
US15/539,826 US11400166B2 (en) | 2014-12-30 | 2015-12-24 | AAV/XBP1s-HA virus, gene therapy method and use thereof in the optimisation and improvement of learning, memory and cognitive capacities |
US16/858,435 US20210060178A1 (en) | 2014-12-30 | 2020-04-24 | Aav/xbp1s-ha virus, gene therapy method and use thereof in the optimisation and improvement of learning, memory and cognitive capacities |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2014003590A CL2014003590A1 (es) | 2014-12-30 | 2014-12-30 | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2014003590A1 true CL2014003590A1 (es) | 2015-07-10 |
Family
ID=56283749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014003590A CL2014003590A1 (es) | 2014-12-30 | 2014-12-30 | Virus aav/xbp1s-ha, método de tratamiento genético y su uso en la optimizacion y mejoramiento de las capacidades cognitivas, de memoria y de aprendizaje. |
Country Status (6)
Country | Link |
---|---|
US (2) | US11400166B2 (es) |
EP (1) | EP3254702B1 (es) |
CL (1) | CL2014003590A1 (es) |
ES (1) | ES2949828T3 (es) |
PL (1) | PL3254702T3 (es) |
WO (1) | WO2016106458A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017059554A1 (es) * | 2015-10-09 | 2017-04-13 | Universidad De Chile | Método de tratamiento genético utilizando el virus aav-xbp1s/gfp, y su uso en la prevención y tratamiento de la esclerosis lateral amiotrófica |
WO2017075729A1 (es) * | 2015-11-04 | 2017-05-11 | Universidad De Chile | Virus aav/upr-plus, proteina de fusion upr-plus, metodo de tratamiento genetico y su uso en el tratamiento enfermedades neurodegenerativas, tales como la enfermedad de parkinson y huntington, entre otras |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2016003282A1 (es) * | 2016-12-21 | 2017-08-18 | Univ Chile | Virus aav/igf2, método de tratamiento genético y su uso en enfermedades relacionadas con mal plegamiento de proteínas tal como la enfermedad de huntington |
US20220184175A1 (en) * | 2019-02-01 | 2022-06-16 | Universidad De Chile | Treatment of aging or age-related disorders using xbp1 |
TW202115126A (zh) | 2019-06-11 | 2021-04-16 | 美商舒爾人類基因療法公司 | 用於治療血漿激肽釋放酶失調所介導之疾病的抗體腺相關病毒載體遞送 |
EP3999647A1 (en) * | 2019-07-18 | 2022-05-25 | Lysogene | Compositions and methods for the treatment of sanfilippo disease and other disorders |
EP4048800A1 (en) | 2019-10-23 | 2022-08-31 | Shire Human Genetic Therapies, Inc. | Adeno-associated virus vectors based gene therapy for hereditary angioedema |
EP4263614A1 (en) | 2020-12-16 | 2023-10-25 | Takeda Pharmaceutical Company Limited | Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein |
WO2023143435A1 (zh) * | 2022-01-29 | 2023-08-03 | 上海日馨医药科技股份有限公司 | 表达tpk的重组病毒及其治疗阿尔茨海默病的用途 |
CN115779083B (zh) * | 2022-08-05 | 2024-04-02 | 河南省精神病医院(新乡医学院第二附属医院) | 下调Tp73蛋白表达的物质在制备治疗酒依赖的药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7090836B2 (en) | 2002-06-21 | 2006-08-15 | Institut Pasteur | Vector for expressing α-L-iduronidase and method of treating MPS I by stereotactic injection into the brain of a mammal |
WO2009034127A1 (en) | 2007-09-12 | 2009-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of the cyp46a1 gene for the treatment of alzheimer's disease |
-
2014
- 2014-12-30 CL CL2014003590A patent/CL2014003590A1/es unknown
-
2015
- 2015-12-24 ES ES15874441T patent/ES2949828T3/es active Active
- 2015-12-24 PL PL15874441.7T patent/PL3254702T3/pl unknown
- 2015-12-24 US US15/539,826 patent/US11400166B2/en active Active
- 2015-12-24 WO PCT/CL2015/000069 patent/WO2016106458A1/es active Application Filing
- 2015-12-24 EP EP15874441.7A patent/EP3254702B1/en active Active
-
2020
- 2020-04-24 US US16/858,435 patent/US20210060178A1/en not_active Abandoned
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017059554A1 (es) * | 2015-10-09 | 2017-04-13 | Universidad De Chile | Método de tratamiento genético utilizando el virus aav-xbp1s/gfp, y su uso en la prevención y tratamiento de la esclerosis lateral amiotrófica |
US10512698B2 (en) | 2015-10-09 | 2019-12-24 | Universidad De Chile | Method for genetic treatment using the AAV-XBP1s/GFP virus and use thereof in the prevention and treatment of amyotrophic lateral sclerosis |
AU2016336063B2 (en) * | 2015-10-09 | 2023-07-13 | Universidad De Chile | Method for genetic treatment using the AAV-XBP1S/GFP virus and use thereof in the prevention and treatment of amyotrophic lateral sclerosis |
WO2017075729A1 (es) * | 2015-11-04 | 2017-05-11 | Universidad De Chile | Virus aav/upr-plus, proteina de fusion upr-plus, metodo de tratamiento genetico y su uso en el tratamiento enfermedades neurodegenerativas, tales como la enfermedad de parkinson y huntington, entre otras |
US10889831B2 (en) | 2015-11-04 | 2021-01-12 | Universidad De Chile | AAV/UPR-plus virus, UPR-plus fusion protein, genetic treatment method and its use in treatment of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease, among others |
US11795476B2 (en) | 2015-11-04 | 2023-10-24 | Universidad De Chile | AAV/UPR-plus virus, UPR-plus fusion protein, genetic treatment method and its use in the treatment of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease, among others |
Also Published As
Publication number | Publication date |
---|---|
WO2016106458A8 (es) | 2021-12-23 |
ES2949828T3 (es) | 2023-10-03 |
US20170360961A1 (en) | 2017-12-21 |
EP3254702A1 (en) | 2017-12-13 |
US20210060178A1 (en) | 2021-03-04 |
US11400166B2 (en) | 2022-08-02 |
WO2016106458A1 (es) | 2016-07-07 |
EP3254702B1 (en) | 2023-05-10 |
PL3254702T3 (pl) | 2023-09-11 |
EP3254702A4 (en) | 2019-02-20 |
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