JP2022536092A5 - - Google Patents
Info
- Publication number
- JP2022536092A5 JP2022536092A5 JP2021571989A JP2021571989A JP2022536092A5 JP 2022536092 A5 JP2022536092 A5 JP 2022536092A5 JP 2021571989 A JP2021571989 A JP 2021571989A JP 2021571989 A JP2021571989 A JP 2021571989A JP 2022536092 A5 JP2022536092 A5 JP 2022536092A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitors
- antibodies
- mmol
- pyrimidine
- uplc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19305713 | 2019-06-04 | ||
| EP19305713.0 | 2019-06-04 | ||
| EP19306144.7 | 2019-09-20 | ||
| EP19306144 | 2019-09-20 | ||
| PCT/IB2020/000559 WO2020245664A1 (en) | 2019-06-04 | 2020-06-04 | N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2h-pyran-4-carboxamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022536092A JP2022536092A (ja) | 2022-08-12 |
| JP2022536092A5 true JP2022536092A5 (cg-RX-API-DMAC7.html) | 2023-06-23 |
| JP7595593B2 JP7595593B2 (ja) | 2024-12-06 |
Family
ID=71895028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021571989A Active JP7595593B2 (ja) | 2019-06-04 | 2020-06-04 | 増殖性疾患の治療のための、ヒトｃｔｐｓ１阻害剤としてのｎ－（５－（６－エトキシピラジン－２－イル）ピリジン－２－イル）－４－（２－（メチルスルホンアミド）ピリミジン－４－イル）テトラヒドロ－２ｈ－ピラン－４－カルボキサミド誘導体及び関連化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12466810B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3980411B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7595593B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN114008039B (cg-RX-API-DMAC7.html) |
| DK (1) | DK3980411T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES3044436T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI3980411T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE073329T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL288508B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2020245664A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3717465B1 (en) | 2017-11-30 | 2026-01-21 | Step Pharma S.A.S. | Compounds |
| WO2019106156A1 (en) | 2017-11-30 | 2019-06-06 | Step Pharma S.A.S. | Compounds |
| US12331046B2 (en) | 2020-10-23 | 2025-06-17 | Nimbus Clotho, Inc. | CTPS1 inhibitors and uses thereof |
| US20240425473A2 (en) * | 2021-02-01 | 2024-12-26 | University Of Southern California | Enzyme inhibitors and viral infection therapy |
| WO2023166078A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination treatments comprising a ctps1 inhibitor and a chek1 inhibitor |
| WO2023166077A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination of a ctps1 inhibitor and a atr inhibitor in cancer therapy |
| WO2023166080A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor |
| WO2023166076A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combinations of ctps1 and bcl2 inhibitors for cancer |
| WO2024133730A1 (en) | 2022-12-21 | 2024-06-27 | Step Pharma S.A.S. | Ctps1 inhibitors for use in the treatment of ctps2 deficient cancer |
| WO2024133721A1 (en) | 2022-12-21 | 2024-06-27 | Step Pharma S.A.S. | Combinations of ctps1 inhibitor with iap inhibitor for use in the treatment of cancer |
| CN118359588A (zh) * | 2023-01-19 | 2024-07-19 | 杭州英创医药科技有限公司 | 作为ctps1抑制剂的化合物 |
| WO2026027753A1 (en) * | 2024-08-02 | 2026-02-05 | Step Pharma S.A.S. | Ctps1 inhibitors for the treatment of myeloproliferative neoplasms |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2417507A1 (en) | 2000-08-21 | 2002-02-28 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| US7091201B2 (en) * | 2000-09-25 | 2006-08-15 | Actelion Pharmaceuticals Ltd. | Arylalkane-sulfonamides having endothelin-antagonist activity |
| US20030158218A1 (en) | 2001-12-21 | 2003-08-21 | Nantermet Philippe G. | Thrombin inhibitors |
| US8008302B2 (en) | 2004-07-26 | 2011-08-30 | Merck Serono Sa | N-hydroxyamide derivatives and use thereof |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| AU2008335709A1 (en) | 2007-12-13 | 2009-06-18 | Amgen Inc. | Gamma secretase modulators |
| ES2522346T3 (es) * | 2008-08-22 | 2014-11-14 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de CDK |
| KR101097312B1 (ko) | 2009-08-10 | 2011-12-23 | 삼성모바일디스플레이주식회사 | 유기 발광 소자 |
| UY33469A (es) | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
| EP2601185B1 (en) * | 2010-08-03 | 2015-10-07 | Nerviano Medical Sciences S.r.l. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
| MX2013005567A (es) * | 2010-11-17 | 2013-10-30 | Amgen Inc | Derivados de quinolina como inhibidores de pik3. |
| JP6097998B2 (ja) | 2010-12-16 | 2017-03-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のビアリールアミドインヒビター |
| JP2016028795A (ja) | 2013-03-28 | 2016-03-03 | 国立研究開発法人科学技術振興機構 | 触媒金属ナノ粒子含有複合体及びその利用 |
| EP2986287A2 (en) | 2013-04-18 | 2016-02-24 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions (ctps 1 inhibitors, e.g. norleucine) for inhibiting t cell proliferation in a subject in need thereof |
| ES2702126T3 (es) * | 2013-12-10 | 2019-02-27 | Bristol Myers Squibb Co | Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa |
| GB201322333D0 (en) | 2013-12-17 | 2014-01-29 | Agency Science Tech & Res | WNT pathway modulators |
| KR102525131B1 (ko) | 2014-10-08 | 2023-04-24 | 레드엑스 파마 피엘씨 | Wnt 신호 경로의 억제제로서의 N-피리디닐 아세트아미드 유도체 |
| CN104262071A (zh) | 2014-10-16 | 2015-01-07 | 中国科学院山西煤炭化学研究所 | 一种联苯类化合物的光催化合成方法 |
| WO2019106156A1 (en) | 2017-11-30 | 2019-06-06 | Step Pharma S.A.S. | Compounds |
| EP3492454A1 (en) * | 2017-11-30 | 2019-06-05 | Step Pharma S.A.S. | Compounds |
| EP3717465B1 (en) | 2017-11-30 | 2026-01-21 | Step Pharma S.A.S. | Compounds |
| MX2020009887A (es) * | 2018-03-23 | 2020-10-12 | Step Pharma S A S | Derivados de aminopiridina como inhibidores de ctps1. |
| US20230192673A1 (en) | 2018-06-04 | 2023-06-22 | Step Pharma S.A.S. | Compounds |
| BR112021005986A2 (pt) | 2018-10-23 | 2021-06-29 | Step Pharma S.A.S. | derivados de aminopirimidina como inibidores de ctps1 |
| EP3980410B1 (en) | 2019-06-04 | 2025-02-19 | Step Pharma S.A.S. | N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl)butanamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases |
| EP4041715A1 (en) | 2019-09-20 | 2022-08-17 | Step Pharma S.A.S. | Sulfonamide inhibitors as ctps 1 inhibitors |
| WO2021053402A2 (en) | 2019-09-20 | 2021-03-25 | Step Pharma S.A.S. | Compounds |
| US12331046B2 (en) | 2020-10-23 | 2025-06-17 | Nimbus Clotho, Inc. | CTPS1 inhibitors and uses thereof |
| WO2023166080A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor |
| WO2023166078A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination treatments comprising a ctps1 inhibitor and a chek1 inhibitor |
| WO2023166077A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combination of a ctps1 inhibitor and a atr inhibitor in cancer therapy |
| WO2023166076A1 (en) | 2022-03-01 | 2023-09-07 | Step Pharma S.A.S. | Combinations of ctps1 and bcl2 inhibitors for cancer |
| WO2023205475A1 (en) | 2022-04-21 | 2023-10-26 | Nimbus Clotho, Inc. | Ctps1 inhibitors and uses thereof |
| WO2024133721A1 (en) | 2022-12-21 | 2024-06-27 | Step Pharma S.A.S. | Combinations of ctps1 inhibitor with iap inhibitor for use in the treatment of cancer |
| WO2024133730A1 (en) | 2022-12-21 | 2024-06-27 | Step Pharma S.A.S. | Ctps1 inhibitors for use in the treatment of ctps2 deficient cancer |
| CN118359588A (zh) | 2023-01-19 | 2024-07-19 | 杭州英创医药科技有限公司 | 作为ctps1抑制剂的化合物 |
-
2020
- 2020-06-04 IL IL288508A patent/IL288508B2/en unknown
- 2020-06-04 FI FIEP20749934.4T patent/FI3980411T3/fi active
- 2020-06-04 JP JP2021571989A patent/JP7595593B2/ja active Active
- 2020-06-04 DK DK20749934.4T patent/DK3980411T3/da active
- 2020-06-04 ES ES20749934T patent/ES3044436T3/es active Active
- 2020-06-04 US US17/615,873 patent/US12466810B2/en active Active
- 2020-06-04 EP EP20749934.4A patent/EP3980411B1/en active Active
- 2020-06-04 WO PCT/IB2020/000559 patent/WO2020245664A1/en not_active Ceased
- 2020-06-04 CN CN202080041337.0A patent/CN114008039B/zh active Active
- 2020-06-04 HU HUE20749934A patent/HUE073329T2/hu unknown
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