FI3980411T3 - N-(5-(6-etoksipyratsin-2-yyli)pyridin-2-yyli)-4-(2-(etyylisulfonamido)pyrimidin-4-yyli)tetrahydro-2h-pyran-4-karboksamidi ihmisen ctps1:n estäjänä proliferatiivisten sairauksien hoitoon - Google Patents

N-(5-(6-etoksipyratsin-2-yyli)pyridin-2-yyli)-4-(2-(etyylisulfonamido)pyrimidin-4-yyli)tetrahydro-2h-pyran-4-karboksamidi ihmisen ctps1:n estäjänä proliferatiivisten sairauksien hoitoon

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Publication number
FI3980411T3
FI3980411T3 FIEP20749934.4T FI20749934T FI3980411T3 FI 3980411 T3 FI3980411 T3 FI 3980411T3 FI 20749934 T FI20749934 T FI 20749934T FI 3980411 T3 FI3980411 T3 FI 3980411T3
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Finland
Prior art keywords
solvate
compound
lymphoma
pharmaceutically acceptable
acceptable salt
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FIEP20749934.4T
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English (en)
Finnish (fi)
Inventor
Abdul Quddus
Andrew Novak
David Cousin
Emma Blackham
Geraint Jones
Joseph Wrigglesworth
Lorna Duffy
Louise Birch
Pascal George
Saleh Ahmed
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Step Pharma S A S
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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FIEP20749934.4T 2019-06-04 2020-06-04 N-(5-(6-etoksipyratsin-2-yyli)pyridin-2-yyli)-4-(2-(etyylisulfonamido)pyrimidin-4-yyli)tetrahydro-2h-pyran-4-karboksamidi ihmisen ctps1:n estäjänä proliferatiivisten sairauksien hoitoon FI3980411T3 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19305713 2019-06-04
EP19306144 2019-09-20
PCT/IB2020/000559 WO2020245664A1 (en) 2019-06-04 2020-06-04 N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2h-pyran-4-carboxamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases

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FI3980411T3 true FI3980411T3 (fi) 2025-10-28

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US (1) US12466810B2 (cg-RX-API-DMAC7.html)
EP (1) EP3980411B1 (cg-RX-API-DMAC7.html)
JP (1) JP7595593B2 (cg-RX-API-DMAC7.html)
CN (1) CN114008039B (cg-RX-API-DMAC7.html)
DK (1) DK3980411T3 (cg-RX-API-DMAC7.html)
ES (1) ES3044436T3 (cg-RX-API-DMAC7.html)
FI (1) FI3980411T3 (cg-RX-API-DMAC7.html)
HU (1) HUE073329T2 (cg-RX-API-DMAC7.html)
IL (1) IL288508B2 (cg-RX-API-DMAC7.html)
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