JP2022533215A5 - - Google Patents
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- Publication number
- JP2022533215A5 JP2022533215A5 JP2021568944A JP2021568944A JP2022533215A5 JP 2022533215 A5 JP2022533215 A5 JP 2022533215A5 JP 2021568944 A JP2021568944 A JP 2021568944A JP 2021568944 A JP2021568944 A JP 2021568944A JP 2022533215 A5 JP2022533215 A5 JP 2022533215A5
- Authority
- JP
- Japan
- Prior art keywords
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- nhc
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025144373A JP2026000940A (ja) | 2019-05-20 | 2025-09-01 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962850094P | 2019-05-20 | 2019-05-20 | |
| US62/850,094 | 2019-05-20 | ||
| PCT/US2020/033648 WO2020236841A2 (en) | 2019-05-20 | 2020-05-19 | Antibody drug conjugates having linkers comprising hydrophilic groups |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025144373A Division JP2026000940A (ja) | 2019-05-20 | 2025-09-01 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022533215A JP2022533215A (ja) | 2022-07-21 |
| JP2022533215A5 true JP2022533215A5 (https=) | 2023-05-26 |
Family
ID=71070004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568944A Pending JP2022533215A (ja) | 2019-05-20 | 2020-05-19 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
| JP2025144373A Pending JP2026000940A (ja) | 2019-05-20 | 2025-09-01 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025144373A Pending JP2026000940A (ja) | 2019-05-20 | 2025-09-01 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230091510A1 (https=) |
| EP (1) | EP3972650A2 (https=) |
| JP (2) | JP2022533215A (https=) |
| KR (1) | KR20220010527A (https=) |
| CN (3) | CN113853219B (https=) |
| AU (2) | AU2020279731B2 (https=) |
| CA (1) | CA3140063A1 (https=) |
| IL (1) | IL287596A (https=) |
| WO (1) | WO2020236841A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202308700A (zh) * | 2021-04-29 | 2023-03-01 | 大陸商上海匯連生物醫藥有限公司 | 抗體偶聯藥物的製備方法及應用 |
| AU2022286137A1 (en) | 2021-06-01 | 2023-12-14 | Ajinomoto Co., Inc. | Conjugate of antibody and functional substance or salt of said conjugate, and compound for use in production of said conjugate or salt of said compound |
| CN117295524A (zh) * | 2021-06-02 | 2023-12-26 | 百奥泰生物制药股份有限公司 | 药物偶联物及其用途 |
| WO2022262516A1 (zh) * | 2021-06-18 | 2022-12-22 | 北京海步医药科技有限公司 | 连接子及其缀合物 |
| EP4509141A1 (en) * | 2022-04-12 | 2025-02-19 | Bio-Thera Solutions, Ltd. | Method for treating her2-positive solid tumor |
| US20260061065A1 (en) * | 2022-05-20 | 2026-03-05 | Novartis Ag | Antibody drug conjugates |
| WO2024083162A1 (en) * | 2022-10-19 | 2024-04-25 | Multitude Therapeutics Inc. | Antibodies, antibody-drug conjugates, preparations and uses thereof |
| CN116036303B (zh) * | 2023-01-10 | 2025-06-24 | 金麦安博生物制药(苏州)有限公司 | 一种抗体-药物偶联物及其制备方法和应用 |
| WO2024149345A1 (en) * | 2023-01-11 | 2024-07-18 | Profoundbio Us Co. | Linkers, drug linkers and conjugates thereof and methods of using the same |
| CN118852442A (zh) | 2023-04-26 | 2024-10-29 | 上海麦科思生物医药有限公司 | 抗ptk7抗体及其用途 |
| WO2025171055A1 (en) | 2024-02-06 | 2025-08-14 | Kumquat Biosciences Inc. | Heterocyclic conjugates and uses thereof |
| WO2025228305A1 (zh) * | 2024-04-28 | 2025-11-06 | 中国科学院上海药物研究所 | 一种蛋白降解剂缀合物及其偶联物 |
| KR20250164033A (ko) * | 2024-05-14 | 2025-11-24 | 주식회사 지놈앤컴퍼니 | 항-bcam 항체 및 이의 컨쥬게이트 |
| WO2025255381A1 (en) * | 2024-06-05 | 2025-12-11 | Sigma-Aldrich Co. Llc | Chito-oligosaccharide drug constructs |
| WO2026046186A1 (en) * | 2024-08-27 | 2026-03-05 | Suzhou Bioreinno Biotechnology Limited Company | Linkers, linker conjugates and conjugate compounds thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| CA2109528A1 (en) | 1991-05-01 | 1992-11-02 | Gregory A. Prince | A method for treating infectious respiratory diseases |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| ATE508733T1 (de) | 1996-03-04 | 2011-05-15 | Penn State Res Found | Materialien und verfahren zur steigerung der zellulären internalisierung |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| CA2277801C (en) | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| WO1999066903A2 (en) | 1998-06-24 | 1999-12-29 | Advanced Inhalation Research, Inc. | Large porous particles emitted from an inhaler |
| PL209392B1 (pl) | 1999-01-15 | 2011-08-31 | Genentech Inc | Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała |
| CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
| CA2463879C (en) | 2001-10-25 | 2012-12-04 | Genentech, Inc. | Glycoprotein compositions |
| EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
| ES2732574T3 (es) | 2012-11-30 | 2019-11-25 | Novartis Ag | Métodos para preparar conjugados a partir de proteínas que contienen disulfuro |
| US9089614B2 (en) * | 2012-12-21 | 2015-07-28 | Bioalliance C.V. | Hydrophilic self-immolative linkers and conjugates thereof |
| EP2953976B1 (en) | 2013-02-08 | 2021-03-24 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| NZ758049A (en) * | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| US10550190B2 (en) * | 2014-04-04 | 2020-02-04 | Merck Sharp & Dohme Corp. | Phosphate based linkers for intracellular delivery of drug conjugates |
| US9950077B2 (en) * | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
| SG11201610624WA (en) * | 2014-06-20 | 2017-01-27 | Bioalliance Cv | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| CN111620861A (zh) * | 2014-12-09 | 2020-09-04 | 艾伯维公司 | 具有低细胞渗透性的bcl-xl抑制性化合物以及包括它的抗体药物缀合物 |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| RU2018147224A (ru) * | 2016-06-08 | 2020-07-14 | Эббви Инк. | Конъюгаты антитела к egfr и лекарственного средства |
| CN108066772B (zh) | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| US11135307B2 (en) * | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| US10646585B2 (en) * | 2017-09-15 | 2020-05-12 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and ligand-drug conjugates thereof |
| JP7381478B2 (ja) * | 2017-10-23 | 2023-11-15 | マブリンク ビオシオンス | 単一分子量ポリサルコシンを含むリガンド-薬物-複合体 |
| MX2020004691A (es) * | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
-
2020
- 2020-05-19 CN CN202080036837.5A patent/CN113853219B/zh active Active
- 2020-05-19 CN CN202411876945.XA patent/CN119613487A/zh active Pending
- 2020-05-19 CA CA3140063A patent/CA3140063A1/en active Pending
- 2020-05-19 CN CN202411876882.8A patent/CN119613486A/zh active Pending
- 2020-05-19 WO PCT/US2020/033648 patent/WO2020236841A2/en not_active Ceased
- 2020-05-19 JP JP2021568944A patent/JP2022533215A/ja active Pending
- 2020-05-19 KR KR1020217041090A patent/KR20220010527A/ko active Pending
- 2020-05-19 US US17/612,280 patent/US20230091510A1/en active Pending
- 2020-05-19 AU AU2020279731A patent/AU2020279731B2/en active Active
- 2020-05-19 EP EP20731697.7A patent/EP3972650A2/en active Pending
-
2021
- 2021-10-26 IL IL287596A patent/IL287596A/en unknown
-
2025
- 2025-04-08 AU AU2025202473A patent/AU2025202473A1/en active Pending
- 2025-09-01 JP JP2025144373A patent/JP2026000940A/ja active Pending
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