|
US3453266A
(en)
|
1966-03-14 |
1969-07-01 |
American Home Prod |
1,2,5-benzothiadiazepine 1,1-dioxides
|
|
US3506646A
(en)
|
1966-06-27 |
1970-04-14 |
American Home Prod |
Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides
|
|
US3875162A
(en)
|
1973-07-26 |
1975-04-01 |
Squibb & Sons Inc |
Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds
|
|
US4003905A
(en)
|
1974-12-11 |
1977-01-18 |
E. R. Squibb & Sons, Inc. |
Diels-alder adducts of benzdiazepines
|
|
US4444688A
(en)
|
1981-05-11 |
1984-04-24 |
Ciba-Geigy Corporation |
Imidazobenzothiadiazepines
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
JP2920385B2
(ja)
|
1988-08-18 |
1999-07-19 |
武田薬品工業株式会社 |
１，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP0563475B1
(en)
|
1992-03-25 |
2000-05-31 |
Immunogen Inc |
Cell binding agent conjugates of derivatives of CC-1065
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US20080152586A1
(en)
|
1992-09-25 |
2008-06-26 |
Avipep Pty Limited |
High avidity polyvalent and polyspecific reagents
|
|
US6355780B1
(en)
|
1995-02-22 |
2002-03-12 |
Yeda Research And Development Co. Ltd. |
Antibodies to the death domain motifs of regulatory proteins
|
|
US6156746A
(en)
|
1998-08-25 |
2000-12-05 |
Bristol-Myers Squibb Company |
1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
|
|
DE69925133T2
(de)
|
1998-08-27 |
2006-01-19 |
Spirogen Ltd., Ryde |
Pyrrolobenzodiazepine
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
CA2388063C
(en)
|
1999-11-24 |
2010-06-08 |
Immunogen, Inc. |
Cytotoxic agents comprising taxanes and their therapeutic use
|
|
EP1332209B1
(en)
|
2000-09-08 |
2009-11-11 |
Universität Zürich |
Collections of repeat proteins comprising repeat modules
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US6756397B2
(en)
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
GB0209467D0
(en)
|
2002-04-25 |
2002-06-05 |
Astrazeneca Ab |
Chemical compounds
|
|
BR0313197A
(pt)
|
2002-08-02 |
2005-08-09 |
Immunogen Inc |
Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico
|
|
DE60336149D1
(de)
|
2002-08-16 |
2011-04-07 |
Immunogen Inc |
Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
|
|
ZA200503075B
(en)
|
2002-11-07 |
2006-09-27 |
Immunogen Inc |
Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
|
|
FR2850654A1
(fr)
|
2003-02-03 |
2004-08-06 |
Servier Lab |
Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
WO2005040170A2
(en)
|
2003-10-22 |
2005-05-06 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
WO2005085260A1
(en)
|
2004-03-09 |
2005-09-15 |
Spirogen Limited |
Pyrrolobenzodiazepines
|
|
ES2503719T3
(es)
|
2005-02-11 |
2014-10-07 |
Immunogen, Inc. |
Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
|
|
BRPI0613593A2
(pt)
|
2005-07-08 |
2011-01-18 |
Univ Zuerich |
método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo
|
|
ITRM20050416A1
(it)
|
2005-08-03 |
2007-02-04 |
Uni Degli Studi Di Roma Tor Vergata |
Derivati delle benzodiazepine e loro usi in campo medico.
|
|
CA3000520C
(en)
|
2005-08-24 |
2023-04-04 |
Immunogen, Inc. |
Process for preparing antibody maytansinoid conjugates
|
|
EP1962961B1
(en)
|
2005-11-29 |
2013-01-09 |
The University Of Sydney |
Demibodies: dimerisation-activated therapeutic agents
|
|
RS52060B
(sr)
|
2006-01-25 |
2012-04-30 |
Sanofi |
Citotoksični agensi koji sadrže nove derivate tomaimicina
|
|
US7897568B2
(en)
|
2006-03-03 |
2011-03-01 |
Vinay K. Singh |
Compositions for treatment of cancer
|
|
EP2032606B1
(en)
|
2006-05-30 |
2013-11-27 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
CA2655379A1
(en)
|
2006-06-22 |
2007-12-27 |
Walter And Eliza Hall Institute Of Medical Research |
Structure of the insulin receptor ectodomain
|
|
SI2019104T1
(sl)
|
2007-07-19 |
2013-12-31 |
Sanofi |
Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
|
|
US9365629B2
(en)
|
2007-09-24 |
2016-06-14 |
University Of Zurich |
Designed armadillo repeat proteins
|
|
SG189817A1
(en)
|
2008-04-30 |
2013-05-31 |
Immunogen Inc |
Potent conjugates and hydrophilic linkers
|
|
NZ610239A
(en)
|
2008-04-30 |
2014-11-28 |
Immunogen Inc |
Cross-linkers and their uses
|
|
ES2705714T3
(es)
|
2008-10-31 |
2019-03-26 |
Janssen Biotech Inc |
Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones
|
|
RU2683325C2
(ru)
*
|
2009-02-05 |
2019-03-28 |
Иммьюноджен, Инк. |
Новые производные бензодиазепина
|
|
BRPI1008532B1
(pt)
|
2009-02-12 |
2021-12-14 |
Janssen Biotech, Inc |
Arcabouço de proteína isolada, método para construção de uma biblioteca de arcabouço de proteína isolada, molécula de ácido nucleico isolada, vetor de ácido nucleico isolado, célula hospedeira de bactéria ou fungo, composição, dispositivo médico e artigo de manufatura para uso farmacêutico ou de diagnóstico em seres humanos
|
|
JP2013514788A
(ja)
|
2009-12-23 |
2013-05-02 |
アビペップ ピーティーワイ リミテッド |
イムノコンジュゲート及びその作製方法２
|
|
TWI622402B
(zh)
|
2010-02-24 |
2018-05-01 |
免疫遺傳股份有限公司 |
葉酸受體１抗體類和免疫共軛物類及彼等之用途
|
|
US8569227B2
(en)
|
2010-04-30 |
2013-10-29 |
Janssen Biotech, Inc. |
Stabilized fibronectin domain compositions, methods and uses
|
|
JP5826863B2
(ja)
|
2011-02-15 |
2015-12-02 |
イミュノジェン・インコーポレーテッド |
細胞傷害性ベンゾジアゼピン誘導体
|
|
BR112013025415B1
(pt)
|
2011-04-01 |
2021-03-16 |
Immunogen, Inc |
uso de um imunoconjugado antirreceptor de folato 1 (folr1)
|
|
WO2013177481A1
(en)
*
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
|
AU2016285552B2
(en)
|
2015-06-29 |
2022-10-13 |
Immunogen, Inc. |
Anti-CD123 antibodies and conjugates and derivatives thereof
|
|
EP3325482B1
(en)
*
|
2015-07-21 |
2020-06-24 |
ImmunoGen, Inc. |
Methods of preparing cytotoxic benzodiazepine derivatives
|
|
PL3558391T3
(pl)
|
2016-12-23 |
2022-05-16 |
Immunogen, Inc. |
Immunokoniugaty skierowane wobec białka adam9 i sposoby ich stosowania
|
|
EP4148044A1
(en)
*
|
2017-01-25 |
2023-03-15 |
ImmunoGen, Inc. |
Methods of preparing cytotoxic benzodiazepine derivatives
|