JP2022527162A - Ｃａｒを発現する遺伝的にリプログラミングされたｔｒｅｇ - Google Patents

Ｃａｒを発現する遺伝的にリプログラミングされたｔｒｅｇ Download PDF

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JP2022527162A
JP2022527162A JP2021557247A JP2021557247A JP2022527162A JP 2022527162 A JP2022527162 A JP 2022527162A JP 2021557247 A JP2021557247 A JP 2021557247A JP 2021557247 A JP2021557247 A JP 2021557247A JP 2022527162 A JP2022527162 A JP 2022527162A
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nucleic acid
acid molecule
domain
cells
transmembrane
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JP2022527162A5 (https=
JPWO2020194306A5 (https=
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グロス、ギデオン
ウェインスタイン－マロム、ハダス
ポズナー、サラ
クローナー、アミット
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ガビッシュ－ガリラヤ バイオ アプリケーションズ リミテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/34—Antigenic peptides
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/35—Cytokines
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/28—Expressing multiple CARs, TCRs or antigens
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/622—Single chain antibody (scFv)
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JP2021557247A 2019-03-26 2020-03-26 Ｃａｒを発現する遺伝的にリプログラミングされたｔｒｅｇ Pending JP2022527162A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962823711P 2019-03-26 2019-03-26
US62/823,711 2019-03-26
US201962898471P 2019-09-10 2019-09-10
US62/898,471 2019-09-10
PCT/IL2020/050360 WO2020194306A1 (en) 2019-03-26 2020-03-26 Genetically reprogrammed tregs expressing cars

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JP2022527162A true JP2022527162A (ja) 2022-05-31
JP2022527162A5 JP2022527162A5 (https=) 2023-04-03
JPWO2020194306A5 JPWO2020194306A5 (https=) 2023-04-03

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US (1) US20220186232A1 (https=)
EP (1) EP3947690A4 (https=)
JP (1) JP2022527162A (https=)
KR (1) KR20210143856A (https=)
CN (1) CN114127297A (https=)
AU (1) AU2020245329A1 (https=)
CA (1) CA3134878A1 (https=)
IL (1) IL286644A (https=)
WO (1) WO2020194306A1 (https=)

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US20210277354A1 (en) * 2018-06-19 2021-09-09 Fondazione Telethon Production of engineered dendritic cells and uses thereof
WO2022169870A1 (en) * 2021-02-02 2022-08-11 Carisma Therapeutics Inc. Self-polarizing immune cells
JP2024546641A (ja) * 2021-12-09 2024-12-26 カリスマ セラピューティクス インコーポレイテッド 免疫細胞へのインビボ送達
TW202334400A (zh) * 2021-12-30 2023-09-01 美商Ｔｒ１Ｘ股份有限公司 表現il-10及嵌合抗原受體之cd4+ t細胞及其用途
CN117402257B (zh) * 2023-09-13 2025-08-26 武汉大学 人工病毒受体及其应用
WO2025148750A1 (zh) * 2024-01-08 2025-07-17 上药生物治疗（香港）有限公司 膜表达il-10及其用途

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CN114127297A (zh) 2022-03-01
KR20210143856A (ko) 2021-11-29
EP3947690A4 (en) 2022-12-21
AU2020245329A1 (en) 2021-10-28
US20220186232A1 (en) 2022-06-16
EP3947690A1 (en) 2022-02-09
WO2020194306A1 (en) 2020-10-01
CA3134878A1 (en) 2020-10-01
IL286644A (en) 2021-10-31

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