JP2022526159A5 - - Google Patents

Info

Publication number
JP2022526159A5
JP2022526159A5 JP2021557206A JP2021557206A JP2022526159A5 JP 2022526159 A5 JP2022526159 A5 JP 2022526159A5 JP 2021557206 A JP2021557206 A JP 2021557206A JP 2021557206 A JP2021557206 A JP 2021557206A JP 2022526159 A5 JP2022526159 A5 JP 2022526159A5
Authority
JP
Japan
Prior art keywords
tki
egfr
egfr tki
generation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021557206A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022526159A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/058729 external-priority patent/WO2020201097A1/en
Publication of JP2022526159A publication Critical patent/JP2022526159A/ja
Publication of JP2022526159A5 publication Critical patent/JP2022526159A5/ja
Priority to JP2025087802A priority Critical patent/JP2025131642A/ja
Pending legal-status Critical Current

Links

JP2021557206A 2019-03-29 2020-03-27 非小細胞肺がんの治療に使用するためのオシメルチニブ Pending JP2022526159A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025087802A JP2025131642A (ja) 2019-03-29 2025-05-27 非小細胞肺がんの治療に使用するためのオシメルチニブ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962825867P 2019-03-29 2019-03-29
US62/825,867 2019-03-29
PCT/EP2020/058729 WO2020201097A1 (en) 2019-03-29 2020-03-27 Osimertinib for use in the treatment of non-small cell lung cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025087802A Division JP2025131642A (ja) 2019-03-29 2025-05-27 非小細胞肺がんの治療に使用するためのオシメルチニブ

Publications (2)

Publication Number Publication Date
JP2022526159A JP2022526159A (ja) 2022-05-23
JP2022526159A5 true JP2022526159A5 (https=) 2023-03-31

Family

ID=70224330

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021557206A Pending JP2022526159A (ja) 2019-03-29 2020-03-27 非小細胞肺がんの治療に使用するためのオシメルチニブ
JP2025087802A Pending JP2025131642A (ja) 2019-03-29 2025-05-27 非小細胞肺がんの治療に使用するためのオシメルチニブ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025087802A Pending JP2025131642A (ja) 2019-03-29 2025-05-27 非小細胞肺がんの治療に使用するためのオシメルチニブ

Country Status (11)

Country Link
US (1) US12465608B2 (https=)
EP (1) EP3946346A1 (https=)
JP (2) JP2022526159A (https=)
KR (1) KR20210144844A (https=)
CN (1) CN113645976A (https=)
AU (2) AU2020250832A1 (https=)
CA (1) CA3133766A1 (https=)
EA (1) EA202192552A1 (https=)
MA (1) MA55508A (https=)
MX (1) MX2021011810A (https=)
WO (1) WO2020201097A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117098537A (zh) * 2020-12-11 2023-11-21 医睿世康药业研发公司 用于癌症治疗的联合疗法
JP2023553532A (ja) * 2020-12-11 2023-12-21 エラスカ，インク． 癌の処置のための併用療法
CN119768173A (zh) * 2022-09-01 2025-04-04 齐鲁制药有限公司 一种egfr激酶抑制剂的用途
TW202515577A (zh) * 2023-06-27 2025-04-16 日商大鵬藥品工業股份有限公司 患有具有ｅｇｆｒ畸變的非小細胞肺癌之個體的治療方法
CN121177212B (zh) * 2025-11-25 2026-03-03 中南大学湘雅二医院 一种用于治疗egfr突变非小细胞肺癌脑膜转移的药物、应用、药盒及药物的制备方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69720965T2 (de) 1996-02-13 2004-02-05 Astrazeneca Ab Chinazolinderivate und deren verwendung als vegf hemmer
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
PT1154774E (pt) 1999-02-10 2005-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de angiogenese
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
MXPA02012903A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como inhibidores de angiogenesis.
MXPA02012905A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como agentes de dano vascular..
US6881737B2 (en) 2001-04-11 2005-04-19 Amgen Inc. Substituted triazinyl acrylamide derivatives and methods of use
DE10237722A1 (de) 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
KR20080095915A (ko) 2004-05-06 2008-10-29 워너-램버트 캄파니 엘엘씨 4-페닐아미노-퀴나졸린-6-일-아미드
ES2325035T3 (es) 2004-12-21 2009-08-24 Smithkline Beecham Corporation Inhibidores de quinasa erbb de 2-pirimidinil pirazolopiridina.
GB0500492D0 (en) 2005-01-11 2005-02-16 Cyclacel Ltd Compound
KR101313702B1 (ko) 2005-02-03 2013-10-04 와이어쓰 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물
MX2008005814A (es) 2005-11-03 2008-10-15 Vertex Pharma Aminopirimidinas utiles como inhibidores de cinasa.
GB0524436D0 (en) 2005-11-30 2006-01-11 Novartis Ag Organic compounds
JP5103403B2 (ja) 2005-12-05 2012-12-19 スミスクライン ビーチャム コーポレーション ２−ピリミジニルピラゾロピリジンＥｒｂＢキナーゼ阻害剤
US20100267707A1 (en) 2006-06-22 2010-10-21 Merck Sharp & Dohme Corp. Tyrosine Kinase Inhibitors
WO2008009458A1 (en) 2006-07-21 2008-01-24 Novartis Ag 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
AU2007299080B2 (en) * 2006-09-18 2013-04-18 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
JP2012501654A (ja) 2008-09-05 2012-01-26 アビラ セラピューティクス， インコーポレイテッド 不可逆的インヒビターの設計のためのアルゴリズム
US20110183975A1 (en) 2008-10-07 2011-07-28 Yasuhiro Goto Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity
CN101723936B (zh) 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
US9908884B2 (en) 2009-05-05 2018-03-06 Dana-Farber Cancer Institute, Inc. EGFR inhibitors and methods of treating disorders
KR101256018B1 (ko) 2009-08-20 2013-04-18 한국과학기술연구원 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물
US9556426B2 (en) 2009-09-16 2017-01-31 Celgene Avilomics Research, Inc. Protein kinase conjugates and inhibitors
MX2012005162A (es) 2009-11-02 2012-06-01 Abbott Lab Imidazopiridinas como una nueva estructura base para inhibicion de cinasa en multiples objetivos.
WO2011079231A1 (en) 2009-12-23 2011-06-30 Gatekeeper Pharmaceutical, Inc. Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
WO2011140338A1 (en) 2010-05-05 2011-11-10 Gatekeeper Pharmaceuticals, Inc. Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
MX342164B (es) 2010-06-23 2016-09-19 Hanmi Science Co Ltd Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa.
UY33539A (es) 2010-08-02 2012-02-29 Astrazeneca Ab Compuestos químicos alk
EP2704572B1 (en) 2011-05-04 2015-12-30 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US8828391B2 (en) 2011-05-17 2014-09-09 Boehringer Ingelheim International Gmbh Method for EGFR directed combination treatment of non-small cell lung cancer
EP4119551A1 (en) 2011-07-27 2023-01-18 Astrazeneca AB 2-(2,4,5-substituted-anilino)pyrimidine compounds
EP2964638B1 (en) 2013-03-06 2017-08-09 Astrazeneca AB Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor
SG11201602291TA (en) * 2013-09-30 2016-04-28 Daiichi Sankyo Co Ltd Nucleic acid biomarker and use thereof
GB201400034D0 (en) 2014-01-02 2014-02-19 Astrazeneca Ab Pharmaceutical Compositions comprising AZD9291
WO2015176033A1 (en) * 2014-05-15 2015-11-19 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
HUE054848T2 (hu) 2014-10-13 2021-09-28 Yuhan Corp Vegyületek és készítmények EGFR mutáns kináz aktivitás módosítására
RU2017136709A (ru) * 2015-04-23 2019-05-23 Медиммьюн Лимитед Комбинированное лечение немелкоклеточного рака легкого с выявленной мутацией в egfr
US10813933B2 (en) * 2016-05-17 2020-10-27 Japanese Foundation For Cancer Research Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance
WO2018102827A1 (en) 2016-12-04 2018-06-07 Expression Pathology, Inc. Improved methods of treating lung cancer by predicting responders to cisplatin-pemetrexed combination therapy
EP3585389A4 (en) 2017-02-22 2020-12-23 G1 Therapeutics, Inc. EGFR-CAUSED CANCER TREATMENT WITH LESS SIDE EFFECTS
JP2021513517A (ja) 2018-02-12 2021-05-27 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ 非小細胞肺がんの治療に使用するためのオシメルチニブ
US20210369709A1 (en) 2020-05-27 2021-12-02 Astrazeneca Ab EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER

Similar Documents

Publication Publication Date Title
JP2022526159A5 (https=)
KR102713072B1 (ko) 두경부암 치료를 위한 egfr 저해제
Diaz-Rubio et al. Capecitabine (Xeloda®) in combination with oxaliplatin: a phase I, dose-escalation study in patients with advanced or metastatic solid tumors
USRE46284E1 (en) Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor
Park et al. A phase Ib study of the combination of afatinib and ruxolitinib in EGFR mutant NSCLC with progression on EGFR-TKIs
Tewes et al. Capecitabine and irinotecan as first-line chemotherapy in patients with metastatic colorectal cancer: results of an extended phase I study
KR20210068344A (ko) 고시폴, 펜포르민 및 항암제를 포함하는 암 예방 또는 치료용 약학적 조성물
JP2024125139A (ja) アズブジンを含む抗腫瘍医薬組成物
EP1711188B1 (en) Anti-cancer therapies
JP2024539476A5 (https=)
Ruiter et al. PT2. 12.03 Zongertinib in Patients With Previously Treated HER2-Mutant NSCLC and Brain Metastases at Baseline: Beamion LUNG-1
KR20170055536A (ko) 흡연자에서의 비-소세포 폐암 치료용 카보플라틴 및 파클리탁셀과 병용되는 벨리파립
US20080125447A1 (en) Combination Therapy
AU2006264620B2 (en) Combination therapy of cancer with AZD2171 and gemcitabine
US20070135462A1 (en) Combination therapy
JP6458007B2 (ja) 抗腫瘍性白金錯体を含有する抗腫瘍剤及び抗腫瘍効果増強剤
JP6243850B2 (ja) 抗がん剤による末梢神経障害の予防、治療、または軽減剤
US20240173323A1 (en) Combination therapy for cancer treatment
Koukourakis et al. Capecitabine chemotherapy for metastatic colorectal cancer. Chemical structure, combinations and efficacy
Mahdi et al. CTP-07. Phase I study of intravenous and intracerebroventricular C7R-GD2. CAR T cell therapy for pediatric central nervous system (CNS) tumors
Vinitsky et al. CTP-08. Efficacy and tolerability of mirdametinib (PD-0325901) in children, adolescents, and young adults with recurrent/progressive low-grade glioma: update from the SJ901 (NCT04923126) phase 1/2 clinical trial
Han et al. CTP-06. Molecular insights into response and resistance in children with relapsed/refractory brain tumors on ribociclib combination therapy: results from SJDAWN
Mouri et al. FP14. 02 A Phase II Study of Osimertinib versus Combination of Osimertinib and Chemotherapy for EGFR and T790M-Mutation Positive NSCLC
HK40059774A (en) Application of compound or pharmaceutically acceptable salt, dimer or trimer thereof in the preparation of medicament for treating cancer
Martorell et al. 5PSQ-065 Cardiovascular toxicity induced by targeted agents