JP2022520302A - 超活性化サイトカインキラーｔ細胞の増殖させ濃縮された集団を含む細胞製品を含有する組成物及びその作製方法 - Google Patents

超活性化サイトカインキラーｔ細胞の増殖させ濃縮された集団を含む細胞製品を含有する組成物及びその作製方法 Download PDF

Info

Publication number
JP2022520302A
JP2022520302A JP2021526450A JP2021526450A JP2022520302A JP 2022520302 A JP2022520302 A JP 2022520302A JP 2021526450 A JP2021526450 A JP 2021526450A JP 2021526450 A JP2021526450 A JP 2021526450A JP 2022520302 A JP2022520302 A JP 2022520302A
Authority
JP
Japan
Prior art keywords
cells
population
scktc
cell
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021526450A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022520302A5 (https=
Inventor
ジャン チン シュ
シャオ ヤン ジャン
ジン ワン
リン ヤン ズー
ビヴァリー ダブリュ ルビット
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2022520302A publication Critical patent/JP2022520302A/ja
Publication of JP2022520302A5 publication Critical patent/JP2022520302A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/052—Lipopolysaccharides [LPS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2312—Interleukin-12 (IL-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121—Dendritic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2021526450A 2018-11-13 2019-11-13 超活性化サイトカインキラーｔ細胞の増殖させ濃縮された集団を含む細胞製品を含有する組成物及びその作製方法 Pending JP2022520302A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760077P 2018-11-13 2018-11-13
US62/760,077 2018-11-13
PCT/US2019/061191 WO2020102360A1 (en) 2018-11-13 2019-11-13 Compositions containing an expanded and enriched population of superactivated cytokine killer t cells and methods for making same

Publications (2)

Publication Number Publication Date
JP2022520302A true JP2022520302A (ja) 2022-03-30
JP2022520302A5 JP2022520302A5 (https=) 2022-11-22

Family

ID=70551406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021526450A Pending JP2022520302A (ja) 2018-11-13 2019-11-13 超活性化サイトカインキラーｔ細胞の増殖させ濃縮された集団を含む細胞製品を含有する組成物及びその作製方法

Country Status (7)

Country Link
US (1) US20210161955A2 (https=)
EP (1) EP3880794A4 (https=)
JP (1) JP2022520302A (https=)
CN (1) CN114641561A (https=)
AU (1) AU2019379140A1 (https=)
BR (1) BR112021009222A2 (https=)
WO (1) WO2020102360A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220401477A1 (en) * 2021-05-18 2022-12-22 Verdure Biotech, Inc. Method for controlling viral infections through adoptive transfer of a cell product comprising an expanded and enriched population of superactivated cytokine killer cells
WO2024222701A1 (zh) * 2023-04-25 2024-10-31 苏州沙砾生物科技有限公司 一种t细胞受体及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094553A1 (en) * 2000-06-06 2001-12-13 Kirin Beer Kabushiki Kaisha Method of amplifying natural killer t cells
US20170029777A1 (en) * 2014-01-27 2017-02-02 St. Jude Children's Research Hospital, Inc. Methods of expanding ex vivo natural killer t (nkt) cells and therapeutic uses thereof
WO2018095204A1 (zh) * 2016-11-22 2018-05-31 上海市公共卫生临床中心 一种体外诱导扩增i型nkt细胞的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011528326A (ja) * 2008-07-18 2011-11-17 セントクローネ インターナショナル エービー インビトロ拡大されたｔリンパ球及びガン治療に適切な血管形成インヒビターを含む組成物
CN106434552B (zh) * 2015-08-13 2022-04-29 清华大学 新型nkt样细胞亚群及其治疗肿瘤的用途
CN106011060A (zh) * 2016-06-29 2016-10-12 北京中台恒基生物技术有限公司 一种体外激活和扩增nkt样细胞的方法
KR20190129046A (ko) * 2017-02-15 2019-11-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 Nk 세포를 활성화시키기 위한 조성물 및 방법
EP4417210A1 (en) * 2017-03-15 2024-08-21 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094553A1 (en) * 2000-06-06 2001-12-13 Kirin Beer Kabushiki Kaisha Method of amplifying natural killer t cells
US20170029777A1 (en) * 2014-01-27 2017-02-02 St. Jude Children's Research Hospital, Inc. Methods of expanding ex vivo natural killer t (nkt) cells and therapeutic uses thereof
WO2018095204A1 (zh) * 2016-11-22 2018-05-31 上海市公共卫生临床中心 一种体外诱导扩增i型nkt细胞的方法

Also Published As

Publication number Publication date
EP3880794A4 (en) 2022-08-24
EP3880794A1 (en) 2021-09-22
AU2019379140A1 (en) 2021-06-24
US20210161955A2 (en) 2021-06-03
CN114641561A (zh) 2022-06-17
US20200147139A1 (en) 2020-05-14
WO2020102360A1 (en) 2020-05-22
BR112021009222A2 (pt) 2021-08-10

Similar Documents

Publication Publication Date Title
TWI855499B (zh) 嵌合受體和使用彼之方法
CA2413866C (en) Compositions and methods of monoclonal and polyclonal antibodies specific for t cell subpopulations
Schreibelt et al. Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
Eken et al. Fingolimod alters tissue distribution and cytokine production of human and murine innate lymphoid cells
JP2018516586A (ja) ＴＣＲγδ＋Ｔ細胞の生産方法
TW202336229A (zh) 表現趨化因子受體及細胞接著分子之cd3陰性細胞之集團、及其用途及其製造方法
US20240262909A1 (en) Tim-3 modulates anti-tumor immunity by regulating inflammasome activation
EP4463542A1 (en) Compositions and methods for antigen-specific t cell expansion
Watt et al. Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism
Nguyen et al. Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation
JP2022520302A (ja) 超活性化サイトカインキラーｔ細胞の増殖させ濃縮された集団を含む細胞製品を含有する組成物及びその作製方法
US20250041344A1 (en) Gene editing methods for modulating expression of id-3, an inhibitor of dna-binding transcription factors, thereby affecting t-cell function
WO2026084743A1 (en) Molecular engineering to enhance chimeric antigen receptor-mediated tumor immunotherapy
Wierz Characterization of the Tumor Microenvironment in Chronic Lymphocytic Leukemia by Mass Cytometry: Implications for Immunotherapy
Di Gioacchino et al. Phenotypic and functional alterations of innate lymphoid cells in hematological malignancies: potential clinical application
Liu Roles of Chemokine Receptors in T Cell Accmulation in Omental Tumors
Rhee Regulation of T follicular helper cells in the germinal center reaction of chronic graft-versus-host disease
Kent et al. Beyond aẞ T cells: NK
Stavrou Investigating the immunosuppressive microenvironment created by acute myeloid leukaemia using invariant natural killer T cells as a novel therapeutic approach
McMonigle Delineation Of B Cell Follicle Associated Cd4+ T Cell Subsets
Tuomela The effect of radiotherapy on the susceptibility of cancer cells to natural killer cell cytotoxicity
Di Ricco The role of tumor necrosis factor receptor family (TNFRF) members in regulatory T cell biology
Lewis Neonatal T Cell Immunity and Its Regulation by Innate Immunity and Dendritic Cells
Slaney The Use Of Myeloid Suppressor Cells To Inhibit Experimental Autoimmune Encephalomyelitis: A Potential Immunotherapy For Multiple Sclerosis
Tong Lymphocyte Trafficking, Homing and Function: Insights into the In Vivo Behavior of Regulatory T and Natural Killer Cells

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221114

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221114

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20231020

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231023

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240523