BR112021009222A2 - composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas - Google Patents

composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas Download PDF

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Publication number
BR112021009222A2
BR112021009222A2 BR112021009222-6A BR112021009222A BR112021009222A2 BR 112021009222 A2 BR112021009222 A2 BR 112021009222A2 BR 112021009222 A BR112021009222 A BR 112021009222A BR 112021009222 A2 BR112021009222 A2 BR 112021009222A2
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Brazil
Prior art keywords
cells
cell
population
scktcs
nkt
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BR112021009222-6A
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English (en)
Portuguese (pt)
Inventor
Jian Qing XU
Xiao Yan ZHANG
Jing Wang
Ling Yan ZHU
Beverly W. Lubit
Original Assignee
Cn.Usa Biotech Holdings, Inc.
Jian Qing Xu
Xiao Yan Zhang
Jing Wang
Ling Yan Zhu
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Application filed by Cn.Usa Biotech Holdings, Inc., Jian Qing Xu, Xiao Yan Zhang, Jing Wang, Ling Yan Zhu filed Critical Cn.Usa Biotech Holdings, Inc.
Publication of BR112021009222A2 publication Critical patent/BR112021009222A2/pt

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
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    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2302Interleukin-2 (IL-2)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121Dendritic cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
BR112021009222-6A 2018-11-13 2019-11-13 composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas BR112021009222A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760077P 2018-11-13 2018-11-13
US62/760,077 2018-11-13
PCT/US2019/061191 WO2020102360A1 (en) 2018-11-13 2019-11-13 Compositions containing an expanded and enriched population of superactivated cytokine killer t cells and methods for making same

Publications (1)

Publication Number Publication Date
BR112021009222A2 true BR112021009222A2 (pt) 2021-08-10

Family

ID=70551406

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021009222-6A BR112021009222A2 (pt) 2018-11-13 2019-11-13 composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas

Country Status (7)

Country Link
US (1) US20210161955A2 (https=)
EP (1) EP3880794A4 (https=)
JP (1) JP2022520302A (https=)
CN (1) CN114641561A (https=)
AU (1) AU2019379140A1 (https=)
BR (1) BR112021009222A2 (https=)
WO (1) WO2020102360A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220401477A1 (en) * 2021-05-18 2022-12-22 Verdure Biotech, Inc. Method for controlling viral infections through adoptive transfer of a cell product comprising an expanded and enriched population of superactivated cytokine killer cells
WO2024222701A1 (zh) * 2023-04-25 2024-10-31 苏州沙砾生物科技有限公司 一种t细胞受体及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288291A4 (en) * 2000-06-06 2004-05-12 Kirin Brewery METHOD FOR REPLACING NATURAL KILLER T CELLS
JP2011528326A (ja) * 2008-07-18 2011-11-17 セントクローネ インターナショナル エービー インビトロ拡大されたtリンパ球及びガン治療に適切な血管形成インヒビターを含む組成物
WO2015112793A2 (en) * 2014-01-27 2015-07-30 St. Jude Children's Research Hospital, Inc. Methods of expanding ex vivo natural killer t (nkt) cells and therapeutic uses thereof
CN106434552B (zh) * 2015-08-13 2022-04-29 清华大学 新型nkt样细胞亚群及其治疗肿瘤的用途
CN106011060A (zh) * 2016-06-29 2016-10-12 北京中台恒基生物技术有限公司 一种体外激活和扩增nkt样细胞的方法
CN106434556B (zh) * 2016-11-22 2019-10-11 上海新长安生物科技有限公司 一种体外诱导扩增i型nkt细胞的方法
KR20190129046A (ko) * 2017-02-15 2019-11-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 Nk 세포를 활성화시키기 위한 조성물 및 방법
EP4417210A1 (en) * 2017-03-15 2024-08-21 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants

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Publication number Publication date
EP3880794A4 (en) 2022-08-24
EP3880794A1 (en) 2021-09-22
AU2019379140A1 (en) 2021-06-24
US20210161955A2 (en) 2021-06-03
CN114641561A (zh) 2022-06-17
US20200147139A1 (en) 2020-05-14
WO2020102360A1 (en) 2020-05-22
JP2022520302A (ja) 2022-03-30

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements