AU2019379140A1 - Compositions containing an expanded and enriched population of superactivated cytokine killer T cells and methods for making same - Google Patents

Compositions containing an expanded and enriched population of superactivated cytokine killer T cells and methods for making same Download PDF

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Publication number
AU2019379140A1
AU2019379140A1 AU2019379140A AU2019379140A AU2019379140A1 AU 2019379140 A1 AU2019379140 A1 AU 2019379140A1 AU 2019379140 A AU2019379140 A AU 2019379140A AU 2019379140 A AU2019379140 A AU 2019379140A AU 2019379140 A1 AU2019379140 A1 AU 2019379140A1
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Prior art keywords
cells
cell
population
scktcs
expanded
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Abandoned
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AU2019379140A
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English (en)
Inventor
Beverly W. Lubit
Jing Wang
Jian Qing XU
Xiao Yan ZHANG
Ling Yan ZHU
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CN USA Biotech Holdings Inc
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CN USA Biotech Holdings Inc
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Publication of AU2019379140A1 publication Critical patent/AU2019379140A1/en
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
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    • C12N2501/052Lipopolysaccharides [LPS]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2302Interleukin-2 (IL-2)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121Dendritic cells

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  • Biochemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU2019379140A 2018-11-13 2019-11-13 Compositions containing an expanded and enriched population of superactivated cytokine killer T cells and methods for making same Abandoned AU2019379140A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862760077P 2018-11-13 2018-11-13
US62/760,077 2018-11-13
PCT/US2019/061191 WO2020102360A1 (en) 2018-11-13 2019-11-13 Compositions containing an expanded and enriched population of superactivated cytokine killer t cells and methods for making same

Publications (1)

Publication Number Publication Date
AU2019379140A1 true AU2019379140A1 (en) 2021-06-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019379140A Abandoned AU2019379140A1 (en) 2018-11-13 2019-11-13 Compositions containing an expanded and enriched population of superactivated cytokine killer T cells and methods for making same

Country Status (7)

Country Link
US (1) US20210161955A2 (https=)
EP (1) EP3880794A4 (https=)
JP (1) JP2022520302A (https=)
CN (1) CN114641561A (https=)
AU (1) AU2019379140A1 (https=)
BR (1) BR112021009222A2 (https=)
WO (1) WO2020102360A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220401477A1 (en) * 2021-05-18 2022-12-22 Verdure Biotech, Inc. Method for controlling viral infections through adoptive transfer of a cell product comprising an expanded and enriched population of superactivated cytokine killer cells
WO2024222701A1 (zh) * 2023-04-25 2024-10-31 苏州沙砾生物科技有限公司 一种t细胞受体及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288291A4 (en) * 2000-06-06 2004-05-12 Kirin Brewery METHOD FOR REPLACING NATURAL KILLER T CELLS
JP2011528326A (ja) * 2008-07-18 2011-11-17 セントクローネ インターナショナル エービー インビトロ拡大されたtリンパ球及びガン治療に適切な血管形成インヒビターを含む組成物
WO2015112793A2 (en) * 2014-01-27 2015-07-30 St. Jude Children's Research Hospital, Inc. Methods of expanding ex vivo natural killer t (nkt) cells and therapeutic uses thereof
CN106434552B (zh) * 2015-08-13 2022-04-29 清华大学 新型nkt样细胞亚群及其治疗肿瘤的用途
CN106011060A (zh) * 2016-06-29 2016-10-12 北京中台恒基生物技术有限公司 一种体外激活和扩增nkt样细胞的方法
CN106434556B (zh) * 2016-11-22 2019-10-11 上海新长安生物科技有限公司 一种体外诱导扩增i型nkt细胞的方法
KR20190129046A (ko) * 2017-02-15 2019-11-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 Nk 세포를 활성화시키기 위한 조성물 및 방법
EP4417210A1 (en) * 2017-03-15 2024-08-21 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants

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Publication number Publication date
EP3880794A4 (en) 2022-08-24
EP3880794A1 (en) 2021-09-22
US20210161955A2 (en) 2021-06-03
CN114641561A (zh) 2022-06-17
US20200147139A1 (en) 2020-05-14
WO2020102360A1 (en) 2020-05-22
JP2022520302A (ja) 2022-03-30
BR112021009222A2 (pt) 2021-08-10

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