|
JPH0747045B2
(ja)
|
1986-10-15 |
1995-05-24 |
株式会社大協精工 |
積層した注射器用滑栓
|
|
US5670373A
(en)
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
|
CA1341152C
(en)
|
1988-01-22 |
2000-12-12 |
Tadamitsu Kishimoto |
Receptor protein for human b cell stimulatory factor-2
|
|
US5216128A
(en)
|
1989-06-01 |
1993-06-01 |
Yeda Research And Development Co., Ltd. |
IFN-β2/IL-6 receptor its preparation and pharmaceutical compositions containing it
|
|
ES2093017T3
(es)
|
1989-07-20 |
1996-12-16 |
Tadamitsu Kishimoto |
Anticuerpo contra el receptor de la interleuquina-6 humana.
|
|
US5605690A
(en)
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5016784A
(en)
|
1990-02-15 |
1991-05-21 |
Dexus Research Inc. |
Applicator for highly reactive materials
|
|
EP1857553A1
(en)
|
1991-03-18 |
2007-11-21 |
New York University |
Monoclonal and chimeric antibodies specific for human tumor necrosis factor
|
|
US5795965A
(en)
|
1991-04-25 |
1998-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
Reshaped human to human interleukin-6 receptor
|
|
US5215534A
(en)
|
1991-12-02 |
1993-06-01 |
Lawrence De Harde |
Safety syringe system
|
|
JP3100727B2
(ja)
|
1992-01-23 |
2000-10-23 |
株式会社大協精工 |
変性ポリシロキサン組成物及び該組成物を被覆した衛生ゴム製品
|
|
FR2694767B1
(fr)
|
1992-08-13 |
1994-10-21 |
Innotherapie Lab Sa |
Anticorps monoclonaux anti-IL6R, et leurs applications.
|
|
AU670125B2
(en)
|
1992-09-15 |
1996-07-04 |
Immunex Corporation |
Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
|
|
WO1994009138A1
(en)
|
1992-10-20 |
1994-04-28 |
Cetus Oncology Corporation |
Interleukin-6 receptor antagonists
|
|
US5888511A
(en)
|
1993-02-26 |
1999-03-30 |
Advanced Biotherapy Concepts, Inc. |
Treatment of autoimmune diseases, including AIDS
|
|
US5888510A
(en)
|
1993-07-21 |
1999-03-30 |
Chugai Seiyaku Kabushiki Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
AU7967294A
(en)
|
1993-10-06 |
1995-05-01 |
Board Of Regents, The University Of Texas System |
A monoclonal anti-human il-6 receptor antibody
|
|
ES2384222T3
(es)
|
1994-10-07 |
2012-07-02 |
Chugai Seiyaku Kabushiki Kaisha |
Inhibición del crecimiento anómalo de células sinoviales utilizando un antagonista de IL-6 como principio activo
|
|
CN1306963C
(zh)
|
1994-10-21 |
2007-03-28 |
岸本忠三 |
用于治疗il－6产生所致疾病的药物组合物
|
|
EP0800829B2
(en)
|
1994-12-29 |
2012-07-25 |
Chugai Seiyaku Kabushiki Kaisha |
Use of a pm-1 antibody or of a mh 166 antibody for enhancing the anti-tumor effect of cisplatin or carboplatin
|
|
EP0811384B1
(en)
|
1995-02-13 |
2006-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Muscle protein decomposition inhibitor containing il-6 receptor antibody
|
|
JP3172057B2
(ja)
|
1995-04-05 |
2001-06-04 |
株式会社大協精工 |
ラミネートゴム栓
|
|
UA66757C2
(en)
|
1996-02-26 |
2004-06-15 |
Advanced Res & Tech Inst |
Ophthalmologic composition of carbonic anhydrase inhibitors, method for treating or preventing macular edema or age-related macular degeneration
|
|
US6692742B1
(en)
|
1996-06-27 |
2004-02-17 |
Chugai Seiyaku Kabushiki Kaisha |
Remedies for myeloma to be used together with nitrogen mustard antitumor agents
|
|
US7312196B2
(en)
|
1997-01-08 |
2007-12-25 |
Amylin Pharmaceuticals, Inc. |
Formulations for amylin agonist peptides
|
|
PT1004315E
(pt)
|
1997-08-15 |
2008-07-09 |
Chugai Pharmaceutical Co Ltd |
Profilácticos e/ou medicamentos contendo anticorpos neutralizantes anti-receptor de il-6 para reduzir a excreção de proteínas urinárias no lúpus eritematoso sistémico
|
|
US20020187150A1
(en)
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
CN100374159C
(zh)
|
1998-03-17 |
2008-03-12 |
中外制药株式会社 |
一种包含il-6拮抗剂活性成分的炎性肠道疾病的预防或治疗剂
|
|
ES2276525T3
(es)
|
1998-08-24 |
2007-06-16 |
Chugai Seiyaku Kabushiki Kaisha |
Preventivos o remedios para la pancreatitis que contienen anticuerpos anti-receptor il-6 como ingrediente activo.
|
|
JP3512349B2
(ja)
|
1999-01-29 |
2004-03-29 |
株式会社大協精工 |
柱状ゴム要素の成形型
|
|
DE60025744D1
(de)
|
1999-10-07 |
2006-04-13 |
Lilly Co Eli |
Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1
|
|
US6659982B2
(en)
|
2000-05-08 |
2003-12-09 |
Sterling Medivations, Inc. |
Micro infusion drug delivery device
|
|
US6629949B1
(en)
|
2000-05-08 |
2003-10-07 |
Sterling Medivations, Inc. |
Micro infusion drug delivery device
|
|
JP5485489B2
(ja)
|
2000-08-11 |
2014-05-07 |
中外製薬株式会社 |
抗体含有安定化製剤
|
|
US7148197B2
(en)
|
2000-08-24 |
2006-12-12 |
The Regents Of The University Of California |
Orally administered small peptides synergize statin activity
|
|
AU1091802A
(en)
|
2000-10-20 |
2002-04-29 |
Chugai Pharmaceutical Co Ltd |
Degraded agonist antibody
|
|
CN1259973C
(zh)
|
2000-10-25 |
2006-06-21 |
中外制药株式会社 |
含有il－6拮抗剂作为有效成分的牛皮癣的预防或治疗剂
|
|
JP4889187B2
(ja)
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤
|
|
JP2002209975A
(ja)
|
2001-01-19 |
2002-07-30 |
Daikyo Seiko Ltd |
医薬バイアル用ラミネートゴム栓
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
CA2817619A1
(en)
|
2001-06-08 |
2002-12-08 |
Abbott Laboratories (Bermuda) Ltd. |
Methods of administering anti-tnf.alpha. antibodies
|
|
MXPA04000747A
(es)
|
2001-07-25 |
2004-07-08 |
Protein Desing Labs Inc |
Formulacion farmaceutica liofilizada estable de anticuerpos igg.
|
|
PT2308888T
(pt)
|
2001-11-14 |
2017-05-03 |
Janssen Biotech Inc |
Anticorpos anti-il-6, composições, métodos e utilizações
|
|
CN101721362B
(zh)
|
2002-02-14 |
2018-07-03 |
中外制药株式会社 |
包含抗体的溶液制剂
|
|
US20060078533A1
(en)
|
2004-10-12 |
2006-04-13 |
Omoigui Osemwota S |
Method of prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimer's disease and cancer
|
|
US20060275294A1
(en)
|
2002-08-22 |
2006-12-07 |
Omoigui Osemwota S |
Method of prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimers disease and cancer
|
|
US20060078531A1
(en)
|
2004-10-12 |
2006-04-13 |
Osemwota Sota |
Method of prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease
|
|
US20060078532A1
(en)
|
2004-10-12 |
2006-04-13 |
Omoigui Osemwota S |
Method of prevention and treatment of Atherosclerosis, Peripheral vascular disease, Coronary artery disease, aging and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
MXPA05010555A
(es)
|
2003-04-04 |
2006-03-09 |
Genentech Inc |
Formulaciones de proteina y anticuerpo de alta concentracion.
|
|
EP1613350B1
(en)
|
2003-04-09 |
2009-03-18 |
Genentech, Inc. |
Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
JP4960096B2
(ja)
|
2003-09-22 |
2012-06-27 |
ペントラコール ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｉｌ−６の生物学的効果を減じる化合物の使用
|
|
DE10355251A1
(de)
|
2003-11-26 |
2005-06-23 |
Merck Patent Gmbh |
Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor
|
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
|
ATE464908T1
(de)
|
2004-02-11 |
2010-05-15 |
Warner Lambert Co |
Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern
|
|
CN1989439B
(zh)
|
2004-05-06 |
2010-12-29 |
美国政府健康及人类服务部 |
治疗葡萄膜炎的方法以及组合物
|
|
AU2005287406B2
(en)
|
2004-07-26 |
2011-08-18 |
Biogen Ma Inc. |
Anti-CD154 antibodies
|
|
US20070036788A1
(en)
|
2004-09-22 |
2007-02-15 |
Ahmed Sheriff |
Use of a compound for reducing the biological effectiveness of il-6
|
|
WO2006046661A1
(ja)
|
2004-10-28 |
2006-05-04 |
Osaka University |
インターロイキン－６阻害剤
|
|
US20060177436A1
(en)
|
2004-12-16 |
2006-08-10 |
Genentech, Inc. |
Methods for Treating Autoimmune Disorders
|
|
AU2006318583A1
(en)
|
2005-11-22 |
2007-05-31 |
Wyeth |
Immunoglobulin fusion protein formulations
|
|
EP1963368B3
(en)
|
2005-12-13 |
2020-06-10 |
Eli Lilly And Company |
Anti-il-17 antibodies
|
|
US20080131374A1
(en)
|
2006-04-19 |
2008-06-05 |
Medich John R |
Uses and compositions for treatment of rheumatoid arthritis
|
|
JP5307708B2
(ja)
|
2006-06-02 |
2013-10-02 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒトｉｌ−６受容体に対する高親和性抗体
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
CA2654794A1
(en)
|
2006-06-14 |
2007-12-21 |
Imclone Systems Incorporated |
Lyophilized formulations of anti-egfr antibodies
|
|
WO2008020079A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
CA2667466A1
(en)
|
2006-10-27 |
2008-05-02 |
Ablynx N.V. |
Intranasal delivery of polypeptides and proteins
|
|
JP6071165B2
(ja)
|
2007-05-31 |
2017-02-01 |
ゲンマブ エー／エス |
安定なＩｇＧ４抗体
|
|
MX2010003329A
(es)
|
2007-09-26 |
2010-04-27 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-receptor de il-6.
|
|
WO2009095489A2
(en)
|
2008-02-01 |
2009-08-06 |
Ablynx N.V. |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling
|
|
WO2009109584A1
(en)
|
2008-03-07 |
2009-09-11 |
Ferring International Center S. A. |
ANTIBODY BINDING ONLY TO IL6-sIL6R COMPLEX
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
WO2010106812A1
(en)
|
2009-03-19 |
2010-09-23 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical formulation containing improved antibody molecules
|
|
JO3030B1
(ar)
|
2009-06-26 |
2016-09-05 |
Galapagos Nv |
مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
BR112012028557A2
(pt)
|
2010-05-07 |
2019-09-24 |
Xoma Technology Ltd. |
uso de um anticorpo anti-il-1b ou de fragmentos de ligação do mesmo.
|
|
US9427531B2
(en)
|
2010-06-28 |
2016-08-30 |
Sanofi-Aventis Deutschland Gmbh |
Auto-injector
|
|
KR20190120439A
(ko)
*
|
2010-11-08 |
2019-10-23 |
제넨테크, 인크. |
피하 투여용 항―ｉｌ―6 수용체 항체
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
|
US9248242B2
(en)
|
2012-04-20 |
2016-02-02 |
Safety Syringes, Inc. |
Anti-needle stick safety device for injection device
|
|
US20140155827A1
(en)
|
2012-12-03 |
2014-06-05 |
Mylan, Inc. |
Medicament information system and method
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
MX377190B
(es)
*
|
2013-11-22 |
2025-03-07 |
Sanofi Biotechnology |
Uso de un anticuerpo anti-il6r para el tratamiento de la artritis reumatoide.
|
|
US10428158B2
(en)
|
2014-03-27 |
2019-10-01 |
Dyax Corp. |
Compositions and methods for treatment of diabetic macular edema
|
|
EA035419B9
(ru)
*
|
2014-05-29 |
2020-08-07 |
Мэкроудженикс, Инк. |
Триспецифичные связывающие молекулы и способы их применения
|
|
AU2015317905A1
(en)
|
2014-09-16 |
2017-03-16 |
Regeneron Pharmaceuticals, Inc. |
Compositions for improving the health related quality of life of rheumatoid arthritis patients
|
|
WO2017079443A1
(en)
|
2015-11-03 |
2017-05-11 |
Sanofi Biotechnology |
Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same
|
|
CA3016880A1
(en)
*
|
2016-03-07 |
2017-09-14 |
Sanofi Biotechnology |
Compositions and methods for treating rheumatoid arthritis
|
|
EP3735421A4
(en)
*
|
2018-01-05 |
2021-09-22 |
Corvidia Therapeutics, Inc. |
METHOD OF TREATMENT OF IL-6 MEDIATED INFLAMMATION WITHOUT IMMUNSUPPRESSION
|
|
MA54861A
(fr)
*
|
2019-01-31 |
2021-12-08 |
Regeneron Pharma |
Anticorps anti-récepteur de l'il6 pour traiter l'arthrite idiopathique juvénile
|