JP2022516684A5 - - Google Patents

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Publication number
JP2022516684A5
JP2022516684A5 JP2021562929A JP2021562929A JP2022516684A5 JP 2022516684 A5 JP2022516684 A5 JP 2022516684A5 JP 2021562929 A JP2021562929 A JP 2021562929A JP 2021562929 A JP2021562929 A JP 2021562929A JP 2022516684 A5 JP2022516684 A5 JP 2022516684A5
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JP2021562929A
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Japanese (ja)
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JP2022516684A (ja
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Priority claimed from PCT/US2020/012595 external-priority patent/WO2020146397A1/en
Publication of JP2022516684A publication Critical patent/JP2022516684A/ja
Publication of JP2022516684A5 publication Critical patent/JP2022516684A5/ja
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JP2021562929A 2019-01-08 2020-01-07 ヌクレオチドの開裂可能なリンカーおよびその使用 Pending JP2022516684A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962789879P 2019-01-08 2019-01-08
US62/789,879 2019-01-08
US201962841168P 2019-04-30 2019-04-30
US62/841,168 2019-04-30
PCT/US2020/012595 WO2020146397A1 (en) 2019-01-08 2020-01-07 Nucleotide cleavable linkers and uses thereof

Publications (2)

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JP2022516684A JP2022516684A (ja) 2022-03-01
JP2022516684A5 true JP2022516684A5 (enExample) 2022-10-17

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JP2021562929A Pending JP2022516684A (ja) 2019-01-08 2020-01-07 ヌクレオチドの開裂可能なリンカーおよびその使用

Country Status (5)

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US (4) US11970735B2 (enExample)
EP (1) EP3908286A4 (enExample)
JP (1) JP2022516684A (enExample)
CN (1) CN113453692A (enExample)
WO (1) WO2020146397A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3596099B1 (en) 2017-03-06 2024-07-24 Singular Genomics Systems, Inc. Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps
US12215124B2 (en) * 2018-02-21 2025-02-04 Singular Genomics Systems, Inc. Fluorinated nucleotides and uses thereof
WO2019222653A1 (en) 2018-05-18 2019-11-21 Singular Genomics Systems, Inc. Silicon containing detectable compounds
CN113039191B (zh) 2018-10-25 2024-07-16 奇异基因组学系统公司 核苷酸类似物
JP2022516684A (ja) 2019-01-08 2022-03-01 シンギュラー・ゲノミクス・システムズ・インコーポレイテッド ヌクレオチドの開裂可能なリンカーおよびその使用
EP4055023A4 (en) 2019-11-07 2024-01-03 Singular Genomics Systems, Inc. SILICON-CONTAINING DETECTED COMPOUNDS AND USES THEREOF
US11174281B1 (en) 2020-04-24 2021-11-16 Singular Genomics Systems, Inc. Modified nucleotides and uses thereof
WO2022094415A1 (en) 2020-10-30 2022-05-05 Singular Genomics Systems, Inc. Methods and compositions for reducing nucleotide impurities
CA3214986A1 (en) * 2021-04-01 2022-10-06 Bgi Shenzhen Nucleotide analogue for sequencing
WO2023107673A2 (en) 2021-12-10 2023-06-15 Singular Genomics Systems, Inc. Cleavable disulfide linkers and uses thereof
JP2025505253A (ja) * 2022-02-11 2025-02-21 ミルテニー バイオテック ベー.フェー. ウント コー. カー・ゲー 酵素的dnaおよびrna合成のための3’-オキシメチレンアルキルジスルフィド保護ヌクレオチドの使用
US12359068B2 (en) 2023-02-10 2025-07-15 Singular Genomics Systems, Inc. Rhodamine fluorescent compounds and production methods thereof

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936696A (ja) 1982-08-20 1984-02-28 Taiho Yakuhin Kogyo Kk 2′―デオキシ―5―置換ウリジン誘導体及びそれを含有する抗腫瘍剤
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5804386A (en) 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
US5876936A (en) 1997-01-15 1999-03-02 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators
US6046005A (en) 1997-01-15 2000-04-04 Incyte Pharmaceuticals, Inc. Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
US20060057565A1 (en) 2000-09-11 2006-03-16 Jingyue Ju Combinatorial fluorescence energy transfer tags and uses thereof
US6627748B1 (en) 2000-09-11 2003-09-30 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
CA2421582A1 (en) 2000-09-11 2002-03-21 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and uses thereof
AU2001296645A1 (en) 2000-10-06 2002-04-15 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
US20030027140A1 (en) 2001-03-30 2003-02-06 Jingyue Ju High-fidelity DNA sequencing using solid phase capturable dideoxynucleotides and mass spectrometry
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7074597B2 (en) 2002-07-12 2006-07-11 The Trustees Of Columbia University In The City Of New York Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
US20040022764A1 (en) 2002-07-31 2004-02-05 Hanan Polansky Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
WO2004018497A2 (en) 2002-08-23 2004-03-04 Solexa Limited Modified nucleotides for polynucleotide sequencing
GB0324456D0 (en) 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
EP2436778A3 (en) 2004-03-03 2012-07-11 The Trustees of Columbia University in the City of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
US20080103053A1 (en) 2005-11-22 2008-05-01 Helicos Biosciences Corporation Methods and compositions for sequencing a nucleic acid
US8114973B2 (en) 2004-05-25 2012-02-14 Helicos Biosciences Corporation Nucleotide analogs
US20070009980A1 (en) 2004-06-01 2007-01-11 Applera Corporation Continuous fluorogenic analyte assays with dendritic amplification of signal
US20060003383A1 (en) 2004-06-07 2006-01-05 Applera Corporation Fluorogenic enzyme activity assay methods and compositions using fragmentable linkers
US9169510B2 (en) 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
GB2446083B (en) 2005-10-31 2011-03-02 Univ Columbia Chemically cleavable 3'-0-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
US7982029B2 (en) 2005-10-31 2011-07-19 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
WO2007146158A1 (en) 2006-06-07 2007-12-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by nanopore using modified nucleotides
WO2008037568A2 (en) 2006-09-04 2008-04-03 Quiatech Ab Reversible terminators for efficient sequencing by synthesis
WO2008042067A2 (en) 2006-09-28 2008-04-10 Illumina, Inc. Compositions and methods for nucleotide sequencing
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
DK2725107T3 (da) 2007-10-19 2019-01-02 Univ Columbia DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
WO2009051807A1 (en) 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
US8772473B2 (en) 2009-03-30 2014-07-08 The Regents Of The University Of California Mostly natural DNA sequencing by synthesis
WO2012083249A2 (en) 2010-12-17 2012-06-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using modified nucleotides and nanopore detection
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
WO2013040257A1 (en) 2011-09-13 2013-03-21 Lasergen, Inc. 5-methoxy. 3'-oh unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
WO2013154999A2 (en) 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Method of preparation of nanopore and uses thereof
EP3674412A1 (en) 2012-06-20 2020-07-01 The Trustees of Columbia University in the City of New York Nucleic acid sequencing by nanopore detection of tag molecules
US10732183B2 (en) 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
WO2014139596A1 (en) 2013-03-15 2014-09-18 Illumina Cambridge Limited Modified nucleosides or nucleotides
EP2876166B1 (en) 2013-11-20 2016-12-14 Roche Diagnostics GmbH New compound for sequencing by synthesis
US10718011B2 (en) 2014-02-12 2020-07-21 The Trustees Of Columbia University In The City Of New York Single molecule electronic multiplex SNP assay and PCR analysis
MA39774A (fr) 2014-03-24 2021-05-12 Roche Sequencing Solutions Inc Procédés chimiques pour produire des nucléotides étiquetés
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
EP3699283A1 (en) 2014-10-20 2020-08-26 Molecular Assemblies Inc. Modified template-independent enzymes for polydeoxynucleotide systhesis
GB201418718D0 (en) 2014-10-21 2014-12-03 Cambridge Epigenetix Ltd Improved nucleic acid re-sequencing using a reduced number of identified bases
WO2016144973A1 (en) 2015-03-09 2016-09-15 The Trustees Of Columbia University In The City Of New York Pore-forming protein conjugate compositions and methods
CN107922968B (zh) 2015-03-23 2022-05-17 哥伦比亚大学董事会 用于单分子电子snp测定的聚合物标记的核苷酸
EP3091026B1 (en) * 2015-05-08 2019-02-20 Centrillion Technology Holdings Corporation Disulfide-linked reversible terminators
CN108779138B (zh) 2015-09-28 2022-06-17 哥伦比亚大学董事会 用作dna合成测序的可逆终止物的基于新的二硫键接头的核苷酸的设计与合成
TWI639614B (zh) 2015-11-06 2018-11-01 美商齊亞雋科學公司 核苷酸類似物
US11421264B2 (en) 2015-11-06 2022-08-23 IsoPlexis Corporation Thiol-containing cleave reagents and oxidative wash
WO2017087887A1 (en) 2015-11-18 2017-05-26 The Trustees Of Columbia University In The City Of New York Ion sensor dna and rna sequencing by synthesis using nucleotide reversible terminators
US11384391B2 (en) 2016-04-04 2022-07-12 The Trustees Of Columbia University In The City Of New York Flourescene energy transfer-based single molecule/ensemble DNA sequencing by synthesis
EP3458082A4 (en) 2016-04-04 2020-07-29 The Trustees of Columbia University in the City of New York SYNTHESIS DNA SEQUENCING WITH NUCLEOTID ANALOGUES AND RAMAN DETECTION
WO2017205336A1 (en) 2016-05-23 2017-11-30 The Trustees Of Columbia University In The City Of New York Nucleotide derivatives and methods of use thereof
AU2017354876A1 (en) * 2016-11-04 2019-06-20 Qiagen Sciences, Llc Thiol-containing cleave reagents and oxidative wash
EP3596099B1 (en) 2017-03-06 2024-07-24 Singular Genomics Systems, Inc. Nucleic acid sequencing-by-synthesis (sbs) methods that combine sbs cycle steps
WO2018183538A1 (en) 2017-03-28 2018-10-04 The Trustees Of Columbia University In The City Of New York 3'-o-modified nucleotide analogues with different cleavable linkers for attaching fluorescent labels to the base for dna sequencing by synthesis
US20190077726A1 (en) 2017-09-13 2019-03-14 Singular Genomics Systems, Inc. Methods of synthesizing labeled nucleosides
WO2019071474A1 (zh) 2017-10-11 2019-04-18 深圳华大智造科技有限公司 修饰的核苷或核苷酸
EP3733683A4 (en) 2017-11-30 2022-04-06 GeneMind Biosciences Company Limited NUCLEOSIDE ANALOGUES, METHOD OF MANUFACTURE AND USE
US12215124B2 (en) 2018-02-21 2025-02-04 Singular Genomics Systems, Inc. Fluorinated nucleotides and uses thereof
CN113039191B (zh) * 2018-10-25 2024-07-16 奇异基因组学系统公司 核苷酸类似物
JP2022516684A (ja) 2019-01-08 2022-03-01 シンギュラー・ゲノミクス・システムズ・インコーポレイテッド ヌクレオチドの開裂可能なリンカーおよびその使用
WO2020146497A1 (en) 2019-01-09 2020-07-16 The Regents Of The University Of California An electrochemiluminescence elisa for ps129-a-synuclein

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