JP2022512643A5 - - Google Patents
Info
- Publication number
- JP2022512643A5 JP2022512643A5 JP2021519602A JP2021519602A JP2022512643A5 JP 2022512643 A5 JP2022512643 A5 JP 2022512643A5 JP 2021519602 A JP2021519602 A JP 2021519602A JP 2021519602 A JP2021519602 A JP 2021519602A JP 2022512643 A5 JP2022512643 A5 JP 2022512643A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- nhc
- nhnh
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025017433A JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862743337P | 2018-10-09 | 2018-10-09 | |
| US62/743,337 | 2018-10-09 | ||
| PCT/US2019/055461 WO2020076996A1 (en) | 2018-10-09 | 2019-10-09 | Covalent targeting of e3 ligases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017433A Division JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512643A JP2022512643A (ja) | 2022-02-07 |
| JP2022512643A5 true JP2022512643A5 (enExample) | 2022-10-18 |
| JP7631191B2 JP7631191B2 (ja) | 2025-02-18 |
Family
ID=70164411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021519602A Active JP7631191B2 (ja) | 2018-10-09 | 2019-10-09 | Ｅ３リガーゼの共有結合による標的化 |
| JP2025017433A Pending JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017433A Pending JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US12161648B2 (enExample) |
| EP (1) | EP3863642A4 (enExample) |
| JP (2) | JP7631191B2 (enExample) |
| CN (2) | CN120468320A (enExample) |
| WO (1) | WO2020076996A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019183600A1 (en) | 2018-03-23 | 2019-09-26 | The Regents Of The University Of California | Methods and compounds for targeted autophagy |
| GB202005876D0 (en) * | 2020-04-22 | 2020-06-03 | Univ Dundee | Protein degradation |
| US12441679B2 (en) | 2020-07-30 | 2025-10-14 | Sanofi | Acrylamide-substituted indane compounds and therapeutic use thereof |
| KR20230144008A (ko) * | 2021-01-08 | 2023-10-13 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 님볼리드 유사체 및 이의 사용 방법 |
| CN117042765A (zh) * | 2021-01-08 | 2023-11-10 | 德克萨斯大学系统董事会 | 印苦楝内酯类似物及其使用方法 |
| WO2022187650A1 (en) * | 2021-03-04 | 2022-09-09 | The Scripps Research Institute | Heterobifunctional compositions for targeted protein degradation and methods for their use |
| EP4313979A4 (en) * | 2021-03-25 | 2025-02-19 | Technion Research & Development Foundation Limited | RNF4-TARGETED COMPOUNDS AND USES THEREOF |
| CN113527270B (zh) * | 2021-07-16 | 2024-03-01 | 河南大学 | 一种靶向单酰基甘油脂肪酶的protac分子的医药中间体、制备方法及应用 |
| CN116676273A (zh) * | 2022-02-22 | 2023-09-01 | 中国科学院深圳先进技术研究院 | 一种蛋白水解靶向流感病毒及其制备方法和应用 |
| CN114560908B (zh) * | 2022-03-11 | 2024-10-25 | 国家纳米科学中心 | 一种多肽protac分子及其制备方法和应用 |
| EP4514780A4 (en) * | 2022-04-29 | 2026-04-29 | Dong A St Co Ltd | BICYCLIC COMPOUNDS USED AS TEAD INHIBITORS |
| CN115417913B (zh) * | 2022-08-26 | 2024-10-29 | 天津医科大学 | 靶向雌激素受体的谷胱甘肽响应protac降解剂的制备方法及应用 |
| WO2024080793A1 (en) * | 2022-10-13 | 2024-04-18 | Hanmi Pharm. Co., Ltd. | Novel heterobicyclic compound for inhibiting yap-tead interaction and pharmaceutical composition comprising same |
| WO2024086361A1 (en) * | 2022-10-21 | 2024-04-25 | Novartis Ag | Molecular glue degrader compounds and uses thereof |
| CN117263865B (zh) * | 2023-08-04 | 2026-03-27 | 南开大学 | 以6,6-二甲基双环[3.1.1]-2-甲胺为疏水基团的蛋白降解剂及其制备方法、药物组合物和应用 |
| WO2025226951A1 (en) * | 2024-04-24 | 2025-10-30 | Novartis Ag | Molecular glue degrader compounds and uses thereof |
| CN119331047B (zh) * | 2024-10-09 | 2025-09-30 | 重庆医科大学 | 一种蛋白水解靶向嵌合体及其制备方法 |
| CN119405823B (zh) * | 2024-11-15 | 2025-10-21 | 湖南大学 | 一种基于g四链体rna的蛋白降解靶向嵌合体及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040171074A1 (en) * | 2002-10-17 | 2004-09-02 | Mount Sinai Hospital | Structures of substrate binding pockets of SCF complexes |
| PL2902030T3 (pl) | 2010-05-14 | 2017-07-31 | Dana-Farber Cancer Institute, Inc. | Związki tienotriazolodiazepinowe do leczenia nowotworu |
| CN101928747B (zh) * | 2010-08-31 | 2012-08-08 | 中国人民解放军第二军医大学 | E3泛素连接酶chip在脑胶质瘤疾病中的应用 |
| WO2013170147A1 (en) | 2012-05-11 | 2013-11-14 | Yale University | Compounds useful for promoting protein degradation and methods using same |
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CN104017879A (zh) * | 2014-06-16 | 2014-09-03 | 山东大学 | Fbxo31基因及其相关产物在制备胃癌诊断试剂中的应用 |
| MX2017015373A (es) * | 2015-05-29 | 2018-07-06 | Univ Pennsylvania | COMPOSICIONES Y MíTODOS PARA LA DEGRADACIíN DE PROTEíNAS MAL PLEGADAS. |
| MX2018006499A (es) * | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| KR20180132861A (ko) * | 2016-04-12 | 2018-12-12 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Bet 단백질 분해제 |
| CA3036834A1 (en) * | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines as bet protein degraders |
| WO2020146779A1 (en) | 2019-01-11 | 2020-07-16 | The Regents Of The University Of California | mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY |
-
2019
- 2019-10-09 EP EP19872219.1A patent/EP3863642A4/en active Pending
- 2019-10-09 CN CN202510552209.7A patent/CN120468320A/zh active Pending
- 2019-10-09 JP JP2021519602A patent/JP7631191B2/ja active Active
- 2019-10-09 US US17/282,277 patent/US12161648B2/en active Active
- 2019-10-09 CN CN201980079494.8A patent/CN113164495B/zh active Active
- 2019-10-09 WO PCT/US2019/055461 patent/WO2020076996A1/en not_active Ceased
-
2024
- 2024-10-02 US US18/904,492 patent/US20250120982A1/en active Pending
-
2025
- 2025-02-05 JP JP2025017433A patent/JP2025072508A/ja active Pending
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