JP2022512643A5 - - Google Patents
Info
- Publication number
- JP2022512643A5 JP2022512643A5 JP2021519602A JP2021519602A JP2022512643A5 JP 2022512643 A5 JP2022512643 A5 JP 2022512643A5 JP 2021519602 A JP2021519602 A JP 2021519602A JP 2021519602 A JP2021519602 A JP 2021519602A JP 2022512643 A5 JP2022512643 A5 JP 2022512643A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- nhc
- nhnh
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025017433A JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862743337P | 2018-10-09 | 2018-10-09 | |
| US62/743,337 | 2018-10-09 | ||
| PCT/US2019/055461 WO2020076996A1 (en) | 2018-10-09 | 2019-10-09 | Covalent targeting of e3 ligases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017433A Division JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512643A JP2022512643A (ja) | 2022-02-07 |
| JP2022512643A5 true JP2022512643A5 (enExample) | 2022-10-18 |
| JP7631191B2 JP7631191B2 (ja) | 2025-02-18 |
Family
ID=70164411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021519602A Active JP7631191B2 (ja) | 2018-10-09 | 2019-10-09 | Ｅ３リガーゼの共有結合による標的化 |
| JP2025017433A Pending JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017433A Pending JP2025072508A (ja) | 2018-10-09 | 2025-02-05 | Ｅ３リガーゼの共有結合による標的化 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US12161648B2 (enExample) |
| EP (1) | EP3863642A4 (enExample) |
| JP (2) | JP7631191B2 (enExample) |
| CN (2) | CN120468320A (enExample) |
| WO (1) | WO2020076996A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11666661B2 (en) | 2018-03-23 | 2023-06-06 | The Regents Of The University Of California | Methods and compounds for targeted autophagy |
| GB202005876D0 (en) * | 2020-04-22 | 2020-06-03 | Univ Dundee | Protein degradation |
| CN116057042B (zh) * | 2020-07-30 | 2024-10-18 | 赛诺菲 | 丙烯酰胺取代的茚满化合物及其治疗用途 |
| CN117042765A (zh) * | 2021-01-08 | 2023-11-10 | 德克萨斯大学系统董事会 | 印苦楝内酯类似物及其使用方法 |
| WO2022150667A1 (en) * | 2021-01-08 | 2022-07-14 | The Board Of Regents Of The University Of Texas System | Nimbolide analogs and methods of use thereof |
| US20250276069A1 (en) * | 2021-03-04 | 2025-09-04 | The Scripps Research Institute | Heterobifunctional compositions for targeted protein degradation and methods for their use |
| EP4313979A4 (en) | 2021-03-25 | 2025-02-19 | Technion Research & Development Foundation Limited | RNF4-TARGETED COMPOUNDS AND USES THEREOF |
| CN113527270B (zh) * | 2021-07-16 | 2024-03-01 | 河南大学 | 一种靶向单酰基甘油脂肪酶的protac分子的医药中间体、制备方法及应用 |
| CN116676273A (zh) * | 2022-02-22 | 2023-09-01 | 中国科学院深圳先进技术研究院 | 一种蛋白水解靶向流感病毒及其制备方法和应用 |
| CN114560908B (zh) * | 2022-03-11 | 2024-10-25 | 国家纳米科学中心 | 一种多肽protac分子及其制备方法和应用 |
| WO2023209651A1 (en) * | 2022-04-29 | 2023-11-02 | Dong-A St Co., Ltd. | Bicycle compounds as tead inhibitor |
| CN115417913B (zh) * | 2022-08-26 | 2024-10-29 | 天津医科大学 | 靶向雌激素受体的谷胱甘肽响应protac降解剂的制备方法及应用 |
| JP2025533275A (ja) * | 2022-10-13 | 2025-10-03 | ハンミ ファーマシューティカルズ カンパニー リミテッド | Ｙａｐ－ｔｅａｄ相互作用を阻害するための新規なヘテロ二環式化合物及びそれを含む薬学的組成物 |
| EP4605088A1 (en) * | 2022-10-21 | 2025-08-27 | Novartis AG | Molecular glue degrader compounds and uses thereof |
| CN117263865B (zh) * | 2023-08-04 | 2026-03-27 | 南开大学 | 以6,6-二甲基双环[3.1.1]-2-甲胺为疏水基团的蛋白降解剂及其制备方法、药物组合物和应用 |
| WO2025226951A1 (en) * | 2024-04-24 | 2025-10-30 | Novartis Ag | Molecular glue degrader compounds and uses thereof |
| CN119331047B (zh) * | 2024-10-09 | 2025-09-30 | 重庆医科大学 | 一种蛋白水解靶向嵌合体及其制备方法 |
| CN119405823B (zh) * | 2024-11-15 | 2025-10-21 | 湖南大学 | 一种基于g四链体rna的蛋白降解靶向嵌合体及其制备方法与应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2443370A1 (en) * | 2002-10-17 | 2004-04-17 | Mount Sinai Hospital | Structures of substrate binding pockets of scf complexes |
| KR100874209B1 (ko) * | 2007-08-17 | 2008-12-15 | 한국화학연구원 | 3,10-다이하이드로-1Ｈ-[1,4]다이아제피노[5,6-ｂ]인돌-2-온 유도체 및 약학적으로 허용 가능한 염, 그의 제조방법및 그의 용도 |
| GB0725214D0 (en) * | 2007-12-24 | 2008-02-06 | Karobio Ab | Pharmaceutical compounds |
| ES2606958T3 (es) * | 2010-05-14 | 2017-03-28 | Dana-Farber Cancer Institute, Inc. | Compuestos de tienotriazolodiazepina para tratar una neoplasia |
| CN101928747B (zh) | 2010-08-31 | 2012-08-08 | 中国人民解放军第二军医大学 | E3泛素连接酶chip在脑胶质瘤疾病中的应用 |
| WO2013170147A1 (en) * | 2012-05-11 | 2013-11-14 | Yale University | Compounds useful for promoting protein degradation and methods using same |
| KR101497979B1 (ko) * | 2013-02-04 | 2015-03-03 | 서울대학교산학협력단 | 인돌 유도체 및 이를 포함하는 ｒａｇｅ 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2015035199A1 (en) * | 2013-09-06 | 2015-03-12 | Mayo Foundation For Medical Education And Research | Neem compositions used for the treatment of cancer |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CN104017879A (zh) * | 2014-06-16 | 2014-09-03 | 山东大学 | Fbxo31基因及其相关产物在制备胃癌诊断试剂中的应用 |
| RU2761564C9 (ru) * | 2015-05-29 | 2022-03-17 | Дзе Трастиз Оф Дзе Юнивёрсити Оф Пенсильвания | Композиции и способы деградации неправильно упакованных белков |
| CR20180336A (es) | 2015-11-25 | 2018-08-06 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos |
| AU2017250076B2 (en) * | 2016-04-12 | 2021-07-22 | The Regents Of The University Of Michigan | Bet protein degraders |
| CA3036834A1 (en) | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines as bet protein degraders |
| US20200054651A1 (en) * | 2017-02-03 | 2020-02-20 | The Regents Of The University Of California | Compositions and methods for modulating ppp2r1a |
| SG11201906671SA (en) * | 2017-02-03 | 2019-08-27 | Univ California | Compositions and methods for inhibiting reticulon 4 |
| WO2018144869A1 (en) * | 2017-02-03 | 2018-08-09 | The Regents Of The University Of California | Compositons and methods for modulating uba5 |
| WO2020146779A1 (en) | 2019-01-11 | 2020-07-16 | The Regents Of The University Of California | mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY |
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2019
- 2019-10-09 CN CN202510552209.7A patent/CN120468320A/zh active Pending
- 2019-10-09 EP EP19872219.1A patent/EP3863642A4/en active Pending
- 2019-10-09 JP JP2021519602A patent/JP7631191B2/ja active Active
- 2019-10-09 CN CN201980079494.8A patent/CN113164495B/zh active Active
- 2019-10-09 WO PCT/US2019/055461 patent/WO2020076996A1/en not_active Ceased
- 2019-10-09 US US17/282,277 patent/US12161648B2/en active Active
-
2024
- 2024-10-02 US US18/904,492 patent/US20250120982A1/en active Pending
-
2025
- 2025-02-05 JP JP2025017433A patent/JP2025072508A/ja active Pending