JP2022514352A5 - - Google Patents
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- Publication number
- JP2022514352A5 JP2022514352A5 JP2021535552A JP2021535552A JP2022514352A5 JP 2022514352 A5 JP2022514352 A5 JP 2022514352A5 JP 2021535552 A JP2021535552 A JP 2021535552A JP 2021535552 A JP2021535552 A JP 2021535552A JP 2022514352 A5 JP2022514352 A5 JP 2022514352A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862784291P | 2018-12-21 | 2018-12-21 | |
| US62/784,291 | 2018-12-21 | ||
| US201962863853P | 2019-06-19 | 2019-06-19 | |
| US62/863,853 | 2019-06-19 | ||
| PCT/US2019/068189 WO2020132661A2 (en) | 2018-12-21 | 2019-12-21 | Inhibitors of fibroblast activation protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022514352A JP2022514352A (ja) | 2022-02-10 |
| JPWO2020132661A5 JPWO2020132661A5 (https=) | 2022-12-28 |
| JP2022514352A5 true JP2022514352A5 (https=) | 2022-12-28 |
Family
ID=71101996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021535552A Pending JP2022514352A (ja) | 2018-12-21 | 2019-12-21 | 線維芽細胞活性化タンパク質の阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11504364B2 (https=) |
| EP (1) | EP3898654A4 (https=) |
| JP (1) | JP2022514352A (https=) |
| CN (1) | CN113811529A (https=) |
| WO (1) | WO2020132661A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021506972A (ja) | 2017-12-15 | 2021-02-22 | プラクシス バイオテック エルエルシー | 線維芽細胞活性化タンパク質の阻害剤 |
| BR112021011861A2 (pt) * | 2019-01-04 | 2021-09-08 | Praxis Biotech LLC | Inibidores da proteína de ativação de fibroblastos |
| WO2021155292A1 (en) * | 2020-01-31 | 2021-08-05 | Philip Stewart Low | Fibroblast activation protein (fap) - targeted antifibrotic therapy |
| CA3176497A1 (en) | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| CN114380795A (zh) * | 2020-10-22 | 2022-04-22 | 四川大学华西医院 | 氘代fap抑制剂及其应用 |
| CN114621155A (zh) * | 2020-12-14 | 2022-06-14 | 四川科伦药物研究院有限公司 | 一种制备卡马替尼的方法 |
| CN116745291A (zh) * | 2020-12-17 | 2023-09-12 | 阿斯利康(瑞典)有限公司 | N-(2-(4-氰基噻唑烷-3-基)-2-氧代乙基)-喹啉-4-甲酰胺 |
| EP4122499A1 (en) * | 2021-07-23 | 2023-01-25 | 3B Pharmaceuticals GmbH | Fibroblast activation protein inhibitors and use thereof |
| EP4531932A1 (en) | 2022-06-03 | 2025-04-09 | Universiteit Antwerpen | Inhibitors of fibroblast activation protein |
| JP2025525344A (ja) * | 2022-06-21 | 2025-08-05 | アストラゼネカ・アクチエボラーグ | Ｎ－（２－（４－シアノチアゾリジン－３－イル）－２－オキソエチル）－キノリン－４－カルボキサミド |
| WO2023247488A1 (en) * | 2022-06-21 | 2023-12-28 | Astrazeneca Ab | N-(2-(3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)- quinoline-4-carboxamides |
| CA3260370A1 (en) * | 2022-06-21 | 2023-12-28 | Astrazeneca Ab | SOLID FORMS OF N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOEETHYL)-6-MORPHOLINOQUINOLEIN-4-CARBOXAMIDE |
| WO2025037000A1 (en) | 2023-08-17 | 2025-02-20 | Universiteit Antwerpen | Novel fibroblast activation protein inhibitors and medical uses thereof |
| CN121752300A (zh) | 2023-08-31 | 2026-03-27 | 荷兰拉德堡德大学学术医学中心 | 子宫内膜异位症示踪剂 |
| WO2025106939A1 (en) * | 2023-11-16 | 2025-05-22 | Praxis Biotech LLC | Conjugates targeting fibroblast activation protein and uses thereof |
| WO2025106926A1 (en) * | 2023-11-16 | 2025-05-22 | Praxis Biotech LLC | Conjugates targeting fibroblast activation protein and uses thereof |
| CN120400145A (zh) * | 2025-04-03 | 2025-08-01 | 江南大学 | 基因fap在制备非酒精性脂肪型肝炎的药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60221983T2 (de) | 2001-06-27 | 2008-05-15 | Smithkline Beecham Corp. | Fluorpyrrolidine als dipeptidyl-peptidase inhibitoren |
| WO2004071454A2 (en) * | 2003-02-13 | 2004-08-26 | Guilford Pharmaceuticals Inc. | Substituted azetidine compounds as inhibitors of dipeptidyl peptidase iv |
| EP1943257A2 (en) | 2005-05-19 | 2008-07-16 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| AU2006278039B2 (en) | 2005-08-11 | 2010-10-21 | F. Hoffmann-La Roche Ag | Pharmaceutical composition comprising a DPP-lV inhibitor |
| EP1760076A1 (en) | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
| CN101230058A (zh) | 2007-01-23 | 2008-07-30 | 上海恒瑞医药有限公司 | 双环氮杂烷类衍生物、其制备方法及其在医药上的用途 |
| US8338450B2 (en) | 2007-09-21 | 2012-12-25 | Lupin Limited | Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors |
| MX2010007593A (es) | 2008-01-10 | 2010-10-13 | Sun Pharma Advanced Res Co Ltd | Derivados novedosos de acil cianopirrolidinas. |
| WO2010083570A1 (en) | 2009-01-23 | 2010-07-29 | The University Of Sydney | Novel metabolic disease therapy |
| WO2013107820A1 (en) * | 2012-01-17 | 2013-07-25 | Universiteit Antwerpen | Novel fap inhibitors |
| EP2730571A1 (en) | 2012-11-12 | 2014-05-14 | Universitat De Barcelona | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives |
| CN116059219A (zh) | 2015-07-16 | 2023-05-05 | 比奥克斯塞尔医疗股份有限公司 | 一种使用免疫调节治疗癌症的新颖方法 |
| WO2017189569A1 (en) | 2016-04-25 | 2017-11-02 | Trustees Of Tufts College | Multimediator dpp4 and fap inhibitors, and uses related thereto |
| IL267093B (en) | 2016-12-14 | 2022-08-01 | Medimmune Llc | Embedded multiple-part sensor within a plunger rod to capture and transmit injection information |
| CN116474108A (zh) * | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| EA202090776A1 (ru) | 2017-10-23 | 2020-07-27 | Дзе Джонс Хопкинс Юниверсити | Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha) |
| JP2021506972A (ja) * | 2017-12-15 | 2021-02-22 | プラクシス バイオテック エルエルシー | 線維芽細胞活性化タンパク質の阻害剤 |
| SG11202007180QA (en) | 2018-02-06 | 2020-08-28 | Univ Heidelberg | Fap inhibitor |
| BR112021011861A2 (pt) | 2019-01-04 | 2021-09-08 | Praxis Biotech LLC | Inibidores da proteína de ativação de fibroblastos |
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2019
- 2019-12-21 CN CN201980092135.6A patent/CN113811529A/zh active Pending
- 2019-12-21 EP EP19901288.1A patent/EP3898654A4/en not_active Withdrawn
- 2019-12-21 WO PCT/US2019/068189 patent/WO2020132661A2/en not_active Ceased
- 2019-12-21 US US16/724,198 patent/US11504364B2/en active Active
- 2019-12-21 JP JP2021535552A patent/JP2022514352A/ja active Pending
-
2022
- 2022-09-14 US US17/944,963 patent/US20230144841A1/en not_active Abandoned