JP2022512935A5 - - Google Patents
Info
- Publication number
- JP2022512935A5 JP2022512935A5 JP2021524303A JP2021524303A JP2022512935A5 JP 2022512935 A5 JP2022512935 A5 JP 2022512935A5 JP 2021524303 A JP2021524303 A JP 2021524303A JP 2021524303 A JP2021524303 A JP 2021524303A JP 2022512935 A5 JP2022512935 A5 JP 2022512935A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- forming
- reacted
- steps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024018294A JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862758814P | 2018-11-12 | 2018-11-12 | |
| US62/758,814 | 2018-11-12 | ||
| PCT/US2019/060677 WO2020102051A1 (en) | 2018-11-12 | 2019-11-11 | Methods of preparing cytotoxic benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024018294A Division JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512935A JP2022512935A (ja) | 2022-02-07 |
| JP2022512935A5 true JP2022512935A5 (cg-RX-API-DMAC10.html) | 2022-11-17 |
| JP7437395B2 JP7437395B2 (ja) | 2024-02-22 |
Family
ID=68835289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524303A Active JP7437395B2 (ja) | 2018-11-12 | 2019-11-11 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
| JP2024018294A Withdrawn JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024018294A Withdrawn JP2024056819A (ja) | 2018-11-12 | 2024-02-09 | 細胞傷害性ベンゾジアゼピン誘導体の調製方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10851117B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3880681B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP7437395B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20210098470A (cg-RX-API-DMAC10.html) |
| CN (2) | CN112996792B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2019379104A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA3119358A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL283045A (cg-RX-API-DMAC10.html) |
| MA (1) | MA54228A (cg-RX-API-DMAC10.html) |
| SG (1) | SG11202104360YA (cg-RX-API-DMAC10.html) |
| TW (1) | TW202033530A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2020102051A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3612533A1 (en) * | 2017-04-20 | 2020-02-26 | Immunogen, Inc. | Methods of preparing indolinobenzodiazepine derivatives |
| CN112996792B (zh) | 2018-11-12 | 2024-04-26 | 伊缪诺金公司 | 制备细胞毒性苯并二氮杂卓衍生物的方法 |
| AU2023298568A1 (en) | 2022-06-30 | 2025-01-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902707A (en) * | 1985-04-30 | 1990-02-20 | Eli Lilly And Company | Bicyclic pyrazolidinones, compositions and use |
| US5015738A (en) * | 1989-08-07 | 1991-05-14 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(b)pyrrolobenzodiazepines |
| CN102050824A (zh) * | 2009-11-04 | 2011-05-11 | 上海阳帆医药科技有限公司 | 哌嗪并三唑衍生物 |
| SI2675480T1 (sl) | 2011-02-15 | 2019-05-31 | Immunogen, Inc. | Metode priprave konjugatov |
| RU2539658C1 (ru) | 2013-12-10 | 2015-01-20 | Федеральное государственное казенное учреждение "33 Центральный научно-исследовательский испытательный институт Министерства обороны Российской Федерации" | Способ получения бензилхлорида |
| SI3313845T1 (sl) * | 2015-06-29 | 2021-01-29 | Immunogen, Inc. | Konjugati spremenjenih protiteles cisteina |
| SMT202100092T1 (it) * | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| EP3778602B1 (en) * | 2015-07-21 | 2023-07-12 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| RS65120B1 (sr) * | 2015-11-25 | 2024-02-29 | Immunogen Inc | Farmaceutske formulacije i postupci za njihovu upotrebu |
| HRP20230002T1 (hr) | 2017-01-25 | 2023-02-17 | Immunogen, Inc. | Postupci pripreme citotoksičnih derivata benzodiazepina |
| WO2019133652A1 (en) * | 2017-12-28 | 2019-07-04 | Immunogen, Inc. | Benzodiazepine derivatives |
| CN112996792B (zh) | 2018-11-12 | 2024-04-26 | 伊缪诺金公司 | 制备细胞毒性苯并二氮杂卓衍生物的方法 |
-
2019
- 2019-11-11 CN CN201980074241.1A patent/CN112996792B/zh not_active Expired - Fee Related
- 2019-11-11 EP EP19817455.9A patent/EP3880681B1/en active Active
- 2019-11-11 AU AU2019379104A patent/AU2019379104A1/en not_active Abandoned
- 2019-11-11 SG SG11202104360YA patent/SG11202104360YA/en unknown
- 2019-11-11 MA MA054228A patent/MA54228A/fr unknown
- 2019-11-11 JP JP2021524303A patent/JP7437395B2/ja active Active
- 2019-11-11 WO PCT/US2019/060677 patent/WO2020102051A1/en not_active Ceased
- 2019-11-11 KR KR1020217017972A patent/KR20210098470A/ko not_active Withdrawn
- 2019-11-11 EP EP24163044.1A patent/EP4361128A3/en not_active Withdrawn
- 2019-11-11 US US16/679,563 patent/US10851117B2/en active Active
- 2019-11-11 TW TW108140769A patent/TW202033530A/zh unknown
- 2019-11-11 CA CA3119358A patent/CA3119358A1/en active Pending
- 2019-11-11 CN CN202410421643.7A patent/CN118324848A/zh active Pending
-
2020
- 2020-10-01 US US17/060,611 patent/US11396519B2/en active Active
-
2021
- 2021-05-09 IL IL283045A patent/IL283045A/en unknown
-
2022
- 2022-06-15 US US17/841,046 patent/US11981688B2/en active Active
-
2024
- 2024-02-09 JP JP2024018294A patent/JP2024056819A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018526340A5 (cg-RX-API-DMAC10.html) | ||
| CN103772624B (zh) | 一种早强型聚羧酸盐混凝土减水剂及其制备方法 | |
| JP2021063097A5 (cg-RX-API-DMAC10.html) | ||
| CN110563660B (zh) | 一种减少1,2,4-三氮唑烷基化反应过程中1,3,4-三氮唑取代物的方法 | |
| JP2018522018A5 (cg-RX-API-DMAC10.html) | ||
| CN1069637C (zh) | 吡唑及其衍生物的制备方法 | |
| JP2018528182A5 (cg-RX-API-DMAC10.html) | ||
| JP2018524387A5 (cg-RX-API-DMAC10.html) | ||
| CN104031216A (zh) | 一种聚醚-酰胺型聚羧酸高效减水剂及其制备方法 | |
| CN114315655A (zh) | 一种吸电子基团的不饱和烷烃的磺化方法 | |
| JPWO2014034681A1 (ja) | ポリオキシエチレンアルキルエーテル硫酸塩の製造方法 | |
| CN100374192C (zh) | 一种双醚双苯磺酸盐双子表面活性剂及其制备方法 | |
| CN108191288A (zh) | 一种高保坍型聚羧酸高性能减水剂及其制备方法 | |
| CN114196005A (zh) | N,n-二取代基氨基磺酸化合物的制备方法及其应用 | |
| TWI357898B (en) | Process for the preparation of pyrazoles | |
| JPH10330401A (ja) | 新規多糖誘導体及びその製造方法 | |
| CN107892699B (zh) | 一种吡啶-4-硼酸的合成工艺 | |
| RU2021114996A (ru) | Способы получения цитотоксических производных бензодиазепина | |
| CN103435530B (zh) | 一种高光学纯度的d-色氨酸低级醇酯盐酸盐的制备方法 | |
| CN105348853B (zh) | 一种橙色活性染料化合物及其制备方法和应用 | |
| CN109503552A (zh) | 一种合成阿西替尼的方法 | |
| CN108558710A (zh) | 一种n，n-二丁基间氨基苯酚的制备方法 | |
| CN115536677A (zh) | 零维四核金属卤化物团簇材料、团簇发光材料及其制备方法与应用 | |
| CN106748835A (zh) | 一种盐酸肾上腺酮的制备方法 | |
| CN101983958B (zh) | 一种2-重氮乙酰乙酸对硝基苄酯的制备方法 |