JP2022502460A - フィセチンの含量が増加したウルシ抽出物の製造方法及びこれを含む転移抑制用抗癌剤組成物 - Google Patents
フィセチンの含量が増加したウルシ抽出物の製造方法及びこれを含む転移抑制用抗癌剤組成物 Download PDFInfo
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- extract
- sumac
- fisetin
- cancer
- sumac extract
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Abstract
Description
韓国産ウルシをキョンドン市場(ソウルにある韓国最大の漢方薬材市場)で10Kg購入して、充分に乾燥させた後、これに水90Lを加え、95℃で6時間抽出し、濾過した後、真空濃縮し、粉末化することにより、ウルシ抽出粉末580gを得た(これを試料1という)。
既存の技術との差を比較するために、前記実施例1におけるようにウルシ1Kgについて充分に乾燥した後、これに水10Lを加え、95℃で6時間抽出した。そして、濾過した後に真空濃縮して、固形分の濃度が10.5Bxになったときの濃縮液610mlを得た。次いで、ガラスフラスコにて酸素をバブリングすることで90℃にて3時間処理した。そして、これを粉末化して最終的に粉末57gを得た(これを比較例1という)。
触媒を添加する段階による転換率の差を比較するために、前記実施例1と同様に10Kgのウルシから抽出液を製造した。そして、抽出液のうちの1Lを濾過し、濃縮して固形分含量11.2%(w/v)になるようにし、これに活性炭に担持したクロム触媒(前記実施例1の試料3と同一)を固形分に対して1%(w/w)加えた。ついで、同様に反応させた後、これに酒精を250ml加えて溶解した。そして、濾過した後、粉末化して最終的にフィセチンの増加したウルシ抽出物57.3gを得た。これを高速液体クロマトグラフィーで分析した結果、フィセチンの含量は9.9%(w/w)であり、フィセチンへの転換率は68%であった。
前記得られた試料を対象としてフィセチンの増加による抗癌活性を比較した。一般に、癌の転移を抑制する効能を確認する方法として、癒着(Adhesion)、侵入(Invasion)、転移(Migration)を比較する方法が、主に用いられている。本発明では、試料1と試料4を対象として転移癌抑制効果を比較しようとした。胃癌由来の細胞であるAGS細胞を対象とした、転移抑制の比較結果を図3に示した。本発明の試料4は、無処理群の試料1と比較すると、フィセチンの含量が増加したウルシ抽出物によって、胃癌来由の細胞であるAGS細胞の転移を著しく抑制させた、向上した結果を示した。よって、本発明の製造方法によって製造されたウルシ抽出物は、癌の転移を抑制する効能を示すことを立証することができた。
Claims (8)
- 白金、クロム、ニッケル、珪素、銅及びこれら金属の酸化物からなる群から選択される1種以上の触媒を、ウルシ抽出液又はウルシ抽出濃縮液に添加して反応させることにより、前記ウルシに含有されたフスチンをフィセチンに転換させる、フィセチンの含量が増加したウルシ抽出物の製造方法。
- 前記金属又は金属の酸化物である触媒は、それ自体で、又は担体に含浸させて、前記ウルシ抽出液又はウルシ抽出濃縮液に添加する、請求項1に記載のフィセチンの含量が増加したウルシ抽出物の製造方法。
- 前記触媒は、ウルシ抽出液の抽出工程の際、抽出工程の完了の後、及び前記抽出液の濃縮の後からなる群から選択される段階にて添加する、請求項1に記載のフィセチンの含量が増加したウルシ抽出物の製造方法。
- 前記ウルシ抽出液又はウルシ抽出濃縮液に対する、前記触媒による触媒反応中に、不活性気体をバブリングする工程を含む、請求項1に記載のフィセチンの含量が増加したウルシ抽出物の製造方法。
- 請求項1〜4のいずれか一項に記載の製造方法によって製造された、フィセチンの含量が増加したウルシ抽出物。
- 請求項5に記載のウルシ抽出物を主成分とする、癌予防又は改善用健康機能性食品用組成物。
- 請求項5に記載のウルシ抽出物を主成分とする、癌の転移を抑制する抗癌用薬学的組成物。
- 前記転移が抑制された癌は、胃癌、肝臓癌、大腸癌、肺癌、乳房癌、直腸癌、血液癌及び膵臓癌からなる群から選択される癌種である、請求項7に記載の抗癌用薬学的組成物。
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JP2013535500A (ja) * | 2010-08-11 | 2013-09-12 | アジ カンパニー リミテッド | 活性型フラボノイド化合物の含量が増加されたウルシ抽出物及びその製造方法 |
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Patent Citations (2)
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JPH1149693A (ja) * | 1997-08-01 | 1999-02-23 | Forest Genetics Res Inst | ウルシ抽出物を含む抗癌剤組成物 |
JP2013535500A (ja) * | 2010-08-11 | 2013-09-12 | アジ カンパニー リミテッド | 活性型フラボノイド化合物の含量が増加されたウルシ抽出物及びその製造方法 |
Non-Patent Citations (1)
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JOURNAL OF MEDICAL FOOD, vol. 19(2), JPN6022014969, 2016, pages 120 - 126, ISSN: 0005104792 * |
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JP7331094B2 (ja) | 2023-08-22 |
US20210038667A1 (en) | 2021-02-11 |
CN112888449A (zh) | 2021-06-01 |
US11376295B2 (en) | 2022-07-05 |
WO2020075887A1 (ko) | 2020-04-16 |
CN112888449B (zh) | 2023-04-07 |
KR102098042B1 (ko) | 2020-04-08 |
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