JP2022502413A - アルコキシメチレン−ベンゾイルアセトニトリルの調製のための合成方法 - Google Patents

アルコキシメチレン−ベンゾイルアセトニトリルの調製のための合成方法 Download PDF

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JP2022502413A
JP2022502413A JP2021516981A JP2021516981A JP2022502413A JP 2022502413 A JP2022502413 A JP 2022502413A JP 2021516981 A JP2021516981 A JP 2021516981A JP 2021516981 A JP2021516981 A JP 2021516981A JP 2022502413 A JP2022502413 A JP 2022502413A
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compound
orthoformate
formula
reaction mass
reaction
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Japanese (ja)
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JP2022502413A5 (enExample
Inventor
マイゼンバハ，マーク
マーティン，ベンジャミン
ヨハネス ロンド，ニエック
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メレオ バイオファーマ １ リミテッド
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Publication of JP2022502413A5 publication Critical patent/JP2022502413A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/009—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping in combination with chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021516981A 2018-09-26 2019-09-26 アルコキシメチレン−ベンゾイルアセトニトリルの調製のための合成方法 Ceased JP2022502413A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1815699.2 2018-09-26
GBGB1815699.2A GB201815699D0 (en) 2018-09-26 2018-09-26 Synthetic method
PCT/GB2019/052720 WO2020065325A1 (en) 2018-09-26 2019-09-26 Synthetic methodfor the preparation of an alkoxymethylene-benzoylacetonitrile

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JP2022502413A true JP2022502413A (ja) 2022-01-11
JP2022502413A5 JP2022502413A5 (enExample) 2022-09-02

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JP2021516981A Ceased JP2022502413A (ja) 2018-09-26 2019-09-26 アルコキシメチレン−ベンゾイルアセトニトリルの調製のための合成方法

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US (1) US20220033352A1 (enExample)
EP (1) EP3856712B1 (enExample)
JP (1) JP2022502413A (enExample)
KR (1) KR20210065110A (enExample)
CN (1) CN112805269A (enExample)
AU (1) AU2019348974A1 (enExample)
CA (1) CA3113000A1 (enExample)
DK (1) DK3856712T3 (enExample)
ES (1) ES2933687T3 (enExample)
GB (1) GB201815699D0 (enExample)
IL (1) IL281635A (enExample)
WO (1) WO2020065325A1 (enExample)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658838A (en) * 1968-11-16 1972-04-25 Bayer Ag Process for the preparation of 1 5-disubstituted-4-cyano-pyrazoles
JPS62174055A (ja) * 1985-10-01 1987-07-30 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
JP2002513784A (ja) * 1998-05-05 2002-05-14 エフ．ホフマン−ラ ロシュ アーゲー Ｐ−３８ｍａｐキナーゼインヒビターとしてのピラゾール誘導体
JP2007521278A (ja) * 2003-06-26 2007-08-02 ノバルティス アクチエンゲゼルシャフト ５員ヘテロ環を基礎とするｐ３８キナーゼ阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658838A (en) * 1968-11-16 1972-04-25 Bayer Ag Process for the preparation of 1 5-disubstituted-4-cyano-pyrazoles
JPS62174055A (ja) * 1985-10-01 1987-07-30 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
JP2002513784A (ja) * 1998-05-05 2002-05-14 エフ．ホフマン−ラ ロシュ アーゲー Ｐ−３８ｍａｐキナーゼインヒビターとしてのピラゾール誘導体
JP2007521278A (ja) * 2003-06-26 2007-08-02 ノバルティス アクチエンゲゼルシャフト ５員ヘテロ環を基礎とするｐ３８キナーゼ阻害剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHU G., ET AL: "New Synthesis of 7-(3-chloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile, a Key Intermediate", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 54, no. 4, JPN5022001201, 2017, pages 2237 - 2241, ISSN: 0004898985 *

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Publication number Publication date
WO2020065325A1 (en) 2020-04-02
KR20210065110A (ko) 2021-06-03
EP3856712B1 (en) 2022-10-26
ES2933687T3 (es) 2023-02-13
AU2019348974A1 (en) 2021-04-22
GB201815699D0 (en) 2018-11-07
CN112805269A (zh) 2021-05-14
DK3856712T3 (da) 2022-12-12
EP3856712A1 (en) 2021-08-04
IL281635A (en) 2021-05-31
US20220033352A1 (en) 2022-02-03
CA3113000A1 (en) 2020-04-02

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