IL281635A - A synthetic method for the preparation of Alkoxymethylene-Benzoyllactonitrile - Google Patents

A synthetic method for the preparation of Alkoxymethylene-Benzoyllactonitrile

Info

Publication number
IL281635A
IL281635A IL281635A IL28163521A IL281635A IL 281635 A IL281635 A IL 281635A IL 281635 A IL281635 A IL 281635A IL 28163521 A IL28163521 A IL 28163521A IL 281635 A IL281635 A IL 281635A
Authority
IL
Israel
Prior art keywords
benzoylacetonitrile
alkoxymethylene
preparation
synthetic method
synthetic
Prior art date
Application number
IL281635A
Other languages
English (en)
Hebrew (he)
Original Assignee
Mereo Biopharma 1 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 1 Ltd filed Critical Mereo Biopharma 1 Ltd
Publication of IL281635A publication Critical patent/IL281635A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/009—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping in combination with chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL281635A 2018-09-26 2021-03-18 A synthetic method for the preparation of Alkoxymethylene-Benzoyllactonitrile IL281635A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1815699.2A GB201815699D0 (en) 2018-09-26 2018-09-26 Synthetic method
PCT/GB2019/052720 WO2020065325A1 (en) 2018-09-26 2019-09-26 Synthetic methodfor the preparation of an alkoxymethylene-benzoylacetonitrile

Publications (1)

Publication Number Publication Date
IL281635A true IL281635A (en) 2021-05-31

Family

ID=64024259

Family Applications (1)

Application Number Title Priority Date Filing Date
IL281635A IL281635A (en) 2018-09-26 2021-03-18 A synthetic method for the preparation of Alkoxymethylene-Benzoyllactonitrile

Country Status (12)

Country Link
US (1) US20220033352A1 (enExample)
EP (1) EP3856712B1 (enExample)
JP (1) JP2022502413A (enExample)
KR (1) KR20210065110A (enExample)
CN (1) CN112805269A (enExample)
AU (1) AU2019348974A1 (enExample)
CA (1) CA3113000A1 (enExample)
DK (1) DK3856712T3 (enExample)
ES (1) ES2933687T3 (enExample)
GB (1) GB201815699D0 (enExample)
IL (1) IL281635A (enExample)
WO (1) WO2020065325A1 (enExample)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1809386A1 (de) * 1968-11-16 1970-06-11 Bayer Ag Verfahren zur Herstellung von 1,5-disubstituierten 4-Cyanopyrazolen
JPS62174055A (ja) * 1985-10-01 1987-07-30 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
PL344004A1 (en) * 1998-05-05 2001-09-10 Hoffmann La Roche Pyrazole derivatives as p-38 map kinase inhibitors
CN1832928B (zh) * 2003-06-26 2012-07-04 诺瓦提斯公司 以5元杂环为基础的p38激酶抑制剂

Also Published As

Publication number Publication date
WO2020065325A1 (en) 2020-04-02
KR20210065110A (ko) 2021-06-03
EP3856712B1 (en) 2022-10-26
ES2933687T3 (es) 2023-02-13
AU2019348974A1 (en) 2021-04-22
GB201815699D0 (en) 2018-11-07
CN112805269A (zh) 2021-05-14
DK3856712T3 (da) 2022-12-12
JP2022502413A (ja) 2022-01-11
EP3856712A1 (en) 2021-08-04
US20220033352A1 (en) 2022-02-03
CA3113000A1 (en) 2020-04-02

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