|
US3674836A
(en)
|
1968-05-21 |
1972-07-04 |
Parke Davis & Co |
2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
|
|
US4027009A
(en)
|
1973-06-11 |
1977-05-31 |
Merck & Co., Inc. |
Compositions and methods for depressing blood serum cholesterol
|
|
JPS5612114B2
(https=)
|
1974-06-07 |
1981-03-18 |
|
|
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
MX7065E
(es)
|
1980-06-06 |
1987-04-10 |
Sankyo Co |
Un procedimiento microbiologico para preparar derivados de ml-236b
|
|
US4450171A
(en)
|
1980-08-05 |
1984-05-22 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
|
US4448784A
(en)
|
1982-04-12 |
1984-05-15 |
Hoechst-Roussel Pharmaceuticals, Inc. |
1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
|
|
US5354772A
(en)
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
|
US4499289A
(en)
|
1982-12-03 |
1985-02-12 |
G. D. Searle & Co. |
Octahydronapthalenes
|
|
CA1327360C
(en)
|
1983-11-14 |
1994-03-01 |
William F. Hoffman |
Oxo-analogs of mevinolin-like antihypercholesterolemic agents
|
|
US4613610A
(en)
|
1984-06-22 |
1986-09-23 |
Sandoz Pharmaceuticals Corp. |
Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
|
|
US4686237A
(en)
|
1984-07-24 |
1987-08-11 |
Sandoz Pharmaceuticals Corp. |
Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
|
|
US4647576A
(en)
|
1984-09-24 |
1987-03-03 |
Warner-Lambert Company |
Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
|
|
EP0216785B1
(en)
|
1984-12-04 |
1991-01-30 |
Sandoz Ag |
Indene analogs of mevalonolactone and derivatives thereof
|
|
US4668794A
(en)
|
1985-05-22 |
1987-05-26 |
Sandoz Pharm. Corp. |
Intermediate imidazole acrolein analogs
|
|
HUT48208A
(en)
|
1985-10-25 |
1989-05-29 |
Sandoz Ag |
Process for producing heterocyclic analogues of mevalolactone derivatives and pharmaceutical compositions comprising such compounds
|
|
FR2596393B1
(fr)
|
1986-04-01 |
1988-06-03 |
Sanofi Sa |
Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
|
|
US5614492A
(en)
|
1986-05-05 |
1997-03-25 |
The General Hospital Corporation |
Insulinotropic hormone GLP-1 (7-36) and uses thereof
|
|
US4681893A
(en)
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
|
FI89493C
(fi)
|
1987-05-22 |
1993-10-11 |
Squibb & Sons Inc |
Foerfarande foer framstaellning av terapeutiskt aktiva, fosforhaltiga inhibitorer av hmg-coa-reduktas och vid foerfarandet anvaendbar ny mellanprodukt
|
|
US4759923A
(en)
|
1987-06-25 |
1988-07-26 |
Hercules Incorporated |
Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
|
|
JP2569746B2
(ja)
|
1987-08-20 |
1997-01-08 |
日産化学工業株式会社 |
キノリン系メバロノラクトン類
|
|
US4871721A
(en)
|
1988-01-11 |
1989-10-03 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors
|
|
US4924024A
(en)
|
1988-01-11 |
1990-05-08 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
|
|
NO177005C
(no)
|
1988-01-20 |
1995-07-05 |
Bayer Ag |
Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
|
|
US5506219A
(en)
|
1988-08-29 |
1996-04-09 |
E. R. Squibb & Sons, Inc. |
Pyridine anchors for HMG-CoA reductase inhibitors
|
|
US5753675A
(en)
|
1989-03-03 |
1998-05-19 |
Novartis Pharmaceuticals Corporation |
Quinoline analogs of mevalonolactone and derivatives thereof
|
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
US5177080A
(en)
|
1990-12-14 |
1993-01-05 |
Bayer Aktiengesellschaft |
Substituted pyridyl-dihydroxy-heptenoic acid and its salts
|
|
JP2648897B2
(ja)
|
1991-07-01 |
1997-09-03 |
塩野義製薬株式会社 |
ピリミジン誘導体
|
|
US5595872A
(en)
|
1992-03-06 |
1997-01-21 |
Bristol-Myers Squibb Company |
Nucleic acids encoding microsomal trigyceride transfer protein
|
|
US5470845A
(en)
|
1992-10-28 |
1995-11-28 |
Bristol-Myers Squibb Company |
Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia
|
|
US5594016A
(en)
|
1992-12-28 |
1997-01-14 |
Mitsubishi Chemical Corporation |
Naphthalene derivatives
|
|
ES2133158T3
(es)
|
1993-01-19 |
1999-09-01 |
Warner Lambert Co |
Formulacion ci-981 oral, estable y proceso de preparacion del mismo.
|
|
US5739135A
(en)
|
1993-09-03 |
1998-04-14 |
Bristol-Myers Squibb Company |
Inhibitors of microsomal triglyceride transfer protein and method
|
|
US5776983A
(en)
|
1993-12-21 |
1998-07-07 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
|
US5488064A
(en)
|
1994-05-02 |
1996-01-30 |
Bristol-Myers Squibb Company |
Benzo 1,3 dioxole derivatives
|
|
US5385929A
(en)
|
1994-05-04 |
1995-01-31 |
Warner-Lambert Company |
[(Hydroxyphenylamino) carbonyl] pyrroles
|
|
US5612359A
(en)
|
1994-08-26 |
1997-03-18 |
Bristol-Myers Squibb Company |
Substituted biphenyl isoxazole sulfonamides
|
|
US5491134A
(en)
|
1994-09-16 |
1996-02-13 |
Bristol-Myers Squibb Company |
Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
|
|
US5541204A
(en)
|
1994-12-02 |
1996-07-30 |
Bristol-Myers Squibb Company |
Aryloxypropanolamine β 3 adrenergic agonists
|
|
US5620997A
(en)
|
1995-05-31 |
1997-04-15 |
Warner-Lambert Company |
Isothiazolones
|
|
WO1997012613A1
(en)
|
1995-10-05 |
1997-04-10 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
AU717743B2
(en)
|
1995-12-13 |
2000-03-30 |
Regents Of The University Of California, The |
Nuclear receptor ligands and ligand binding domains
|
|
US5770615A
(en)
|
1996-04-04 |
1998-06-23 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
|
US5962440A
(en)
|
1996-05-09 |
1999-10-05 |
Bristol-Myers Squibb Company |
Cyclic phosphonate ester inhibitors of microsomal triglyceride transfer protein and method
|
|
US5827875A
(en)
|
1996-05-10 |
1998-10-27 |
Bristol-Myers Squibb Company |
Inhibitors of microsomal triglyceride transfer protein and method
|
|
US5885983A
(en)
|
1996-05-10 |
1999-03-23 |
Bristol-Myers Squibb Company |
Inhibitors of microsomal triglyceride transfer protein and method
|
|
US5760246A
(en)
|
1996-12-17 |
1998-06-02 |
Biller; Scott A. |
Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
|
|
TW536540B
(en)
|
1997-01-30 |
2003-06-11 |
Bristol Myers Squibb Co |
Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
|
|
GB9713739D0
(en)
|
1997-06-27 |
1997-09-03 |
Karobio Ab |
Thyroid receptor ligands
|
|
AU766219B2
(en)
|
1998-02-02 |
2003-10-09 |
1149336 Ontario Inc. |
Method of regulating glucose metabolism, and reagents related thereto
|
|
AU3034299A
(en)
|
1998-03-09 |
1999-09-27 |
Fondatech Benelux N.V. |
Serine peptidase modulators
|
|
DE19823831A1
(de)
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
|
DE19828114A1
(de)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
|
|
WO2000001389A1
(en)
|
1998-07-06 |
2000-01-13 |
Bristol-Myers Squibb Co. |
Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
|
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
TWI302149B
(en)
|
1999-09-22 |
2008-10-21 |
Bristol Myers Squibb Co |
Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
|
|
US6395767B2
(en)
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
|
WO2002083066A2
(en)
*
|
2001-04-11 |
2002-10-24 |
Bristol-Myers Squibb Company |
Amino acid complexes of c-aryl glucosides for treatment of diabetes and method
|
|
CA2463908A1
(en)
|
2001-10-18 |
2003-04-24 |
Bristol-Myers Squibb Company |
Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
|
|
US7919598B2
(en)
*
|
2006-06-28 |
2011-04-05 |
Bristol-Myers Squibb Company |
Crystal structures of SGLT2 inhibitors and processes for preparing same
|
|
TWI472521B
(zh)
*
|
2008-07-17 |
2015-02-11 |
Lexicon Pharmaceuticals Inc |
（２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法
|
|
BR112012007364A2
(pt)
*
|
2009-10-23 |
2017-06-06 |
Astellas Pharma Inc |
composição farmacêutica para administração oral
|
|
TWI562775B
(en)
*
|
2010-03-02 |
2016-12-21 |
Lexicon Pharmaceuticals Inc |
Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
|
|
TWI542596B
(zh)
*
|
2011-05-09 |
2016-07-21 |
健生藥品公司 |
（２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
|
|
PL3489226T3
(pl)
*
|
2012-11-20 |
2021-08-02 |
Lexicon Pharmaceuticals, Inc. |
Inhibitory kotransportera glukozowo-sodowego 1
|