JP2010514758A5 - - Google Patents
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- Publication number
- JP2010514758A5 JP2010514758A5 JP2009543946A JP2009543946A JP2010514758A5 JP 2010514758 A5 JP2010514758 A5 JP 2010514758A5 JP 2009543946 A JP2009543946 A JP 2009543946A JP 2009543946 A JP2009543946 A JP 2009543946A JP 2010514758 A5 JP2010514758 A5 JP 2010514758A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- dihydroxy
- formula
- pyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*([n]1nnc(SS=*)c1)=C Chemical compound C*([n]1nnc(SS=*)c1)=C 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2006-0139200 | 2006-12-30 | ||
| KR1020060139200A KR100868959B1 (ko) | 2006-12-30 | 2006-12-30 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| PCT/KR2007/006889 WO2008082156A1 (en) | 2006-12-30 | 2007-12-27 | Alpha-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation method and pharmaceutical composition for the immune adjuvant containing the same as an active ingredient |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514758A JP2010514758A (ja) | 2010-05-06 |
| JP2010514758A5 true JP2010514758A5 (https=) | 2012-08-02 |
| JP5167273B2 JP5167273B2 (ja) | 2013-03-21 |
Family
ID=39588766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543946A Active JP5167273B2 (ja) | 2006-12-30 | 2007-12-27 | αガラクトシルセラミド誘導体、その薬学的に許容可能な塩、その製造方法及びそれを有効成分として含む免疫補助用薬学的組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8883746B2 (https=) |
| EP (1) | EP2102225A4 (https=) |
| JP (1) | JP5167273B2 (https=) |
| KR (1) | KR100868959B1 (https=) |
| CN (2) | CN101573369A (https=) |
| WO (1) | WO2008082156A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916164B2 (en) | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| US8207135B2 (en) | 2007-12-05 | 2012-06-26 | Wittycell | Compositions for and methods of enhancing the immune response to antigens |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| JP5809560B2 (ja) * | 2008-10-08 | 2015-11-11 | アビヴァックス | インフルエンザに対して使用するためのワクチン組成物 |
| KR20110045545A (ko) * | 2009-10-27 | 2011-05-04 | 서울대학교산학협력단 | 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물 |
| EP2532671B1 (en) | 2010-02-05 | 2014-09-17 | Riken | Novel synthetic glycolipid and use thereof |
| HK1197068A1 (en) * | 2011-01-05 | 2015-01-02 | 台湾大学 | Methods for preparation of glycosphingolipids and uses thereof |
| KR101307331B1 (ko) * | 2012-02-01 | 2013-09-10 | 서울대학교산학협력단 | 신규 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 면역보조용 약학적 조성물 |
| EP2811831B1 (en) * | 2012-02-07 | 2018-04-11 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| KR101969129B1 (ko) * | 2012-08-03 | 2019-04-15 | (주)스파크바이오파마 | 알파-갈락토실세라마이드 유사체, 이의 제조방법 및 이를 포함하는 면역조절 이상으로 인한 질환의 치료 또는 예방용 약학적 조성물 |
| US9464105B2 (en) | 2012-08-03 | 2016-10-11 | Riken | Hydroxylated KRN7000 analogue and use thereof |
| WO2014053482A1 (en) | 2012-10-03 | 2014-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists |
| CA2925878A1 (en) | 2012-10-12 | 2014-04-17 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| JP7026354B2 (ja) * | 2016-03-22 | 2022-02-28 | 学校法人慶應義塾 | 化合物又はその塩、ナチュラルキラーｔ細胞活性化剤、及び医薬組成物 |
| WO2017207040A1 (en) | 2016-06-01 | 2017-12-07 | Vib Vzw | ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR |
| EP4174074A1 (en) | 2021-10-29 | 2023-05-03 | Consejo Superior de Investigaciones Científicas (CSIC) | Multiantennary glycolipid mimetics |
| CN115286667B (zh) * | 2022-08-02 | 2024-03-26 | 华中农业大学 | 一种α-半乳糖基神经酰胺类似物及其制备方法和应用 |
| WO2025035125A1 (en) * | 2023-08-10 | 2025-02-13 | The Curators Of The University Of Missouri | Suppression of type 1 diabetes by intrathymic il-4 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61502124A (ja) * | 1984-05-09 | 1986-09-25 | ジ オ−ストラリアン ナシヨナル ユニヴア−シテイ− | 免疫応答の調節方法 |
| JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
| US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
| ATE286735T1 (de) | 1997-04-10 | 2005-01-15 | Kirin Brewery | Verwendung von a-glycosylceramiden zur herstellung eines therapeutischen mittelszur behandlung von autoimmunkrankheiten |
| DE60215530T2 (de) * | 2001-08-16 | 2007-05-31 | Daiichi Asubio Pharma Co., Ltd. | Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält |
| WO2003105769A2 (en) * | 2002-06-13 | 2003-12-24 | New York University | Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases |
| CA2577009C (en) * | 2004-08-27 | 2017-05-02 | Albert Einstein College Of Medicine, Inc. | Ceramide derivatives as modulators of immunity and autoimmunity |
-
2006
- 2006-12-30 KR KR1020060139200A patent/KR100868959B1/ko not_active Expired - Fee Related
-
2007
- 2007-12-27 CN CNA2007800486889A patent/CN101573369A/zh active Pending
- 2007-12-27 US US12/521,487 patent/US8883746B2/en active Active
- 2007-12-27 WO PCT/KR2007/006889 patent/WO2008082156A1/en not_active Ceased
- 2007-12-27 EP EP07851806A patent/EP2102225A4/en not_active Withdrawn
- 2007-12-27 CN CN201210275308.8A patent/CN102816189B/zh active Active
- 2007-12-27 JP JP2009543946A patent/JP5167273B2/ja active Active
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