MX2021003545A - Formas solidas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2 -metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5- trihidroxi-6-(metiltio)tetrahidro-2h-piran-2-il)bencil)fenil)buta namida y metodos para su sintesis. - Google Patents
Formas solidas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2 -metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5- trihidroxi-6-(metiltio)tetrahidro-2h-piran-2-il)bencil)fenil)buta namida y metodos para su sintesis.Info
- Publication number
- MX2021003545A MX2021003545A MX2021003545A MX2021003545A MX2021003545A MX 2021003545 A MX2021003545 A MX 2021003545A MX 2021003545 A MX2021003545 A MX 2021003545A MX 2021003545 A MX2021003545 A MX 2021003545A MX 2021003545 A MX2021003545 A MX 2021003545A
- Authority
- MX
- Mexico
- Prior art keywords
- ethyl
- methyl
- butanamide
- trihydroxy
- pyran
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- BNPZTRDIESRGTC-IXYVTWBDSA-N n-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](SC)O[C@H]1C1=CC=C(C)C(CC=2C=CC(CCCC(=O)NC(C)(C)C(=O)NCCN(C)C)=CC=2)=C1 BNPZTRDIESRGTC-IXYVTWBDSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862736871P | 2018-09-26 | 2018-09-26 | |
| PCT/US2019/052414 WO2020068661A1 (en) | 2018-09-26 | 2019-09-23 | Crystalline forms of n-(1 -((2-(dimethylamino)ethyl)amino)-2-m ethyl-1 -oopropan-2-yl)-4-(4-(2-methyl-5- (2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl) phenl)butanamide and methods of their synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021003545A true MX2021003545A (es) | 2021-05-27 |
Family
ID=68165724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021003545A MX2021003545A (es) | 2018-09-26 | 2019-09-23 | Formas solidas cristalinas de n-(1-((2-(dimetilamino)etil)amino)-2 -metil-1-oxopropan-2-il)-4-(4-(2-metil-5-((2s,3r,4r,5s,6r)-3,4,5- trihidroxi-6-(metiltio)tetrahidro-2h-piran-2-il)bencil)fenil)buta namida y metodos para su sintesis. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10968192B2 (https=) |
| EP (1) | EP3856714A1 (https=) |
| JP (1) | JP2022502393A (https=) |
| KR (1) | KR20210065974A (https=) |
| CN (1) | CN113039176A (https=) |
| AU (1) | AU2019346497A1 (https=) |
| BR (1) | BR112021004839A2 (https=) |
| CA (1) | CA3113037A1 (https=) |
| CO (1) | CO2021005141A2 (https=) |
| IL (1) | IL281728A (https=) |
| MX (1) | MX2021003545A (https=) |
| SG (1) | SG11202102498UA (https=) |
| WO (1) | WO2020068661A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021227439A1 (zh) * | 2020-05-15 | 2021-11-18 | 上海喆邺生物科技有限公司 | 一种芳基葡糖苷衍生物 |
| ES3040243T3 (en) * | 2020-05-15 | 2025-10-29 | Shanghai Zheye Biotechnology Co Ltd | Aryl glucoside derivative and use thereof in drug |
| CN117018204A (zh) | 2020-07-06 | 2023-11-10 | 诺未科技（北京）有限公司 | 一种治疗癌症的组合物及其应用和药物 |
| WO2025101731A1 (en) | 2023-11-10 | 2025-05-15 | Lexicon Pharmaceuticals, Inc. | Sglt1 inhibitors for use in the treatment of hepatic encephalopathy |
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| BR112012007364A2 (pt) * | 2009-10-23 | 2017-06-06 | Astellas Pharma Inc | composição farmacêutica para administração oral |
| TWI562775B (en) * | 2010-03-02 | 2016-12-21 | Lexicon Pharmaceuticals Inc | Methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
| TWI542596B (zh) * | 2011-05-09 | 2016-07-21 | 健生藥品公司 | （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體 |
| PL3489226T3 (pl) * | 2012-11-20 | 2021-08-02 | Lexicon Pharmaceuticals, Inc. | Inhibitory kotransportera glukozowo-sodowego 1 |
-
2019
- 2019-09-23 US US16/579,106 patent/US10968192B2/en active Active
- 2019-09-23 CA CA3113037A patent/CA3113037A1/en active Pending
- 2019-09-23 BR BR112021004839-1A patent/BR112021004839A2/pt not_active Application Discontinuation
- 2019-09-23 SG SG11202102498UA patent/SG11202102498UA/en unknown
- 2019-09-23 CN CN201980062714.6A patent/CN113039176A/zh active Pending
- 2019-09-23 WO PCT/US2019/052414 patent/WO2020068661A1/en not_active Ceased
- 2019-09-23 JP JP2021516806A patent/JP2022502393A/ja active Pending
- 2019-09-23 KR KR1020217011819A patent/KR20210065974A/ko not_active Ceased
- 2019-09-23 AU AU2019346497A patent/AU2019346497A1/en not_active Abandoned
- 2019-09-23 MX MX2021003545A patent/MX2021003545A/es unknown
- 2019-09-23 EP EP19783783.4A patent/EP3856714A1/en not_active Withdrawn
-
2021
- 2021-03-22 IL IL281728A patent/IL281728A/en unknown
- 2021-04-22 CO CONC2021/0005141A patent/CO2021005141A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022502393A (ja) | 2022-01-11 |
| IL281728A (en) | 2021-05-31 |
| CO2021005141A2 (es) | 2021-06-10 |
| KR20210065974A (ko) | 2021-06-04 |
| CN113039176A (zh) | 2021-06-25 |
| AU2019346497A1 (en) | 2021-04-08 |
| CA3113037A1 (en) | 2020-04-02 |
| US10968192B2 (en) | 2021-04-06 |
| BR112021004839A2 (pt) | 2021-06-08 |
| US20200255394A1 (en) | 2020-08-13 |
| WO2020068661A1 (en) | 2020-04-02 |
| SG11202102498UA (en) | 2021-04-29 |
| EP3856714A1 (en) | 2021-08-04 |
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