JP2022501338A5 - - Google Patents
Info
- Publication number
- JP2022501338A5 JP2022501338A5 JP2021514381A JP2021514381A JP2022501338A5 JP 2022501338 A5 JP2022501338 A5 JP 2022501338A5 JP 2021514381 A JP2021514381 A JP 2021514381A JP 2021514381 A JP2021514381 A JP 2021514381A JP 2022501338 A5 JP2022501338 A5 JP 2022501338A5
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- yloxy
- pyrimidine
- methylphenyl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024120830A JP2024164018A (ja) | 2018-09-18 | 2024-07-26 | 抗腫瘍剤としてのキナゾリン誘導体 |
| JP2025150799A JP2026009898A (ja) | 2018-09-18 | 2025-09-11 | 抗腫瘍剤としてのキナゾリン誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018106098 | 2018-09-18 | ||
| CNPCT/CN2018/106098 | 2018-09-18 | ||
| CN2019091078 | 2019-06-13 | ||
| CNPCT/CN2019/091078 | 2019-06-13 | ||
| PCT/CN2019/106233 WO2020057511A1 (en) | 2018-09-18 | 2019-09-17 | Quinazoline derivatives as antitumor agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024120830A Division JP2024164018A (ja) | 2018-09-18 | 2024-07-26 | 抗腫瘍剤としてのキナゾリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022501338A JP2022501338A (ja) | 2022-01-06 |
| JP2022501338A5 true JP2022501338A5 (https=) | 2022-09-28 |
| JP7546550B2 JP7546550B2 (ja) | 2024-09-06 |
Family
ID=69888359
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021514381A Active JP7546550B2 (ja) | 2018-09-18 | 2019-09-17 | 抗腫瘍剤としてのキナゾリン誘導体 |
| JP2024120830A Withdrawn JP2024164018A (ja) | 2018-09-18 | 2024-07-26 | 抗腫瘍剤としてのキナゾリン誘導体 |
| JP2025150799A Pending JP2026009898A (ja) | 2018-09-18 | 2025-09-11 | 抗腫瘍剤としてのキナゾリン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024120830A Withdrawn JP2024164018A (ja) | 2018-09-18 | 2024-07-26 | 抗腫瘍剤としてのキナゾリン誘導体 |
| JP2025150799A Pending JP2026009898A (ja) | 2018-09-18 | 2025-09-11 | 抗腫瘍剤としてのキナゾリン誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11723908B2 (https=) |
| EP (3) | EP4523755A3 (https=) |
| JP (3) | JP7546550B2 (https=) |
| KR (2) | KR102889933B1 (https=) |
| CN (2) | CN118255772A (https=) |
| AU (2) | AU2019341273B2 (https=) |
| CA (1) | CA3099776A1 (https=) |
| DK (2) | DK4360713T3 (https=) |
| ES (2) | ES3007082T3 (https=) |
| FI (2) | FI4360713T3 (https=) |
| HR (2) | HRP20241743T1 (https=) |
| HU (2) | HUE069764T2 (https=) |
| LT (2) | LT4360713T (https=) |
| PL (2) | PL3853220T3 (https=) |
| PT (2) | PT3853220T (https=) |
| RS (2) | RS66314B1 (https=) |
| SI (2) | SI3853220T1 (https=) |
| SM (1) | SMT202400524T1 (https=) |
| WO (1) | WO2020057511A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110357858B (zh) | 2018-04-09 | 2022-02-18 | 威尚（上海）生物医药有限公司 | 具有穿过血脑屏障能力的5取代二氟哌啶化合物 |
| WO2019196622A1 (zh) * | 2018-04-09 | 2019-10-17 | 威尚（上海）生物医药有限公司 | 具有穿过血脑屏障能力的5取代二氟哌啶化合物 |
| EP4523755A3 (en) * | 2018-09-18 | 2025-06-11 | F. Hoffmann-La Roche AG | Quinazoline derivatives as antitumor agents |
| CN111377850B (zh) * | 2018-12-31 | 2022-10-18 | 艾琪康医药科技（上海）有限公司 | 一种手性n-取代-3,3-二氟-4-羟基哌啶衍生物及其制备方法 |
| WO2021209039A1 (zh) * | 2020-04-17 | 2021-10-21 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、制备方法及其应用 |
| CN113527215B (zh) * | 2020-04-17 | 2023-12-05 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、制备方法及其应用 |
| TW202214641A (zh) | 2020-06-30 | 2022-04-16 | 美商艾瑞生藥股份有限公司 | Ｈｅｒ２突變抑制劑 |
| CN115109036B (zh) * | 2021-03-19 | 2024-06-11 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、组合物及其应用 |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| CN117940424A (zh) * | 2021-06-22 | 2024-04-26 | 缆图药品公司 | Egfr抑制剂 |
| CN117858872A (zh) * | 2021-06-22 | 2024-04-09 | 缆图药品公司 | 用于治疗癌症的杂环egfr抑制剂 |
| WO2022271613A1 (en) * | 2021-06-22 | 2022-12-29 | Blueprint Medicines Corporation | Heterocyclic egfr inhibitors for use in the treatment of cancer |
| US20240299387A1 (en) * | 2021-06-22 | 2024-09-12 | Blueprint Medicines Corporation | Heterocyclic egfr inhibitors for use in the treatment of cancer |
| CN121135654A (zh) * | 2021-09-30 | 2025-12-16 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、组合物及其应用 |
| CN115894455B (zh) * | 2021-09-30 | 2024-04-19 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、组合物及其应用 |
| IL312004A (en) * | 2021-10-20 | 2024-06-01 | Hoffmann La Roche | Crystalline forms of quinazoline derivatives, their preparation, assembly and use |
| WO2023138675A1 (zh) * | 2022-01-21 | 2023-07-27 | 默达药物（香港）有限公司 | 喹啉化合物及其用途 |
| CA3245866A1 (en) * | 2022-03-14 | 2023-09-21 | Huyabio International, Llc | BLOOD-BRAIN BARRIER CROSSING PROTEIN-PROTEIN INTERACTION INHIBITORS (MLL1-WDR5) AND THEIR USES |
| CN118715216A (zh) * | 2022-03-28 | 2024-09-27 | 江苏恒瑞医药股份有限公司 | 含氮杂环类化合物、其制备方法及其在医药上的应用 |
| CN115650977A (zh) * | 2022-10-09 | 2023-01-31 | 广东润兴生物科技有限公司 | 一种妥卡替尼的合成方法 |
| TW202446386A (zh) * | 2023-04-14 | 2024-12-01 | 大陸商迪哲（江蘇）醫藥股份有限公司 | 喹唑啉ＥｒｂＢ抑制劑的藥物形式 |
| WO2024249642A1 (en) * | 2023-06-02 | 2024-12-05 | Acerand Therapeutics (Hong Kong) Limited | Egfr inhibitors |
| CN121969632A (zh) * | 2023-09-27 | 2026-05-01 | 江苏恒瑞医药股份有限公司 | 一种喹唑啉衍生物的可药用盐、其结晶形式及用途 |
| WO2025195333A1 (en) | 2024-03-19 | 2025-09-25 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation of erbb2 inhibitors |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0171407B1 (en) | 1984-01-30 | 1993-11-18 | Imperial Cancer Research Technology Limited | Improvements relating to growth factors |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US6743782B1 (en) | 1987-10-28 | 2004-06-01 | Wellstat Therapeutics Corporation | Acyl deoxyribonucleoside derivatives and uses thereof |
| WO1991005264A1 (en) | 1989-09-29 | 1991-04-18 | Oncogenetics Partners | Detection and quantification of neu related proteins in the biological fluids of humans |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE69720965T2 (de) | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| EP1292591B1 (en) | 2000-06-22 | 2005-02-02 | Pfizer Products Inc. | Substituted bicyclic derivatives for the treatment of abnormal cell growth |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
| US20050043336A1 (en) | 2001-11-03 | 2005-02-24 | Hennequin Laurent Francois Andre | Quinazoline derivatives as antitumor agents |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| WO2004000529A1 (de) | 2002-06-24 | 2003-12-31 | Fagerdala Deutschland Gmbh | Verfahren zur herstellung von bauteilen aus hochgradig lignocellulosefaser-gefüllten thermoplasten |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| DK1660090T3 (da) | 2003-08-14 | 2012-12-17 | Array Biopharma Inc | Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer |
| ATE446294T1 (de) | 2005-11-15 | 2009-11-15 | Array Biopharma Inc | N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten |
| US20100004238A1 (en) | 2006-12-12 | 2010-01-07 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| WO2017148391A1 (zh) * | 2016-03-01 | 2017-09-08 | 上海医药集团股份有限公司 | 一种含氮杂环化合物、制备方法、中间体、组合物和应用 |
| EP3516071B1 (en) | 2016-09-22 | 2021-02-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of lung cancer |
| JP7333313B2 (ja) | 2017-09-01 | 2023-08-24 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | 窒素含有複素環化合物、製造方法、中間体、組成物および使用 |
| WO2019120213A1 (zh) | 2017-12-19 | 2019-06-27 | 南京明德新药研发股份有限公司 | 喹唑啉衍生物及其应用 |
| WO2019214651A1 (zh) | 2018-05-08 | 2019-11-14 | 南京明德新药研发有限公司 | 作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用 |
| TWI858848B (zh) * | 2018-05-08 | 2024-10-11 | 大陸商迪哲（江蘇）醫藥股份有限公司 | ＥｒｂＢ受體抑制劑 |
| EP4523755A3 (en) * | 2018-09-18 | 2025-06-11 | F. Hoffmann-La Roche AG | Quinazoline derivatives as antitumor agents |
-
2019
- 2019-09-17 EP EP24208940.7A patent/EP4523755A3/en active Pending
- 2019-09-17 LT LTEP23219357.3T patent/LT4360713T/lt unknown
- 2019-09-17 SI SI201930718T patent/SI3853220T1/sl unknown
- 2019-09-17 HR HRP20241743TT patent/HRP20241743T1/hr unknown
- 2019-09-17 PT PT198621468T patent/PT3853220T/pt unknown
- 2019-09-17 KR KR1020217003251A patent/KR102889933B1/ko active Active
- 2019-09-17 CA CA3099776A patent/CA3099776A1/en active Pending
- 2019-09-17 KR KR1020257038595A patent/KR20250171398A/ko active Pending
- 2019-09-17 PL PL19862146.8T patent/PL3853220T3/pl unknown
- 2019-09-17 EP EP19862146.8A patent/EP3853220B1/en active Active
- 2019-09-17 AU AU2019341273A patent/AU2019341273B2/en active Active
- 2019-09-17 PT PT232193573T patent/PT4360713T/pt unknown
- 2019-09-17 SI SI201930872T patent/SI4360713T1/sl unknown
- 2019-09-17 US US17/051,176 patent/US11723908B2/en active Active
- 2019-09-17 ES ES23219357T patent/ES3007082T3/es active Active
- 2019-09-17 FI FIEP23219357.3T patent/FI4360713T3/fi active
- 2019-09-17 RS RS20241396A patent/RS66314B1/sr unknown
- 2019-09-17 SM SM20240524T patent/SMT202400524T1/it unknown
- 2019-09-17 HU HUE23219357A patent/HUE069764T2/hu unknown
- 2019-09-17 ES ES19862146T patent/ES2971927T3/es active Active
- 2019-09-17 PL PL23219357.3T patent/PL4360713T3/pl unknown
- 2019-09-17 HR HRP20240293TT patent/HRP20240293T1/hr unknown
- 2019-09-17 JP JP2021514381A patent/JP7546550B2/ja active Active
- 2019-09-17 LT LTEPPCT/CN2019/106233T patent/LT3853220T/lt unknown
- 2019-09-17 EP EP23219357.3A patent/EP4360713B1/en active Active
- 2019-09-17 CN CN202410230537.0A patent/CN118255772A/zh active Pending
- 2019-09-17 DK DK23219357.3T patent/DK4360713T3/da active
- 2019-09-17 CN CN201980044137.8A patent/CN112654612A/zh active Pending
- 2019-09-17 DK DK19862146.8T patent/DK3853220T3/da active
- 2019-09-17 RS RS20240267A patent/RS65413B1/sr unknown
- 2019-09-17 HU HUE19862146A patent/HUE065578T2/hu unknown
- 2019-09-17 FI FIEP19862146.8T patent/FI3853220T3/fi active
- 2019-09-17 WO PCT/CN2019/106233 patent/WO2020057511A1/en not_active Ceased
-
2023
- 2023-05-18 US US18/319,509 patent/US20230293533A1/en active Pending
-
2024
- 2024-07-15 AU AU2024204847A patent/AU2024204847A1/en active Pending
- 2024-07-26 JP JP2024120830A patent/JP2024164018A/ja not_active Withdrawn
-
2025
- 2025-09-11 JP JP2025150799A patent/JP2026009898A/ja active Pending
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