JP2022173349A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022173349A5 JP2022173349A5 JP2022152461A JP2022152461A JP2022173349A5 JP 2022173349 A5 JP2022173349 A5 JP 2022173349A5 JP 2022152461 A JP2022152461 A JP 2022152461A JP 2022152461 A JP2022152461 A JP 2022152461A JP 2022173349 A5 JP2022173349 A5 JP 2022173349A5
- Authority
- JP
- Japan
- Prior art keywords
- integer
- formula
- independently
- bond
- inclusive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024195755A JP2025016776A (ja) | 2016-12-30 | 2024-11-08 | 合成ガイド分子、それに関連する組成物および方法 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662441046P | 2016-12-30 | 2016-12-30 | |
| US62/441,046 | 2016-12-30 | ||
| US201762492001P | 2017-04-28 | 2017-04-28 | |
| US62/492,001 | 2017-04-28 | ||
| JP2019535879A JP7167029B2 (ja) | 2016-12-30 | 2017-12-29 | 合成ガイド分子、それに関連する組成物および方法 |
| PCT/US2017/069019 WO2018126176A1 (en) | 2016-12-30 | 2017-12-29 | Synthetic guide molecules, compositions and methods relating thereto |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535879A Division JP7167029B2 (ja) | 2016-12-30 | 2017-12-29 | 合成ガイド分子、それに関連する組成物および方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024195755A Division JP2025016776A (ja) | 2016-12-30 | 2024-11-08 | 合成ガイド分子、それに関連する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022173349A JP2022173349A (ja) | 2022-11-18 |
| JP2022173349A5 true JP2022173349A5 (https=) | 2023-01-04 |
| JP7610559B2 JP7610559B2 (ja) | 2025-01-08 |
Family
ID=61187807
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535879A Active JP7167029B2 (ja) | 2016-12-30 | 2017-12-29 | 合成ガイド分子、それに関連する組成物および方法 |
| JP2022152461A Active JP7610559B2 (ja) | 2016-12-30 | 2022-09-26 | 合成ガイド分子、それに関連する組成物および方法 |
| JP2024195755A Withdrawn JP2025016776A (ja) | 2016-12-30 | 2024-11-08 | 合成ガイド分子、それに関連する組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535879A Active JP7167029B2 (ja) | 2016-12-30 | 2017-12-29 | 合成ガイド分子、それに関連する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024195755A Withdrawn JP2025016776A (ja) | 2016-12-30 | 2024-11-08 | 合成ガイド分子、それに関連する組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230111575A1 (https=) |
| EP (1) | EP3565895A1 (https=) |
| JP (3) | JP7167029B2 (https=) |
| KR (2) | KR102618864B1 (https=) |
| CN (2) | CN110249052B (https=) |
| AU (2) | AU2017388753A1 (https=) |
| CA (1) | CA3048434A1 (https=) |
| MX (1) | MX420023B (https=) |
| WO (1) | WO2018126176A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11028388B2 (en) | 2014-03-05 | 2021-06-08 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa |
| ES2745769T3 (es) | 2014-03-10 | 2020-03-03 | Editas Medicine Inc | Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10) |
| US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
| US11339437B2 (en) | 2014-03-10 | 2022-05-24 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
| EP3122880B1 (en) | 2014-03-26 | 2021-05-05 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating sickle cell disease |
| EP3540061A1 (en) | 2014-04-02 | 2019-09-18 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating primary open angle glaucoma |
| JP2018522249A (ja) | 2015-04-24 | 2018-08-09 | エディタス・メディシン、インコーポレイテッド | Ｃａｓ９分子／ガイドｒｎａ分子複合体の評価 |
| US11512311B2 (en) | 2016-03-25 | 2022-11-29 | Editas Medicine, Inc. | Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency |
| WO2017220751A1 (en) | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| BR112019001887A2 (pt) | 2016-08-02 | 2019-07-09 | Editas Medicine Inc | composições e métodos para o tratamento de doença associada a cep290 |
| CN110352244B (zh) | 2016-09-01 | 2023-03-21 | ProQR治疗上市公司Ⅱ | 化学修饰的编辑rna的单链寡核苷酸 |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| RU2019130504A (ru) | 2017-02-28 | 2021-03-30 | Вор Байофарма, Инк. | Композиции и способы ингибирования линиеспецифических белков |
| WO2018170184A1 (en) | 2017-03-14 | 2018-09-20 | Editas Medicine, Inc. | Systems and methods for the treatment of hemoglobinopathies |
| US11499151B2 (en) | 2017-04-28 | 2022-11-15 | Editas Medicine, Inc. | Methods and systems for analyzing guide RNA molecules |
| EP3622070A2 (en) | 2017-05-10 | 2020-03-18 | Editas Medicine, Inc. | Crispr/rna-guided nuclease systems and methods |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| US20190076814A1 (en) | 2017-09-11 | 2019-03-14 | Synthego Corporation | Biopolymer synthesis system and method |
| KR102907245B1 (ko) | 2018-03-14 | 2026-01-05 | 에디타스 메디신, 인코포레이티드 | 혈색소병증 치료를 위한 시스템 및 방법 |
| KR20210045360A (ko) | 2018-05-16 | 2021-04-26 | 신테고 코포레이션 | 가이드 rna 설계 및 사용을 위한 방법 및 시스템 |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| EP3823633A4 (en) | 2018-06-29 | 2023-05-03 | Editas Medicine, Inc. | SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| GB201901873D0 (en) * | 2019-02-11 | 2019-04-03 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for nucleic acid editing |
| AU2020280103A1 (en) | 2019-05-23 | 2021-12-23 | Vor Biopharma Inc. | Compositions and methods for CD33 modification |
| AU2020338011A1 (en) | 2019-08-28 | 2022-03-10 | Vor Biopharma Inc. | Compositions and methods for CLL1 modification |
| WO2021041977A1 (en) | 2019-08-28 | 2021-03-04 | Vor Biopharma, Inc. | Compositions and methods for cd123 modification |
| US20240238344A1 (en) | 2020-08-28 | 2024-07-18 | Vor Biopharma Inc. | Compositions and methods for cd123 modification |
| WO2022047168A1 (en) | 2020-08-28 | 2022-03-03 | Vor Biopharma Inc. | Compositions and methods for cll1 modification |
| JP2023541457A (ja) | 2020-09-14 | 2023-10-02 | ブイオーアール バイオファーマ インコーポレーテッド | Ｃｄ３８修飾のための化合物および方法 |
| WO2022056459A1 (en) | 2020-09-14 | 2022-03-17 | Vor Biopharma, Inc. | Compositions and methods for cd5 modification |
| WO2022061115A1 (en) | 2020-09-18 | 2022-03-24 | Vor Biopharma Inc. | Compositions and methods for cd7 modification |
| US20230364233A1 (en) | 2020-09-28 | 2023-11-16 | Vor Biopharma Inc. | Compositions and methods for cd6 modification |
| WO2022072643A1 (en) | 2020-09-30 | 2022-04-07 | Vor Biopharma Inc. | Compositions and methods for cd30 gene modification |
| WO2022093983A1 (en) | 2020-10-27 | 2022-05-05 | Vor Biopharma, Inc. | Compositions and methods for treating hematopoietic malignancy |
| WO2022094245A1 (en) | 2020-10-30 | 2022-05-05 | Vor Biopharma, Inc. | Compositions and methods for bcma modification |
| EP4243858A1 (en) | 2020-11-13 | 2023-09-20 | Vor Biopharma Inc. | Methods and compositions relating to genetically engineered cells expressing chimeric antigen receptors |
| JP2024502820A (ja) | 2020-12-31 | 2024-01-23 | ブイオーアール バイオファーマ インコーポレーテッド | Ｃｄ３４遺伝子改変のための組成物及び方法 |
| US20240200059A1 (en) | 2021-04-09 | 2024-06-20 | Vor Biopharma Inc. | Photocleavable guide rnas and methods of use thereof |
| WO2023283585A2 (en) | 2021-07-06 | 2023-01-12 | Vor Biopharma Inc. | Inhibitor oligonucleotides and methods of use thereof |
| AU2022324093A1 (en) | 2021-08-02 | 2024-02-08 | Vor Biopharma Inc. | Compositions and methods for gene modification |
| US20240417755A1 (en) | 2021-09-27 | 2024-12-19 | Vor Biopharma Inc. | Fusion polypeptides for genetic editing and methods of use thereof |
| JP2024543369A (ja) | 2021-11-09 | 2024-11-21 | ブイオーアール バイオファーマ インコーポレーテッド | Ｅｍｒ２修飾のための化合物及び方法 |
| US20250179531A1 (en) | 2022-02-25 | 2025-06-05 | Vor Biopharma Inc. | Compositions and methods for homology-directed repair gene modification |
| AU2023251040A1 (en) | 2022-04-04 | 2024-10-17 | Vor Biopharma Inc. | Compositions and methods for mediating epitope engineering |
| WO2024015925A2 (en) | 2022-07-13 | 2024-01-18 | Vor Biopharma Inc. | Compositions and methods for artificial protospacer adjacent motif (pam) generation |
| WO2024073751A1 (en) | 2022-09-29 | 2024-04-04 | Vor Biopharma Inc. | Methods and compositions for gene modification and enrichment |
| EP4623081A2 (en) * | 2022-11-23 | 2025-10-01 | Prime Medicine, Inc. | Split synthesis of long rnas |
| WO2024168312A1 (en) | 2023-02-09 | 2024-08-15 | Vor Biopharma Inc. | Methods for treating hematopoietic malignancy |
| EP4735161A2 (en) * | 2023-06-29 | 2026-05-06 | Synthego Corporation | Methods and systems for automated fraction selection in nucleic acid manufacturing |
| WO2025030010A1 (en) | 2023-08-01 | 2025-02-06 | Vor Biopharma Inc. | Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof |
| WO2025194138A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | St1cas9 compositions and methods for modulating a genome |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2851647C (en) | 2011-10-10 | 2019-08-13 | Kmt Waterjet Systems Inc. | Gasketless high pressure connection |
| CN106459995B (zh) * | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| ES2745769T3 (es) | 2014-03-10 | 2020-03-03 | Editas Medicine Inc | Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10) |
| EP3122880B1 (en) * | 2014-03-26 | 2021-05-05 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating sickle cell disease |
| US9879283B2 (en) * | 2014-10-09 | 2018-01-30 | Life Technologies Corporation | CRISPR oligonucleotides and gene editing |
| EP4464338A3 (en) | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| US10059940B2 (en) | 2015-01-27 | 2018-08-28 | Minghong Zhong | Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| JP2018522249A (ja) * | 2015-04-24 | 2018-08-09 | エディタス・メディシン、インコーポレイテッド | Ｃａｓ９分子／ガイドｒｎａ分子複合体の評価 |
| US11572543B2 (en) | 2015-05-08 | 2023-02-07 | The Children's Medical Center. Corporation | Targeting BCL11A enhancer functional regions for fetal hemoglobin reinduction |
| JP2018515142A (ja) * | 2015-05-15 | 2018-06-14 | ダーマコン，インコーポレイテッド． | Ｃａｓ９介在遺伝子編集用の合成シングルガイドｒｎａ |
| CN109072224B (zh) * | 2016-01-30 | 2022-07-15 | 株式会社博纳克 | 人工单导rna及其用途 |
| EP3443088B1 (en) | 2016-04-13 | 2024-09-18 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
-
2017
- 2017-12-29 CA CA3048434A patent/CA3048434A1/en active Pending
- 2017-12-29 WO PCT/US2017/069019 patent/WO2018126176A1/en not_active Ceased
- 2017-12-29 KR KR1020197022278A patent/KR102618864B1/ko active Active
- 2017-12-29 KR KR1020237043357A patent/KR102758180B1/ko active Active
- 2017-12-29 EP EP17840468.7A patent/EP3565895A1/en active Pending
- 2017-12-29 JP JP2019535879A patent/JP7167029B2/ja active Active
- 2017-12-29 MX MX2019007750A patent/MX420023B/es unknown
- 2017-12-29 CN CN201780085248.4A patent/CN110249052B/zh active Active
- 2017-12-29 CN CN202410342599.0A patent/CN118345072A/zh active Pending
- 2017-12-29 US US16/474,198 patent/US20230111575A1/en active Pending
- 2017-12-29 AU AU2017388753A patent/AU2017388753A1/en not_active Abandoned
-
2022
- 2022-09-26 JP JP2022152461A patent/JP7610559B2/ja active Active
-
2024
- 2024-07-30 AU AU2024205204A patent/AU2024205204A1/en active Pending
- 2024-11-08 JP JP2024195755A patent/JP2025016776A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022173349A5 (https=) | ||
| JP2020503049A5 (https=) | ||
| JP6839650B2 (ja) | 核酸合成用修飾ヌクレオチド及び前記ヌクレオチドを含むキット、並びに合成核酸配列又は遺伝子の製造のためのそれらの使用 | |
| JP5548852B2 (ja) | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 | |
| AU2015350001B2 (en) | Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds | |
| EP0415901A2 (en) | Improved nucleic acid probes | |
| JP2016074701A (ja) | リボヌクレオシドホスホロチオエートの製造方法 | |
| US20210283263A1 (en) | Method of conjugating oligomeric compounds | |
| AU769619B2 (en) | Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids | |
| KR20190104392A (ko) | 분자의 막투과 전달을 위한 화합물 및 방법 | |
| JPH09510206A (ja) | オリゴヌクレオチドの合成に用いる組成物および方法 | |
| CN115335521A (zh) | 合成rna分子的方法 | |
| CA2436665A1 (en) | Nucleic acid derivatives | |
| JP2011184318A (ja) | リボヌクレシドｈ−ボラノホスホネート | |
| US5652350A (en) | Complementary DNA and toxins | |
| TW202112795A (zh) | 使用經修改之氧化準則製備寡核苷酸之方法 | |
| AU2022291626A1 (en) | Improved process for preparing imetelstat | |
| US20180251485A1 (en) | Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them | |
| CN101238213B (zh) | 使用扭转嵌入核酸(TINA)稳定并选择性地形成Hoogsteen型三链体和双链体以及制备TINA的工艺 | |
| JPH06511236A (ja) | シリルアルコールの合成方法 | |
| Lin et al. | Hybridization properties of deoxyoligonucleotides containing anthraquinone pseudonucleosides | |
| CN116333007B (zh) | 一种基于点击化学的光响应性环形rna合成方法及其应用 | |
| WO2020158687A1 (ja) | 光応答性ヌクレオチドアナログの製造方法 | |
| CN114269764A (zh) | 立体控制寡核苷酸合成用光学活性片段及其制造方法、以及使用其的立体控制寡核苷酸的合成方法 | |
| JP2020132604A (ja) | 核酸合成用固相担体及びそれを用いた核酸の製造方法 |