JP2022125283A5

JP2022125283A5 -

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Publication number: JP2022125283A5
Authority: JP; Japan
Prior art keywords: amino; acrylamide; pyrimidin; isoxazolidin; methoxyphenyl
Prior art date: 2022-07-07
Legal status : Granted

Application number

JP2022109721A

Other languages

English (en)

Japanese (ja)

Other versions

JP7394298B2 (ja

JP2022125283A (ja

Filing date

2022-07-07

Publication date

2023-03-28

2020-03-19 Priority claimed from PCT/KR2020/095044 external-priority patent/WO2020190119A1/ko

2022-07-07 Application filed filed Critical

2022-08-26 Publication of JP2022125283A publication Critical patent/JP2022125283A/ja

2023-03-28 Publication of JP2022125283A5 publication Critical patent/JP2022125283A5/ja

2023-12-08 Application granted granted Critical

2023-12-08 Publication of JP7394298B2 publication Critical patent/JP7394298B2/ja

Status Active legal-status Critical Current

2040-03-19 Anticipated expiration legal-status Critical

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HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 84
125000000217 alkyl group Chemical group 0.000 claims 74
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 63
125000004429 atom Chemical group 0.000 claims 36
229910052739 hydrogen Inorganic materials 0.000 claims 36
239000001257 hydrogen Substances 0.000 claims 36
125000003282 alkyl amino group Chemical group 0.000 claims 35
125000001424 substituent group Chemical group 0.000 claims 35
229910052736 halogen Inorganic materials 0.000 claims 32
150000002367 halogens Chemical class 0.000 claims 32
125000003545 alkoxy group Chemical group 0.000 claims 31
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 24
125000000592 heterocycloalkyl group Chemical group 0.000 claims 20
125000004433 nitrogen atom Chemical group N* 0.000 claims 14
150000001875 compounds Chemical class 0.000 claims 13
-1 methylene, ethylene, propylene Chemical group 0.000 claims 13
206010028980 Neoplasm Diseases 0.000 claims 11
125000004448 alkyl carbonyl group Chemical group 0.000 claims 11
201000011510 cancer Diseases 0.000 claims 11
150000002431 hydrogen Chemical class 0.000 claims 11
150000003839 salts Chemical class 0.000 claims 11
GWNADOKGQKZFAK-UHFFFAOYSA-N N-[3-[[2-[4-[1-(2-fluoroethyl)piperidin-4-yl]-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound FCCN1CCC(CC1)C1=CC(=C(C=C1)NC1=NC=C(C(=N1)NC=1C=C(C=CC=1)NC(C=C)=O)C(F)(F)F)OC GWNADOKGQKZFAK-UHFFFAOYSA-N 0.000 claims 10
239000008194 pharmaceutical composition Substances 0.000 claims 9
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
125000003342 alkenyl group Chemical group 0.000 claims 7
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
125000001072 heteroaryl group Chemical group 0.000 claims 6
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
230000037431 insertion Effects 0.000 claims 6
238000003780 insertion Methods 0.000 claims 6
208000003174 Brain Neoplasms Diseases 0.000 claims 5
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 5
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
125000004093 cyano group Chemical group *C#N 0.000 claims 5
102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 5
108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 5
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 5
PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
125000005090 alkenylcarbonyl group Chemical group 0.000 claims 4
125000000304 alkynyl group Chemical group 0.000 claims 4
125000003118 aryl group Chemical group 0.000 claims 4
125000005842 heteroatom Chemical group 0.000 claims 4
230000001394 metastastic effect Effects 0.000 claims 4
206010061289 metastatic neoplasm Diseases 0.000 claims 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
206010006187 Breast cancer Diseases 0.000 claims 3
208000026310 Breast neoplasm Diseases 0.000 claims 3
208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
206010005949 Bone cancer Diseases 0.000 claims 2
208000018084 Bone neoplasm Diseases 0.000 claims 2
ALFKLGULNZWUCB-MUUNZHRXSA-N CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F)OC Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F)OC ALFKLGULNZWUCB-MUUNZHRXSA-N 0.000 claims 2
DQSWXELATOTHIL-HHHXNRCGSA-N COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F DQSWXELATOTHIL-HHHXNRCGSA-N 0.000 claims 2
KYXFLDPQSMQIDB-RUZDIDTESA-N COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl KYXFLDPQSMQIDB-RUZDIDTESA-N 0.000 claims 2
206010009944 Colon cancer Diseases 0.000 claims 2
208000008839 Kidney Neoplasms Diseases 0.000 claims 2
206010025323 Lymphomas Diseases 0.000 claims 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
GPOBIYQWIXJDOE-HHHXNRCGSA-N N-[2-(4-cyclopentylpiperazin-1-yl)-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C6CCCC6)OC GPOBIYQWIXJDOE-HHHXNRCGSA-N 0.000 claims 2
BBEUEBFHTUEHSS-SSEXGKCCSA-N N-[2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)F)OC BBEUEBFHTUEHSS-SSEXGKCCSA-N 0.000 claims 2
MJCURVYXKKSOQU-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC MJCURVYXKKSOQU-GDLZYMKVSA-N 0.000 claims 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
206010038389 Renal cancer Diseases 0.000 claims 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
239000003937 drug carrier Substances 0.000 claims 2
125000001153 fluoro group Chemical group F* 0.000 claims 2
201000010982 kidney cancer Diseases 0.000 claims 2
230000003211 malignant effect Effects 0.000 claims 2
201000001441 melanoma Diseases 0.000 claims 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
230000035772 mutation Effects 0.000 claims 2
102200048928 rs121434568 Human genes 0.000 claims 2
102200048955 rs121434569 Human genes 0.000 claims 2
WNBXWWYREJYLFG-DIJOXEGBSA-N (E)-N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(3-methoxy-3-methylbutoxy)phenyl]-4-(dimethylamino)but-2-enamide Chemical compound CC(C)(CCOC(C=C(C(NC1=NC=NC(N2OCC[C@@H]2C2=CC(F)=CC(F)=C2)=C1)=C1)OC)=C1NC(/C=C/CN(C)C)=O)OC WNBXWWYREJYLFG-DIJOXEGBSA-N 0.000 claims 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
206010003571 Astrocytoma Diseases 0.000 claims 1
208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
206010004146 Basal cell carcinoma Diseases 0.000 claims 1
206010005003 Bladder cancer Diseases 0.000 claims 1
JORPQQBCMUGRKR-GFCCVEGCSA-N C1[C@H](C2=CC=CC=C2)N(C2=CC=NC=N2)OC1 Chemical compound C1[C@H](C2=CC=CC=C2)N(C2=CC=NC=N2)OC1 JORPQQBCMUGRKR-GFCCVEGCSA-N 0.000 claims 1
JTXAMKOOONUGIM-XMMPIXPASA-N CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC JTXAMKOOONUGIM-XMMPIXPASA-N 0.000 claims 1
XAFBBESCQKLLFS-XMMPIXPASA-N CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)Cl)OC Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)Cl)OC XAFBBESCQKLLFS-XMMPIXPASA-N 0.000 claims 1
UYTNUJZHXMUMJO-HHHXNRCGSA-N CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)Cl)F)OC Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)Cl)F)OC UYTNUJZHXMUMJO-HHHXNRCGSA-N 0.000 claims 1
HLCOALQXHAJBAR-MUUNZHRXSA-N CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC HLCOALQXHAJBAR-MUUNZHRXSA-N 0.000 claims 1
DLBZIYQGCZFAER-GDLZYMKVSA-N CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC DLBZIYQGCZFAER-GDLZYMKVSA-N 0.000 claims 1
PWBUSUDICZNPHN-XMMPIXPASA-N CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC Chemical compound CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC PWBUSUDICZNPHN-XMMPIXPASA-N 0.000 claims 1
UMILQXJLYLYSQM-SSEXGKCCSA-N CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC UMILQXJLYLYSQM-SSEXGKCCSA-N 0.000 claims 1
VFNQLVIGRFXKSR-SSEXGKCCSA-N CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC VFNQLVIGRFXKSR-SSEXGKCCSA-N 0.000 claims 1
CMKCYBOLGZEBCY-SSEXGKCCSA-N CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC CMKCYBOLGZEBCY-SSEXGKCCSA-N 0.000 claims 1
JXCUSGGEPFEYER-WJOKGBTCSA-N CC1(CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl)OC)C Chemical compound CC1(CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl)OC)C JXCUSGGEPFEYER-WJOKGBTCSA-N 0.000 claims 1
IICQVPYWSVOXRH-WJOKGBTCSA-N CC1(CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC)C Chemical compound CC1(CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC)C IICQVPYWSVOXRH-WJOKGBTCSA-N 0.000 claims 1
QDHIIEZQJFSYOA-RUZDIDTESA-N CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N(C)C)OC)F Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N(C)C)OC)F QDHIIEZQJFSYOA-RUZDIDTESA-N 0.000 claims 1
GAVXRZQXXNLBAH-SSEXGKCCSA-N CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C(C)C)OC)F Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C(C)C)OC)F GAVXRZQXXNLBAH-SSEXGKCCSA-N 0.000 claims 1
NYZOISNIDDHGKD-MUUNZHRXSA-N CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C)OC)F Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C)OC)F NYZOISNIDDHGKD-MUUNZHRXSA-N 0.000 claims 1
PEPSYBQKGPWTEZ-SSEXGKCCSA-N CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC)F Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC)F PEPSYBQKGPWTEZ-SSEXGKCCSA-N 0.000 claims 1
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WOVUWKLAFZLRLV-HSZRJFAPSA-N CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C)OC)F Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C)OC)F WOVUWKLAFZLRLV-HSZRJFAPSA-N 0.000 claims 1
JXDFWAMCSJAJFT-JOCHJYFZSA-N CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC)F Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC)F JXDFWAMCSJAJFT-JOCHJYFZSA-N 0.000 claims 1
BEWPXMCYNQKVOL-GDLZYMKVSA-N CC1=C(C=CC=C1Cl)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC Chemical compound CC1=C(C=CC=C1Cl)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC BEWPXMCYNQKVOL-GDLZYMKVSA-N 0.000 claims 1
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MFPAUCGTMTXKAU-TXAHVWHTSA-N C[C@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C)C7CC7 Chemical compound C[C@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C)C7CC7 MFPAUCGTMTXKAU-TXAHVWHTSA-N 0.000 claims 1
JRTXQMUJLLICGX-RCXVBCEZSA-N C[C@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6F)C)OC)C)C7CC7 Chemical compound C[C@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6F)C)OC)C)C7CC7 JRTXQMUJLLICGX-RCXVBCEZSA-N 0.000 claims 1
UXTUWVVPZVKQGO-RBTNQOKQSA-N C[C@H]1COCCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC Chemical compound C[C@H]1COCCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC UXTUWVVPZVKQGO-RBTNQOKQSA-N 0.000 claims 1
MZBQLTADXONJIP-UVNCRYBCSA-N C[C@]1(CCON1C2=NC=NC(=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CCC(CC4)N5C[C@H]6C[C@@H]5CO6)OC)C7=CC=CC=C7 Chemical compound C[C@]1(CCON1C2=NC=NC(=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CCC(CC4)N5C[C@H]6C[C@@H]5CO6)OC)C7=CC=CC=C7 MZBQLTADXONJIP-UVNCRYBCSA-N 0.000 claims 1
201000009030 Carcinoma Diseases 0.000 claims 1
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208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
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206010061825 Duodenal neoplasm Diseases 0.000 claims 1
101150029707 ERBB2 gene Proteins 0.000 claims 1
206010014733 Endometrial cancer Diseases 0.000 claims 1
206010014759 Endometrial neoplasm Diseases 0.000 claims 1
208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
208000031852 Gastrointestinal stromal cancer Diseases 0.000 claims 1
208000032612 Glial tumor Diseases 0.000 claims 1
206010018338 Glioma Diseases 0.000 claims 1
101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
208000007766 Kaposi sarcoma Diseases 0.000 claims 1
206010023825 Laryngeal cancer Diseases 0.000 claims 1
206010062038 Lip neoplasm Diseases 0.000 claims 1
206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
208000004059 Male Breast Neoplasms Diseases 0.000 claims 1
208000032271 Malignant tumor of penis Diseases 0.000 claims 1
208000005410 Mediastinal Neoplasms Diseases 0.000 claims 1
208000003445 Mouth Neoplasms Diseases 0.000 claims 1
208000034578 Multiple myelomas Diseases 0.000 claims 1
201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
JNFXMXYDTMUESQ-XMMPIXPASA-N N-[2-(4-acetylpiperazin-1-yl)-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC=C5)OC JNFXMXYDTMUESQ-XMMPIXPASA-N 0.000 claims 1
CORJHXKHLONUCU-HSZRJFAPSA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC CORJHXKHLONUCU-HSZRJFAPSA-N 0.000 claims 1
WYUNHZHNEVGTDM-XMMPIXPASA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC WYUNHZHNEVGTDM-XMMPIXPASA-N 0.000 claims 1
AXGWOYFAKRAHKE-XMMPIXPASA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)Cl)OC AXGWOYFAKRAHKE-XMMPIXPASA-N 0.000 claims 1
UZFDVZCDQWFFFL-XMMPIXPASA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl)OC UZFDVZCDQWFFFL-XMMPIXPASA-N 0.000 claims 1
DXDHTSWUZMLTPP-XMMPIXPASA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)F)OC DXDHTSWUZMLTPP-XMMPIXPASA-N 0.000 claims 1
QTFQBTXADLYFAR-XMMPIXPASA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)F)OC QTFQBTXADLYFAR-XMMPIXPASA-N 0.000 claims 1
MULROTVSAJEJSC-HSZRJFAPSA-N N-[2-(4-acetylpiperazin-1-yl)-5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=CC=CC=C5)OC MULROTVSAJEJSC-HSZRJFAPSA-N 0.000 claims 1
NORZRNGSNBNUIH-AREMUKBSSA-N N-[2-(4-cyclopentylpiperazin-1-yl)-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl NORZRNGSNBNUIH-AREMUKBSSA-N 0.000 claims 1
QXPQNAOUJWWOLV-HHHXNRCGSA-N N-[2-(4-cyclopentylpiperazin-1-yl)-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F QXPQNAOUJWWOLV-HHHXNRCGSA-N 0.000 claims 1
UNZXEJYEHDUONK-RUZDIDTESA-N N-[2-(4-cyclopropylpiperazin-1-yl)-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6 UNZXEJYEHDUONK-RUZDIDTESA-N 0.000 claims 1
JLMKFZZUOYQPIQ-XMMPIXPASA-N N-[2-(4-cyclopropylpiperazin-1-yl)-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl JLMKFZZUOYQPIQ-XMMPIXPASA-N 0.000 claims 1
DSMRYQYQQHXJPQ-RUZDIDTESA-N N-[2-(4-cyclopropylpiperazin-1-yl)-5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C6CC6)OC)F DSMRYQYQQHXJPQ-RUZDIDTESA-N 0.000 claims 1
ZZFCSMYTQGTLIX-RUZDIDTESA-N N-[2-(4-cyclopropylpiperazin-1-yl)-5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl ZZFCSMYTQGTLIX-RUZDIDTESA-N 0.000 claims 1
KAYASKYHRFQXBV-RUZDIDTESA-N N-[2-(4-cyclopropylpiperazin-1-yl)-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F KAYASKYHRFQXBV-RUZDIDTESA-N 0.000 claims 1
QINOOHLIUJBZMN-RUZDIDTESA-N N-[2-(4-ethylpiperazin-1-yl)-4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)OC)OC QINOOHLIUJBZMN-RUZDIDTESA-N 0.000 claims 1
RGXMYGXNQDCOQF-XMMPIXPASA-N N-[2-(4-ethylpiperazin-1-yl)-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CN=C(C=C5)C)OC RGXMYGXNQDCOQF-XMMPIXPASA-N 0.000 claims 1
VAAHCOUZJWZZST-XMMPIXPASA-N N-[2-(4-ethylpiperazin-1-yl)-4-methoxy-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)C(F)(F)F)OC VAAHCOUZJWZZST-XMMPIXPASA-N 0.000 claims 1
FLGCPLBBRCFQFU-AREMUKBSSA-N N-[2-(4-ethylpiperazin-1-yl)-5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#C)OC FLGCPLBBRCFQFU-AREMUKBSSA-N 0.000 claims 1
PVZREUTZCHTSEP-TZBSWOFLSA-N N-[2-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CN=C(C=C6)C)OC PVZREUTZCHTSEP-TZBSWOFLSA-N 0.000 claims 1
GACVUWIMUZJNLK-TZBSWOFLSA-N N-[2-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC GACVUWIMUZJNLK-TZBSWOFLSA-N 0.000 claims 1
PVZREUTZCHTSEP-WRALFONMSA-N N-[2-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CN=C(C=C6)C)OC PVZREUTZCHTSEP-WRALFONMSA-N 0.000 claims 1
GACVUWIMUZJNLK-WRALFONMSA-N N-[2-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC GACVUWIMUZJNLK-WRALFONMSA-N 0.000 claims 1
CGHCMMYTHJACJO-NIYFSFCBSA-N N-[2-[(2R)-4-cyclopropyl-2-methylpiperazin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC)C6CC6 CGHCMMYTHJACJO-NIYFSFCBSA-N 0.000 claims 1
GHJSUQGLPJPYMQ-RZIGYZOXSA-N N-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC GHJSUQGLPJPYMQ-RZIGYZOXSA-N 0.000 claims 1
NOVAECBODVHKPR-AFMDSPMNSA-N N-[2-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC)C6CC6 NOVAECBODVHKPR-AFMDSPMNSA-N 0.000 claims 1
CGHCMMYTHJACJO-AFMDSPMNSA-N N-[2-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC)C6CC6 CGHCMMYTHJACJO-AFMDSPMNSA-N 0.000 claims 1
GHJSUQGLPJPYMQ-RXYILKCJSA-N N-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(C[C@@H](O1)C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC GHJSUQGLPJPYMQ-RXYILKCJSA-N 0.000 claims 1
CQRRTSCWWCIYOK-VGOFRKELSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)F)F)F)OC CQRRTSCWWCIYOK-VGOFRKELSA-N 0.000 claims 1
LITCDOWJDPEJLT-VGOFRKELSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5F)F)F)OC LITCDOWJDPEJLT-VGOFRKELSA-N 0.000 claims 1
UFIRWFVYXQJAJI-PXDATVDWSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)OC)OC UFIRWFVYXQJAJI-PXDATVDWSA-N 0.000 claims 1
UMSCOMYKIXQPBB-ZJSXRUAMSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CC[C@H](C5)N(C)C)OC UMSCOMYKIXQPBB-ZJSXRUAMSA-N 0.000 claims 1
CIPARWQNFJGFAB-ZJSXRUAMSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)C(F)(F)F)OC CIPARWQNFJGFAB-ZJSXRUAMSA-N 0.000 claims 1
UMCFYYHKDRTOIQ-QDPGVEIFSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC6=CC=CC=C65)OC UMCFYYHKDRTOIQ-QDPGVEIFSA-N 0.000 claims 1
OKNKWGIPKJCBSQ-LEAFIULHSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC OKNKWGIPKJCBSQ-LEAFIULHSA-N 0.000 claims 1
AUKXFCQMYTZRPA-ZEQKJWHPSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#C)OC AUKXFCQMYTZRPA-ZEQKJWHPSA-N 0.000 claims 1
GXQGZCPVWGHSEY-ZJSXRUAMSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)F)OC GXQGZCPVWGHSEY-ZJSXRUAMSA-N 0.000 claims 1
XRGAWRLCPQGBAA-DHIUTWEWSA-N N-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-5-[[6-[(3S)-3-[(3-fluoro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1F)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CC[C@H](C5)N(C)C)OC XRGAWRLCPQGBAA-DHIUTWEWSA-N 0.000 claims 1
BECOVWJWGSDDIT-KBMIEXCESA-N N-[2-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC BECOVWJWGSDDIT-KBMIEXCESA-N 0.000 claims 1
PVGJNCRGEUYVGU-RBISFHTESA-N N-[2-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC PVGJNCRGEUYVGU-RBISFHTESA-N 0.000 claims 1
UMSCOMYKIXQPBB-XUZZJYLKSA-N N-[2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CC[C@@H](C5)N(C)C)OC UMSCOMYKIXQPBB-XUZZJYLKSA-N 0.000 claims 1
OHXVTQYUOTVLSS-XUZZJYLKSA-N N-[2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC=C5)OC OHXVTQYUOTVLSS-XUZZJYLKSA-N 0.000 claims 1
TYFIAQKQNKFAFE-AFMDSPMNSA-N N-[2-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC TYFIAQKQNKFAFE-AFMDSPMNSA-N 0.000 claims 1
XLYLTDGVSJPHFK-MQVPCNEGSA-N N-[2-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC XLYLTDGVSJPHFK-MQVPCNEGSA-N 0.000 claims 1
MFFMKNUCHAMAMC-UFKXBGGNSA-N N-[2-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC MFFMKNUCHAMAMC-UFKXBGGNSA-N 0.000 claims 1
SKUWICUIGYHCGU-UFKXBGGNSA-N N-[2-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC SKUWICUIGYHCGU-UFKXBGGNSA-N 0.000 claims 1
NFAJGFVAKRJJNZ-JBBQQGGESA-N N-[2-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC NFAJGFVAKRJJNZ-JBBQQGGESA-N 0.000 claims 1
PJEGQHUHWDBNLC-DPQOWFAMSA-N N-[2-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC PJEGQHUHWDBNLC-DPQOWFAMSA-N 0.000 claims 1
MFFMKNUCHAMAMC-GJECAEJISA-N N-[2-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@@H]2[C@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC MFFMKNUCHAMAMC-GJECAEJISA-N 0.000 claims 1
SKUWICUIGYHCGU-GJECAEJISA-N N-[2-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@@H]2[C@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC SKUWICUIGYHCGU-GJECAEJISA-N 0.000 claims 1
PJEGQHUHWDBNLC-VVMVZBAXSA-N N-[2-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]-5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@@H]2[C@H]1CN(C2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC PJEGQHUHWDBNLC-VVMVZBAXSA-N 0.000 claims 1
RKRCJXNBQJOZCQ-OAQYLSRUSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=C(C=CC(=C4F)F)F)OC RKRCJXNBQJOZCQ-OAQYLSRUSA-N 0.000 claims 1
YDFOYMKPXUQSHN-HHHXNRCGSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC=CC5=CC=CC=C54)OC YDFOYMKPXUQSHN-HHHXNRCGSA-N 0.000 claims 1
RYDUVIYWMJJLNG-HHHXNRCGSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC5=CC=CC=C5C=C4)OC RYDUVIYWMJJLNG-HHHXNRCGSA-N 0.000 claims 1
GLQFKYLKNLQMGA-HXUWFJFHSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-[(3R)-3-thiophen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC=CS4)OC GLQFKYLKNLQMGA-HXUWFJFHSA-N 0.000 claims 1
ZXVQYWLQPVCLOG-QHCPKHFHSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[6-[(3S)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@@H](CCO3)C4=CC=CC=C4)OC ZXVQYWLQPVCLOG-QHCPKHFHSA-N 0.000 claims 1
LSWNOGVKPMERDT-RUZDIDTESA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC=CC(=C4)C#C)OC LSWNOGVKPMERDT-RUZDIDTESA-N 0.000 claims 1
JBLCSUZFGNVKCB-HSZRJFAPSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC=C4)F)OC JBLCSUZFGNVKCB-HSZRJFAPSA-N 0.000 claims 1
LDOAWTQTDLWMHE-HSZRJFAPSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC=C(C=C4)F)OC LDOAWTQTDLWMHE-HSZRJFAPSA-N 0.000 claims 1
ZVMGFQJFPFUCGG-JOCHJYFZSA-N N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[6-[(3S)-3-[(3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)CC4=CC(=CC=C4)F)OC ZVMGFQJFPFUCGG-JOCHJYFZSA-N 0.000 claims 1
PZBOCYTVLVXVLU-MUUNZHRXSA-N N-[2-[3-(4-cyclopropylpiperazin-1-yl)azetidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC(C2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F PZBOCYTVLVXVLU-MUUNZHRXSA-N 0.000 claims 1
JCYHOSVHVKHFEE-DINWUYGQSA-N N-[2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN4CCCC4C3)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F JCYHOSVHVKHFEE-DINWUYGQSA-N 0.000 claims 1
YMTJUFLPBUPXKE-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C(=O)C)OC YMTJUFLPBUPXKE-GDLZYMKVSA-N 0.000 claims 1
WFMDIDCMELSJMD-MGBGTMOVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC7=CC=CC=C7C=C6)OC WFMDIDCMELSJMD-MGBGTMOVSA-N 0.000 claims 1
FEBTYPBFCCWVGV-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC FEBTYPBFCCWVGV-GDLZYMKVSA-N 0.000 claims 1
MEJZAOYQPRIHHJ-MUUNZHRXSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC MEJZAOYQPRIHHJ-MUUNZHRXSA-N 0.000 claims 1
IGRALXKEFZPBEL-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC IGRALXKEFZPBEL-GDLZYMKVSA-N 0.000 claims 1
BGVGWMAXAMYGRU-HHHXNRCGSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC BGVGWMAXAMYGRU-HHHXNRCGSA-N 0.000 claims 1
LEYMJYVWJSOYTM-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC LEYMJYVWJSOYTM-GDLZYMKVSA-N 0.000 claims 1
LTXJXRLBDWUOHI-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC LTXJXRLBDWUOHI-GDLZYMKVSA-N 0.000 claims 1
ALTNVWZFSBTMGU-SSEXGKCCSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC ALTNVWZFSBTMGU-SSEXGKCCSA-N 0.000 claims 1
LXBVHGIDKUSMHO-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F)OC LXBVHGIDKUSMHO-GDLZYMKVSA-N 0.000 claims 1
ZDLLFBYGNPQCLX-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC ZDLLFBYGNPQCLX-GDLZYMKVSA-N 0.000 claims 1
LSUOFQPHJQIUAS-GDLZYMKVSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)F)OC LSUOFQPHJQIUAS-GDLZYMKVSA-N 0.000 claims 1
AVXQGCLTQSRYAP-NDEPHWFRSA-N N-[2-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC(=O)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC AVXQGCLTQSRYAP-NDEPHWFRSA-N 0.000 claims 1
LBYKHIMPXKUHKU-BMXGUMNWSA-N N-[2-[4-(4-butan-2-ylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CCC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC LBYKHIMPXKUHKU-BMXGUMNWSA-N 0.000 claims 1
PMNOULWJTQXLHM-GDLZYMKVSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)F)F)F PMNOULWJTQXLHM-GDLZYMKVSA-N 0.000 claims 1
CDJJRTTULBVXSI-GDLZYMKVSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7F)F)F CDJJRTTULBVXSI-GDLZYMKVSA-N 0.000 claims 1
ADEKODUYAZNBAM-PGUFJCEWSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87 ADEKODUYAZNBAM-PGUFJCEWSA-N 0.000 claims 1
LGKLINIFGIAURR-PGUFJCEWSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC8=CC=CC=C8C=C7 LGKLINIFGIAURR-PGUFJCEWSA-N 0.000 claims 1
MTHMXBFZGRMQPN-SSEXGKCCSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)F MTHMXBFZGRMQPN-SSEXGKCCSA-N 0.000 claims 1
GSYGCVUQECARJP-WJOKGBTCSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F GSYGCVUQECARJP-WJOKGBTCSA-N 0.000 claims 1
ANDLVYYHUBNRIP-GDLZYMKVSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)Cl)Cl)F ANDLVYYHUBNRIP-GDLZYMKVSA-N 0.000 claims 1
DOTSUJMWZLRHEJ-WJOKGBTCSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F DOTSUJMWZLRHEJ-WJOKGBTCSA-N 0.000 claims 1
XLIWNPLQNUMYIT-MGBGTMOVSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC(=C7)C#C XLIWNPLQNUMYIT-MGBGTMOVSA-N 0.000 claims 1
FCUCOMCRJRLGEV-WJOKGBTCSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)F FCUCOMCRJRLGEV-WJOKGBTCSA-N 0.000 claims 1
ALBSBMMKPDAKAG-WJOKGBTCSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=C(C=C7)F ALBSBMMKPDAKAG-WJOKGBTCSA-N 0.000 claims 1
KKAOZGGHKGOKNB-MUUNZHRXSA-N N-[2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)Cl KKAOZGGHKGOKNB-MUUNZHRXSA-N 0.000 claims 1
MDKZCSTWHVZWRD-JGCGQSQUSA-N N-[2-[4-(4-cyclopentylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC=C7 MDKZCSTWHVZWRD-JGCGQSQUSA-N 0.000 claims 1
ATRZPDYAYWKTBH-WJOKGBTCSA-N N-[2-[4-(4-cyclopentylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)Cl ATRZPDYAYWKTBH-WJOKGBTCSA-N 0.000 claims 1
XTFUXTQQTDWPNT-JGCGQSQUSA-N N-[2-[4-(4-cyclopentylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F XTFUXTQQTDWPNT-JGCGQSQUSA-N 0.000 claims 1
DIVYYZFUVCBXIK-JGCGQSQUSA-N N-[2-[4-(4-cyclopentylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F DIVYYZFUVCBXIK-JGCGQSQUSA-N 0.000 claims 1
WGDDQWZYMBEAAG-JGCGQSQUSA-N N-[2-[4-(4-cyclopentylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F WGDDQWZYMBEAAG-JGCGQSQUSA-N 0.000 claims 1
YVIVAHFHFMJPPE-WJOKGBTCSA-N N-[2-[4-(4-cyclopropyl-1,4-diazepan-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F YVIVAHFHFMJPPE-WJOKGBTCSA-N 0.000 claims 1
FNNHONGMJWWYKD-WJOKGBTCSA-N N-[2-[4-(4-cyclopropyl-1,4-diazepan-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F FNNHONGMJWWYKD-WJOKGBTCSA-N 0.000 claims 1
LUQGXLRFFFLLKK-MUUNZHRXSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)F)F)F LUQGXLRFFFLLKK-MUUNZHRXSA-N 0.000 claims 1
LMKKYZHVUUCGFU-MUUNZHRXSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7F)F)F LMKKYZHVUUCGFU-MUUNZHRXSA-N 0.000 claims 1
HWUSFELJYCZQIQ-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC HWUSFELJYCZQIQ-SSEXGKCCSA-N 0.000 claims 1
AIKUCBLKFUBUIF-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)C(F)(F)F AIKUCBLKFUBUIF-SSEXGKCCSA-N 0.000 claims 1
ZIFKUWGNJKBNHY-UUWRZZSWSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87 ZIFKUWGNJKBNHY-UUWRZZSWSA-N 0.000 claims 1
OLGLFWIKRUMFDN-UUWRZZSWSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC8=CC=CC=C8C=C7 OLGLFWIKRUMFDN-UUWRZZSWSA-N 0.000 claims 1
PEPGTONRSLFDQO-HHHXNRCGSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-thiophen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CS7 PEPGTONRSLFDQO-HHHXNRCGSA-N 0.000 claims 1
LMKKYZHVUUCGFU-NDEPHWFRSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3S)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@@H](CCO6)C7=C(C=CC(=C7F)F)F LMKKYZHVUUCGFU-NDEPHWFRSA-N 0.000 claims 1
SBXJZWZEJOYIER-MUUNZHRXSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3S)-3-(pyridin-2-ylmethyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC=CC=N7 SBXJZWZEJOYIER-MUUNZHRXSA-N 0.000 claims 1
CTWWENQRPUIDLI-MUUNZHRXSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3S)-3-(pyridin-3-ylmethyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CN=CC=C7 CTWWENQRPUIDLI-MUUNZHRXSA-N 0.000 claims 1
MQQJSUWHGZJBNB-GDLZYMKVSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3S)-3-[[4-(trifluoromethyl)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC=C(C=C7)C(F)(F)F MQQJSUWHGZJBNB-GDLZYMKVSA-N 0.000 claims 1
DMIIPWNZLCDWQQ-GDLZYMKVSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)F DMIIPWNZLCDWQQ-GDLZYMKVSA-N 0.000 claims 1
FMJXBRQJSOPXQV-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F FMJXBRQJSOPXQV-SSEXGKCCSA-N 0.000 claims 1
SFCLNRWVDUNNGY-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F SFCLNRWVDUNNGY-SSEXGKCCSA-N 0.000 claims 1
NXIUBTLXWGTWRO-MUUNZHRXSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)Cl)Cl)F NXIUBTLXWGTWRO-MUUNZHRXSA-N 0.000 claims 1
LWUQTDOUAPAMTJ-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)Cl)Cl LWUQTDOUAPAMTJ-SSEXGKCCSA-N 0.000 claims 1
OGTWWRPHKHHLLX-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)F OGTWWRPHKHHLLX-SSEXGKCCSA-N 0.000 claims 1
MDKQQAXZNVYACA-SLGOVJDISA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-[(2R)-1,1,1-trifluoropropan-2-yl]oxyphenyl]prop-2-enamide Chemical compound C[C@H](C(F)(F)F)OC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F MDKQQAXZNVYACA-SLGOVJDISA-N 0.000 claims 1
XBDBPFFEILMSLO-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-fluorophenyl]prop-2-enamide Chemical compound C=CC(=O)NC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C4CC4)F)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F XBDBPFFEILMSLO-SSEXGKCCSA-N 0.000 claims 1
HZAJPMODSROWIV-WJOKGBTCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methylphenyl]prop-2-enamide Chemical compound CC1=CC(=C(C=C1NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC(=C4)F)F)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7 HZAJPMODSROWIV-WJOKGBTCSA-N 0.000 claims 1
DNHKSZBVFKNBGY-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)F DNHKSZBVFKNBGY-SSEXGKCCSA-N 0.000 claims 1
CNMXOUFKWFVVIK-SSEXGKCCSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=C(C=C7)F CNMXOUFKWFVVIK-SSEXGKCCSA-N 0.000 claims 1
VMAKHROGMQAJFH-LJAQVGFWSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@@H](CCO6)C7=C(C=CC=C7F)F VMAKHROGMQAJFH-LJAQVGFWSA-N 0.000 claims 1
RBQZIYNSIBUKTC-HHHXNRCGSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)Cl RBQZIYNSIBUKTC-HHHXNRCGSA-N 0.000 claims 1
AYJDXQQQJZECOP-GDLZYMKVSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-[(3,5-difluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC(=C7)F)F AYJDXQQQJZECOP-GDLZYMKVSA-N 0.000 claims 1
PPMVHMUACGGHDT-GDLZYMKVSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-[(3-fluoro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1F)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC PPMVHMUACGGHDT-GDLZYMKVSA-N 0.000 claims 1
FELOMTNITMXHEA-GDLZYMKVSA-N N-[2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3S)-3-[(3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC=C7)F FELOMTNITMXHEA-GDLZYMKVSA-N 0.000 claims 1
YQZBMNGKYPJNOQ-UHFFFAOYSA-N N-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-(3-methyl-3-phenyl-1,2-oxazolidin-2-yl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5C(CCO5)(C)C6=CC=CC=C6)OC YQZBMNGKYPJNOQ-UHFFFAOYSA-N 0.000 claims 1
CMSHDGNFWSQZAC-GDLZYMKVSA-N N-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CN=C(C=C6)C)OC CMSHDGNFWSQZAC-GDLZYMKVSA-N 0.000 claims 1
PBTOFSJNRKBRTD-MGBGTMOVSA-N N-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76)OC PBTOFSJNRKBRTD-MGBGTMOVSA-N 0.000 claims 1
CZUKKTJDNVFZDV-MGBGTMOVSA-N N-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC7=CC=CC=C7C=C6)OC CZUKKTJDNVFZDV-MGBGTMOVSA-N 0.000 claims 1
WFKAFDOBXIUZTG-GDLZYMKVSA-N N-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC WFKAFDOBXIUZTG-GDLZYMKVSA-N 0.000 claims 1
RZZGBLKZBWVIHE-GDLZYMKVSA-N N-[2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F)OC RZZGBLKZBWVIHE-GDLZYMKVSA-N 0.000 claims 1
HYJDSUYMTTUPDV-GDLZYMKVSA-N N-[2-[4-(6-azaspiro[2.5]octan-6-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC4(CC4)CC3)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F HYJDSUYMTTUPDV-GDLZYMKVSA-N 0.000 claims 1
VGRUCXDHGSRINI-GDLZYMKVSA-N N-[2-[4-(6-azaspiro[2.5]octan-6-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC4(CC4)CC3)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F VGRUCXDHGSRINI-GDLZYMKVSA-N 0.000 claims 1
QYHXHKBMUNFWSH-MUUNZHRXSA-N N-[2-[4-(6-azaspiro[2.5]octan-6-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC4(CC4)CC3)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F QYHXHKBMUNFWSH-MUUNZHRXSA-N 0.000 claims 1
VCXKDQXWGWIYMB-GDLZYMKVSA-N N-[2-[4-(6-azaspiro[2.5]octan-6-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC4(CC4)CC3)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl VCXKDQXWGWIYMB-GDLZYMKVSA-N 0.000 claims 1
AEZVITNIVYKNQE-FJGWTWLBSA-N N-[2-[4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CC4CCC(C3)N4C5CC5)NC(=O)C=C)NC6=CC(=NC=N6)N7[C@H](CCO7)C8=C(C(=CC=C8)F)F AEZVITNIVYKNQE-FJGWTWLBSA-N 0.000 claims 1
KHXNSHIMPAHLCM-GNVRUEKJSA-N N-[2-[4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CC4CCC(C3)N4C5CC5)NC(=O)C=C)NC6=CC(=NC=N6)N7[C@H](CCO7)C8=C(C=CC(=C8)F)F KHXNSHIMPAHLCM-GNVRUEKJSA-N 0.000 claims 1
XNXJJQPFFGHMIP-RUZDIDTESA-N N-[2-[4-(cyclopropylmethyl)piperazin-1-yl]-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)CC3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl XNXJJQPFFGHMIP-RUZDIDTESA-N 0.000 claims 1
GPMZCXNTWMODEP-RUZDIDTESA-N N-[2-[4-(dimethylamino)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)C(F)(F)F)OC GPMZCXNTWMODEP-RUZDIDTESA-N 0.000 claims 1
VJNWHQSLLWUFSK-GDLZYMKVSA-N N-[2-[4-(dimethylamino)piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC6=CC=CC=C65)OC VJNWHQSLLWUFSK-GDLZYMKVSA-N 0.000 claims 1
ZALYHEUMUAZQSR-HHHXNRCGSA-N N-[2-[4-(dimethylamino)piperidin-1-yl]-5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#C)OC ZALYHEUMUAZQSR-HHHXNRCGSA-N 0.000 claims 1
YGLBCWMIDXLIKO-RUZDIDTESA-N N-[2-[4-(dimethylamino)piperidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)F)OC YGLBCWMIDXLIKO-RUZDIDTESA-N 0.000 claims 1
IBMXIHGVOHXICQ-YCVRVPNXSA-N N-[2-[4-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC=C7)OC IBMXIHGVOHXICQ-YCVRVPNXSA-N 0.000 claims 1
KNHUJPJHJYKQKA-OLUZHXLYSA-N N-[2-[4-[(1R,5S)-8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[(3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4CC[C@@H](C3)N4C5CC5)NC(=O)C=C)NC6=CC(=NC=N6)N7[C@H](CCO7)CC8=CC(=CC=C8)F KNHUJPJHJYKQKA-OLUZHXLYSA-N 0.000 claims 1
IBMXIHGVOHXICQ-FEVNIDIWSA-N N-[2-[4-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC=C7)OC IBMXIHGVOHXICQ-FEVNIDIWSA-N 0.000 claims 1
VKUPPBMIPDKDNN-FEVNIDIWSA-N N-[2-[4-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)F)OC VKUPPBMIPDKDNN-FEVNIDIWSA-N 0.000 claims 1
AASGIRPSOPWPKT-VQCQPQSOSA-N N-[2-[4-[(1S,5R)-8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4CC[C@@H](C3)N4C5CC5)NC(=O)C=C)NC6=CC(=NC=N6)N7[C@H](CCO7)C8=CC(=CC(=C8)F)F AASGIRPSOPWPKT-VQCQPQSOSA-N 0.000 claims 1
LPYVUTWXCKLXHL-SLGOVJDISA-N N-[2-[4-[(2R)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C7CC7 LPYVUTWXCKLXHL-SLGOVJDISA-N 0.000 claims 1
UVJITVNIQVCNAH-GOFIJKOKSA-N N-[2-[4-[(2R,5R)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN([C@@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC)C)C7CC7 UVJITVNIQVCNAH-GOFIJKOKSA-N 0.000 claims 1
MFPAUCGTMTXKAU-GOFIJKOKSA-N N-[2-[4-[(2R,5R)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN([C@@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C)C7CC7 MFPAUCGTMTXKAU-GOFIJKOKSA-N 0.000 claims 1
UVJITVNIQVCNAH-JOUUIMRQSA-N N-[2-[4-[(2R,5S)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC)C)C7CC7 UVJITVNIQVCNAH-JOUUIMRQSA-N 0.000 claims 1
MFPAUCGTMTXKAU-JOUUIMRQSA-N N-[2-[4-[(2R,5S)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C)C7CC7 MFPAUCGTMTXKAU-JOUUIMRQSA-N 0.000 claims 1
MJDWAVCYIHHFJN-PBDKAQRYSA-N N-[2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)F)F)OC MJDWAVCYIHHFJN-PBDKAQRYSA-N 0.000 claims 1
PTIWJAPZXOKCKU-UAABGXCFSA-N N-[2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6F)C)OC PTIWJAPZXOKCKU-UAABGXCFSA-N 0.000 claims 1
LPYVUTWXCKLXHL-GTYOFVGBSA-N N-[2-[4-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C7CC7 LPYVUTWXCKLXHL-GTYOFVGBSA-N 0.000 claims 1
UVJITVNIQVCNAH-MKVNITDJSA-N N-[2-[4-[(2S,5R)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN([C@@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC)C)C7CC7 UVJITVNIQVCNAH-MKVNITDJSA-N 0.000 claims 1
UVJITVNIQVCNAH-TXAHVWHTSA-N N-[2-[4-[(2S,5S)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC)C)C7CC7 UVJITVNIQVCNAH-TXAHVWHTSA-N 0.000 claims 1
CWGHIDQETUPTMM-PBDKAQRYSA-N N-[2-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6F)F)F)OC CWGHIDQETUPTMM-PBDKAQRYSA-N 0.000 claims 1
RNLJOPYIMRLUOE-YPMZNXIVSA-N N-[2-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76)OC RNLJOPYIMRLUOE-YPMZNXIVSA-N 0.000 claims 1
FNQJLTFCJIUXNP-UAABGXCFSA-N N-[2-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC FNQJLTFCJIUXNP-UAABGXCFSA-N 0.000 claims 1
WSWUPAPXWIASFW-PDDLMNHVSA-N N-[2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)OC)OC WSWUPAPXWIASFW-PDDLMNHVSA-N 0.000 claims 1
QJSPUWVRDMFILA-GGXMVOPNSA-N N-[2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CC[C@H](C6)N(C)C)OC QJSPUWVRDMFILA-GGXMVOPNSA-N 0.000 claims 1
YVPUXFVMRWHJDO-GGXMVOPNSA-N N-[2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC YVPUXFVMRWHJDO-GGXMVOPNSA-N 0.000 claims 1
NEBALADWEMZOOZ-VAVYLYDRSA-N N-[2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CC[C@H](C6)N(C)C)OC)F NEBALADWEMZOOZ-VAVYLYDRSA-N 0.000 claims 1
UXFAABWYPSYGFH-GGXMVOPNSA-N N-[2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)F)OC UXFAABWYPSYGFH-GGXMVOPNSA-N 0.000 claims 1
KSKNPCKIGYDUIT-QZWVJJBASA-N N-[2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-5-[[6-[3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5C(CCO5)C6=CC(=CC=C6)F)OC KSKNPCKIGYDUIT-QZWVJJBASA-N 0.000 claims 1
BZRRTUIWFCAKGJ-KPURRNSFSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7F)F)F)OC BZRRTUIWFCAKGJ-KPURRNSFSA-N 0.000 claims 1
LNQNXQWMWXKSBL-QYTMHSNXSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87)OC LNQNXQWMWXKSBL-QYTMHSNXSA-N 0.000 claims 1
XCVPDPYXTQVDQE-WVXBCFDCSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)F)OC XCVPDPYXTQVDQE-WVXBCFDCSA-N 0.000 claims 1
QRBXTRVWLLZMKI-WVXBCFDCSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC=C7F)F)OC QRBXTRVWLLZMKI-WVXBCFDCSA-N 0.000 claims 1
IGDPFRDALMMVEQ-UFHPHHKVSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)Cl)OC IGDPFRDALMMVEQ-UFHPHHKVSA-N 0.000 claims 1
NWQRIMCSEBUHSU-FYBSXPHGSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[(3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC=C7)F)OC NWQRIMCSEBUHSU-FYBSXPHGSA-N 0.000 claims 1
JFLCVPWSPDYXGE-WXGMZPBLSA-N N-[2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[[3-(dimethylamino)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC=C7)N(C)C)OC JFLCVPWSPDYXGE-WXGMZPBLSA-N 0.000 claims 1
NEBALADWEMZOOZ-ABYGYWHVSA-N N-[2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CC[C@@H](C6)N(C)C)OC)F NEBALADWEMZOOZ-ABYGYWHVSA-N 0.000 claims 1
UXFAABWYPSYGFH-LITSAYRRSA-N N-[2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)F)OC UXFAABWYPSYGFH-LITSAYRRSA-N 0.000 claims 1
BZRRTUIWFCAKGJ-PZGXJGMVSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7F)F)F)OC BZRRTUIWFCAKGJ-PZGXJGMVSA-N 0.000 claims 1
PWVOKEMEZYVRJL-QXNWPYRLSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)C(F)(F)F)OC PWVOKEMEZYVRJL-QXNWPYRLSA-N 0.000 claims 1
LNQNXQWMWXKSBL-JCVFDAPQSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87)OC LNQNXQWMWXKSBL-JCVFDAPQSA-N 0.000 claims 1
UXOKYGCOVDTURK-ABYGYWHVSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3S)-3-(pyridin-3-ylmethyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CN=CC=C7)OC UXOKYGCOVDTURK-ABYGYWHVSA-N 0.000 claims 1
XCVPDPYXTQVDQE-YUDQIZAISA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)F)OC XCVPDPYXTQVDQE-YUDQIZAISA-N 0.000 claims 1
QRBXTRVWLLZMKI-YUDQIZAISA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC=C7F)F)OC QRBXTRVWLLZMKI-YUDQIZAISA-N 0.000 claims 1
HCDQOTBDBVCTKM-GTYOFVGBSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC HCDQOTBDBVCTKM-GTYOFVGBSA-N 0.000 claims 1
IGDPFRDALMMVEQ-RBJSKKJNSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)Cl)OC IGDPFRDALMMVEQ-RBJSKKJNSA-N 0.000 claims 1
XSDFUFAYRFPPDJ-SETSBSEESA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[(3-fluoro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)F)C)OC XSDFUFAYRFPPDJ-SETSBSEESA-N 0.000 claims 1
JFLCVPWSPDYXGE-QVWWMRLHSA-N N-[2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[[3-(dimethylamino)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC=C7)N(C)C)OC JFLCVPWSPDYXGE-QVWWMRLHSA-N 0.000 claims 1
OQUMIGODMBAQSV-BOGJOCPPSA-N N-[2-[4-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)Cl)OC OQUMIGODMBAQSV-BOGJOCPPSA-N 0.000 claims 1
JSCYAMKCGZJICJ-GJMJJNOCSA-N N-[2-[4-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC JSCYAMKCGZJICJ-GJMJJNOCSA-N 0.000 claims 1
KACLPDBXMGVCIX-GJMJJNOCSA-N N-[2-[4-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)Cl)F)OC KACLPDBXMGVCIX-GJMJJNOCSA-N 0.000 claims 1
GFDWMINYJSMIAO-WKOFMMCFSA-N N-[2-[4-[(3aR,6aR)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@H]2[C@@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=C(C=C7)F)OC GFDWMINYJSMIAO-WKOFMMCFSA-N 0.000 claims 1
OQUMIGODMBAQSV-JWCTUAFDSA-N N-[2-[4-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@@H]2[C@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)Cl)OC OQUMIGODMBAQSV-JWCTUAFDSA-N 0.000 claims 1
JSCYAMKCGZJICJ-JOHVVKFNSA-N N-[2-[4-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@@H]2[C@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC JSCYAMKCGZJICJ-JOHVVKFNSA-N 0.000 claims 1
KACLPDBXMGVCIX-JOHVVKFNSA-N N-[2-[4-[(3aS,6aS)-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN1CC[C@@H]2[C@H]1CN(C2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)Cl)F)OC KACLPDBXMGVCIX-JOHVVKFNSA-N 0.000 claims 1
UHUNFUNIIAYRSZ-WJOKGBTCSA-N N-[2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC=C7 UHUNFUNIIAYRSZ-WJOKGBTCSA-N 0.000 claims 1
QKAFQAGRNXHLSN-SSEXGKCCSA-N N-[2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)Cl QKAFQAGRNXHLSN-SSEXGKCCSA-N 0.000 claims 1
GDGWZBBFYLOELG-WJOKGBTCSA-N N-[2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F GDGWZBBFYLOELG-WJOKGBTCSA-N 0.000 claims 1
OUBYORNANYUNFV-WJOKGBTCSA-N N-[2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F OUBYORNANYUNFV-WJOKGBTCSA-N 0.000 claims 1
HYIAIAQQZYQCBQ-WJOKGBTCSA-N N-[2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F HYIAIAQQZYQCBQ-WJOKGBTCSA-N 0.000 claims 1
XUWNSJZOJLPJSY-PMERELPUSA-N N-[2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@@H](CCO6)C7=C(C=CC=C7F)F XUWNSJZOJLPJSY-PMERELPUSA-N 0.000 claims 1
WZTOUFIHJKEPIW-WJOKGBTCSA-N N-[2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)OC)OC WZTOUFIHJKEPIW-WJOKGBTCSA-N 0.000 claims 1
SFXPTPAQORMVQV-SSEXGKCCSA-N N-[2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCC(CC6)N(C)C)OC)F SFXPTPAQORMVQV-SSEXGKCCSA-N 0.000 claims 1
AYJPJBWNTYRDBA-JGCGQSQUSA-N N-[2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#C)OC AYJPJBWNTYRDBA-JGCGQSQUSA-N 0.000 claims 1
WKOLVQSJFIWOSB-WJOKGBTCSA-N N-[2-[4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]piperidin-1-yl]-4-methoxy-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC WKOLVQSJFIWOSB-WJOKGBTCSA-N 0.000 claims 1
XSQHSVCQPUQQDI-XMMPIXPASA-N N-[3-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-5-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=CC(=C2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)F)F XSQHSVCQPUQQDI-XMMPIXPASA-N 0.000 claims 1
QEWBVYWEQSSZTF-JOCHJYFZSA-N N-[4-methoxy-2-(2-methylimidazol-1-yl)-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=CN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC=C5)OC QEWBVYWEQSSZTF-JOCHJYFZSA-N 0.000 claims 1
CERBERVOBVLFGD-OAQYLSRUSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)F)F)F)OC CERBERVOBVLFGD-OAQYLSRUSA-N 0.000 claims 1
AMYPSKWRZIAZSA-HSZRJFAPSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C)OC AMYPSKWRZIAZSA-HSZRJFAPSA-N 0.000 claims 1
QXBXBUDZFOGDGU-HSZRJFAPSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)C(F)(F)F)OC QXBXBUDZFOGDGU-HSZRJFAPSA-N 0.000 claims 1
WBZDEMNUMZPFHW-HHHXNRCGSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC6=CC=CC=C65)OC WBZDEMNUMZPFHW-HHHXNRCGSA-N 0.000 claims 1
LMCUKUPAIRXZTP-HHHXNRCGSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC LMCUKUPAIRXZTP-HHHXNRCGSA-N 0.000 claims 1
IQZBVBGKHQWMFD-HXUWFJFHSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3R)-3-thiophen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CS5)OC IQZBVBGKHQWMFD-HXUWFJFHSA-N 0.000 claims 1
KSPGINHHUZTTAV-QHCPKHFHSA-N N-[4-methoxy-2-(4-methylpiperazin-1-yl)-5-[[6-[(3S)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)C5=CC=CC=C5)OC KSPGINHHUZTTAV-QHCPKHFHSA-N 0.000 claims 1
HIDSDLORZROYAQ-RUZDIDTESA-N N-[4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)F)F HIDSDLORZROYAQ-RUZDIDTESA-N 0.000 claims 1
JZSZSXVWMOSZHW-RUZDIDTESA-N N-[4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6F)F)F JZSZSXVWMOSZHW-RUZDIDTESA-N 0.000 claims 1
YNKPAEPLEGXSMZ-HHHXNRCGSA-N N-[4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)C(F)(F)F YNKPAEPLEGXSMZ-HHHXNRCGSA-N 0.000 claims 1
PVHAOXJAENUVSY-WJOKGBTCSA-N N-[4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76 PVHAOXJAENUVSY-WJOKGBTCSA-N 0.000 claims 1
HTGLJRVSUADBKD-WJOKGBTCSA-N N-[4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC7=CC=CC=C7C=C6 HTGLJRVSUADBKD-WJOKGBTCSA-N 0.000 claims 1
JNQKDDGBMOQIRX-HHHXNRCGSA-N N-[4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6 JNQKDDGBMOQIRX-HHHXNRCGSA-N 0.000 claims 1
VFLWJIIGZJJUBB-SLXFGWRHSA-N N-[4-methoxy-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CC2CC1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6)OC VFLWJIIGZJJUBB-SLXFGWRHSA-N 0.000 claims 1
QNLZBUDGKDRAJP-TXTKFYIRSA-N N-[4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6 QNLZBUDGKDRAJP-TXTKFYIRSA-N 0.000 claims 1
QNLZBUDGKDRAJP-SXWKCWPCSA-N N-[4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC=C6 QNLZBUDGKDRAJP-SXWKCWPCSA-N 0.000 claims 1
DUCYROZPLWHQDO-JIPXPUAJSA-N N-[4-methoxy-2-[(2R)-2-methylmorpholin-4-yl]-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCO1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC DUCYROZPLWHQDO-JIPXPUAJSA-N 0.000 claims 1
DUCYROZPLWHQDO-KDYSTLNUSA-N N-[4-methoxy-2-[(2S)-2-methylmorpholin-4-yl]-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC6=CC=CC=C6C=C5)OC DUCYROZPLWHQDO-KDYSTLNUSA-N 0.000 claims 1
LFVKEQAFXPFGJZ-ZEQKJWHPSA-N N-[4-methoxy-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)C(F)(F)F LFVKEQAFXPFGJZ-ZEQKJWHPSA-N 0.000 claims 1
LFVKEQAFXPFGJZ-JYFHCDHNSA-N N-[4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)C(F)(F)F LFVKEQAFXPFGJZ-JYFHCDHNSA-N 0.000 claims 1
PGLZYYLZSQAZJE-JOCHJYFZSA-N N-[4-methoxy-2-[2-methoxyethyl(methyl)amino]-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCOC)OC PGLZYYLZSQAZJE-JOCHJYFZSA-N 0.000 claims 1
HXGRSQBVCDTTAH-AREMUKBSSA-N N-[4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)F)F)OC HXGRSQBVCDTTAH-AREMUKBSSA-N 0.000 claims 1
DELJMVURKYVQLI-MUUNZHRXSA-N N-[4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C)OC DELJMVURKYVQLI-MUUNZHRXSA-N 0.000 claims 1
PZWGCPUUCJIKHB-MUUNZHRXSA-N N-[4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)C(F)(F)F)OC PZWGCPUUCJIKHB-MUUNZHRXSA-N 0.000 claims 1
KRBXMZLXMVZSOH-JGCGQSQUSA-N N-[4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76)OC KRBXMZLXMVZSOH-JGCGQSQUSA-N 0.000 claims 1
MCJRJCLVUWNYAB-JGCGQSQUSA-N N-[4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC7=CC=CC=C7C=C6)OC MCJRJCLVUWNYAB-JGCGQSQUSA-N 0.000 claims 1
MBPJNAQAMVXMCN-MUUNZHRXSA-N N-[4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6F)F)F)OC MBPJNAQAMVXMCN-MUUNZHRXSA-N 0.000 claims 1
YIVSTHVIQQNIDN-IPVFLDMMSA-N N-[4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)F)F)F YIVSTHVIQQNIDN-IPVFLDMMSA-N 0.000 claims 1
XTBXCUFTDXANFZ-IPVFLDMMSA-N N-[4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7F)F)F XTBXCUFTDXANFZ-IPVFLDMMSA-N 0.000 claims 1
YMFSMTIIJZWNPN-INNMJMHTSA-N N-[4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)C(F)(F)F YMFSMTIIJZWNPN-INNMJMHTSA-N 0.000 claims 1
WVJKUOLKLMQMND-TZBSWOFLSA-N N-[4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-thiophen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CS7 WVJKUOLKLMQMND-TZBSWOFLSA-N 0.000 claims 1
AMUSTOULZRWKCO-ZONZVBGPSA-N N-[4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[[4-(trifluoromethyl)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC=C(C=C7)C(F)(F)F AMUSTOULZRWKCO-ZONZVBGPSA-N 0.000 claims 1
XPXOMBPDTKHOMH-WWPJHQMMSA-N N-[4-methoxy-2-[4-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@H]7C[C@@H]6CN7C)OC XPXOMBPDTKHOMH-WWPJHQMMSA-N 0.000 claims 1
YIVSTHVIQQNIDN-ISJBWFOZSA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,4-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)F)F)F YIVSTHVIQQNIDN-ISJBWFOZSA-N 0.000 claims 1
XTBXCUFTDXANFZ-ISJBWFOZSA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7F)F)F XTBXCUFTDXANFZ-ISJBWFOZSA-N 0.000 claims 1
MCJFSIMTJDARCQ-GSDHBNRESA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(pyridin-3-ylmethyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@@H](CCO6)CC7=CN=CC=C7 MCJFSIMTJDARCQ-GSDHBNRESA-N 0.000 claims 1
YMFSMTIIJZWNPN-PNIUZAESSA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-[3-(trifluoromethyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)C(F)(F)F YMFSMTIIJZWNPN-PNIUZAESSA-N 0.000 claims 1
GFNWRQUSVSQKHV-PNIUZAESSA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC=C7 GFNWRQUSVSQKHV-PNIUZAESSA-N 0.000 claims 1
MCJFSIMTJDARCQ-ZNZIZOMTSA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3S)-3-(pyridin-3-ylmethyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CN=CC=C7 MCJFSIMTJDARCQ-ZNZIZOMTSA-N 0.000 claims 1
AMUSTOULZRWKCO-PVHODMMVSA-N N-[4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-5-[[6-[(3S)-3-[[4-(trifluoromethyl)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC=C(C=C7)C(F)(F)F AMUSTOULZRWKCO-PVHODMMVSA-N 0.000 claims 1
OFTPFWSUITZKDV-FQRUVTKNSA-N N-[4-methoxy-2-[4-[(2R)-2-methylmorpholin-4-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6F)F)F)OC OFTPFWSUITZKDV-FQRUVTKNSA-N 0.000 claims 1
BDEAPPNAJGHULV-NLGDKJDOSA-N N-[4-methoxy-2-[4-[(2R)-2-methylmorpholin-4-yl]piperidin-1-yl]-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76)OC BDEAPPNAJGHULV-NLGDKJDOSA-N 0.000 claims 1
OFTPFWSUITZKDV-RXFWQSSRSA-N N-[4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]-5-[[6-[(3R)-3-(2,3,6-trifluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6F)F)F)OC OFTPFWSUITZKDV-RXFWQSSRSA-N 0.000 claims 1
BDEAPPNAJGHULV-ZOYWYXQUSA-N N-[4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76)OC BDEAPPNAJGHULV-ZOYWYXQUSA-N 0.000 claims 1
BFUAXMIANOLMFD-HHHXNRCGSA-N N-[4-methoxy-2-[4-[2-methoxyethyl(methyl)amino]piperidin-1-yl]-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N(C)CCOC)OC BFUAXMIANOLMFD-HHHXNRCGSA-N 0.000 claims 1
ULPKEYBTCPHABZ-HHHXNRCGSA-N N-[4-methoxy-2-[4-[2-methoxyethyl(methyl)amino]piperidin-1-yl]-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound CN(CCOC)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC=C5)OC ULPKEYBTCPHABZ-HHHXNRCGSA-N 0.000 claims 1
PMYVKBSIMXSNCE-JOCHJYFZSA-N N-[4-methoxy-2-morpholin-4-yl-5-[[6-[(3R)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCOCC2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC=C5 PMYVKBSIMXSNCE-JOCHJYFZSA-N 0.000 claims 1
PMYVKBSIMXSNCE-QFIPXVFZSA-N N-[4-methoxy-2-morpholin-4-yl-5-[[6-[(3S)-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCOCC2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)C5=CC=CC=C5 PMYVKBSIMXSNCE-QFIPXVFZSA-N 0.000 claims 1
WVOQQHGQKANKFG-MUUNZHRXSA-N N-[4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=CC=CC(=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCOCC6)OC WVOQQHGQKANKFG-MUUNZHRXSA-N 0.000 claims 1
XPECXIMFZJBVFE-YIXXDRMTSA-N N-[4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=CC=CC(=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CC[C@H](C5)N6CCOCC6)OC XPECXIMFZJBVFE-YIXXDRMTSA-N 0.000 claims 1
NRQJOWBYDNLZHB-GDLZYMKVSA-N N-[4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)OC)OC NRQJOWBYDNLZHB-GDLZYMKVSA-N 0.000 claims 1
XGQRHCQJCYYLSM-WJOKGBTCSA-N N-[4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-propylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CCCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)OC)OC XGQRHCQJCYYLSM-WJOKGBTCSA-N 0.000 claims 1
BGEGHEBBDBZZIQ-NJIBMQBXSA-N N-[4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=CC=CC(=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@@H]7C[C@H]6CO7)OC BGEGHEBBDBZZIQ-NJIBMQBXSA-N 0.000 claims 1
XHHPTMAREYTOSG-WJOKGBTCSA-N N-[4-methoxy-5-[[6-[(3R)-3-(3-methoxyphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=CC=CC(=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7COC7)OC XHHPTMAREYTOSG-WJOKGBTCSA-N 0.000 claims 1
CXORDETVIVUYHL-HHHXNRCGSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCOCC6)OC CXORDETVIVUYHL-HHHXNRCGSA-N 0.000 claims 1
QCBYWRLBNDTDFA-TXTKFYIRSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5C[C@H]6C[C@@H]5CO6)OC QCBYWRLBNDTDFA-TXTKFYIRSA-N 0.000 claims 1
QCBYWRLBNDTDFA-SXWKCWPCSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5C[C@@H]6C[C@H]5CO6)OC QCBYWRLBNDTDFA-SXWKCWPCSA-N 0.000 claims 1
CUZYZTVHBUVPKX-JGCGQSQUSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-morpholin-4-ylpiperidin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCC(CC6)N7CCOCC7)OC CUZYZTVHBUVPKX-JGCGQSQUSA-N 0.000 claims 1
HFNSLNHZZAFXLY-SSEXGKCCSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C(C)C)OC HFNSLNHZZAFXLY-SSEXGKCCSA-N 0.000 claims 1
ZVETWKPWLALEIY-INNMJMHTSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@H]7C[C@@H]6CO7)OC ZVETWKPWLALEIY-INNMJMHTSA-N 0.000 claims 1
ZVETWKPWLALEIY-PNIUZAESSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@@H]7C[C@H]6CO7)OC ZVETWKPWLALEIY-PNIUZAESSA-N 0.000 claims 1
PUHVSSOIWKGTEK-JOCHJYFZSA-N N-[4-methoxy-5-[[6-[(3R)-3-(6-methylpyridin-3-yl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-morpholin-4-ylphenyl]prop-2-enamide Chemical compound CC1=NC=C(C=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC PUHVSSOIWKGTEK-JOCHJYFZSA-N 0.000 claims 1
MZBQLTADXONJIP-WAWDLJLISA-N N-[4-methoxy-5-[[6-[(3R)-3-methyl-3-phenyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@@]1(CCON1C2=NC=NC(=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CCC(CC4)N5C[C@H]6C[C@@H]5CO6)OC)C7=CC=CC=C7 MZBQLTADXONJIP-WAWDLJLISA-N 0.000 claims 1
CLTFGPVUGJGIKK-UUWRZZSWSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76)OC CLTFGPVUGJGIKK-UUWRZZSWSA-N 0.000 claims 1
GVNWWVPNFVAYAE-GDLZYMKVSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC7=CC=CC=C76 GVNWWVPNFVAYAE-GDLZYMKVSA-N 0.000 claims 1
TXGCVGWJXOMLFS-MUIGKXGOSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87 TXGCVGWJXOMLFS-MUIGKXGOSA-N 0.000 claims 1
TXGCVGWJXOMLFS-KWHBQZNLSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87 TXGCVGWJXOMLFS-KWHBQZNLSA-N 0.000 claims 1
YGUNHLWCFKWJGC-UUWRZZSWSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-1-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC8=CC=CC=C87 YGUNHLWCFKWJGC-UUWRZZSWSA-N 0.000 claims 1
YMKMJMDCNYNUBO-UUWRZZSWSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC7=CC=CC=C7C=C6)OC YMKMJMDCNYNUBO-UUWRZZSWSA-N 0.000 claims 1
UZMXTFOQNQMARW-LYVYPOQBSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC8=CC=CC=C8C=C7 UZMXTFOQNQMARW-LYVYPOQBSA-N 0.000 claims 1
VGFJPYHYWVQLDG-UUWRZZSWSA-N N-[4-methoxy-5-[[6-[(3R)-3-naphthalen-2-yl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC8=CC=CC=C8C=C7 VGFJPYHYWVQLDG-UUWRZZSWSA-N 0.000 claims 1
FLFNUHONKNMFKT-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC FLFNUHONKNMFKT-HSZRJFAPSA-N 0.000 claims 1
KFGQNIYKICLLDM-KHCICDEESA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC KFGQNIYKICLLDM-KHCICDEESA-N 0.000 claims 1
KFGQNIYKICLLDM-AXHZCLLHSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC KFGQNIYKICLLDM-AXHZCLLHSA-N 0.000 claims 1
FVQAAGQEPNSQPS-WZONZLPQSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC FVQAAGQEPNSQPS-WZONZLPQSA-N 0.000 claims 1
ZILFTYRZYTWXQK-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC ZILFTYRZYTWXQK-MUUNZHRXSA-N 0.000 claims 1
CCIBIMMZRBXONA-NDIVSWGXSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)Cl)OC CCIBIMMZRBXONA-NDIVSWGXSA-N 0.000 claims 1
UFSGMFJOTABFGG-QDPGVEIFSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC UFSGMFJOTABFGG-QDPGVEIFSA-N 0.000 claims 1
CDYOOLXETJRXDK-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl-methylamino]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC CDYOOLXETJRXDK-HHHXNRCGSA-N 0.000 claims 1
DNTDLIWUBAXKNG-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC DNTDLIWUBAXKNG-RUZDIDTESA-N 0.000 claims 1
QIMYVDSKCCMZSW-OAQYLSRUSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylimidazol-1-yl)phenyl]prop-2-enamide Chemical compound CC1=CN(C=N1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC QIMYVDSKCCMZSW-OAQYLSRUSA-N 0.000 claims 1
JJLZZYDGZPBGON-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl)OC JJLZZYDGZPBGON-JOCHJYFZSA-N 0.000 claims 1
PNZHRDVZMLVXRU-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl PNZHRDVZMLVXRU-AREMUKBSSA-N 0.000 claims 1
HJISQYZXAQLUFV-DRSNIGMVSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl HJISQYZXAQLUFV-DRSNIGMVSA-N 0.000 claims 1
HJISQYZXAQLUFV-PNLZDCPESA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl HJISQYZXAQLUFV-PNLZDCPESA-N 0.000 claims 1
PJMXBIZOVUHZTI-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCC(CC1)N2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC PJMXBIZOVUHZTI-HHHXNRCGSA-N 0.000 claims 1
YAULKRJNFUSJKB-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC YAULKRJNFUSJKB-HHHXNRCGSA-N 0.000 claims 1
YCGIWJJGNKDFCS-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-morpholin-4-ylpiperidin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC(CC3)N4CCOCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)Cl YCGIWJJGNKDFCS-WJOKGBTCSA-N 0.000 claims 1
GNDYDXZMXSCAKU-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl)OC GNDYDXZMXSCAKU-GDLZYMKVSA-N 0.000 claims 1
DGRSRVIFUYDYSM-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxan-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl DGRSRVIFUYDYSM-AREMUKBSSA-N 0.000 claims 1
MCCBTTWYOIVLGN-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)Cl MCCBTTWYOIVLGN-XMMPIXPASA-N 0.000 claims 1
MLZRTDXLSMAOIY-JGCGQSQUSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCC(CC1)N2CCN(CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)Cl)OC MLZRTDXLSMAOIY-JGCGQSQUSA-N 0.000 claims 1
YCBZTURTLMNGNN-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxan-4-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCOCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)Cl YCBZTURTLMNGNN-WJOKGBTCSA-N 0.000 claims 1
KJWOANFLGTZPSL-OAQYLSRUSA-N N-[5-[[6-[(3R)-3-(2,3-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCOCC2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)Cl KJWOANFLGTZPSL-OAQYLSRUSA-N 0.000 claims 1
FJOFIMAZPYVHTL-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC FJOFIMAZPYVHTL-HSZRJFAPSA-N 0.000 claims 1
NLAFHTPURBQRID-WZONZLPQSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(2R)-2,4-dimethylpiperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC)C NLAFHTPURBQRID-WZONZLPQSA-N 0.000 claims 1
NLAFHTPURBQRID-FDDCHVKYSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(2S)-2,4-dimethylpiperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC)C NLAFHTPURBQRID-FDDCHVKYSA-N 0.000 claims 1
HPAOUAXAXQUOFB-WZONZLPQSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC HPAOUAXAXQUOFB-WZONZLPQSA-N 0.000 claims 1
REOZGZOEGZIRHB-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=C(C(=CC=C4)F)F)OC REOZGZOEGZIRHB-JOCHJYFZSA-N 0.000 claims 1
YIGONJDGNYMHQD-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC YIGONJDGNYMHQD-MUUNZHRXSA-N 0.000 claims 1
PVMWNOQPCNEISE-RBISFHTESA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3,4-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC PVMWNOQPCNEISE-RBISFHTESA-N 0.000 claims 1
ATNSAQXBLBCLPQ-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC ATNSAQXBLBCLPQ-JOCHJYFZSA-N 0.000 claims 1
PABVOCFEWMRKNP-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F PABVOCFEWMRKNP-AREMUKBSSA-N 0.000 claims 1
AVEWBZICVVVSHX-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-propan-2-ylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC AVEWBZICVVVSHX-XMMPIXPASA-N 0.000 claims 1
CSUQIBYOCHWSCN-HTAPYJJXSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(2S)-2-methylmorpholin-4-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)F)OC CSUQIBYOCHWSCN-HTAPYJJXSA-N 0.000 claims 1
WWKJUCUTNOLMNQ-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC WWKJUCUTNOLMNQ-HHHXNRCGSA-N 0.000 claims 1
OPFFRANAIZGERZ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CCCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)F)OC OPFFRANAIZGERZ-GDLZYMKVSA-N 0.000 claims 1
AAJDHNKPWRZPNH-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2,3-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)F AAJDHNKPWRZPNH-GDLZYMKVSA-N 0.000 claims 1
PIUZJKNERPHXKP-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC PIUZJKNERPHXKP-XMMPIXPASA-N 0.000 claims 1
PKLKYJHJFOKUGR-UMEGOILYSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC PKLKYJHJFOKUGR-UMEGOILYSA-N 0.000 claims 1
PKLKYJHJFOKUGR-ZYLNGJIFSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC PKLKYJHJFOKUGR-ZYLNGJIFSA-N 0.000 claims 1
JRSRYNXCTWRYBR-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC JRSRYNXCTWRYBR-NTKDMRAZSA-N 0.000 claims 1
ZXMXFBZHSYFKPC-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=C(C=C(C=C4)F)F)OC ZXMXFBZHSYFKPC-HSZRJFAPSA-N 0.000 claims 1
RHOQBHBELKAOFZ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC RHOQBHBELKAOFZ-GDLZYMKVSA-N 0.000 claims 1
HFPGNAYESWXTRU-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC HFPGNAYESWXTRU-RUZDIDTESA-N 0.000 claims 1
GMCSJSPJCSQJEZ-OYPUMOIUSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F)OC GMCSJSPJCSQJEZ-OYPUMOIUSA-N 0.000 claims 1
GMCSJSPJCSQJEZ-SAGWHXFDSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F)OC GMCSJSPJCSQJEZ-SAGWHXFDSA-N 0.000 claims 1
ZMXSCLVTQLWYPC-FUFSCUOVSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC ZMXSCLVTQLWYPC-FUFSCUOVSA-N 0.000 claims 1
ZOJKCWNJFQYLBI-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl-methylamino]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC ZOJKCWNJFQYLBI-MUUNZHRXSA-N 0.000 claims 1
CVKITJUZPHJFDE-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC CVKITJUZPHJFDE-AREMUKBSSA-N 0.000 claims 1
AVVCQNGVFHRRCS-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC AVVCQNGVFHRRCS-SSEXGKCCSA-N 0.000 claims 1
GKKKILNJLDDKMT-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC GKKKILNJLDDKMT-WJOKGBTCSA-N 0.000 claims 1
HWAZBMRLBVZJDE-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylimidazol-1-yl)phenyl]prop-2-enamide Chemical compound CC1=CN(C=N1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC HWAZBMRLBVZJDE-JOCHJYFZSA-N 0.000 claims 1
XWZXDNURXCUVMC-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC XWZXDNURXCUVMC-HSZRJFAPSA-N 0.000 claims 1
HVSTYIUEZYYQPD-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F HVSTYIUEZYYQPD-HHHXNRCGSA-N 0.000 claims 1
UPIKXRSOZHWQSH-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-propan-2-ylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC UPIKXRSOZHWQSH-RUZDIDTESA-N 0.000 claims 1
GJZBVZQQCSFNNH-PMAPCBKXSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F GJZBVZQQCSFNNH-PMAPCBKXSA-N 0.000 claims 1
GJZBVZQQCSFNNH-IUKKYPGJSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F GJZBVZQQCSFNNH-IUKKYPGJSA-N 0.000 claims 1
GRQDECWKWGUUGJ-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCC(CC1)N2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC GRQDECWKWGUUGJ-MUUNZHRXSA-N 0.000 claims 1
KWYLSTKYWIVPQK-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F)OC KWYLSTKYWIVPQK-MUUNZHRXSA-N 0.000 claims 1
KDABGDVENIQHJH-JGCGQSQUSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-morpholin-4-ylpiperidin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC(CC3)N4CCOCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F KDABGDVENIQHJH-JGCGQSQUSA-N 0.000 claims 1
KGEDPOVUPMPMMB-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxan-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F KGEDPOVUPMPMMB-HHHXNRCGSA-N 0.000 claims 1
UQAJDLPXGNSDFX-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)F)F UQAJDLPXGNSDFX-RUZDIDTESA-N 0.000 claims 1
GTURQQQYXVWFOX-NDDXJGTKSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1C[C@H]2C[C@@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F)OC GTURQQQYXVWFOX-NDDXJGTKSA-N 0.000 claims 1
BUWTVMCMZDHMLM-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[2-methoxyethyl(methyl)amino]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN(CCOC)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)F)F)OC BUWTVMCMZDHMLM-HHHXNRCGSA-N 0.000 claims 1
ZLULYVFDYORAMF-MGBGTMOVSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCC(CC1)N2CCN(CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F)OC ZLULYVFDYORAMF-MGBGTMOVSA-N 0.000 claims 1
LMMJWYVDRKBHNG-MGBGTMOVSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F)OC LMMJWYVDRKBHNG-MGBGTMOVSA-N 0.000 claims 1
PMTDZCJOPPJAGW-JGCGQSQUSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxan-4-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCOCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F PMTDZCJOPPJAGW-JGCGQSQUSA-N 0.000 claims 1
NPBUNVHQNROFSS-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)F)F NPBUNVHQNROFSS-SSEXGKCCSA-N 0.000 claims 1
NSLSIITYQKSSGO-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC NSLSIITYQKSSGO-XMMPIXPASA-N 0.000 claims 1
NGDDQVVCIZCJLU-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC NGDDQVVCIZCJLU-NTKDMRAZSA-N 0.000 claims 1
GDDITPUTRHCIPS-BVFVYWQFSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3S,5R)-4-ethyl-3,5-dimethylpiperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1[C@@H](CN(C[C@@H]1C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC)C GDDITPUTRHCIPS-BVFVYWQFSA-N 0.000 claims 1
WDQAECYRBBNHKQ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC WDQAECYRBBNHKQ-GDLZYMKVSA-N 0.000 claims 1
UCDFPDUSOVEAKS-UETOGOEVSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC UCDFPDUSOVEAKS-UETOGOEVSA-N 0.000 claims 1
MOUUNQJJTXGWSR-KPURRNSFSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3,4-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC MOUUNQJJTXGWSR-KPURRNSFSA-N 0.000 claims 1
CXVNKWOGDBZUGF-FUFSCUOVSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC CXVNKWOGDBZUGF-FUFSCUOVSA-N 0.000 claims 1
MOUUNQJJTXGWSR-PZGXJGMVSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3,4-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC MOUUNQJJTXGWSR-PZGXJGMVSA-N 0.000 claims 1
SBODRVRMHVGJRT-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC SBODRVRMHVGJRT-SSEXGKCCSA-N 0.000 claims 1
SXKYRFLETOHZED-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F SXKYRFLETOHZED-HHHXNRCGSA-N 0.000 claims 1
HUEMBWGPQDGWHG-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-propylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CCCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=CC(=C5)F)F)OC HUEMBWGPQDGWHG-RUZDIDTESA-N 0.000 claims 1
WISBCMMEVYROKX-PMAPCBKXSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F WISBCMMEVYROKX-PMAPCBKXSA-N 0.000 claims 1
WISBCMMEVYROKX-IUKKYPGJSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F WISBCMMEVYROKX-IUKKYPGJSA-N 0.000 claims 1
OGBGDDYFVPADPM-HFZDXXHNSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F OGBGDDYFVPADPM-HFZDXXHNSA-N 0.000 claims 1
YQBLYKNYLZDBLZ-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC YQBLYKNYLZDBLZ-MUUNZHRXSA-N 0.000 claims 1
FSZGRVIAWNCALO-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC FSZGRVIAWNCALO-SSEXGKCCSA-N 0.000 claims 1
VVCVIKHIKPQCHM-UMVVBEGXSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CC2CC1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F)OC VVCVIKHIKPQCHM-UMVVBEGXSA-N 0.000 claims 1
FCRRBZYPBAXDNY-UMVVBEGXSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CC4CCC(C3)O4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7)F)F FCRRBZYPBAXDNY-UMVVBEGXSA-N 0.000 claims 1
VYQLTOHLSOPDHQ-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F VYQLTOHLSOPDHQ-RUZDIDTESA-N 0.000 claims 1
ZYCSDWUMGBRJPP-LYZGTLIUSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2R)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC ZYCSDWUMGBRJPP-LYZGTLIUSA-N 0.000 claims 1
ZYCSDWUMGBRJPP-RBTNQOKQSA-N N-[5-[[6-[(3R)-3-(2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6)F)F)OC ZYCSDWUMGBRJPP-RBTNQOKQSA-N 0.000 claims 1
IPQAAHYNJGTFKD-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(2-chloro-3,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-cyclopropylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=CC(=C6Cl)F)F IPQAAHYNJGTFKD-HSZRJFAPSA-N 0.000 claims 1
IDSNWEGIKQUFFX-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2-chloro-3,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7Cl)F)F IDSNWEGIKQUFFX-MUUNZHRXSA-N 0.000 claims 1
HTPXNVLKSNQSSQ-KPURRNSFSA-N N-[5-[[6-[(3R)-3-(2-chloro-3,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7Cl)F)F)OC HTPXNVLKSNQSSQ-KPURRNSFSA-N 0.000 claims 1
HTPXNVLKSNQSSQ-PZGXJGMVSA-N N-[5-[[6-[(3R)-3-(2-chloro-3,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=CC(=C7Cl)F)F)OC HTPXNVLKSNQSSQ-PZGXJGMVSA-N 0.000 claims 1
MTTNDAZZUWPSSR-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)Cl)OC MTTNDAZZUWPSSR-HSZRJFAPSA-N 0.000 claims 1
HNFKADYCMBHJOG-WZONZLPQSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)Cl)OC HNFKADYCMBHJOG-WZONZLPQSA-N 0.000 claims 1
GAOGHCSQBGCRDP-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)Cl GAOGHCSQBGCRDP-SSEXGKCCSA-N 0.000 claims 1
FEMHZRHQOYGUFW-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)Cl)OC FEMHZRHQOYGUFW-MUUNZHRXSA-N 0.000 claims 1
MIQYFPCGOKCMCG-FJGWTWLBSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CC4CCC(C3)N4C5CC5)NC(=O)C=C)NC6=CC(=NC=N6)N7[C@H](CCO7)C8=C(C(=CC=C8)F)Cl MIQYFPCGOKCMCG-FJGWTWLBSA-N 0.000 claims 1
ZZUWTOINTDRLOF-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)Cl)OC ZZUWTOINTDRLOF-XMMPIXPASA-N 0.000 claims 1
LREXLVGMRPUXQU-YUDQIZAISA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)Cl)OC)C7CC7 LREXLVGMRPUXQU-YUDQIZAISA-N 0.000 claims 1
HAHXSEYOEANNDP-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)F)Cl)OC HAHXSEYOEANNDP-JOCHJYFZSA-N 0.000 claims 1
IODQWEKHUAVQFL-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)Cl IODQWEKHUAVQFL-AREMUKBSSA-N 0.000 claims 1
BRSRBMJCDVJSEO-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)Cl)OC BRSRBMJCDVJSEO-HHHXNRCGSA-N 0.000 claims 1
ONORDCUKBMZSQR-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)F)Cl)OC ONORDCUKBMZSQR-GDLZYMKVSA-N 0.000 claims 1
VNTURBYRHGPZDG-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(2-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)F)Cl VNTURBYRHGPZDG-GDLZYMKVSA-N 0.000 claims 1
BRPWCAYKPNMDQS-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCOCC6)OC)F BRPWCAYKPNMDQS-HHHXNRCGSA-N 0.000 claims 1
JZHRXDMWOGLIDG-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[2-methoxyethyl(methyl)amino]phenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCOC)OC)F JZHRXDMWOGLIDG-JOCHJYFZSA-N 0.000 claims 1
WERMVBJWJLRATF-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(2-fluoro-3-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=C(C(=CC=C1)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C6COC6)OC)F WERMVBJWJLRATF-RUZDIDTESA-N 0.000 claims 1
FDXNVLYLARXINJ-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)Cl)Cl)F)OC FDXNVLYLARXINJ-JOCHJYFZSA-N 0.000 claims 1
HIXHFNPFZUORHM-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC HIXHFNPFZUORHM-HHHXNRCGSA-N 0.000 claims 1
WRSIOXGJHQASRG-PBDKAQRYSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC WRSIOXGJHQASRG-PBDKAQRYSA-N 0.000 claims 1
JUNLITOUCBJHPB-AJTFRIOCSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC JUNLITOUCBJHPB-AJTFRIOCSA-N 0.000 claims 1
JUNLITOUCBJHPB-WXVAWEFUSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC JUNLITOUCBJHPB-WXVAWEFUSA-N 0.000 claims 1
UDDBJKAJSVDTFD-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC UDDBJKAJSVDTFD-MUUNZHRXSA-N 0.000 claims 1
RKVHTEOIDRFCAP-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F RKVHTEOIDRFCAP-RUZDIDTESA-N 0.000 claims 1
OBEWXULIMPNKGJ-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F OBEWXULIMPNKGJ-NTKDMRAZSA-N 0.000 claims 1
OBEWXULIMPNKGJ-YADARESESA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F OBEWXULIMPNKGJ-YADARESESA-N 0.000 claims 1
YBOFBCIDXVKMBJ-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC YBOFBCIDXVKMBJ-AREMUKBSSA-N 0.000 claims 1
ABEHSRLFDJHCAN-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F)OC ABEHSRLFDJHCAN-MUUNZHRXSA-N 0.000 claims 1
UIHKQGHIFLBYLN-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)Cl)Cl)F UIHKQGHIFLBYLN-HSZRJFAPSA-N 0.000 claims 1
PDKRXHNDAMZZKI-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3,4-dichloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)Cl)Cl)F PDKRXHNDAMZZKI-MUUNZHRXSA-N 0.000 claims 1
IDQGKWDCXZLODD-UMEGOILYSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl)OC IDQGKWDCXZLODD-UMEGOILYSA-N 0.000 claims 1
IDQGKWDCXZLODD-ZYLNGJIFSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl)OC IDQGKWDCXZLODD-ZYLNGJIFSA-N 0.000 claims 1
WJXGCSPOGDANCP-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)Cl)OC WJXGCSPOGDANCP-NTKDMRAZSA-N 0.000 claims 1
NFXDSHMEBCJMFM-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=C(C=C4)Cl)Cl)OC NFXDSHMEBCJMFM-HSZRJFAPSA-N 0.000 claims 1
GVELGXKKXURVKC-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)Cl)OC GVELGXKKXURVKC-AREMUKBSSA-N 0.000 claims 1
BUHUVHHIXQHGCE-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-propan-2-ylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)Cl)OC BUHUVHHIXQHGCE-RUZDIDTESA-N 0.000 claims 1
FFTNQBMWOBYFAS-PMAPCBKXSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl FFTNQBMWOBYFAS-PMAPCBKXSA-N 0.000 claims 1
ILKQIGRYHOVUCE-KHCICDEESA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]prop-2-enamide Chemical compound CN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl)OC ILKQIGRYHOVUCE-KHCICDEESA-N 0.000 claims 1
FFTNQBMWOBYFAS-IUKKYPGJSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl FFTNQBMWOBYFAS-IUKKYPGJSA-N 0.000 claims 1
ILKQIGRYHOVUCE-AXHZCLLHSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]prop-2-enamide Chemical compound CN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl)OC ILKQIGRYHOVUCE-AXHZCLLHSA-N 0.000 claims 1
SOASRBDVYGFVRS-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[2-methoxyethyl(methyl)amino]phenyl]prop-2-enamide Chemical compound CN(CCOC)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=C(C=C4)Cl)Cl)OC SOASRBDVYGFVRS-JOCHJYFZSA-N 0.000 claims 1
IVWAXBHOVSKKPN-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl)OC IVWAXBHOVSKKPN-MUUNZHRXSA-N 0.000 claims 1
OSCQULIFIHFTCQ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)Cl)OC OSCQULIFIHFTCQ-SSEXGKCCSA-N 0.000 claims 1
PXBAIDOHVJHTJB-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,4-dichlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)Cl)Cl PXBAIDOHVJHTJB-SSEXGKCCSA-N 0.000 claims 1
TTYONILBMVZWEP-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)F)OC TTYONILBMVZWEP-XMMPIXPASA-N 0.000 claims 1
RZOFICRDXKVWHJ-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)F)OC RZOFICRDXKVWHJ-NTKDMRAZSA-N 0.000 claims 1
WHLWAMYAXLSGHE-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC WHLWAMYAXLSGHE-GDLZYMKVSA-N 0.000 claims 1
BWQVTPOWQKALCA-FUFSCUOVSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC BWQVTPOWQKALCA-FUFSCUOVSA-N 0.000 claims 1
BWQVTPOWQKALCA-PWUYWRBVSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC BWQVTPOWQKALCA-PWUYWRBVSA-N 0.000 claims 1
SVVUBVWYBGZLNQ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC SVVUBVWYBGZLNQ-SSEXGKCCSA-N 0.000 claims 1
GXYCYFZHCRSWKW-RGELYXPASA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(3-methyl-3,6-diazabicyclo[3.1.1]heptan-6-yl)phenyl]prop-2-enamide Chemical compound CN1CC2CC(C1)N2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC GXYCYFZHCRSWKW-RGELYXPASA-N 0.000 claims 1
FEFBLOLPQJYEIT-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F FEFBLOLPQJYEIT-HHHXNRCGSA-N 0.000 claims 1
QOFCUKNZDDOIMY-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC QOFCUKNZDDOIMY-SSEXGKCCSA-N 0.000 claims 1
JMZVXGUEHONQHJ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CCCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)F)OC JMZVXGUEHONQHJ-SSEXGKCCSA-N 0.000 claims 1
PYRDCJNOBSTABG-MHECFPHRSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(2S)-2,4-dimethylpiperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)F)F)OC)C PYRDCJNOBSTABG-MHECFPHRSA-N 0.000 claims 1
QFBZLRLYGDZFSI-HOYKHHGWSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3,4-dimethylpiperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)F)F)OC QFBZLRLYGDZFSI-HOYKHHGWSA-N 0.000 claims 1
LCIMSQBAUFFSLT-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC(=C4)F)F)OC LCIMSQBAUFFSLT-HSZRJFAPSA-N 0.000 claims 1
MNIJCXMOTBTTLA-YCVRVPNXSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC MNIJCXMOTBTTLA-YCVRVPNXSA-N 0.000 claims 1
MNIJCXMOTBTTLA-FEVNIDIWSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC MNIJCXMOTBTTLA-FEVNIDIWSA-N 0.000 claims 1
DWBHIPODLVQPAT-UETOGOEVSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC DWBHIPODLVQPAT-UETOGOEVSA-N 0.000 claims 1
DWBHIPODLVQPAT-IHMCZWCLSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC DWBHIPODLVQPAT-IHMCZWCLSA-N 0.000 claims 1
MDMSOOHADCFFMQ-ULPIOCOXSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R,5S)-4-ethyl-3,5-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1[C@@H](CN(C[C@@H]1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC)C MDMSOOHADCFFMQ-ULPIOCOXSA-N 0.000 claims 1
HIRWJLMQMSLEKT-YUDQIZAISA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-[(dimethylamino)methyl]pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC HIRWJLMQMSLEKT-YUDQIZAISA-N 0.000 claims 1
HDZHKULAQZEOSQ-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl-methylamino]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)F)F)OC HDZHKULAQZEOSQ-MUUNZHRXSA-N 0.000 claims 1
NTNJJCYERPLQOG-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[3-(dimethylamino)azetidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC NTNJJCYERPLQOG-MUUNZHRXSA-N 0.000 claims 1
CSKCUVPIXJCILM-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC CSKCUVPIXJCILM-WJOKGBTCSA-N 0.000 claims 1
HICDXPAYHXWQDB-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(3-methoxy-3-methylbutoxy)phenyl]prop-2-enamide Chemical compound CC(C)(CCOC1=C(C=C(C(=C1)OC)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC(=C4)F)F)NC(=O)C=C)OC HICDXPAYHXWQDB-HSZRJFAPSA-N 0.000 claims 1
KUGYBAWIJOGBFP-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-piperazin-1-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCNCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F KUGYBAWIJOGBFP-HHHXNRCGSA-N 0.000 claims 1
ACVMXYUUBLVFDP-SXWKCWPCSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F ACVMXYUUBLVFDP-SXWKCWPCSA-N 0.000 claims 1
CBQWAQNXULTYOI-ZEQKJWHPSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F CBQWAQNXULTYOI-ZEQKJWHPSA-N 0.000 claims 1
ZKMNRZLRAASXIA-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CC4(C3)COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F ZKMNRZLRAASXIA-HHHXNRCGSA-N 0.000 claims 1
BWUQIFISWRLMMN-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methyl-2-oxopiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(C(=O)C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC BWUQIFISWRLMMN-HHHXNRCGSA-N 0.000 claims 1
PMGIDOBSPBDBFP-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methyl-3-oxopiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1=O)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC PMGIDOBSPBDBFP-HHHXNRCGSA-N 0.000 claims 1
LJCVEDDZACABAJ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC LJCVEDDZACABAJ-SSEXGKCCSA-N 0.000 claims 1
VXAPGHKCGOYHKE-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F VXAPGHKCGOYHKE-RUZDIDTESA-N 0.000 claims 1
QQRBPPOXYMUALI-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1-propan-2-ylpiperidin-4-yl)amino]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCC(CC1)NC2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)F)F)OC QQRBPPOXYMUALI-WJOKGBTCSA-N 0.000 claims 1
NXEGBZSAJIGQJM-QXTIUPHPSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1C[C@@H]2C[C@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F)OC NXEGBZSAJIGQJM-QXTIUPHPSA-N 0.000 claims 1
FIMYTTXKETUWSH-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)F)F FIMYTTXKETUWSH-SSEXGKCCSA-N 0.000 claims 1
PHWLWUVFQHDREL-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCOCC2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)F)F PHWLWUVFQHDREL-JOCHJYFZSA-N 0.000 claims 1
RCQFELLYJVTWQW-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)F)Cl)F)OC RCQFELLYJVTWQW-JOCHJYFZSA-N 0.000 claims 1
DBIZBHYXJHXLPJ-HYFFOGBASA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)F)Cl)F)OC DBIZBHYXJHXLPJ-HYFFOGBASA-N 0.000 claims 1
RJEDXGGUTYPQHP-HTAPYJJXSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)F)Cl)F)OC RJEDXGGUTYPQHP-HTAPYJJXSA-N 0.000 claims 1
DFEBIYSBZIASRF-OAQYLSRUSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=C(C(=C(C=C4)F)Cl)F)OC DFEBIYSBZIASRF-OAQYLSRUSA-N 0.000 claims 1
AXNRHAMKKKPFNH-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)F)Cl)F AXNRHAMKKKPFNH-GDLZYMKVSA-N 0.000 claims 1
LBGCDYUQOSSXLE-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=C(C=C7)F)Cl)F LBGCDYUQOSSXLE-MUUNZHRXSA-N 0.000 claims 1
NGRWZYXUTXIJBF-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)Cl)F)OC NGRWZYXUTXIJBF-HHHXNRCGSA-N 0.000 claims 1
SCMHDHOMKGDXTM-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=C(C=C5)F)Cl)F)OC SCMHDHOMKGDXTM-HSZRJFAPSA-N 0.000 claims 1
RZRJXJWZWDIXED-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)Cl)F RZRJXJWZWDIXED-RUZDIDTESA-N 0.000 claims 1
UOZHVWNIYIPKQQ-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)Cl)F)OC UOZHVWNIYIPKQQ-AREMUKBSSA-N 0.000 claims 1
TWHYANQNJKOYLQ-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,4-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=C(C=C6)F)Cl)F)OC TWHYANQNJKOYLQ-MUUNZHRXSA-N 0.000 claims 1
VBASAVXCBCFUIS-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2,5-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC(=C7)F)Cl)F VBASAVXCBCFUIS-GDLZYMKVSA-N 0.000 claims 1
PUBBEXNHZFDKRV-WZONZLPQSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)F)OC PUBBEXNHZFDKRV-WZONZLPQSA-N 0.000 claims 1
AXBFTEQDKJJEPW-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F AXBFTEQDKJJEPW-SSEXGKCCSA-N 0.000 claims 1
JUGKJLVYJBHCJK-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopentylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F JUGKJLVYJBHCJK-WJOKGBTCSA-N 0.000 claims 1
NEQUGRGADKYOPQ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropyl-1,4-diazepan-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F NEQUGRGADKYOPQ-SSEXGKCCSA-N 0.000 claims 1
UPBDLVNSVISLTD-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC UPBDLVNSVISLTD-MUUNZHRXSA-N 0.000 claims 1
QIEHYEKQWFAYRT-YUDQIZAISA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC)C7CC7 QIEHYEKQWFAYRT-YUDQIZAISA-N 0.000 claims 1
UUIOYSWDRGWKSN-ISTJGCCRSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S,5S)-4-cyclopropyl-2,5-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN([C@H](CN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC)C)C7CC7 UUIOYSWDRGWKSN-ISTJGCCRSA-N 0.000 claims 1
OMAMPXGDHCQIBH-QDPGVEIFSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC OMAMPXGDHCQIBH-QDPGVEIFSA-N 0.000 claims 1
MZZYLPILZNYZBN-WVXBCFDCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F)OC MZZYLPILZNYZBN-WVXBCFDCSA-N 0.000 claims 1
OMAMPXGDHCQIBH-NEKDWFFYSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC OMAMPXGDHCQIBH-NEKDWFFYSA-N 0.000 claims 1
WCVMMNHNLLRZNH-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F WCVMMNHNLLRZNH-SSEXGKCCSA-N 0.000 claims 1
MHKCNWURISXESZ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC MHKCNWURISXESZ-GDLZYMKVSA-N 0.000 claims 1
BGMGLYPWCFUYQS-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)F)OC BGMGLYPWCFUYQS-JOCHJYFZSA-N 0.000 claims 1
LDOQNBYSLUMMGO-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC LDOQNBYSLUMMGO-HHHXNRCGSA-N 0.000 claims 1
BKGKPHHYTWDNEH-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC BKGKPHHYTWDNEH-GDLZYMKVSA-N 0.000 claims 1
PJJNVGJTZXYTFB-KDYSTLNUSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)F)OC PJJNVGJTZXYTFB-KDYSTLNUSA-N 0.000 claims 1
REKBSRIIOIHYLJ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)F REKBSRIIOIHYLJ-GDLZYMKVSA-N 0.000 claims 1
LVYKMEPRFKIGKK-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C(=CC=C5)Cl)C)OC LVYKMEPRFKIGKK-RUZDIDTESA-N 0.000 claims 1
HSFHYNDGUCKMPX-CJFMBICVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CC[C@H](C5)N(C)C)OC HSFHYNDGUCKMPX-CJFMBICVSA-N 0.000 claims 1
BXXNLEUZNGHKNY-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC BXXNLEUZNGHKNY-XMMPIXPASA-N 0.000 claims 1
WDPDQNYADSYGDH-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4,4-difluoropiperidin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCC(CC6)(F)F)OC WDPDQNYADSYGDH-MUUNZHRXSA-N 0.000 claims 1
ZRQWMRGUDISSGG-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C7CC7)OC ZRQWMRGUDISSGG-WJOKGBTCSA-N 0.000 claims 1
YTAABZYNRXEITL-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)C)OC YTAABZYNRXEITL-SSEXGKCCSA-N 0.000 claims 1
PACVLDBOWZYDOZ-YXOJATPKSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CC7CCC(C6)N7C8CC8)OC PACVLDBOWZYDOZ-YXOJATPKSA-N 0.000 claims 1
MBGMCQYWRNHYES-DUELTEGESA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)C)OC MBGMCQYWRNHYES-DUELTEGESA-N 0.000 claims 1
OZLBIUUKMBCSKU-GPNASLBKSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)C)OC OZLBIUUKMBCSKU-GPNASLBKSA-N 0.000 claims 1
OZLBIUUKMBCSKU-NRUKRWIHSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C(=CC=C7)Cl)C)OC OZLBIUUKMBCSKU-NRUKRWIHSA-N 0.000 claims 1
AURYXDVOOMAZQR-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C)OC AURYXDVOOMAZQR-XMMPIXPASA-N 0.000 claims 1
ZHQQPKFTYLUWTB-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6CCN(CC6)C)OC ZHQQPKFTYLUWTB-GDLZYMKVSA-N 0.000 claims 1
QGIUBZVNLBYMGM-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CCCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)C)OC QGIUBZVNLBYMGM-WJOKGBTCSA-N 0.000 claims 1
KDTMRUWVSAATIA-KPURRNSFSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2R)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)C)OC KDTMRUWVSAATIA-KPURRNSFSA-N 0.000 claims 1
KDTMRUWVSAATIA-PZGXJGMVSA-N N-[5-[[6-[(3R)-3-(3-chloro-2-methylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C(=CC=C6)Cl)C)OC KDTMRUWVSAATIA-PZGXJGMVSA-N 0.000 claims 1
GBBUTADSNBMWJI-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)Cl)OC GBBUTADSNBMWJI-XMMPIXPASA-N 0.000 claims 1
WANXBVPQYIADMA-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)Cl)OC WANXBVPQYIADMA-NTKDMRAZSA-N 0.000 claims 1
IQTAHIABRXBEHR-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=C(C=C4)F)Cl)OC IQTAHIABRXBEHR-HSZRJFAPSA-N 0.000 claims 1
JKJBINDCKYMAMO-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl JKJBINDCKYMAMO-WJOKGBTCSA-N 0.000 claims 1
AVBLLOZDDHXWGQ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl AVBLLOZDDHXWGQ-SSEXGKCCSA-N 0.000 claims 1
QCLLHSZJRLGWHR-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)Cl)OC QCLLHSZJRLGWHR-RUZDIDTESA-N 0.000 claims 1
QEWGMWGUMDRHFB-UETOGOEVSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC QEWGMWGUMDRHFB-UETOGOEVSA-N 0.000 claims 1
LDVGTOCOXBDDQK-FUFSCUOVSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC LDVGTOCOXBDDQK-FUFSCUOVSA-N 0.000 claims 1
ZIQZJSDQKBROKR-ULPIOCOXSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R,5S)-4-ethyl-3,5-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1[C@@H](CN(C[C@@H]1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC)C ZIQZJSDQKBROKR-ULPIOCOXSA-N 0.000 claims 1
DMSMFXJYHGKNQN-PZGXJGMVSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3,4-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC DMSMFXJYHGKNQN-PZGXJGMVSA-N 0.000 claims 1
LDVGTOCOXBDDQK-PWUYWRBVSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC LDVGTOCOXBDDQK-PWUYWRBVSA-N 0.000 claims 1
APBDXXLVKHMNIQ-GTYOFVGBSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl)OC APBDXXLVKHMNIQ-GTYOFVGBSA-N 0.000 claims 1
XOBJQCZCXABQLK-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(cyclopropylmethyl)piperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)CC4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)F)Cl XOBJQCZCXABQLK-WJOKGBTCSA-N 0.000 claims 1
BQAGEWLIWWYQMZ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC BQAGEWLIWWYQMZ-SSEXGKCCSA-N 0.000 claims 1
NFDLANXQQNPRRF-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl NFDLANXQQNPRRF-HHHXNRCGSA-N 0.000 claims 1
UMXSSYHCFHTBIL-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-propan-2-ylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)Cl)OC UMXSSYHCFHTBIL-RUZDIDTESA-N 0.000 claims 1
AHCMIWDZQNQUEG-PMAPCBKXSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl AHCMIWDZQNQUEG-PMAPCBKXSA-N 0.000 claims 1
AHCMIWDZQNQUEG-IUKKYPGJSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl AHCMIWDZQNQUEG-IUKKYPGJSA-N 0.000 claims 1
IWKNJJXMWJAMMG-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[2-methoxyethyl(methyl)amino]phenyl]prop-2-enamide Chemical compound CN(CCOC)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=C(C=C4)F)Cl)OC IWKNJJXMWJAMMG-JOCHJYFZSA-N 0.000 claims 1
YCEXABDCFOMSEF-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC YCEXABDCFOMSEF-MUUNZHRXSA-N 0.000 claims 1
TYWODMDQWNRILH-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC TYWODMDQWNRILH-SSEXGKCCSA-N 0.000 claims 1
ISFMNGUENHLOAE-LYZGTLIUSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2R)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC ISFMNGUENHLOAE-LYZGTLIUSA-N 0.000 claims 1
ISFMNGUENHLOAE-RBTNQOKQSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)F)Cl)OC ISFMNGUENHLOAE-RBTNQOKQSA-N 0.000 claims 1
XKNUTDJDFANBGS-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3-chloro-4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCOCC2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)F)Cl XKNUTDJDFANBGS-JOCHJYFZSA-N 0.000 claims 1
HLWKMUYIZUAPHQ-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-hydroxypiperidin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)O)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)Cl)F HLWKMUYIZUAPHQ-HSZRJFAPSA-N 0.000 claims 1
DTSXQSJUQZPXGU-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC(=C4)Cl)F)OC DTSXQSJUQZPXGU-HSZRJFAPSA-N 0.000 claims 1
PKRAAFNEYXERRI-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[3-(4-cyclopropylpiperazin-1-yl)azetidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC(C2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)Cl)F PKRAAFNEYXERRI-MUUNZHRXSA-N 0.000 claims 1
GWPXFFDCYJBHLL-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)Cl)F GWPXFFDCYJBHLL-WJOKGBTCSA-N 0.000 claims 1
QZDWIWTZQCEUHH-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)Cl)F)OC QZDWIWTZQCEUHH-RUZDIDTESA-N 0.000 claims 1
ZNDAYLXQGCMBLZ-SLGOVJDISA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F)OC)C7CC7 ZNDAYLXQGCMBLZ-SLGOVJDISA-N 0.000 claims 1
KCPVBAAZYVCKLA-UETOGOEVSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F)OC KCPVBAAZYVCKLA-UETOGOEVSA-N 0.000 claims 1
ZNDAYLXQGCMBLZ-GTYOFVGBSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F)OC)C7CC7 ZNDAYLXQGCMBLZ-GTYOFVGBSA-N 0.000 claims 1
VLELRWBNDFNSIQ-SLGOVJDISA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)Cl)F)OC VLELRWBNDFNSIQ-SLGOVJDISA-N 0.000 claims 1
VLELRWBNDFNSIQ-GTYOFVGBSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC(=C7)Cl)F)OC VLELRWBNDFNSIQ-GTYOFVGBSA-N 0.000 claims 1
MIABYZZXIVWFGN-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC(=C5)Cl)F)OC MIABYZZXIVWFGN-HSZRJFAPSA-N 0.000 claims 1
DNQOPGDHGFKMLP-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F DNQOPGDHGFKMLP-HHHXNRCGSA-N 0.000 claims 1
AWTRDDBQZOGWAV-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F)OC AWTRDDBQZOGWAV-SSEXGKCCSA-N 0.000 claims 1
XCYLQZFQVOEBQS-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F XCYLQZFQVOEBQS-RUZDIDTESA-N 0.000 claims 1
MWBWZAYXGCXUQF-RBTNQOKQSA-N N-[5-[[6-[(3R)-3-(3-chloro-5-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC(=C6)Cl)F)OC MWBWZAYXGCXUQF-RBTNQOKQSA-N 0.000 claims 1
XLVAZNALQITASH-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-cyclopropylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl XLVAZNALQITASH-RUZDIDTESA-N 0.000 claims 1
ONQBACMMFXWVAW-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl)OC ONQBACMMFXWVAW-XMMPIXPASA-N 0.000 claims 1
VWOAPEBVKQEHOO-ZJSXRUAMSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl)OC VWOAPEBVKQEHOO-ZJSXRUAMSA-N 0.000 claims 1
VWOAPEBVKQEHOO-XUZZJYLKSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl)OC VWOAPEBVKQEHOO-XUZZJYLKSA-N 0.000 claims 1
AWBMSZXOCVLXOL-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC=C4)Cl)OC AWBMSZXOCVLXOL-HSZRJFAPSA-N 0.000 claims 1
SQNDKSQJZQFSJG-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC SQNDKSQJZQFSJG-GDLZYMKVSA-N 0.000 claims 1
OGFGFCAVWGNIGQ-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl)OC OGFGFCAVWGNIGQ-RUZDIDTESA-N 0.000 claims 1
YOUOWGFIDDIGJH-RLPNJSHFSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC YOUOWGFIDDIGJH-RLPNJSHFSA-N 0.000 claims 1
VGQOLOYFHPNSES-GGXMVOPNSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC VGQOLOYFHPNSES-GGXMVOPNSA-N 0.000 claims 1
VGQOLOYFHPNSES-LITSAYRRSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC VGQOLOYFHPNSES-LITSAYRRSA-N 0.000 claims 1
DMLZCYYJWBUIOX-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC DMLZCYYJWBUIOX-SSEXGKCCSA-N 0.000 claims 1
PTZXGRJEQQCGAO-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl)OC PTZXGRJEQQCGAO-HSZRJFAPSA-N 0.000 claims 1
UMLUPZPEQORLMZ-ZEQKJWHPSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl UMLUPZPEQORLMZ-ZEQKJWHPSA-N 0.000 claims 1
SOVJMXWHDQLPOE-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC SOVJMXWHDQLPOE-MUUNZHRXSA-N 0.000 claims 1
MNGXWAGSROZABK-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl)OC MNGXWAGSROZABK-SSEXGKCCSA-N 0.000 claims 1
SEMFATAHTPWNEB-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)Cl SEMFATAHTPWNEB-RUZDIDTESA-N 0.000 claims 1
BLQYCPMPNNVDRP-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)Cl BLQYCPMPNNVDRP-SSEXGKCCSA-N 0.000 claims 1
GUIOQJRTIHPLGL-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCOCC2)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=CC=C5)Cl GUIOQJRTIHPLGL-JOCHJYFZSA-N 0.000 claims 1
UHFAQIOLDRPAIH-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#N)OC UHFAQIOLDRPAIH-RUZDIDTESA-N 0.000 claims 1
HJSGYDQYSBDGNN-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-hydroxypiperidin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)O)NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#N HJSGYDQYSBDGNN-XMMPIXPASA-N 0.000 claims 1
QURGQKRDZVFBGT-RCZVLFRGSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#N)OC QURGQKRDZVFBGT-RCZVLFRGSA-N 0.000 claims 1
QKOCDHPAEMSDQQ-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC=CC(=C4)C#N)OC QKOCDHPAEMSDQQ-XMMPIXPASA-N 0.000 claims 1
ZMSAWPPRFKXLPN-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4,4-difluoropiperidin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCC(CC3)(F)F)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N ZMSAWPPRFKXLPN-MUUNZHRXSA-N 0.000 claims 1
KIUKADFSMOUZFB-JGCGQSQUSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC(=C7)C#N KIUKADFSMOUZFB-JGCGQSQUSA-N 0.000 claims 1
SVDCNKNFFLUEKR-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC SVDCNKNFFLUEKR-SSEXGKCCSA-N 0.000 claims 1
UWXIMQUQPYDRFP-IAHUFCAJSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CC4CCC(C3)N4C5CC5)NC(=O)C=C)NC6=CC(=NC=N6)N7[C@H](CCO7)C8=CC=CC(=C8)C#N UWXIMQUQPYDRFP-IAHUFCAJSA-N 0.000 claims 1
RFVWVRJKPLZAFG-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#N)OC RFVWVRJKPLZAFG-AREMUKBSSA-N 0.000 claims 1
SDBMESYHNLQZCS-NLGDKJDOSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC)C7CC7 SDBMESYHNLQZCS-NLGDKJDOSA-N 0.000 claims 1
SDBMESYHNLQZCS-ZOYWYXQUSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2S)-4-cyclopropyl-2-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC)C7CC7 SDBMESYHNLQZCS-ZOYWYXQUSA-N 0.000 claims 1
JIFLJGRNYVDGCO-POURPWNDSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC JIFLJGRNYVDGCO-POURPWNDSA-N 0.000 claims 1
JIFLJGRNYVDGCO-BHBYDHKZSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC JIFLJGRNYVDGCO-BHBYDHKZSA-N 0.000 claims 1
XCEFBAZKKNQGAB-ZOYWYXQUSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC(=C7)C#N)OC XCEFBAZKKNQGAB-ZOYWYXQUSA-N 0.000 claims 1
IENVLEKECQCBRP-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#N)OC IENVLEKECQCBRP-XMMPIXPASA-N 0.000 claims 1
FSDHPGRZRGKRLK-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N FSDHPGRZRGKRLK-MUUNZHRXSA-N 0.000 claims 1
RRGTVMAEUBMVGQ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC RRGTVMAEUBMVGQ-GDLZYMKVSA-N 0.000 claims 1
ROAGACKWPBWGGL-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC ROAGACKWPBWGGL-WJOKGBTCSA-N 0.000 claims 1
CIDPJCDZPAOJFR-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CCCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC CIDPJCDZPAOJFR-WJOKGBTCSA-N 0.000 claims 1
NBFWVAXPWMAFEP-AREMUKBSSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N NBFWVAXPWMAFEP-AREMUKBSSA-N 0.000 claims 1
LAMZXHKEDWJMHW-RNWIMVQKSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(3R)-3-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@@H]1COCCN1C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#N)OC LAMZXHKEDWJMHW-RNWIMVQKSA-N 0.000 claims 1
IEGBWBMSAGJGIH-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(3-cyanophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=CC(=C7)C#N IEGBWBMSAGJGIH-WJOKGBTCSA-N 0.000 claims 1
LUYZMWQBSYTMFF-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=CC(=C5)C#C)OC LUYZMWQBSYTMFF-RUZDIDTESA-N 0.000 claims 1
GNFLKDRMWHZEMK-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#C GNFLKDRMWHZEMK-GDLZYMKVSA-N 0.000 claims 1
ACPDYACBRYILSR-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-ethynylphenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=CC(=C6)C#C)OC ACPDYACBRYILSR-SSEXGKCCSA-N 0.000 claims 1
SWGVNVUNGRXORB-TXTKFYIRSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F SWGVNVUNGRXORB-TXTKFYIRSA-N 0.000 claims 1
SWGVNVUNGRXORB-SXWKCWPCSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F SWGVNVUNGRXORB-SXWKCWPCSA-N 0.000 claims 1
BSRZFOSWSMRWPT-ZEQKJWHPSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F BSRZFOSWSMRWPT-ZEQKJWHPSA-N 0.000 claims 1
BSRZFOSWSMRWPT-JYFHCDHNSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F BSRZFOSWSMRWPT-JYFHCDHNSA-N 0.000 claims 1
KPACORHTEBHUTE-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[2-methoxyethyl(methyl)amino]phenyl]prop-2-enamide Chemical compound CN(CCOC)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=CC=C4)F)OC KPACORHTEBHUTE-JOCHJYFZSA-N 0.000 claims 1
LPUQXQMFIQQCLJ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=CC=C6)F)OC LPUQXQMFIQQCLJ-SSEXGKCCSA-N 0.000 claims 1
CCIKGPQHDCAEOK-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=CC=C7)F CCIKGPQHDCAEOK-SSEXGKCCSA-N 0.000 claims 1
KJSFISFQQQBOET-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)Cl)F)OC KJSFISFQQQBOET-XMMPIXPASA-N 0.000 claims 1
ITFWBABHRAQGJH-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)Cl)F)OC ITFWBABHRAQGJH-NTKDMRAZSA-N 0.000 claims 1
GTZIRONOFJJBDW-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=C(C=C(C=C7)Cl)F GTZIRONOFJJBDW-SSEXGKCCSA-N 0.000 claims 1
NEDCXHPYFSIKGZ-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC NEDCXHPYFSIKGZ-GDLZYMKVSA-N 0.000 claims 1
AWRRGUKDCOXSTA-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)Cl)F)OC AWRRGUKDCOXSTA-RUZDIDTESA-N 0.000 claims 1
CKCJFQNZXDWJCU-FUFSCUOVSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC CKCJFQNZXDWJCU-FUFSCUOVSA-N 0.000 claims 1
CKCJFQNZXDWJCU-PWUYWRBVSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC CKCJFQNZXDWJCU-PWUYWRBVSA-N 0.000 claims 1
GBVSVQJVOFSSNQ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC GBVSVQJVOFSSNQ-SSEXGKCCSA-N 0.000 claims 1
VXXKHLKJMZUPQT-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=C(C=C(C=C5)Cl)F)OC VXXKHLKJMZUPQT-HSZRJFAPSA-N 0.000 claims 1
QEEWNEFWCYJURW-HFZDXXHNSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F QEEWNEFWCYJURW-HFZDXXHNSA-N 0.000 claims 1
HOJRAEFKPITOPE-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC HOJRAEFKPITOPE-MUUNZHRXSA-N 0.000 claims 1
RKNJYRODAAKQED-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC RKNJYRODAAKQED-SSEXGKCCSA-N 0.000 claims 1
KATPQQLVOLPJIJ-MGBGTMOVSA-N N-[5-[[6-[(3R)-3-(4-chloro-2-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1-propan-2-ylpiperidin-4-yl)-prop-2-enoylamino]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCC(CC1)N(C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=C(C=C(C=C6)Cl)F)OC)C(=O)C=C KATPQQLVOLPJIJ-MGBGTMOVSA-N 0.000 claims 1
VRDPULLIMCFHGB-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-cyclopropylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F VRDPULLIMCFHGB-RUZDIDTESA-N 0.000 claims 1
OTBNIJQWNYZIQE-NTKDMRAZSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC(=C(C=C5)Cl)F)OC OTBNIJQWNYZIQE-NTKDMRAZSA-N 0.000 claims 1
CNHIAMKRPUQYSB-WJOKGBTCSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclobutylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CCC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)Cl)F CNHIAMKRPUQYSB-WJOKGBTCSA-N 0.000 claims 1
KGUSYMJUAUSNEY-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)Cl)F KGUSYMJUAUSNEY-SSEXGKCCSA-N 0.000 claims 1
KFDBBMFJBUWNBD-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC KFDBBMFJBUWNBD-GDLZYMKVSA-N 0.000 claims 1
SADLSUGBCPNEDY-OYPUMOIUSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)Cl)F)OC SADLSUGBCPNEDY-OYPUMOIUSA-N 0.000 claims 1
KPAMICGXSGBIGL-UETOGOEVSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC KPAMICGXSGBIGL-UETOGOEVSA-N 0.000 claims 1
KLKYUIDUXDVUJY-FUFSCUOVSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC KLKYUIDUXDVUJY-FUFSCUOVSA-N 0.000 claims 1
KLKYUIDUXDVUJY-PWUYWRBVSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC KLKYUIDUXDVUJY-PWUYWRBVSA-N 0.000 claims 1
VDLAUKOPVIKONZ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F)OC VDLAUKOPVIKONZ-SSEXGKCCSA-N 0.000 claims 1
AUEGIMUTQSLANU-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F AUEGIMUTQSLANU-HHHXNRCGSA-N 0.000 claims 1
IAGYCTXSOATHNE-PMAPCBKXSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F IAGYCTXSOATHNE-PMAPCBKXSA-N 0.000 claims 1
IAGYCTXSOATHNE-IUKKYPGJSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F IAGYCTXSOATHNE-IUKKYPGJSA-N 0.000 claims 1
ATNSYZJWDNHZJM-HFZDXXHNSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F ATNSYZJWDNHZJM-HFZDXXHNSA-N 0.000 claims 1
KDVFFQXKHYJUDX-JOCHJYFZSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[2-methoxyethyl(methyl)amino]phenyl]prop-2-enamide Chemical compound CN(CCOC)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC(=C(C=C4)Cl)F)OC KDVFFQXKHYJUDX-JOCHJYFZSA-N 0.000 claims 1
PRFJLTQWQOHQFW-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC(=C(C=C6)Cl)F PRFJLTQWQOHQFW-RUZDIDTESA-N 0.000 claims 1
DUGHNFIUQNWQKP-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chloro-3-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC(=C(C=C7)Cl)F DUGHNFIUQNWQKP-SSEXGKCCSA-N 0.000 claims 1
VDSFSCMHVPMYOP-XMMPIXPASA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=C(C=C5)Cl)OC VDSFSCMHVPMYOP-XMMPIXPASA-N 0.000 claims 1
BFSZNBKHFSHXBH-ZJSXRUAMSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=C(C=C5)Cl)OC BFSZNBKHFSHXBH-ZJSXRUAMSA-N 0.000 claims 1
HVTOXOMPVTUAHR-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)C4=CC=C(C=C4)Cl)OC HVTOXOMPVTUAHR-HSZRJFAPSA-N 0.000 claims 1
IBBGMJIMYGHRRY-GDLZYMKVSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC IBBGMJIMYGHRRY-GDLZYMKVSA-N 0.000 claims 1
JVKXQNZWRBRHQV-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=C(C=C5)Cl)OC JVKXQNZWRBRHQV-RUZDIDTESA-N 0.000 claims 1
RBDFXZZCDDZHOC-GGXMVOPNSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC RBDFXZZCDDZHOC-GGXMVOPNSA-N 0.000 claims 1
RBDFXZZCDDZHOC-LITSAYRRSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC RBDFXZZCDDZHOC-LITSAYRRSA-N 0.000 claims 1
ZFRUJHXSMMUHPJ-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC ZFRUJHXSMMUHPJ-SSEXGKCCSA-N 0.000 claims 1
NJTINRCGXKWEDZ-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=C(C=C5)Cl)OC NJTINRCGXKWEDZ-HSZRJFAPSA-N 0.000 claims 1
ODMCHGILMVJMIV-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl ODMCHGILMVJMIV-HHHXNRCGSA-N 0.000 claims 1
XBXGSMUHKAITOA-ZEQKJWHPSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3R)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl XBXGSMUHKAITOA-ZEQKJWHPSA-N 0.000 claims 1
HUTMXLZDXFYQAS-MUUNZHRXSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC HUTMXLZDXFYQAS-MUUNZHRXSA-N 0.000 claims 1
YFPWUTIPXUQGFE-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl)OC YFPWUTIPXUQGFE-SSEXGKCCSA-N 0.000 claims 1
CYFXACOQPQTFCP-RUZDIDTESA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)Cl CYFXACOQPQTFCP-RUZDIDTESA-N 0.000 claims 1
CFBDLCKWHVOGQX-SSEXGKCCSA-N N-[5-[[6-[(3R)-3-(4-chlorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4COC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)C7=CC=C(C=C7)Cl CFBDLCKWHVOGQX-SSEXGKCCSA-N 0.000 claims 1
BQHDJYKYLARFDC-HSZRJFAPSA-N N-[5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)C5=CC=C(C=C5)F)OC BQHDJYKYLARFDC-HSZRJFAPSA-N 0.000 claims 1
SIDRRELGXYBCDN-HHHXNRCGSA-N N-[5-[[6-[(3R)-3-(4-fluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)C6=CC=C(C=C6)F SIDRRELGXYBCDN-HHHXNRCGSA-N 0.000 claims 1
OMXLLWWIWKCWET-QFIPXVFZSA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@@H](CCO3)CC4=CC=CC=C4)OC OMXLLWWIWKCWET-QFIPXVFZSA-N 0.000 claims 1
RPZAZLSYYBIQGK-LJAQVGFWSA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@@H](CCO6)CC7=CC=CC=C7 RPZAZLSYYBIQGK-LJAQVGFWSA-N 0.000 claims 1
SSEYNURSNADSNC-VWLOTQADSA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(cyclopropylmethyl)piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)CC3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)CC6=CC=CC=C6 SSEYNURSNADSNC-VWLOTQADSA-N 0.000 claims 1
OEVHPIKRYHFMIL-VWLOTQADSA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)CC5=CC=CC=C5)OC OEVHPIKRYHFMIL-VWLOTQADSA-N 0.000 claims 1
IPQXCKYMRGZVOO-QFIPXVFZSA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)CC5=CC=CC=C5)OC IPQXCKYMRGZVOO-QFIPXVFZSA-N 0.000 claims 1
BNCNCGGUXCILAP-MHZLTWQESA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCC(CC1)N2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)CC6=CC=CC=C6)OC BNCNCGGUXCILAP-MHZLTWQESA-N 0.000 claims 1
SGIDKFSUHBETGB-SANMLTNESA-N N-[5-[[6-[(3R)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxan-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)CC6=CC=CC=C6 SGIDKFSUHBETGB-SANMLTNESA-N 0.000 claims 1
FJKSPMCDPWECIP-QHCPKHFHSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)C5=C(C=CC=C5F)F)OC FJKSPMCDPWECIP-QHCPKHFHSA-N 0.000 claims 1
GDLVIQCYPDBISL-JPYJTQIMSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)C5=C(C=CC=C5F)F)OC GDLVIQCYPDBISL-JPYJTQIMSA-N 0.000 claims 1
NALPSSWPALAPDS-NDEPHWFRSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC NALPSSWPALAPDS-NDEPHWFRSA-N 0.000 claims 1
ANKUKMFYZZCGJU-DEOSSOPVSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(dimethylamino)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)C5=C(C=CC=C5F)F)OC ANKUKMFYZZCGJU-DEOSSOPVSA-N 0.000 claims 1
PYGZCPBIVZMYTI-TYPXCFOJSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC PYGZCPBIVZMYTI-TYPXCFOJSA-N 0.000 claims 1
QVLBBSFOCJQRDY-LXFBAYGMSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC QVLBBSFOCJQRDY-LXFBAYGMSA-N 0.000 claims 1
UYKZHJQHQFHHDH-DWACAAAGSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3,4-dimethylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC UYKZHJQHQFHHDH-DWACAAAGSA-N 0.000 claims 1
QVLBBSFOCJQRDY-FIPFOOKPSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@H]1CCN(C1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC QVLBBSFOCJQRDY-FIPFOOKPSA-N 0.000 claims 1
HXTBQWLMJKWQBH-LJAQVGFWSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[4-(dimethylamino)piperidin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)C1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC HXTBQWLMJKWQBH-LJAQVGFWSA-N 0.000 claims 1
NKLILUDWOJAYTA-QFIPXVFZSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@@H](CCO4)C5=C(C=CC=C5F)F)OC NKLILUDWOJAYTA-QFIPXVFZSA-N 0.000 claims 1
YTFZNNHDZGUHRF-SANMLTNESA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F YTFZNNHDZGUHRF-SANMLTNESA-N 0.000 claims 1
PEUIHCGIECXFJL-CPJSRVTESA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(3S)-3-morpholin-4-ylpyrrolidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CC[C@@H](C2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F PEUIHCGIECXFJL-CPJSRVTESA-N 0.000 claims 1
JPXSJZZUEQUPHN-MHZLTWQESA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC JPXSJZZUEQUPHN-MHZLTWQESA-N 0.000 claims 1
JORKGLIWDMZTDA-LJAQVGFWSA-N N-[5-[[6-[(3S)-3-(2,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@@H](CCO5)C6=C(C=CC=C6F)F)OC JORKGLIWDMZTDA-LJAQVGFWSA-N 0.000 claims 1
IDSNWEGIKQUFFX-NDEPHWFRSA-N N-[5-[[6-[(3S)-3-(2-chloro-3,6-difluorophenyl)-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@@H](CCO6)C7=C(C=CC(=C7Cl)F)F IDSNWEGIKQUFFX-NDEPHWFRSA-N 0.000 claims 1
ASVPQISHHRBAIJ-NHCUHLMSSA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=C(C(=CC=C5)Cl)Cl)OC ASVPQISHHRBAIJ-NHCUHLMSSA-N 0.000 claims 1
WUJBPOGFKVTKSI-MVERNJQCSA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(C[C@@H](O1)C)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=C(C(=CC=C6)Cl)Cl)OC WUJBPOGFKVTKSI-MVERNJQCSA-N 0.000 claims 1
HBRDQHLLAXOZRQ-HXUWFJFHSA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=C(C(=CC=C5)Cl)Cl)OC HBRDQHLLAXOZRQ-HXUWFJFHSA-N 0.000 claims 1
LZYBFVJRCLUQEL-XMMPIXPASA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=C(C(=CC=C6)Cl)Cl LZYBFVJRCLUQEL-XMMPIXPASA-N 0.000 claims 1
IKXCQVKWYOTPJL-HHHXNRCGSA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-propan-2-ylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=C(C(=CC=C6)Cl)Cl)OC IKXCQVKWYOTPJL-HHHXNRCGSA-N 0.000 claims 1
XEHMTSCTBBIJEZ-DSITVLBTSA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)Cl XEHMTSCTBBIJEZ-DSITVLBTSA-N 0.000 claims 1
UEMJITLULHWMOV-WIOPSUGQSA-N N-[5-[[6-[(3S)-3-[(2,3-dichlorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(2S)-2-methylmorpholin-4-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCO1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=C(C(=CC=C6)Cl)Cl)OC UEMJITLULHWMOV-WIOPSUGQSA-N 0.000 claims 1
IXAXPRFNPDGJQZ-HHHXNRCGSA-N N-[5-[[6-[(3S)-3-[(2-chloro-3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)F)Cl IXAXPRFNPDGJQZ-HHHXNRCGSA-N 0.000 claims 1
JUCUYIHHYXRBJI-UFHPHHKVSA-N N-[5-[[6-[(3S)-3-[(2-chloro-3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)F)Cl)OC JUCUYIHHYXRBJI-UFHPHHKVSA-N 0.000 claims 1
JUCUYIHHYXRBJI-RBJSKKJNSA-N N-[5-[[6-[(3S)-3-[(2-chloro-3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)F)Cl)OC JUCUYIHHYXRBJI-RBJSKKJNSA-N 0.000 claims 1
XGJJQUKFWHSXSY-DSITVLBTSA-N N-[5-[[6-[(3S)-3-[(2-chloro-3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)F)Cl XGJJQUKFWHSXSY-DSITVLBTSA-N 0.000 claims 1
DUZWUIGQNMWIKY-JOCHJYFZSA-N N-[5-[[6-[(3S)-3-[(3,5-difluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)CC4=CC(=CC(=C4)F)F)OC DUZWUIGQNMWIKY-JOCHJYFZSA-N 0.000 claims 1
OIYVJYKKMXGLCD-ZONZVBGPSA-N N-[5-[[6-[(3S)-3-[(3,5-difluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC(=C7)F)F OIYVJYKKMXGLCD-ZONZVBGPSA-N 0.000 claims 1
OIYVJYKKMXGLCD-PVHODMMVSA-N N-[5-[[6-[(3S)-3-[(3,5-difluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC(=C7)F)F OIYVJYKKMXGLCD-PVHODMMVSA-N 0.000 claims 1
MQWKBBJVFGTQPK-HXUWFJFHSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)CC4=C(C(=CC=C4)Cl)F)OC MQWKBBJVFGTQPK-HXUWFJFHSA-N 0.000 claims 1
RPTPZNFYEOEWSP-HHHXNRCGSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)F RPTPZNFYEOEWSP-HHHXNRCGSA-N 0.000 claims 1
MIQMBSICSXXIBV-UFHPHHKVSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)F)OC MIQMBSICSXXIBV-UFHPHHKVSA-N 0.000 claims 1
MIQMBSICSXXIBV-RBJSKKJNSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)F)OC MIQMBSICSXXIBV-RBJSKKJNSA-N 0.000 claims 1
PZRSWUQQCUPSLS-UBFVSLLYSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)F PZRSWUQQCUPSLS-UBFVSLLYSA-N 0.000 claims 1
PZRSWUQQCUPSLS-DSITVLBTSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@@H]4C[C@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)F PZRSWUQQCUPSLS-DSITVLBTSA-N 0.000 claims 1
QRXIITJQSIBZLE-HSZRJFAPSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methoxyphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-cyclopropylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=C(C(=CC=C6)Cl)OC QRXIITJQSIBZLE-HSZRJFAPSA-N 0.000 claims 1
HOIOWEFVHFIWLO-TWJOJJKGSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methoxyphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)OC HOIOWEFVHFIWLO-TWJOJJKGSA-N 0.000 claims 1
WCBOBCDEIZZALZ-XMMPIXPASA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-cyclopropylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C6CC6)OC WCBOBCDEIZZALZ-XMMPIXPASA-N 0.000 claims 1
YDUNXQCWJMDKII-FYBSXPHGSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3R)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)C)OC YDUNXQCWJMDKII-FYBSXPHGSA-N 0.000 claims 1
YDUNXQCWJMDKII-SETSBSEESA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[(3S)-4-cyclopropyl-3-methylpiperazin-1-yl]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound C[C@H]1CN(CCN1C2CC2)C3CCN(CC3)C4=CC(=C(C=C4NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=C(C(=CC=C7)Cl)C)OC YDUNXQCWJMDKII-SETSBSEESA-N 0.000 claims 1
QXYWYRBBKZTVSQ-ZONZVBGPSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@H]7C[C@@H]6CO7)OC QXYWYRBBKZTVSQ-ZONZVBGPSA-N 0.000 claims 1
QXYWYRBBKZTVSQ-PVHODMMVSA-N N-[5-[[6-[(3S)-3-[(3-chloro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1Cl)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@@H]7C[C@H]6CO7)OC QXYWYRBBKZTVSQ-PVHODMMVSA-N 0.000 claims 1
VPGYSXYOANHGGB-JOCHJYFZSA-N N-[5-[[6-[(3S)-3-[(3-fluoro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1F)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCN(CC5)C)OC VPGYSXYOANHGGB-JOCHJYFZSA-N 0.000 claims 1
IJYWZUSWEUKGHU-PVHODMMVSA-N N-[5-[[6-[(3S)-3-[(3-fluoro-2-methylphenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CC1=C(C=CC=C1F)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@@H]7C[C@H]6CO7)OC IJYWZUSWEUKGHU-PVHODMMVSA-N 0.000 claims 1
VQWUWYZSRZRPCF-AREMUKBSSA-N N-[5-[[6-[(3S)-3-[(3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-morpholin-4-ylpiperidin-1-yl)phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC(=CC=C6)F VQWUWYZSRZRPCF-AREMUKBSSA-N 0.000 claims 1
AHUILCXBAFIXCG-ZONZVBGPSA-N N-[5-[[6-[(3S)-3-[(3-fluorophenyl)methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3C[C@H]4C[C@@H]3CO4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC(=CC=C7)F AHUILCXBAFIXCG-ZONZVBGPSA-N 0.000 claims 1
QHPGKJJHDFKGCY-MPFGFTFXSA-N N-[5-[[6-[(3S)-3-[[3-(dimethylamino)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN(C)C1=CC=CC(=C1)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@H]7C[C@@H]6CO7)OC QHPGKJJHDFKGCY-MPFGFTFXSA-N 0.000 claims 1
QHPGKJJHDFKGCY-ULNSLHSMSA-N N-[5-[[6-[(3S)-3-[[3-(dimethylamino)phenyl]methyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN(C)C1=CC=CC(=C1)C[C@H]2CCON2C3=NC=NC(=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCC(CC5)N6C[C@@H]7C[C@H]6CO7)OC QHPGKJJHDFKGCY-ULNSLHSMSA-N 0.000 claims 1
YNBYIQFCBDGXAQ-AREMUKBSSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-cyclopentylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6 YNBYIQFCBDGXAQ-AREMUKBSSA-N 0.000 claims 1
LGSFCPPWKJCKCJ-HSZRJFAPSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=CC=CC=C5)OC LGSFCPPWKJCKCJ-HSZRJFAPSA-N 0.000 claims 1
ZRCQFJJVDSJNEN-WXFUMESZSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@H]2C[C@@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6)OC ZRCQFJJVDSJNEN-WXFUMESZSA-N 0.000 claims 1
ZRCQFJJVDSJNEN-SGNDLWITSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN1C[C@@H]2C[C@H]1CN2C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6)OC ZRCQFJJVDSJNEN-SGNDLWITSA-N 0.000 claims 1
SIJMBWOHMAAFOD-DHIUTWEWSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)[C@@H]1CCN(C1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=CC=CC=C5)OC SIJMBWOHMAAFOD-DHIUTWEWSA-N 0.000 claims 1
OMXLLWWIWKCWET-JOCHJYFZSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=CC(=NC=N2)N3[C@H](CCO3)CC4=CC=CC=C4)OC OMXLLWWIWKCWET-JOCHJYFZSA-N 0.000 claims 1
RPZAZLSYYBIQGK-GDLZYMKVSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCC(CC2)N3CCN(CC3)C4CC4)NC(=O)C=C)NC5=CC(=NC=N5)N6[C@H](CCO6)CC7=CC=CC=C7 RPZAZLSYYBIQGK-GDLZYMKVSA-N 0.000 claims 1
OYSOYUWILFMFNN-HHHXNRCGSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(diethylamino)ethoxy]piperidin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CCN(CC)CCOC1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=CC=CC=C5)OC OYSOYUWILFMFNN-HHHXNRCGSA-N 0.000 claims 1
OEVHPIKRYHFMIL-RUZDIDTESA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]-4-methoxyphenyl]prop-2-enamide Chemical compound CN(C)CCN1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=CC=CC=C5)OC OEVHPIKRYHFMIL-RUZDIDTESA-N 0.000 claims 1
ZPHHGZVERRHCCL-XMMPIXPASA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-(4-propan-2-ylpiperazin-1-yl)phenyl]prop-2-enamide Chemical compound CC(C)N1CCN(CC1)C2=CC(=C(C=C2NC(=O)C=C)NC3=CC(=NC=N3)N4[C@H](CCO4)CC5=CC=CC=C5)OC ZPHHGZVERRHCCL-XMMPIXPASA-N 0.000 claims 1
KGEPNKLGUUSTBS-YPAWHYETSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@H]3C[C@@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6 KGEPNKLGUUSTBS-YPAWHYETSA-N 0.000 claims 1
KGEPNKLGUUSTBS-FSSWDIPSSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2C[C@@H]3C[C@H]2CO3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6 KGEPNKLGUUSTBS-FSSWDIPSSA-N 0.000 claims 1
BNCNCGGUXCILAP-HHHXNRCGSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCC(CC1)N2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6)OC BNCNCGGUXCILAP-HHHXNRCGSA-N 0.000 claims 1
APCNMAYJHZCBAP-HHHXNRCGSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]prop-2-enamide Chemical compound CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6)OC APCNMAYJHZCBAP-HHHXNRCGSA-N 0.000 claims 1
SGIDKFSUHBETGB-AREMUKBSSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxan-4-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3CCOCC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6 SGIDKFSUHBETGB-AREMUKBSSA-N 0.000 claims 1
HSTFRZNMEBZBDY-HSZRJFAPSA-N N-[5-[[6-[(3S)-3-benzyl-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-4-methoxy-2-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]prop-2-enamide Chemical compound COC1=C(C=C(C(=C1)N2CCN(CC2)C3COC3)NC(=O)C=C)NC4=CC(=NC=N4)N5[C@H](CCO5)CC6=CC=CC=C6 HSTFRZNMEBZBDY-HSZRJFAPSA-N 0.000 claims 1
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102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
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125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
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JP2022109721A 2019-03-19 2022-07-07 ヘテロアリール誘導体、ヘテロアリール誘導体の生成方法、およびヘテロアリール誘導体を有効成分として含む医薬組成物 Active JP7394298B2 (ja)