JP2022095666A5 - - Google Patents
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- JP2022095666A5 JP2022095666A5 JP2022041655A JP2022041655A JP2022095666A5 JP 2022095666 A5 JP2022095666 A5 JP 2022095666A5 JP 2022041655 A JP2022041655 A JP 2022041655A JP 2022041655 A JP2022041655 A JP 2022041655A JP 2022095666 A5 JP2022095666 A5 JP 2022095666A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- positions
- amino acids
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 235000001014 amino acid Nutrition 0.000 claims 51
- 150000001413 amino acids Chemical class 0.000 claims 35
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 22
- 238000006467 substitution reaction Methods 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 238000004132 cross linking Methods 0.000 claims 7
- 241000894006 Bacteria Species 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 5
- 206010018910 Haemolysis Diseases 0.000 claims 4
- 230000003115 biocidal effect Effects 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 4
- 230000008588 hemolysis Effects 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- JWZFECWHKQLRGK-LLVKDONJSA-N (2r)-2-amino-2-methyldec-9-enoic acid Chemical compound OC(=O)[C@@](N)(C)CCCCCCC=C JWZFECWHKQLRGK-LLVKDONJSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229910052729 chemical element Inorganic materials 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301426P | 2016-02-29 | 2016-02-29 | |
| US62/301,426 | 2016-02-29 | ||
| JP2018545479A JP7105696B2 (ja) | 2016-02-29 | 2017-02-28 | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
| PCT/US2017/019953 WO2017151617A1 (en) | 2016-02-29 | 2017-02-28 | Stapled intracellular-targeting antimicrobial peptides to treat infection |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545479A Division JP7105696B2 (ja) | 2016-02-29 | 2017-02-28 | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022095666A JP2022095666A (ja) | 2022-06-28 |
| JP2022095666A5 true JP2022095666A5 (https=) | 2022-07-13 |
| JP7432640B2 JP7432640B2 (ja) | 2024-02-16 |
Family
ID=59679412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545479A Active JP7105696B2 (ja) | 2016-02-29 | 2017-02-28 | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
| JP2022041655A Active JP7432640B2 (ja) | 2016-02-29 | 2022-03-16 | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545479A Active JP7105696B2 (ja) | 2016-02-29 | 2017-02-28 | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20170247423A1 (https=) |
| EP (1) | EP3423075B1 (https=) |
| JP (2) | JP7105696B2 (https=) |
| CN (1) | CN109069578A (https=) |
| AU (1) | AU2017228333C1 (https=) |
| CA (1) | CA3014442A1 (https=) |
| WO (1) | WO2017151617A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017004591A2 (en) * | 2015-07-02 | 2017-01-05 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides |
| JP7105696B2 (ja) | 2016-02-29 | 2022-07-25 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
| JP7305614B2 (ja) | 2017-07-19 | 2023-07-10 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド |
| WO2019090015A1 (en) * | 2017-11-03 | 2019-05-09 | Yale University | Peptidic materials that traffic efficiently to the cell cytosol and nucleus |
| US20200354413A1 (en) | 2017-12-15 | 2020-11-12 | Dana-Farber Cancer Institute, Inc. | Stabilized peptide-mediated targeted protein degradation |
| WO2019157131A1 (en) | 2018-02-07 | 2019-08-15 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US20200408746A1 (en) | 2018-03-14 | 2020-12-31 | Dana-Farber Cancer Institute, Inc. | Stabilized Peptides for Biomarker Detection |
| CN109870583B (zh) * | 2019-04-15 | 2020-03-06 | 德阳市人民医院 | 急性胰腺炎相关的代谢物及其应用 |
| CN116284253A (zh) * | 2023-04-28 | 2023-06-23 | 南方医科大学 | 一种靶向金黄色葡萄球菌且具有抑制群体感应信号和抗菌作用双重功能的抗菌肽 |
| CN119241678B (zh) * | 2024-04-16 | 2025-04-18 | 山东第一医科大学(山东省医学科学院) | 订书肽及其应用 |
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| JP7105696B2 (ja) | 2016-02-29 | 2022-07-25 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 感染症を治療するステープル化細胞内ターゲティング抗微生物ペプチド |
| JP7305614B2 (ja) | 2017-07-19 | 2023-07-10 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド |
| EP4077361A1 (en) | 2019-12-16 | 2022-10-26 | Dana-Farber Cancer Institute, Inc. | Structurally-stabilized oncolytic peptides and uses thereof |
-
2017
- 2017-02-28 JP JP2018545479A patent/JP7105696B2/ja active Active
- 2017-02-28 WO PCT/US2017/019953 patent/WO2017151617A1/en not_active Ceased
- 2017-02-28 AU AU2017228333A patent/AU2017228333C1/en active Active
- 2017-02-28 EP EP17760612.6A patent/EP3423075B1/en active Active
- 2017-02-28 US US15/445,502 patent/US20170247423A1/en not_active Abandoned
- 2017-02-28 CA CA3014442A patent/CA3014442A1/en active Pending
- 2017-02-28 CN CN201780023809.8A patent/CN109069578A/zh active Pending
-
2020
- 2020-03-09 US US16/813,528 patent/US11945846B2/en active Active
-
2022
- 2022-03-16 JP JP2022041655A patent/JP7432640B2/ja active Active
-
2024
- 2024-02-28 US US18/590,636 patent/US12391733B2/en active Active
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