JP2022091998A5 - - Google Patents
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- Publication number
- JP2022091998A5 JP2022091998A5 JP2022064398A JP2022064398A JP2022091998A5 JP 2022091998 A5 JP2022091998 A5 JP 2022091998A5 JP 2022064398 A JP2022064398 A JP 2022064398A JP 2022064398 A JP2022064398 A JP 2022064398A JP 2022091998 A5 JP2022091998 A5 JP 2022091998A5
- Authority
- JP
- Japan
- Prior art keywords
- depot
- use according
- hydrolytically degradable
- travoprost
- xerogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 18
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 17
- 229960002368 travoprost Drugs 0.000 claims 17
- 239000011159 matrix material Substances 0.000 claims 16
- 239000000017 hydrogel Substances 0.000 claims 15
- 239000002202 Polyethylene glycol Substances 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 210000002159 anterior chamber Anatomy 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 239000002243 precursor Substances 0.000 claims 10
- 229920000954 Polyglycolide Polymers 0.000 claims 6
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 6
- 239000004633 polyglycolic acid Substances 0.000 claims 6
- 239000002131 composite material Substances 0.000 claims 5
- 239000002872 contrast media Substances 0.000 claims 5
- 238000013270 controlled release Methods 0.000 claims 5
- 206010058202 Cystoid macular oedema Diseases 0.000 claims 4
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 4
- 208000001344 Macular Edema Diseases 0.000 claims 4
- 201000010206 cystoid macular edema Diseases 0.000 claims 4
- 201000011190 diabetic macular edema Diseases 0.000 claims 4
- 238000004090 dissolution Methods 0.000 claims 4
- QXZGLTYKKZKGLN-UHFFFAOYSA-N 4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)ON1C(=O)CCC1=O QXZGLTYKKZKGLN-UHFFFAOYSA-N 0.000 claims 3
- NWAGXLBTAPTCPR-UHFFFAOYSA-N 5-(2,5-dioxopyrrolidin-1-yl)oxy-5-oxopentanoic acid Chemical compound OC(=O)CCCC(=O)ON1C(=O)CCC1=O NWAGXLBTAPTCPR-UHFFFAOYSA-N 0.000 claims 3
- JWUFSYXQWPXFIL-UHFFFAOYSA-N 6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexanoic acid Chemical compound OC(=O)CCCCC(=O)ON1C(=O)CCC1=O JWUFSYXQWPXFIL-UHFFFAOYSA-N 0.000 claims 3
- 206010030043 Ocular hypertension Diseases 0.000 claims 3
- 206010030348 Open-Angle Glaucoma Diseases 0.000 claims 3
- 229940067597 azelate Drugs 0.000 claims 3
- 208000030533 eye disease Diseases 0.000 claims 3
- 125000000524 functional group Chemical group 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- -1 succinimidyl azelate Chemical compound 0.000 claims 3
- 208000002177 Cataract Diseases 0.000 claims 2
- 208000002691 Choroiditis Diseases 0.000 claims 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000032843 Hemorrhage Diseases 0.000 claims 2
- WBSCNDJQPKSPII-KKUMJFAQSA-N Lys-Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O WBSCNDJQPKSPII-KKUMJFAQSA-N 0.000 claims 2
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 claims 2
- 208000003971 Posterior uveitis Diseases 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 2
- 210000001742 aqueous humor Anatomy 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 201000010041 presbyopia Diseases 0.000 claims 2
- 210000001957 retinal vein Anatomy 0.000 claims 2
- 206010061876 Obstruction Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920006237 degradable polymer Polymers 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662398985P | 2016-09-23 | 2016-09-23 | |
| US62/398,985 | 2016-09-23 | ||
| JP2019515849A JP7430529B2 (ja) | 2016-09-23 | 2017-09-25 | 前房内薬物送達デポ |
| PCT/US2017/053271 WO2018058048A1 (en) | 2016-09-23 | 2017-09-25 | Intracameral drug delivery depots |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515849A Division JP7430529B2 (ja) | 2016-09-23 | 2017-09-25 | 前房内薬物送達デポ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022091998A JP2022091998A (ja) | 2022-06-21 |
| JP2022091998A5 true JP2022091998A5 (enExample) | 2022-11-22 |
| JP7486539B2 JP7486539B2 (ja) | 2024-05-17 |
Family
ID=60022215
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515849A Active JP7430529B2 (ja) | 2016-09-23 | 2017-09-25 | 前房内薬物送達デポ |
| JP2022064398A Active JP7486539B2 (ja) | 2016-09-23 | 2022-04-08 | 前房内薬物送達デポ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019515849A Active JP7430529B2 (ja) | 2016-09-23 | 2017-09-25 | 前房内薬物送達デポ |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US12171869B2 (enExample) |
| EP (2) | EP4197527A1 (enExample) |
| JP (2) | JP7430529B2 (enExample) |
| KR (3) | KR20230053707A (enExample) |
| CN (1) | CN109982683A (enExample) |
| AU (1) | AU2017331444B2 (enExample) |
| CA (1) | CA3038075A1 (enExample) |
| DK (1) | DK3515406T3 (enExample) |
| ES (1) | ES2989941T3 (enExample) |
| IL (1) | IL265421B2 (enExample) |
| WO (1) | WO2018058048A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11458041B2 (en) | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| JP7430529B2 (ja) * | 2016-09-23 | 2024-02-13 | インセプト・リミテッド・ライアビリティ・カンパニー | 前房内薬物送達デポ |
| US20220168472A1 (en) * | 2019-03-13 | 2022-06-02 | Susmita Bose | Enzyme-degradable hydrogel for delivery of a payload |
| CN113939271B (zh) * | 2019-04-25 | 2025-04-04 | 视尔普斯眼科公司 | 眼用水凝胶酪氨酸激酶抑制剂植入物 |
| JP2022530142A (ja) * | 2019-04-25 | 2022-06-27 | オキュラ セラピューティクス，インコーポレイテッド | 麻酔薬を送達するための小管内ヒドロゲル挿入物 |
| WO2020219892A1 (en) * | 2019-04-25 | 2020-10-29 | Ocular Therapeutix, Inc. | Hydrogel implants for lowering intraocular pressure |
| CA3166738A1 (en) * | 2020-02-06 | 2021-08-12 | Charles D. Blizzard | Travoprost compositions and methods for treating ocular diseases |
| FI3884929T3 (fi) * | 2020-03-25 | 2023-08-07 | Ocular Therapeutix Inc | Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti |
| CA3177005A1 (en) * | 2020-04-27 | 2021-11-04 | Michael Goldstein | Methods of treating allergic conjunctivitis |
| KR20230041708A (ko) * | 2020-07-16 | 2023-03-24 | 오큘라 테라퓨틱스, 인코포레이티드 | 글루코코르티코이드를 함유하는 안구 삽입물 |
| EP4216929A1 (en) | 2020-09-24 | 2023-08-02 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent |
| EP4344745A3 (en) | 2020-09-24 | 2024-10-09 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine |
| EP4346720A4 (en) * | 2021-05-28 | 2025-01-01 | Sight Sciences, Inc. | INTRAOCULAR DEVICES, SYSTEMS AND METHODS |
| CN114748436B (zh) * | 2022-05-30 | 2023-05-16 | 迪沙药业集团有限公司 | 一种硝苯地平组合物及其制备方法 |
| CN119947711A (zh) * | 2022-08-12 | 2025-05-06 | 视尔普斯眼科公司 | 用于持续药物递送的有机凝胶、其制备方法和用途 |
| CN115337453A (zh) * | 2022-08-15 | 2022-11-15 | 珠海肤原生物科技有限公司 | 一种载有2-氧杂环庚烷酮的均聚物微球的医用无菌胶原蛋白产品的制备 |
| WO2024191453A1 (en) * | 2023-03-10 | 2024-09-19 | Clearstream Technologies Limited | Radiation spacer hydrogels, methods of forming, and methods of use |
| CN120897764A (zh) | 2023-04-11 | 2025-11-04 | 视尔普斯眼科公司 | 包含阿西替尼多晶型物iv的眼部植入物 |
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-
2017
- 2017-09-25 JP JP2019515849A patent/JP7430529B2/ja active Active
- 2017-09-25 CA CA3038075A patent/CA3038075A1/en active Pending
- 2017-09-25 DK DK17780606.4T patent/DK3515406T3/da active
- 2017-09-25 EP EP23154758.9A patent/EP4197527A1/en active Pending
- 2017-09-25 KR KR1020237011914A patent/KR20230053707A/ko not_active Ceased
- 2017-09-25 KR KR1020197011614A patent/KR102520771B1/ko active Active
- 2017-09-25 US US15/714,633 patent/US12171869B2/en active Active
- 2017-09-25 ES ES17780606T patent/ES2989941T3/es active Active
- 2017-09-25 WO PCT/US2017/053271 patent/WO2018058048A1/en not_active Ceased
- 2017-09-25 AU AU2017331444A patent/AU2017331444B2/en active Active
- 2017-09-25 IL IL265421A patent/IL265421B2/en unknown
- 2017-09-25 CN CN201780072266.9A patent/CN109982683A/zh active Pending
- 2017-09-25 EP EP17780606.4A patent/EP3515406B1/en active Active
- 2017-09-25 KR KR1020247011510A patent/KR102814241B1/ko active Active
-
2022
- 2022-04-08 JP JP2022064398A patent/JP7486539B2/ja active Active
- 2022-08-18 US US17/890,997 patent/US20220401356A1/en not_active Abandoned
-
2024
- 2024-11-11 US US18/943,498 patent/US20250144012A1/en active Pending
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