IL265421B2 - Means for transferring medicine to the anterior chamber in the eye - Google Patents

Means for transferring medicine to the anterior chamber in the eye

Info

Publication number
IL265421B2
IL265421B2 IL265421A IL26542119A IL265421B2 IL 265421 B2 IL265421 B2 IL 265421B2 IL 265421 A IL265421 A IL 265421A IL 26542119 A IL26542119 A IL 26542119A IL 265421 B2 IL265421 B2 IL 265421B2
Authority
IL
Israel
Prior art keywords
depot
hydrogel
depot composition
xerogel
travoprost
Prior art date
Application number
IL265421A
Other languages
English (en)
Hebrew (he)
Other versions
IL265421A (en
IL265421B1 (en
Original Assignee
Incept Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incept Llc filed Critical Incept Llc
Publication of IL265421A publication Critical patent/IL265421A/en
Publication of IL265421B1 publication Critical patent/IL265421B1/en
Publication of IL265421B2 publication Critical patent/IL265421B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL265421A 2016-09-23 2017-09-25 Means for transferring medicine to the anterior chamber in the eye IL265421B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662398985P 2016-09-23 2016-09-23
PCT/US2017/053271 WO2018058048A1 (en) 2016-09-23 2017-09-25 Intracameral drug delivery depots

Publications (3)

Publication Number Publication Date
IL265421A IL265421A (en) 2019-05-30
IL265421B1 IL265421B1 (en) 2023-12-01
IL265421B2 true IL265421B2 (en) 2024-04-01

Family

ID=60022215

Family Applications (1)

Application Number Title Priority Date Filing Date
IL265421A IL265421B2 (en) 2016-09-23 2017-09-25 Means for transferring medicine to the anterior chamber in the eye

Country Status (11)

Country Link
US (3) US12171869B2 (enExample)
EP (2) EP4197527A1 (enExample)
JP (2) JP7430529B2 (enExample)
KR (3) KR102814241B1 (enExample)
CN (1) CN109982683A (enExample)
AU (1) AU2017331444B2 (enExample)
CA (1) CA3038075A1 (enExample)
DK (1) DK3515406T3 (enExample)
ES (1) ES2989941T3 (enExample)
IL (1) IL265421B2 (enExample)
WO (1) WO2018058048A1 (enExample)

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US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
EP4197527A1 (en) 2016-09-23 2023-06-21 Incept, LLC Intracameral drug delivery depots
CA3133172A1 (en) * 2019-03-13 2020-09-17 Susmita Bose Enzyme-degradable hydrogel for delivery of a payload
US20200337990A1 (en) * 2019-04-25 2020-10-29 Ocular Therapeutix, Inc. Hydrogel implants for lowering intraocular pressure
AU2020262932B2 (en) * 2019-04-25 2025-11-13 Ocular Therapeutix, Inc. Intracanalicular hydrogel inserts for the delivery of anesthetics
CN120346152A (zh) * 2019-04-25 2025-07-22 视尔普斯眼科公司 眼用水凝胶酪氨酸激酶抑制剂植入物
PT3861985T (pt) 2020-02-06 2023-08-03 Ocular Therapeutix Inc Composições e métodos para tratar doenças oculares
ES2952677T3 (es) * 2020-03-25 2023-11-03 Ocular Therapeutix Inc Implante ocular que contiene un inhibidor de tirosina cinasa
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
CN116133664A (zh) * 2020-07-16 2023-05-16 视觉治疗股份有限公司 含有糖皮质激素的眼部插入物
JP2023542939A (ja) * 2020-09-24 2023-10-12 オキュラ セラピューティクス，インコーポレイテッド ヒドロゲル及び活性薬剤を含む徐放性生分解性小管内挿入物
DK3973952T3 (da) 2020-09-24 2024-03-18 Ocular Therapeutix Inc Bionedbrydelige intrakanalikulære indsatser med vedvarende frigivelse omfattende en hydrogel og cyclosporin
US20220378612A1 (en) * 2021-05-28 2022-12-01 Sight Sciences, Inc. Intraocular devices, systems, and methods
CN114748436B (zh) * 2022-05-30 2023-05-16 迪沙药业集团有限公司 一种硝苯地平组合物及其制备方法
CA3264199A1 (en) * 2022-08-12 2024-02-15 Ocular Therapeutix Inc ORGANOGELS FOR PROLONGED MEDICINE ADMINISTRATION, THEIR PREPARATION PROCESSES AND USE
CN115337453A (zh) * 2022-08-15 2022-11-15 珠海肤原生物科技有限公司 一种载有2-氧杂环庚烷酮的均聚物微球的医用无菌胶原蛋白产品的制备
WO2024191453A1 (en) * 2023-03-10 2024-09-19 Clearstream Technologies Limited Radiation spacer hydrogels, methods of forming, and methods of use
CN120897764A (zh) 2023-04-11 2025-11-04 视尔普斯眼科公司 包含阿西替尼多晶型物iv的眼部植入物

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Publication number Priority date Publication date Assignee Title
US20100209478A1 (en) * 2009-02-12 2010-08-19 Sawhney Amarpreet S Drug delivery through hydrogel plugs
WO2010111449A1 (en) * 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
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Also Published As

Publication number Publication date
IL265421A (en) 2019-05-30
KR20240051303A (ko) 2024-04-19
JP7486539B2 (ja) 2024-05-17
IL265421B1 (en) 2023-12-01
ES2989941T3 (es) 2024-11-28
KR20230053707A (ko) 2023-04-21
CA3038075A1 (en) 2018-03-29
KR20190057353A (ko) 2019-05-28
US20250144012A1 (en) 2025-05-08
US20220401356A1 (en) 2022-12-22
DK3515406T3 (da) 2024-10-14
US12171869B2 (en) 2024-12-24
WO2018058048A1 (en) 2018-03-29
AU2017331444B2 (en) 2023-08-17
JP7430529B2 (ja) 2024-02-13
US20180085307A1 (en) 2018-03-29
CN109982683A (zh) 2019-07-05
JP2019529455A (ja) 2019-10-17
KR102814241B1 (ko) 2025-05-29
EP3515406A1 (en) 2019-07-31
KR102520771B1 (ko) 2023-04-12
EP4197527A1 (en) 2023-06-21
EP3515406B1 (en) 2024-07-24
BR112019005594A2 (pt) 2019-08-13
JP2022091998A (ja) 2022-06-21
AU2017331444A1 (en) 2019-04-18

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