JP2022017461A5 - - Google Patents
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- Publication number
- JP2022017461A5 JP2022017461A5 JP2021179627A JP2021179627A JP2022017461A5 JP 2022017461 A5 JP2022017461 A5 JP 2022017461A5 JP 2021179627 A JP2021179627 A JP 2021179627A JP 2021179627 A JP2021179627 A JP 2021179627A JP 2022017461 A5 JP2022017461 A5 JP 2022017461A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- group optionally
- halogen atoms
- urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005843 halogen group Chemical group 0.000 claims 27
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- YASXOENRCPGYQB-VIFPVBQESA-N 1-[5-chloro-6-(difluoromethoxy)pyridin-3-yl]-3-[8-[(1S)-1-methoxyethyl]-2-methylimidazo[1,2-b]pyridazin-7-yl]urea Chemical compound ClC=1C=C(C=NC1OC(F)F)NC(=O)NC1=C(C=2N(N=C1)C=C(N2)C)[C@H](C)OC YASXOENRCPGYQB-VIFPVBQESA-N 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- XIZGLLSADFNPPE-LBPRGKRZSA-N 1-[4-[(1S)-1-methoxyethyl]-6-methyl-1,5-naphthyridin-3-yl]-3-[6-(triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea Chemical compound CO[C@@H](C)C1=C(C=NC2=CC=C(N=C12)C)NC(=O)NC=1C=NC(=C(C1)C(F)(F)F)N1N=CC=N1 XIZGLLSADFNPPE-LBPRGKRZSA-N 0.000 claims 1
- DPSKUJVVNPRGCG-UHFFFAOYSA-N 1-[5-chloro-6-(difluoromethoxy)pyridin-3-yl]-3-(2-chloro-8-propan-2-ylimidazo[1,2-b]pyridazin-7-yl)urea Chemical compound ClC=1C=C(C=NC1OC(F)F)NC(=O)NC1=C(C=2N(N=C1)C=C(N2)Cl)C(C)C DPSKUJVVNPRGCG-UHFFFAOYSA-N 0.000 claims 1
- JWALSWVUILVGEM-UHFFFAOYSA-N 1-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]-3-[8-(2-methoxypropan-2-yl)-2-methylimidazo[1,2-b]pyridazin-7-yl]urea Chemical compound ClC=1C=C(C=NC1N1N=CC=N1)NC(=O)NC1=C(C=2N(N=C1)C=C(N2)C)C(C)(C)OC JWALSWVUILVGEM-UHFFFAOYSA-N 0.000 claims 1
- ZRTRVWVBBGGJKA-NSHDSACASA-N 1-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]-3-[8-[(1S)-1-methoxyethyl]-2-methylimidazo[1,2-b]pyridazin-7-yl]urea Chemical compound ClC=1C=C(C=NC1N1N=CC=N1)NC(=O)NC1=C(C=2N(N=C1)C=C(N2)C)[C@H](C)OC ZRTRVWVBBGGJKA-NSHDSACASA-N 0.000 claims 1
- AGXMSTXRPJQSNW-JTQLQIEISA-N 1-[5-cyano-6-(difluoromethoxy)pyridin-3-yl]-3-[8-[(1S)-1-methoxyethyl]-2-methylimidazo[1,2-b]pyridazin-7-yl]urea Chemical compound C(#N)C=1C=C(C=NC1OC(F)F)NC(=O)NC1=C(C=2N(N=C1)C=C(N2)C)[C@H](C)OC AGXMSTXRPJQSNW-JTQLQIEISA-N 0.000 claims 1
- VDXYKDPULPAMFX-NSHDSACASA-N 1-[8-[(1S)-1-methoxyethyl]-2-methylimidazo[1,2-b]pyridazin-7-yl]-3-[6-(triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea Chemical compound CO[C@@H](C)C=1C=2N(N=CC1NC(=O)NC=1C=NC(=C(C1)C(F)(F)F)N1N=CC=N1)C=C(N2)C VDXYKDPULPAMFX-NSHDSACASA-N 0.000 claims 1
- TWJGQZBSEMDPQP-UHFFFAOYSA-N 2-chloro-n-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1,2,4-triazol-1-yl]phenyl]acetamide Chemical compound C=1C=C(NC(=O)CCl)C=CC=1N1N=C(OCCOC)N=C1C1=CC=C(Cl)C(Cl)=C1 TWJGQZBSEMDPQP-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 229940122339 MALT1 inhibitor Drugs 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical class 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000005945 imidazopyridyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018222530 | 2018-11-28 | ||
| JP2018222530 | 2018-11-28 | ||
| JP2020557754A JP6972384B2 (ja) | 2018-11-28 | 2019-11-27 | 複素環化合物 |
| PCT/JP2019/046261 WO2020111087A1 (ja) | 2018-11-28 | 2019-11-27 | 複素環化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557754A Division JP6972384B2 (ja) | 2018-11-28 | 2019-11-27 | 複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022017461A JP2022017461A (ja) | 2022-01-25 |
| JP2022017461A5 true JP2022017461A5 (OSRAM) | 2022-11-29 |
| JP7434249B2 JP7434249B2 (ja) | 2024-02-20 |
Family
ID=70853784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557754A Active JP6972384B2 (ja) | 2018-11-28 | 2019-11-27 | 複素環化合物 |
| JP2021179627A Active JP7434249B2 (ja) | 2018-11-28 | 2021-11-02 | 複素環化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557754A Active JP6972384B2 (ja) | 2018-11-28 | 2019-11-27 | 複素環化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US12152027B2 (OSRAM) |
| EP (1) | EP3888652A4 (OSRAM) |
| JP (2) | JP6972384B2 (OSRAM) |
| KR (2) | KR102646470B1 (OSRAM) |
| CN (2) | CN113038948B (OSRAM) |
| AU (1) | AU2019390863B2 (OSRAM) |
| BR (1) | BR112021009994A2 (OSRAM) |
| CA (1) | CA3120774A1 (OSRAM) |
| IL (2) | IL303962A (OSRAM) |
| MX (2) | MX2021005877A (OSRAM) |
| MY (1) | MY209902A (OSRAM) |
| PH (1) | PH12021551251A1 (OSRAM) |
| SG (1) | SG11202105652XA (OSRAM) |
| TW (3) | TWI784213B (OSRAM) |
| WO (1) | WO2020111087A1 (OSRAM) |
| ZA (1) | ZA202104402B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102646470B1 (ko) * | 2018-11-28 | 2024-03-11 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
| US20230192685A1 (en) * | 2020-05-27 | 2023-06-22 | Takeda Pharmaceutical Company Limited | Method for producing heterocyclic compound |
| CN116916924A (zh) * | 2020-10-16 | 2023-10-20 | 稀有生物科学股份有限公司 | Malt1调节剂及其用途 |
| GB202018412D0 (en) | 2020-11-23 | 2021-01-06 | Exscientia Ltd | Malt-1 modulators ii |
| JP2025501056A (ja) | 2021-12-30 | 2025-01-17 | シャンハイ ハンソー バイオメディカル カンパニー リミテッド | 三環系誘導体阻害剤、その製造方法と応用 |
| KR20240144146A (ko) | 2022-02-02 | 2024-10-02 | 오노 야꾸힝 고교 가부시키가이샤 | Malt1 저해약을 유효 성분으로서 포함하는 암 치료제 |
| US20250188081A1 (en) * | 2023-12-08 | 2025-06-12 | Shaman Pharma, LLC | Method for Production of Spiro-Oxindole and Indoxyl Derivatives of Mitragynine |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2288521A1 (fr) | 1974-10-25 | 1976-05-21 | Merck Patent Gmbh | Nouvelles penicillines et procede pour leur preparation |
| NZ308228A (en) * | 1995-05-31 | 1999-11-29 | Sumitomo Pharma | Substituted 1,8-naphthyridine derivatives |
| GB9720052D0 (en) | 1997-09-19 | 1997-11-19 | Smithkline Beecham Plc | Novel compounds |
| GB201321734D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| PL3149001T3 (pl) * | 2014-05-28 | 2019-10-31 | Novartis Ag | Nowe pochodne pirazolopirymidyny i ich zastosowanie jako inhibitory MALT1 |
| US20200289514A1 (en) | 2015-11-13 | 2020-09-17 | Novartis Ag | Novel Pyrazolo Pyrimidine Derivatives |
| JP2019522035A (ja) | 2016-07-29 | 2019-08-08 | ルピン・リミテッド | Ｍａｌｔ１阻害剤としての置換チアゾロ−ピリジン化合物 |
| WO2018085247A1 (en) * | 2016-11-01 | 2018-05-11 | Cornell University | Compounds for malt1 degradation |
| WO2018165385A1 (en) * | 2017-03-08 | 2018-09-13 | Cornell University | Inhibitors of malt1 and uses thereof |
| US20200111087A1 (en) * | 2018-10-08 | 2020-04-09 | Jinlei Zhou | Method for encrypting digital contract document between contractors |
| KR102646470B1 (ko) * | 2018-11-28 | 2024-03-11 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
-
2019
- 2019-11-27 KR KR1020227003334A patent/KR102646470B1/ko active Active
- 2019-11-27 MY MYPI2021002948A patent/MY209902A/en unknown
- 2019-11-27 TW TW108143201A patent/TWI784213B/zh active
- 2019-11-27 EP EP19890558.0A patent/EP3888652A4/en active Pending
- 2019-11-27 US US17/296,434 patent/US12152027B2/en active Active
- 2019-11-27 CN CN201980078144.XA patent/CN113038948B/zh active Active
- 2019-11-27 AU AU2019390863A patent/AU2019390863B2/en active Active
- 2019-11-27 MX MX2021005877A patent/MX2021005877A/es unknown
- 2019-11-27 TW TW113120662A patent/TW202438498A/zh unknown
- 2019-11-27 KR KR1020217019537A patent/KR102359143B1/ko active Active
- 2019-11-27 CN CN202410510968.2A patent/CN118420620A/zh active Pending
- 2019-11-27 IL IL303962A patent/IL303962A/en unknown
- 2019-11-27 JP JP2020557754A patent/JP6972384B2/ja active Active
- 2019-11-27 BR BR112021009994-8A patent/BR112021009994A2/pt unknown
- 2019-11-27 CA CA3120774A patent/CA3120774A1/en active Pending
- 2019-11-27 IL IL283368A patent/IL283368B2/en unknown
- 2019-11-27 TW TW111139300A patent/TWI848400B/zh active
- 2019-11-27 SG SG11202105652XA patent/SG11202105652XA/en unknown
- 2019-11-27 WO PCT/JP2019/046261 patent/WO2020111087A1/ja not_active Ceased
-
2021
- 2021-05-19 MX MX2024003064A patent/MX2024003064A/es unknown
- 2021-05-28 PH PH12021551251A patent/PH12021551251A1/en unknown
- 2021-06-25 ZA ZA2021/04402A patent/ZA202104402B/en unknown
- 2021-07-02 US US17/367,171 patent/US11230545B2/en active Active
- 2021-11-02 JP JP2021179627A patent/JP7434249B2/ja active Active
- 2021-11-17 US US17/528,677 patent/US11897879B2/en active Active
-
2024
- 2024-10-07 US US18/908,457 patent/US20250034141A1/en active Pending
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