JP2022016605A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022016605A5 JP2022016605A5 JP2021190717A JP2021190717A JP2022016605A5 JP 2022016605 A5 JP2022016605 A5 JP 2022016605A5 JP 2021190717 A JP2021190717 A JP 2021190717A JP 2021190717 A JP2021190717 A JP 2021190717A JP 2022016605 A5 JP2022016605 A5 JP 2022016605A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- recombinant human
- human type
- type
- subjecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 claims 40
- 108010035532 Collagen Proteins 0.000 claims 40
- 229920001436 collagen Polymers 0.000 claims 40
- 238000000034 method Methods 0.000 claims 29
- 239000002904 solvent Substances 0.000 claims 9
- 239000007788 liquid Substances 0.000 claims 8
- 238000000108 ultra-filtration Methods 0.000 claims 8
- 239000004475 Arginine Substances 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 6
- 239000012539 chromatography resin Substances 0.000 claims 5
- 239000012528 membrane Substances 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 4
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 3
- 102000004533 Endonucleases Human genes 0.000 claims 3
- 108010042407 Endonucleases Proteins 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- 238000005277 cation exchange chromatography Methods 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 3
- 239000012535 impurity Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000006228 supernatant Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000000502 dialysis Methods 0.000 claims 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 235000004554 glutamine Nutrition 0.000 claims 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 2
- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 claims 2
- MHCFAGZWMAWTNR-UHFFFAOYSA-M lithium perchlorate Chemical compound [Li+].[O-]Cl(=O)(=O)=O MHCFAGZWMAWTNR-UHFFFAOYSA-M 0.000 claims 2
- 229910001486 lithium perchlorate Inorganic materials 0.000 claims 2
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims 2
- 239000011654 magnesium acetate Substances 0.000 claims 2
- 235000011285 magnesium acetate Nutrition 0.000 claims 2
- 229940069446 magnesium acetate Drugs 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000001509 sodium citrate Substances 0.000 claims 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 2
- 239000001488 sodium phosphate Substances 0.000 claims 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 125000000185 sucrose group Chemical group 0.000 claims 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662309030P | 2016-03-16 | 2016-03-16 | |
| US62/309,030 | 2016-03-16 | ||
| JP2018548754A JP6985282B2 (ja) | 2016-03-16 | 2017-03-10 | ７型コラーゲンの精製方法 |
| PCT/US2017/021815 WO2017160636A1 (en) | 2016-03-16 | 2017-03-10 | Methods of purifying collagen 7 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548754A Division JP6985282B2 (ja) | 2016-03-16 | 2017-03-10 | ７型コラーゲンの精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022016605A JP2022016605A (ja) | 2022-01-21 |
| JP2022016605A5 true JP2022016605A5 (https=) | 2022-04-18 |
| JP7340583B2 JP7340583B2 (ja) | 2023-09-07 |
Family
ID=59852081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548754A Active JP6985282B2 (ja) | 2016-03-16 | 2017-03-10 | ７型コラーゲンの精製方法 |
| JP2021190717A Active JP7340583B2 (ja) | 2016-03-16 | 2021-11-25 | ７型コラーゲンの精製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548754A Active JP6985282B2 (ja) | 2016-03-16 | 2017-03-10 | ７型コラーゲンの精製方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10669327B2 (https=) |
| EP (1) | EP3429615A4 (https=) |
| JP (2) | JP6985282B2 (https=) |
| CN (1) | CN109069592B (https=) |
| CA (1) | CA3015685A1 (https=) |
| MX (1) | MX2018011162A (https=) |
| WO (1) | WO2017160636A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108463470B (zh) * | 2015-12-23 | 2021-10-22 | 菲尼克斯组织修复公司 | 胶原蛋白7的组合物及其使用方法 |
| US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
| US10792618B2 (en) * | 2018-06-19 | 2020-10-06 | Sartorius Stedim Biotech Gmbh | Particle separation and/or purification of a fluid |
| EP3953380A4 (en) | 2019-04-12 | 2023-01-25 | Geltor, Inc. | RECOMBINATION ELASTIN AND ASSOCIATED PRODUCTION |
| EP4061446A4 (en) | 2019-11-20 | 2023-11-29 | NxStage Medical, Inc. | METHODS, DEVICES AND SYSTEMS FOR PROVIDING PERITONEAL DIALYSIS LIQUID FROM A POWDERED CONCENTRATE |
| CN113121638B (zh) * | 2020-01-15 | 2022-06-14 | 鲁南制药集团股份有限公司 | 一种纯化重组蛋白的方法 |
| GB2610313B (en) | 2020-01-24 | 2024-07-03 | Geltor Inc | Animal-free dietary collagen |
| US11504716B2 (en) * | 2020-06-05 | 2022-11-22 | Pall Corporation | Multiwell device and method of use |
| EP4225353A1 (en) * | 2020-10-08 | 2023-08-16 | Jellatech, Inc. | Produce, isolate and/or extract collagen and/or gelatin from animal cell lines and/or tissue explants |
| KR20240004264A (ko) * | 2021-03-04 | 2024-01-11 | 젤라텍, 인크. | 배양된 동물 세포로부터의 콜라겐을 사용한 재료의 제조 방법 |
| CN114805548B (zh) * | 2021-12-29 | 2023-11-14 | 江苏创健医疗科技股份有限公司 | 一种重组胶原蛋白冻干纤维及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO599897A0 (en) * | 1997-04-03 | 1997-05-01 | Vidal, Linus | Clear collagen for facial implants |
| US7855280B2 (en) | 2005-09-15 | 2010-12-21 | Wyeth Llc | Separation methods |
| US9040484B2 (en) * | 2011-04-26 | 2015-05-26 | The Board Of Trustees Of The Leland Stanford Junior University | Production and delivery of a stable collagen |
| EP2753704A4 (en) * | 2011-08-03 | 2015-07-08 | Lotus Tissue Repair Inc | COLLAGEN 7 AND ASSOCIATED METHODS |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US20140031295A1 (en) * | 2012-07-19 | 2014-01-30 | Lotus Tissue Repair, Inc. | Recombinant C7 and Methods of Use |
| CN112126634A (zh) | 2013-01-09 | 2020-12-25 | 夏尔人类遗传性治疗公司 | 含用于纯化芳基硫酸酯酶a的方法 |
| KR20160055940A (ko) | 2013-09-24 | 2016-05-18 | 엘라스타겐 피티와이 리미티드 | 단백질 추출 방법 |
-
2017
- 2017-03-10 MX MX2018011162A patent/MX2018011162A/es unknown
- 2017-03-10 WO PCT/US2017/021815 patent/WO2017160636A1/en not_active Ceased
- 2017-03-10 CN CN201780015536.2A patent/CN109069592B/zh active Active
- 2017-03-10 US US16/084,998 patent/US10669327B2/en active Active
- 2017-03-10 EP EP17767212.8A patent/EP3429615A4/en active Pending
- 2017-03-10 CA CA3015685A patent/CA3015685A1/en active Pending
- 2017-03-10 JP JP2018548754A patent/JP6985282B2/ja active Active
-
2021
- 2021-11-25 JP JP2021190717A patent/JP7340583B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022016605A5 (https=) | ||
| JP2019511498A5 (https=) | ||
| CN102532254B (zh) | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 | |
| JP6985282B2 (ja) | ７型コラーゲンの精製方法 | |
| JP2012532932A5 (https=) | ||
| JP2011524887A5 (https=) | ||
| JP2017195897A5 (https=) | ||
| FI4104859T3 (fi) | Menetelmä vasta-aineiden ja niiden terapeuttisten tuotteiden väkevöimiseksi | |
| CN101838342B (zh) | 一种微藻胞外多糖的膜分离方法 | |
| CN102040531B (zh) | 一种提取l-异亮氨酸的方法 | |
| CN105175548A (zh) | 重组人血管内皮生长因子受体-抗体融合蛋白的纯化方法 | |
| JP5908496B2 (ja) | トランスジェニックイネの子実からヒト血清アルブミンを抽出する方法 | |
| JP2023515123A (ja) | アダリムマブのｎｏｎ－ｐｒｏｔｅｉｎ ａ精製方法 | |
| CN101845089B (zh) | 一种适合规模化生产眼镜蛇蛇毒神经毒素并降低神经毒性的方法 | |
| CN104072636B (zh) | 肝素钠的制备工艺 | |
| IL278584B2 (en) | Method and system of protein extraction | |
| US20260085294A1 (en) | Process for producing a purified rhabdovirus from cell culture | |
| JP2023159309A5 (https=) | ||
| CN1756587A (zh) | 重组白蛋白在肝衰竭后透析中的用途 | |
| CN110272486B (zh) | 一种蓝藻中藻蓝蛋白的提取方法 | |
| CN103724459B (zh) | 一种胶清废水资源化利用的方法 | |
| CN104497135A (zh) | 一种病毒灭活去除纯化乌司他丁的方法及含有乌司他丁的药物组合物 | |
| CN102617727A (zh) | 一种胸腺法新化合物及其新制法 | |
| JP7664185B2 (ja) | グループｂアデノウイルスを含む組成物を精製する方法 | |
| WO2026070787A1 (ja) | 脂質二重膜粒子の製造方法及び溶液組成物 |