JP2021534785A5 - - Google Patents

Info

Publication number
JP2021534785A5
JP2021534785A5 JP2021510707A JP2021510707A JP2021534785A5 JP 2021534785 A5 JP2021534785 A5 JP 2021534785A5 JP 2021510707 A JP2021510707 A JP 2021510707A JP 2021510707 A JP2021510707 A JP 2021510707A JP 2021534785 A5 JP2021534785 A5 JP 2021534785A5
Authority
JP
Japan
Prior art keywords
cells
exposure process
approximately
days
notch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021510707A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021534785A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/048574 external-priority patent/WO2020047099A1/en
Publication of JP2021534785A publication Critical patent/JP2021534785A/ja
Publication of JP2021534785A5 publication Critical patent/JP2021534785A5/ja
Pending legal-status Critical Current

Links

JP2021510707A 2018-08-28 2019-08-28 誘導ノッチシグナル伝達を用いた養子t細胞療法の方法及び組成物 Pending JP2021534785A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862723936P 2018-08-28 2018-08-28
US62/723,936 2018-08-28
PCT/US2019/048574 WO2020047099A1 (en) 2018-08-28 2019-08-28 Methods and compositions for adoptive t cell therapy incorporating induced notch signaling

Publications (2)

Publication Number Publication Date
JP2021534785A JP2021534785A (ja) 2021-12-16
JP2021534785A5 true JP2021534785A5 (https=) 2022-06-03

Family

ID=67982131

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021510707A Pending JP2021534785A (ja) 2018-08-28 2019-08-28 誘導ノッチシグナル伝達を用いた養子t細胞療法の方法及び組成物

Country Status (9)

Country Link
US (1) US20210292711A1 (https=)
EP (1) EP3844266A1 (https=)
JP (1) JP2021534785A (https=)
CN (1) CN112930393A (https=)
AU (1) AU2019329984A1 (https=)
BR (1) BR112021003830A2 (https=)
CA (1) CA3110089A1 (https=)
SG (1) SG11202101455TA (https=)
WO (1) WO2020047099A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220241335A1 (en) * 2019-07-11 2022-08-04 H. Lee Moffitt Cancer Center And Research Inst5Itute, Inc. Engineering notch ligands to enhance the anti-tumor activity of adoptively transferred t cells
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
WO2022165367A1 (en) * 2021-01-29 2022-08-04 Fred Hutchinson Cancer Research Center Methods and compositions for enhancing cd4+ phenotype for adoptive t cell therapy
CN113832102B (zh) * 2021-09-27 2024-03-12 苏州东岭生物技术有限公司 Cd3/cd28/dll4磁珠及其制备方法和应用
CN116716349B (zh) * 2023-08-01 2023-10-31 江苏集萃药康生物科技股份有限公司 一种dll4人源化小鼠模型的构建方法及其应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA136551A (en) 1911-08-03 1911-10-31 Hedwig Heeron Rolling mill
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
US5420032A (en) 1991-12-23 1995-05-30 Universitge Laval Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
US5792632A (en) 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
CN1524583A (zh) * 1996-11-07 2004-09-01 能够表达Notch-配体的基因在制备用于免疫治疗的药物中的应用
EP1109921A4 (en) 1998-09-04 2002-08-28 Sloan Kettering Inst Cancer FUSION RECEPTORS SPECIFIC TO MEMBRANE SPECIFIC PROSTATIC ANTIGEN AND USES THEREOF
US20020131960A1 (en) 2000-06-02 2002-09-19 Michel Sadelain Artificial antigen presenting cells and methods of use thereof
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6689744B2 (en) 2000-09-22 2004-02-10 Genentech, Inc. Notch receptor agonists and uses
US20030119771A1 (en) 2001-08-22 2003-06-26 Rompaey Luc Van Modulators of bone homeostasis identified in a high-throughput screen
JP2003093048A (ja) * 2001-09-26 2003-04-02 Asahi Kasei Corp 新規細胞製剤製造用培養媒体
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
AU2003215869B2 (en) 2002-03-15 2008-04-24 Cellectis Hybrid and single chain meganucleases and use thereof
AU2003226537A1 (en) * 2002-04-05 2003-10-27 Lorantis Limited Modulators of the notch signalling pathway and uses thereof in medical treatment
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
EP1549347A1 (en) * 2002-10-09 2005-07-06 Lorantis Limited Modulation of immune function
JP2006517533A (ja) * 2003-01-23 2006-07-27 ロランティス リミテッド Notchシグナル伝達経路のアクチベーターを用いる自己免疫疾患の治療
EP3202899B1 (en) 2003-01-28 2020-10-21 Cellectis Custom-made meganuclease and use thereof
CA2589279A1 (en) * 2004-11-24 2006-06-01 Val-Chum, S.E.C. Methods to identify, prepare, and use naive t cell recent thymic emigrants
WO2007027226A2 (en) * 2005-04-28 2007-03-08 Board Of Regents, The University Of Texas System Systems and methods for the production of differentiated cells
ES2582091T3 (es) 2005-10-18 2016-09-09 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
PE20080891A1 (es) 2006-10-19 2008-08-25 Genentech Inc Anticuerpos anti-notch3 y composiciones que los comprenden
RU2461569C2 (ru) 2006-10-19 2012-09-20 Дженентек, Инк. Агонистические антитела против notch3 и их применение для лечения notch3-ассоциированных заболеваний
WO2008092445A2 (de) * 2007-01-30 2008-08-07 Deutsches Rheuma-Forschungszentrum Berlin Verfahren zur modulation der immunantwort durch aktivierung oder inaktivierung des notch und/oder stat4 signalweges
SI2856876T1 (en) 2007-03-30 2018-04-30 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
CA2742969A1 (en) 2008-11-07 2010-05-14 Fabrus Llc Anti-dll4 antibodies and uses thereof
US20110286916A1 (en) 2008-11-20 2011-11-24 Jose Miguel Aste-Amezaga Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
WO2010141249A2 (en) 2009-06-02 2010-12-09 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-notch3 antibodies
US8586526B2 (en) 2010-05-17 2013-11-19 Sangamo Biosciences, Inc. DNA-binding proteins and uses thereof
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
US10316289B2 (en) * 2012-09-06 2019-06-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T memory stem cell populations
US20140186843A1 (en) 2012-12-12 2014-07-03 Massachusetts Institute Of Technology Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US10696946B2 (en) * 2013-02-22 2020-06-30 The Board Of Trustees Of The University Of Illinois T-REG cell expansion
US9683039B2 (en) 2013-03-14 2017-06-20 New York University Notch agonists for the treatment of cancer
CA2930877A1 (en) 2013-11-18 2015-05-21 Crispr Therapeutics Ag Crispr-cas system materials and methods
CA2948871A1 (en) 2014-05-22 2015-11-26 Fred Hutchinson Cancer Research Center Lilrb2 and notch-mediated expansion of hematopoietic precursor cells
CN106459919B (zh) 2014-06-04 2021-03-23 弗莱德哈钦森癌症研究中心 使用notch 1和/或notch 2激动剂扩增和植入干细胞
HK1243631A1 (zh) * 2014-10-27 2018-07-20 Fred Hutchinson Cancer Research Center 用於提高过继细胞免疫疗法效力的组合物和方法
US10947502B2 (en) * 2015-10-20 2021-03-16 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
AU2016341529B2 (en) * 2015-10-22 2023-03-30 Juno Therapeutics Gmbh Methods for culturing cells and kits and apparatus for same
SG11201803419PA (en) * 2015-10-30 2018-05-30 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
WO2017173551A1 (en) * 2016-04-08 2017-10-12 The Governing Council Of The University Of Toronto Method for generating progenitor t cells from stem and/or progenitor cells and use of same
US11261250B2 (en) 2016-07-22 2022-03-01 Fred Hutchinson Cancer Research Center Bi-specific molecule for cell-specific Notch inhibition and related methods and compositions

Similar Documents

Publication Publication Date Title
JP2021534785A5 (https=)
JP2024041873A5 (https=)
JP7698672B2 (ja) ガンマデルタt細胞の増幅、組成物およびその使用
Karpus et al. CD4+ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor‐associated determinants on effector cells by interleukin‐4 secretion
Boyman et al. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia
Linterman et al. Signals that influence T follicular helper cell differentiation and function
CA2446981C (fr) Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene
Sredni et al. Antigen-specific human T-cell clones: development of clones requiring HLA-DR-compatible presenting cells for stimulation in presence of antigen.
JP2021502414A5 (https=)
JP2021501596A5 (https=)
CA2133409A1 (en) Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
JP2018531035A5 (https=)
CN110461357A (zh) 抗cd16a抗体与细胞因子的组合
Lee et al. Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis
RU2016151694A (ru) Экспансия лимфоцитов с использованием композиции цитокинов для активной клеточной иммунотерапии
JP2022541523A5 (https=)
Wang et al. Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1
JP2000509604A (ja) サプレッサー細胞集団を生成するためのインターロイキン―10の使用
EP0768890B1 (en) Methods for modulating t cell responses by manipulating a common cytokine receptor gamma chain
JP2023539056A5 (https=)
WO2001038494A1 (en) Method of proliferating natural killer cells
Rohrer et al. Human breast carcinoma patients develop clonable oncofetal antigen-specific effector and regulatory T lymphocytes
US20200248140A1 (en) Methods and materials for expanding antigen-specific t cells in culture
JP2005185275A (ja) T細胞活性化
JP2022510387A5 (https=)