AU2003226537A1 - Modulators of the notch signalling pathway and uses thereof in medical treatment - Google Patents

Modulators of the notch signalling pathway and uses thereof in medical treatment

Info

Publication number
AU2003226537A1
AU2003226537A1 AU2003226537A AU2003226537A AU2003226537A1 AU 2003226537 A1 AU2003226537 A1 AU 2003226537A1 AU 2003226537 A AU2003226537 A AU 2003226537A AU 2003226537 A AU2003226537 A AU 2003226537A AU 2003226537 A1 AU2003226537 A1 AU 2003226537A1
Authority
AU
Australia
Prior art keywords
modulators
medical treatment
signalling pathway
notch signalling
notch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003226537A
Other versions
AU2003226537A8 (en
Inventor
Mark William Bodmer
Emmanuel Cyrille Pascal Briend
Brian Robert Champion
Andrew Christopher Lennard
Grahame James Mckenzie
Tamara Tugal
George Albert Ward
Lesley Lynn Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celldex Therapeutics Ltd
Original Assignee
Lorantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207930A external-priority patent/GB0207930D0/en
Priority claimed from GB0207929A external-priority patent/GB0207929D0/en
Priority claimed from GB0212283A external-priority patent/GB0212283D0/en
Priority claimed from GB0212282A external-priority patent/GB0212282D0/en
Priority claimed from PCT/GB2002/003426 external-priority patent/WO2003011317A1/en
Priority claimed from GB0220912A external-priority patent/GB0220912D0/en
Priority claimed from GB0220913A external-priority patent/GB0220913D0/en
Priority claimed from GB0300234A external-priority patent/GB0300234D0/en
Application filed by Lorantis Ltd filed Critical Lorantis Ltd
Publication of AU2003226537A8 publication Critical patent/AU2003226537A8/en
Publication of AU2003226537A1 publication Critical patent/AU2003226537A1/en
Abandoned legal-status Critical Current

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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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AU2003226537A 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment Abandoned AU2003226537A1 (en)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
GB0207930.9 2002-04-05
GB0207930A GB0207930D0 (en) 2002-04-05 2002-04-05 A method
GB0207929A GB0207929D0 (en) 2002-04-05 2002-04-05 A method
GB0207929.1 2002-04-05
GB0212283A GB0212283D0 (en) 2002-05-28 2002-05-28 A method
GB0212283.6 2002-05-28
GB0212282.8 2002-05-28
GB0212282A GB0212282D0 (en) 2002-05-28 2002-05-28 A method
AU2002317984 2002-07-25
AUPCT/GB2002/003426 2002-07-25
PCT/GB2002/003426 WO2003011317A1 (en) 2001-07-25 2002-07-25 Modulators of notch signalling for use in immunotherapy
PCT/GB2002/003397 WO2003012441A1 (en) 2001-07-25 2002-07-25 Method for detecting modulators of notch signalling
GB0220912A GB0220912D0 (en) 2002-09-10 2002-09-10 Medical treatment
GB0220913.8 2002-09-10
GB0220912.0 2002-09-10
GB0220913A GB0220913D0 (en) 2002-09-10 2002-09-10 Medical treatment
GB0300234.2 2003-01-07
GB0300234A GB0300234D0 (en) 2003-01-07 2003-01-07 Medical treatment
PCT/GB2003/001525 WO2003087159A2 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment

Publications (2)

Publication Number Publication Date
AU2003226537A8 AU2003226537A8 (en) 2003-10-27
AU2003226537A1 true AU2003226537A1 (en) 2003-10-27

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Application Number Title Priority Date Filing Date
AU2003226537A Abandoned AU2003226537A1 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment

Country Status (4)

Country Link
EP (1) EP1492816A2 (en)
JP (1) JP2006506322A (en)
AU (1) AU2003226537A1 (en)
WO (1) WO2003087159A2 (en)

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GB0220658D0 (en) * 2002-09-05 2002-10-16 Lorantis Ltd Immunotherapy
JP2006515177A (en) * 2002-09-10 2006-05-25 ロランティス リミテッド Pharmaceutical composition comprising Notch ligand protein and medical treatment
WO2004060262A2 (en) * 2003-01-07 2004-07-22 Lorantis Limited Modulators of notch signalling for use in immunotherpapy
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
JP2006517533A (en) * 2003-01-23 2006-07-27 ロランティス リミテッド Treatment of autoimmune diseases using activators of the Notch signaling pathway
WO2004083372A2 (en) * 2003-03-21 2004-09-30 Lorantis Limited Modulators of the notch signaling pathway immobilized on particles for modifying immune responses
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
JP2006525026A (en) 2003-05-02 2006-11-09 ヘルス　リサーチ　インコーポレイテッド Use of JAG2 expression in the diagnosis of plasma cell diseases
AU2004294563B2 (en) * 2003-11-26 2009-03-26 Health Research, Inc. Use of notch pathway interfering agents for treatment of plasma cell disorders
WO2005111072A2 (en) 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Notch-based fusion proteins and uses thereof
WO2007027226A2 (en) * 2005-04-28 2007-03-08 Board Of Regents, The University Of Texas System Systems and methods for the production of differentiated cells
US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
NZ583649A (en) * 2007-08-23 2012-06-29 Univ Columbia Compositions of humanized notch fusion proteins and methods of treatment
BRPI0912912A2 (en) 2008-08-22 2016-07-05 Univ Columbia fusion protein, method for treating an individual who has a tumor, method for inhibiting angiogenesis in an individual, method for treating an individual who has ovarian cancer, method for treating an individual who has metabolic disorder, use of fusion protein, method for inhibiting physiological lymphangiogenesis or pathological lymphangiogenesis in an individual, method for inhibiting tumor metastasis in an individual, method for inhibiting the growth of a secondary tumor in an individual, method for inhibiting cooptation of a blood vessel by a tumor in an individual, Method To Treat An Individual's Breast Cancer
TW201329105A (en) 2011-10-04 2013-07-16 Thr Trustees Of Columbia University In The City Of New York Human Notch1 decoys
JP2021514185A (en) * 2018-02-14 2021-06-10 サニーブルック リサーチ インスティチュート Methods for generating cells of the T cell lineage
US20210220434A1 (en) * 2018-07-26 2021-07-22 The Regents Of The University Of California Treatment of Vascular Occlusion by Activation of Notch Signaling
JP2021534785A (en) * 2018-08-28 2021-12-16 フレッド ハッチンソン キャンサー リサーチ センター Methods and Compositions for Adoptive T Cell Therapy Using Induced Notch Signaling

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EP0913404B1 (en) * 1996-07-16 2006-06-14 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
EP0942998B1 (en) * 1996-11-07 2005-07-06 Lorantis Limited Notch
AU1054900A (en) * 1998-10-30 2000-05-22 Smith & Nephew Plc Compositions comprising notch receptor manipulating agents
EP1446424A2 (en) * 2001-11-14 2004-08-18 Lorantis Limited Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system

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AU2003226537A8 (en) 2003-10-27
WO2003087159A8 (en) 2005-05-12
JP2006506322A (en) 2006-02-23
EP1492816A2 (en) 2005-01-05
WO2003087159A2 (en) 2003-10-23
WO2003087159A3 (en) 2004-02-05

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