AU2003226537A8 - Modulators of the notch signalling pathway and uses thereof in medical treatment - Google Patents

Modulators of the notch signalling pathway and uses thereof in medical treatment

Info

Publication number
AU2003226537A8
AU2003226537A8 AU2003226537A AU2003226537A AU2003226537A8 AU 2003226537 A8 AU2003226537 A8 AU 2003226537A8 AU 2003226537 A AU2003226537 A AU 2003226537A AU 2003226537 A AU2003226537 A AU 2003226537A AU 2003226537 A8 AU2003226537 A8 AU 2003226537A8
Authority
AU
Australia
Prior art keywords
modulators
medical treatment
signalling pathway
notch signalling
notch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003226537A
Other versions
AU2003226537A1 (en
Inventor
Andrew Christopher Lennard
Mark William Bodmer
Lesley Lynn Young
Brian Robert Champion
Grahame James Mckenzie
George Albert Ward
Tamara Tugal
Emmanuel Cyrille Pascal Briend
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celldex Therapeutics Ltd
Original Assignee
Lorantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207929A external-priority patent/GB0207929D0/en
Priority claimed from GB0207930A external-priority patent/GB0207930D0/en
Priority claimed from GB0212283A external-priority patent/GB0212283D0/en
Priority claimed from GB0212282A external-priority patent/GB0212282D0/en
Priority claimed from PCT/GB2002/003397 external-priority patent/WO2003012441A1/en
Priority claimed from GB0220913A external-priority patent/GB0220913D0/en
Priority claimed from GB0220912A external-priority patent/GB0220912D0/en
Priority claimed from GB0300234A external-priority patent/GB0300234D0/en
Application filed by Lorantis Ltd filed Critical Lorantis Ltd
Publication of AU2003226537A1 publication Critical patent/AU2003226537A1/en
Publication of AU2003226537A8 publication Critical patent/AU2003226537A8/en
Abandoned legal-status Critical Current

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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
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  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
AU2003226537A 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment Abandoned AU2003226537A1 (en)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
GB0207929.1 2002-04-05
GB0207929A GB0207929D0 (en) 2002-04-05 2002-04-05 A method
GB0207930.9 2002-04-05
GB0207930A GB0207930D0 (en) 2002-04-05 2002-04-05 A method
GB0212282.8 2002-05-28
GB0212283.6 2002-05-28
GB0212283A GB0212283D0 (en) 2002-05-28 2002-05-28 A method
GB0212282A GB0212282D0 (en) 2002-05-28 2002-05-28 A method
AU2002317984 2002-07-25
PCT/GB2002/003397 WO2003012441A1 (en) 2001-07-25 2002-07-25 Method for detecting modulators of notch signalling
PCT/GB2002/003426 WO2003011317A1 (en) 2001-07-25 2002-07-25 Modulators of notch signalling for use in immunotherapy
AUPCT/GB2002/003426 2002-07-25
GB0220912.0 2002-09-10
GB0220913.8 2002-09-10
GB0220913A GB0220913D0 (en) 2002-09-10 2002-09-10 Medical treatment
GB0220912A GB0220912D0 (en) 2002-09-10 2002-09-10 Medical treatment
GB0300234A GB0300234D0 (en) 2003-01-07 2003-01-07 Medical treatment
GB0300234.2 2003-01-07
PCT/GB2003/001525 WO2003087159A2 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment

Publications (2)

Publication Number Publication Date
AU2003226537A1 AU2003226537A1 (en) 2003-10-27
AU2003226537A8 true AU2003226537A8 (en) 2003-10-27

Family

ID=34109266

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003226537A Abandoned AU2003226537A1 (en) 2002-04-05 2003-04-04 Modulators of the notch signalling pathway and uses thereof in medical treatment

Country Status (4)

Country Link
EP (1) EP1492816A2 (en)
JP (1) JP2006506322A (en)
AU (1) AU2003226537A1 (en)
WO (1) WO2003087159A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0220658D0 (en) * 2002-09-05 2002-10-16 Lorantis Ltd Immunotherapy
JP2006515177A (en) * 2002-09-10 2006-05-25 ロランティス リミテッド Pharmaceutical composition comprising Notch ligand protein and medical treatment
WO2004060262A2 (en) * 2003-01-07 2004-07-22 Lorantis Limited Modulators of notch signalling for use in immunotherpapy
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
WO2004064863A1 (en) * 2003-01-23 2004-08-05 Lorantis Limited Treatment of autoimmune diseases using an activator for the notch signaling pathway
WO2004083372A2 (en) * 2003-03-21 2004-09-30 Lorantis Limited Modulators of the notch signaling pathway immobilized on particles for modifying immune responses
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
WO2004099379A2 (en) 2003-05-02 2004-11-18 Health Research, Inc. Use of jag2 expression in diagnosis of plasma cell disorders
JP2007512348A (en) * 2003-11-26 2007-05-17 ヘルス　リサーチ　インコーポレイテッド Use of Notch pathway interference agents for the treatment of plasma cells
WO2005111072A2 (en) 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Notch-based fusion proteins and uses thereof
WO2007027226A2 (en) * 2005-04-28 2007-03-08 Board Of Regents, The University Of Texas System Systems and methods for the production of differentiated cells
US7906116B2 (en) 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
JP2010536855A (en) * 2007-08-23 2010-12-02 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク Compositions and methods of treatment of humanized Notch fusion proteins
KR20110074846A (en) 2008-08-22 2011-07-04 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 Human notch3 based fusion proteins as decoy inhibitors of notch3 signaling
AR088048A1 (en) 2011-10-04 2014-05-07 Univ Columbia NOTCH1 HUMAN LURE
WO2019157597A1 (en) * 2018-02-14 2019-08-22 Sunnybrook Research Institute Method for generating cells of the t cell lineage
WO2020023807A1 (en) * 2018-07-26 2020-01-30 The Regents Of The University Of California Treatment of vascular occlusion by activation of notch signaling
WO2020047099A1 (en) * 2018-08-28 2020-03-05 Fred Hutchinson Cancer Research Center Methods and compositions for adoptive t cell therapy incorporating induced notch signaling

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291210B1 (en) * 1996-07-16 2001-09-18 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
RO120850B1 (en) * 1996-11-07 2006-08-30 Imperial College Of Science Technology & Medic Notch
WO2000025809A1 (en) * 1998-10-30 2000-05-11 Smith & Nephew Plc Compositions comprising notch receptor manipulating agents
CA2465304A1 (en) * 2001-11-14 2003-05-22 Lorantis Limited Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system

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