JP2021533087A - 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー - Google Patents

神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー Download PDF

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JP2021533087A
JP2021533087A JP2020571842A JP2020571842A JP2021533087A JP 2021533087 A JP2021533087 A JP 2021533087A JP 2020571842 A JP2020571842 A JP 2020571842A JP 2020571842 A JP2020571842 A JP 2020571842A JP 2021533087 A JP2021533087 A JP 2021533087A
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JPWO2020006075A5 (https=
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ジー ホルティ アンドリュー
ナイク ラヴィ
エフ ダンナルズ ロバート
ジー ポンパー マーティン
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
JP2020571842A 2018-06-26 2019-06-26 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー Pending JP2021533087A (ja)

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Application Number Priority Date Filing Date Title
JP2024096077A JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689958P 2018-06-26 2018-06-26
US62/689,958 2018-06-26
PCT/US2019/039234 WO2020006075A1 (en) 2018-06-26 2019-06-26 Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation

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JP2024096077A Division JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

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JP2021533087A true JP2021533087A (ja) 2021-12-02
JP2021533087A5 JP2021533087A5 (https=) 2022-07-25
JPWO2020006075A5 JPWO2020006075A5 (https=) 2022-07-25

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JP2020571842A Pending JP2021533087A (ja) 2018-06-26 2019-06-26 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー
JP2024096077A Pending JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

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JP2024096077A Pending JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

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US (1) US20210290784A1 (https=)
EP (1) EP3813890A4 (https=)
JP (2) JP2021533087A (https=)
KR (1) KR20210013769A (https=)
CN (2) CN118743770A (https=)
AU (1) AU2019294699B2 (https=)
BR (1) BR112020026602A2 (https=)
CA (1) CA3104520A1 (https=)
EA (1) EA202092843A1 (https=)
IL (1) IL279768B2 (https=)
MX (1) MX2021000141A (https=)
WO (1) WO2020006075A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022513971A (ja) * 2018-12-20 2022-02-09 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド

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WO2020132651A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Kif18a inhibitors
EP3898616B1 (en) 2018-12-20 2024-10-02 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
US12540129B2 (en) 2019-08-02 2026-02-03 Amgen Inc. KIF18A inhibitors
WO2021026099A1 (en) 2019-08-02 2021-02-11 Amgen Inc. Kif18a inhibitors
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
CA3221884A1 (en) * 2021-06-11 2022-12-15 Norman Lafrance Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor
CN118027009B (zh) * 2024-04-15 2024-07-12 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用
CN119498255B (zh) * 2024-10-24 2025-11-25 香港理工大学深圳研究院 一种抑郁症小鼠模型及其构建方法与应用

Citations (1)

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JP2008517945A (ja) * 2004-10-22 2008-05-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ−ｆｍｓキナーゼのインヒビターとしての芳香族アミド

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CN109069666B (zh) * 2016-04-29 2023-04-04 纪念斯隆凯特琳癌症中心 使靶向颗粒穿透、分布和响应于恶性脑肿瘤中的组合物和方法

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2008517945A (ja) * 2004-10-22 2008-05-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ−ｆｍｓキナーゼのインヒビターとしての芳香族アミド

Non-Patent Citations (4)

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Title
BAUER F. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, JPN6023017447, 2010, pages 5489 - 5497, ISSN: 0005404701 *
BERNARD-GAUTHIER V. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, JPN6023017444, 2014, pages 4784 - 4790, ISSN: 0005052570 *
ILLIG C. R. ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, JPN6023017446, 2008, pages 1642 - 1648, ISSN: 0005404700 *
NAIK R. ET AL.: "PET tracer for imaging the macrophage cology stimulating factor receptor (CSF1R) in rodent brain", JOURNAL OF NUCLEAR MEDICINE, vol. 59(supplement 1), JPN6023017445, 2018, pages 547, ISSN: 0005404699 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022513971A (ja) * 2018-12-20 2022-02-09 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド
JP7676308B2 (ja) 2018-12-20 2025-05-14 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド

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WO2020006075A1 (en) 2020-01-02
EP3813890A4 (en) 2022-03-23
MX2021000141A (es) 2021-03-25
KR20210013769A (ko) 2021-02-05
AU2019294699A1 (en) 2021-01-21
CN118743770A (zh) 2024-10-08
IL279768A (en) 2021-03-01
EP3813890A1 (en) 2021-05-05
IL279768B2 (en) 2025-04-01
US20210290784A1 (en) 2021-09-23
AU2019294699B2 (en) 2025-05-01
JP2024133496A (ja) 2024-10-02
EA202092843A1 (ru) 2021-04-19
CN112638431A (zh) 2021-04-09
CA3104520A1 (en) 2020-01-02
IL279768B1 (en) 2024-12-01
BR112020026602A2 (pt) 2021-03-23

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