CN118743770A - 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 - Google Patents
用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nuclear Medicine (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862689958P | 2018-06-26 | 2018-06-26 | |
| US62/689,958 | 2018-06-26 | ||
| CN201980056945.6A CN112638431A (zh) | 2018-06-26 | 2019-06-26 | 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 |
| PCT/US2019/039234 WO2020006075A1 (en) | 2018-06-26 | 2019-06-26 | Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation |
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| CN201980056945.6A Division CN112638431A (zh) | 2018-06-26 | 2019-06-26 | 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 |
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| CN118743770A true CN118743770A (zh) | 2024-10-08 |
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| CN202410732670.6A Pending CN118743770A (zh) | 2018-06-26 | 2019-06-26 | 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 |
| CN201980056945.6A Pending CN112638431A (zh) | 2018-06-26 | 2019-06-26 | 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201980056945.6A Pending CN112638431A (zh) | 2018-06-26 | 2019-06-26 | 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210290784A1 (https=) |
| EP (1) | EP3813890A4 (https=) |
| JP (2) | JP2021533087A (https=) |
| KR (1) | KR20210013769A (https=) |
| CN (2) | CN118743770A (https=) |
| AU (1) | AU2019294699B2 (https=) |
| BR (1) | BR112020026602A2 (https=) |
| CA (1) | CA3104520A1 (https=) |
| EA (1) | EA202092843A1 (https=) |
| IL (1) | IL279768B2 (https=) |
| MX (1) | MX2021000141A (https=) |
| WO (1) | WO2020006075A1 (https=) |
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| WO2020132651A1 (en) | 2018-12-20 | 2020-06-25 | Amgen Inc. | Kif18a inhibitors |
| EP3898616B1 (en) | 2018-12-20 | 2024-10-02 | Amgen Inc. | Heteroaryl amides useful as kif18a inhibitors |
| JP7676308B2 (ja) * | 2018-12-20 | 2025-05-14 | アムジエン・インコーポレーテツド | Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド |
| US12540129B2 (en) | 2019-08-02 | 2026-02-03 | Amgen Inc. | KIF18A inhibitors |
| WO2021026099A1 (en) | 2019-08-02 | 2021-02-11 | Amgen Inc. | Kif18a inhibitors |
| EP4269404A4 (en) * | 2020-12-25 | 2024-12-04 | Xizang Haisco Pharmaceutical Co., Ltd. | KETOHEXOKINASE INHIBITORS AND USE THEREOF |
| CA3221884A1 (en) * | 2021-06-11 | 2022-12-15 | Norman Lafrance | Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease |
| AU2024214768A1 (en) * | 2023-01-30 | 2025-08-07 | The Johns Hopkins University | 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor |
| CN118027009B (zh) * | 2024-04-15 | 2024-07-12 | 北京师范大学 | 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用 |
| CN119498255B (zh) * | 2024-10-24 | 2025-11-25 | 香港理工大学深圳研究院 | 一种抑郁症小鼠模型及其构建方法与应用 |
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| BR112020026602A2 (pt) | 2021-03-23 |
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